SK284777B6 - Kryštalická polymorfná forma guajacyl esteru kyseliny 1-metyl-5-p-toluoylpyrol-2-acetaminooctovej a spôsob jej prípravy - Google Patents
Kryštalická polymorfná forma guajacyl esteru kyseliny 1-metyl-5-p-toluoylpyrol-2-acetaminooctovej a spôsob jej prípravy Download PDFInfo
- Publication number
- SK284777B6 SK284777B6 SK895-2000A SK8952000A SK284777B6 SK 284777 B6 SK284777 B6 SK 284777B6 SK 8952000 A SK8952000 A SK 8952000A SK 284777 B6 SK284777 B6 SK 284777B6
- Authority
- SK
- Slovakia
- Prior art keywords
- methyl
- toluoylpyrrole
- ester
- acetamidoacetic acid
- mixture
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/323—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to the ring nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pain & Pain Management (AREA)
- Public Health (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrrole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT97RM000811A IT1297140B1 (it) | 1997-12-24 | 1997-12-24 | Forma cristallina del guaiacil estere dell'acido l-metil-5-p-toluoil- pirrol-2-acetammidoacetico, procedimento per la sua preparazione e |
PCT/IT1998/000363 WO1999033797A1 (en) | 1997-12-24 | 1998-12-16 | NEW CRYSTALLINE POLYMORPHIC FORM OF 1-METHYL-5-p-TOLUOYLPYRROLE-2-ACETAMIDOACETIC ACID GUAIACYL ESTER (MED 15) |
Publications (2)
Publication Number | Publication Date |
---|---|
SK8952000A3 SK8952000A3 (en) | 2000-12-11 |
SK284777B6 true SK284777B6 (sk) | 2005-11-03 |
Family
ID=11405418
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SK895-2000A SK284777B6 (sk) | 1997-12-24 | 1998-12-16 | Kryštalická polymorfná forma guajacyl esteru kyseliny 1-metyl-5-p-toluoylpyrol-2-acetaminooctovej a spôsob jej prípravy |
Country Status (22)
Country | Link |
---|---|
US (1) | US6288241B1 (da) |
EP (1) | EP1082304B1 (da) |
JP (1) | JP4693236B2 (da) |
KR (1) | KR100554704B1 (da) |
CN (1) | CN1200930C (da) |
AT (1) | ATE255562T1 (da) |
AU (1) | AU781283B2 (da) |
BR (1) | BR9814476A (da) |
CA (1) | CA2315835C (da) |
CZ (1) | CZ297132B6 (da) |
DE (1) | DE69820301T2 (da) |
DK (1) | DK1082304T3 (da) |
ES (1) | ES2210853T3 (da) |
HK (1) | HK1035717A1 (da) |
HU (1) | HU228112B1 (da) |
IL (1) | IL136828A (da) |
IT (1) | IT1297140B1 (da) |
PL (1) | PL197768B1 (da) |
PT (1) | PT1082304E (da) |
SK (1) | SK284777B6 (da) |
TR (1) | TR200001867T2 (da) |
WO (1) | WO1999033797A1 (da) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3932933A4 (en) * | 2019-02-28 | 2022-11-23 | Tokyo Institute of Technology | AMIDE PRODUCTION PROCESS |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1210673B (it) | 1982-02-26 | 1989-09-20 | Medosan Ind Biochimi | Antinfiammatoria amidi pirrolacetiche ad attivita' |
IT1148117B (it) * | 1982-03-05 | 1986-11-26 | Medosan Ind Biochimi | Attivita'antiflogistica,analgesica,antipiretica,mucolitica e seda tiva della tosse dell'1 metil-5-p-tolilpirrol-2-acetato di 2'metossi-fenile |
IT1197688B (it) * | 1983-07-29 | 1988-12-06 | Medosan Ind Biochimi | Attivita' antiflogistica,analgesica,antipiretica ed antiaggregante piastrinica di 1-metil-5-metilbenzoilpirrol-2-acetamido acetanilidi |
IT1278144B1 (it) * | 1995-07-14 | 1997-11-17 | Medosan Ricerca Srl | Impiego dell'amtolmetineguacil (med 15) come farmaco antisecretivo sulla secrezione gastrica e quindi gastroprotettivo. |
DE69721077T2 (de) * | 1997-08-08 | 2004-02-05 | Medosan Ricerca S.R.L. | Verwendung von 2-methoxyphenyl-1-methyl-5p-methyl-benzoylpyrrol-2-acetamido-acetat zur herstellung eines antientzündungsmittels mit vorbeugung von magenhypersekretion und nierenfunktionsstörung |
-
1997
- 1997-12-24 IT IT97RM000811A patent/IT1297140B1/it active IP Right Grant
-
1998
- 1998-12-16 DE DE69820301T patent/DE69820301T2/de not_active Expired - Lifetime
- 1998-12-16 IL IL13682898A patent/IL136828A/xx not_active IP Right Cessation
- 1998-12-16 EP EP98962664A patent/EP1082304B1/en not_active Expired - Lifetime
- 1998-12-16 SK SK895-2000A patent/SK284777B6/sk not_active IP Right Cessation
- 1998-12-16 TR TR2000/01867T patent/TR200001867T2/xx unknown
- 1998-12-16 BR BR9814476-6A patent/BR9814476A/pt not_active Application Discontinuation
- 1998-12-16 US US09/581,289 patent/US6288241B1/en not_active Expired - Lifetime
- 1998-12-16 PL PL341424A patent/PL197768B1/pl unknown
- 1998-12-16 CZ CZ20002336A patent/CZ297132B6/cs not_active IP Right Cessation
- 1998-12-16 CA CA002315835A patent/CA2315835C/en not_active Expired - Lifetime
- 1998-12-16 PT PT98962664T patent/PT1082304E/pt unknown
- 1998-12-16 HU HU0101025A patent/HU228112B1/hu unknown
- 1998-12-16 AT AT98962664T patent/ATE255562T1/de active
- 1998-12-16 ES ES98962664T patent/ES2210853T3/es not_active Expired - Lifetime
- 1998-12-16 KR KR1020007006998A patent/KR100554704B1/ko not_active IP Right Cessation
- 1998-12-16 WO PCT/IT1998/000363 patent/WO1999033797A1/en active IP Right Grant
- 1998-12-16 CN CNB988126567A patent/CN1200930C/zh not_active Expired - Lifetime
- 1998-12-16 DK DK98962664T patent/DK1082304T3/da active
- 1998-12-16 JP JP2000526481A patent/JP4693236B2/ja not_active Expired - Lifetime
- 1998-12-16 AU AU17828/99A patent/AU781283B2/en not_active Expired
-
2001
- 2001-07-10 HK HK01104771A patent/HK1035717A1/xx not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK4A | Expiry of patent |
Expiry date: 20181216 |