SK284607B6 - Trinásťčlenné azalidy, spôsob ich výroby, farmaceutická kompozícia obsahujúca tieto azalidy a ich použitie ako antibiotiká - Google Patents

Trinásťčlenné azalidy, spôsob ich výroby, farmaceutická kompozícia obsahujúca tieto azalidy a ich použitie ako antibiotiká Download PDF

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Publication number
SK284607B6
SK284607B6 SK663-2001A SK6632001A SK284607B6 SK 284607 B6 SK284607 B6 SK 284607B6 SK 6632001 A SK6632001 A SK 6632001A SK 284607 B6 SK284607 B6 SK 284607B6
Authority
SK
Slovakia
Prior art keywords
alkyl
alkenyl
alkynyl
hydrogen
group
Prior art date
Application number
SK663-2001A
Other languages
English (en)
Slovak (sk)
Other versions
SK6632001A3 (en
Inventor
Robert John Rafka
Barry James Morton
Colman Brendan Ragan
Peter Bertinato
John Philip Dirlam
Alan Elwood Blize
Carl Bernard Ziegler
Original Assignee
Pfizer Products Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22327457&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SK284607(B6) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.
Publication of SK6632001A3 publication Critical patent/SK6632001A3/sk
Publication of SK284607B6 publication Critical patent/SK284607B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
SK663-2001A 1998-11-20 1999-11-09 Trinásťčlenné azalidy, spôsob ich výroby, farmaceutická kompozícia obsahujúca tieto azalidy a ich použitie ako antibiotiká SK284607B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10939998P 1998-11-20 1998-11-20
PCT/IB1999/001803 WO2000031097A1 (fr) 1998-11-20 1999-11-09 Azalides a 13 elements et leur utilisation en tant qu'antibiotiques

Publications (2)

Publication Number Publication Date
SK6632001A3 SK6632001A3 (en) 2002-07-02
SK284607B6 true SK284607B6 (sk) 2005-07-01

Family

ID=22327457

Family Applications (1)

Application Number Title Priority Date Filing Date
SK663-2001A SK284607B6 (sk) 1998-11-20 1999-11-09 Trinásťčlenné azalidy, spôsob ich výroby, farmaceutická kompozícia obsahujúca tieto azalidy a ich použitie ako antibiotiká

Country Status (46)

Country Link
US (1) US6329345B1 (fr)
EP (1) EP1131331B1 (fr)
JP (1) JP3842973B2 (fr)
KR (1) KR100477774B1 (fr)
CN (2) CN101367853A (fr)
AP (1) AP2001002142A0 (fr)
AR (3) AR019496A1 (fr)
AT (1) ATE260927T1 (fr)
AU (1) AU766106B2 (fr)
BG (1) BG65107B1 (fr)
BR (2) BRPI9915480B1 (fr)
CA (1) CA2351429C (fr)
CO (1) CO5380019A1 (fr)
CZ (1) CZ303099B6 (fr)
DE (1) DE69915336T2 (fr)
DK (1) DK1131331T3 (fr)
DZ (1) DZ2944A1 (fr)
EA (2) EA009729B1 (fr)
EG (1) EG23823A (fr)
ES (1) ES2216581T3 (fr)
GT (1) GT199900198A (fr)
HK (1) HK1041269A1 (fr)
HR (1) HRP20010374B1 (fr)
HU (1) HU229008B1 (fr)
ID (1) ID28548A (fr)
IL (3) IL142631A0 (fr)
IS (1) IS2350B (fr)
MA (1) MA26707A1 (fr)
ME (1) ME00467B (fr)
MY (1) MY122353A (fr)
NO (3) NO319796B1 (fr)
NZ (1) NZ511199A (fr)
OA (1) OA11713A (fr)
PA (1) PA8485601A1 (fr)
PE (1) PE20001378A1 (fr)
PL (1) PL198580B1 (fr)
PT (1) PT1131331E (fr)
RS (1) RS50302B (fr)
SI (1) SI1131331T1 (fr)
SK (1) SK284607B6 (fr)
TN (1) TNSN99214A1 (fr)
TW (2) TWI243825B (fr)
UA (1) UA70972C2 (fr)
UY (1) UY25805A1 (fr)
WO (1) WO2000031097A1 (fr)
ZA (1) ZA200104019B (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HN1998000086A (es) 1997-06-11 1999-03-08 Pfizer Prod Inc Derivados de 9 - desofo - 9 aza - 9a - homoeritromicina a - c - 4 sustituidos.
AP9801420A0 (en) * 1998-01-02 1998-12-31 Pfizer Prod Inc Novel macrolides.
UA70972C2 (uk) * 1998-11-20 2004-11-15 Пфайзер Продактс Інк. 13-членні азаліди і їх застосування як антибіотиків
SK15162001A3 (sk) * 1999-05-24 2003-02-04 Pfizer Products Inc. Deriváty 13-metylerytromycínu
US6465437B1 (en) * 1999-06-30 2002-10-15 Pfizer Inc. Diphosphate salt of a 4″-substituted-9-deoxo-9A-AZA-9A- homoerythromycin derivative and its pharmaceutical composition
KR20030031479A (ko) * 2000-04-27 2003-04-21 화이자 프로덕츠 인코포레이티드 포유동물에서 세균 감염 또는 원생생물 감염을 치료 또는 예방하기 위한 아잘라이드 항생제 조성물
BR0209241A (pt) * 2001-04-27 2004-06-15 Pfizer Prod Inc Processo para preparação de derivados de9-deoxo-9a-aza-9a-homoeritromicina a 4-substituida
JP4311203B2 (ja) * 2001-08-08 2009-08-12 大正製薬株式会社 １１ａ−アザライド化合物及びその製造方法
CA2529817C (fr) * 2003-03-10 2013-02-12 Optimer Pharmaceuticals, Inc. Nouveaux agents antibacteriens
WO2004108744A2 (fr) * 2003-05-19 2004-12-16 Prasad K Deshpande Azalides et azaketolides possedant une activite antimicrobienne
CA2546195A1 (fr) * 2003-11-21 2005-06-02 Pfizer Products Inc. L'utilisation d'antibiotiques comme adjuvants de vaccins
WO2007091393A1 (fr) * 2006-02-07 2007-08-16 Taisho Pharmaceutical Co., Ltd. COMPOSÉ 10a-AZALIDE
US8293715B2 (en) 2007-08-06 2012-10-23 Taisho Pharmaceutical Co., Ltd. 10a-Azalide compound crosslinked at 10a- and 12-positions
JPWO2009139181A1 (ja) * 2008-05-15 2011-09-15 大正製薬株式会社 ４員環構造を有する１０ａ−アザライド化合物
ES2532455T3 (es) * 2010-09-20 2015-03-27 Novartis Tiergesundheit Ag Nuevo procedimiento de preparación de 9-desoxo-9a-aza-9a-homoeritromicina modificada en el C-4'' del anillo de cladinosa por un grupo epóxido
CN102295672B (zh) * 2011-07-13 2014-06-04 武汉回盛生物科技有限公司 一种泰拉菌素的合成方法
WO2013013834A1 (fr) 2011-07-27 2013-01-31 Farma Grs, D.O.O. Nouvelles formes cristallines de tulathromycine
CN102786569B (zh) * 2012-09-07 2016-12-07 安徽中升药业有限公司 泰拉霉素中间体及其制备方法与泰拉霉素的制备方法
SI3027634T1 (sl) * 2013-07-31 2018-10-30 Farma Grs, D.O.O. Proces za pripravo tulatromicina
CN109748942A (zh) * 2014-05-16 2019-05-14 普莱柯生物工程股份有限公司 一种大环内酯类化合物
CN104725446B (zh) * 2015-03-26 2017-10-27 宁夏泰瑞制药股份有限公司 一种从泰拉霉素粗品中分离泰拉霉素a和泰拉霉素b的方法
KR20210133950A (ko) * 2018-11-19 2021-11-08 지카니 테라퓨틱스, 인크. C10-알킬렌 치환된 13-원 매크롤라이드 및 이의 용도
SG11202105228SA (en) * 2018-11-19 2021-06-29 Zikani Therapeutics Inc C11-cyclic substituted 13-membered macrolides and uses thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI7910768A8 (en) 1979-04-02 1996-06-30 Pliva Pharm & Chem Works Process for pripering 11-aza-4-0-cladinosyl-6-0-desosaminyl-15-ethyl- 7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl- oxacyclopentadecane-2-one and their derivatives
SI8110592A8 (en) * 1981-03-06 1996-06-30 Pliva Pharm & Chem Works Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof
US4474768A (en) * 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
YU44599B (en) * 1986-09-12 1990-10-31 Pliva Pharm & Chem Works Process for preparing complex of n-methyl-11-aza-10-deoxo-10-dihydroeritromicine a and 11-aza-10-deoxo-10-dihydroeritromicine a with metals
US5106961A (en) 1987-05-26 1992-04-21 Eli Lilly And Company Erythromycin ring-contracted derivatives
SI9011409A (en) 1990-07-18 1995-10-31 Pliva Pharm & Chem Works O-methyl azitromycin derivates, methods and intermediates for their preparation and methods for preparation of pharmaceuticals products which comprise them
HRP931480B1 (en) * 1993-12-08 1997-08-31 Sour Pliva 9a-N-(N'-CARBAMONYL) and 9a-N-(N'-THIOCARBAMONYL) DERIVATES OF 9-DEOXO-9a-HOMOERYTHROMYCIN A
GB2327084A (en) * 1997-07-08 1999-01-13 Merck & Co Inc 9a-Aza-3-ketolide antibiotics
UA70972C2 (uk) * 1998-11-20 2004-11-15 Пфайзер Продактс Інк. 13-членні азаліди і їх застосування як антибіотиків

Also Published As

Publication number Publication date
DZ2944A1 (fr) 2004-03-15
EP1131331A1 (fr) 2001-09-12
ES2216581T3 (es) 2004-10-16
ATE260927T1 (de) 2004-03-15
CA2351429A1 (fr) 2000-06-02
NO319796B1 (no) 2005-09-19
SK6632001A3 (en) 2002-07-02
BG105600A (en) 2001-12-29
HUP0104313A3 (en) 2003-12-29
RS50302B (sr) 2009-09-08
MA26707A1 (fr) 2004-12-20
NZ511199A (en) 2003-08-29
DK1131331T3 (da) 2004-06-14
KR20010086043A (ko) 2001-09-07
IL142631A (en) 2010-05-31
ZA200104019B (en) 2002-06-17
JP2002530422A (ja) 2002-09-17
JP3842973B2 (ja) 2006-11-08
ID28548A (id) 2001-05-31
IL189430A (en) 2010-05-31
NO20050904L (no) 2001-07-17
CN1326460A (zh) 2001-12-12
NO20012464D0 (no) 2001-05-18
ME00467B (me) 2011-10-10
HK1041269A1 (zh) 2002-07-05
PT1131331E (pt) 2004-06-30
NO20012464L (no) 2001-07-17
CZ20011754A3 (cs) 2002-03-13
EG23823A (en) 2007-09-19
OA11713A (en) 2005-01-25
NO20050893L (no) 2001-07-17
PL198580B1 (pl) 2008-06-30
AR059524A2 (es) 2008-04-09
TWI243825B (en) 2005-11-21
BRPI9915480B8 (pt) 2022-05-10
SI1131331T1 (en) 2004-08-31
EA009729B1 (ru) 2008-02-28
CA2351429C (fr) 2005-07-12
EP1131331B1 (fr) 2004-03-03
AP2001002142A0 (en) 2001-05-09
AU766106B2 (en) 2003-10-09
GT199900198A (es) 2001-05-11
IL189430A0 (en) 2008-06-05
NO330249B1 (no) 2011-03-14
HRP20010374A2 (en) 2002-06-30
PA8485601A1 (es) 2000-09-29
CZ303099B6 (cs) 2012-04-04
DE69915336D1 (de) 2004-04-08
CO5380019A1 (es) 2004-03-31
BR9915480A (pt) 2001-07-31
EA200100416A1 (ru) 2001-10-22
TW200404077A (en) 2004-03-16
EA200400701A1 (ru) 2004-12-30
HU229008B1 (en) 2013-07-29
MY122353A (en) 2006-04-29
IS5918A (is) 2001-04-17
YU33401A (sh) 2004-05-12
US6329345B1 (en) 2001-12-11
BRPI9915480B1 (pt) 2015-12-29
TNSN99214A1 (fr) 2005-11-10
DE69915336T2 (de) 2005-01-13
PE20001378A1 (es) 2000-12-14
WO2000031097A1 (fr) 2000-06-02
UA70972C2 (uk) 2004-11-15
EA005156B1 (ru) 2004-12-30
AR019496A1 (es) 2002-02-20
AR059523A2 (es) 2008-04-09
HRP20010374B1 (en) 2006-09-30
IL142631A0 (en) 2002-03-10
PL347784A1 (en) 2002-04-22
UY25805A1 (es) 2001-08-27
NO329629B1 (no) 2010-11-22
BG65107B1 (bg) 2007-02-28
IS2350B (is) 2008-04-15
HUP0104313A2 (hu) 2002-02-28
CN101367853A (zh) 2009-02-18
TWI243824B (en) 2005-11-21
AU1068600A (en) 2000-06-13
KR100477774B1 (ko) 2005-03-21

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Legal Events

Date Code Title Description
PC4A Assignment and transfer of rights

Owner name: PAH USA 15 LLC, NEW YORK, NY, US

Free format text: FORMER OWNER: PFIZER PRODUCTS INC., GROTON, CT, US

Effective date: 20121001

TC4A Change of owner's name

Owner name: ZOETIS P LLC, FLORHAM PARK, NEW JERSEY, US

Effective date: 20130703

PC4A Assignment and transfer of rights

Owner name: ZOETIS SERVICES LLC, FLORHAM PARK, NJ, US

Free format text: FORMER OWNER: ZOETIS P LLC, FLORHAM PARK, NEW JERSEY, US

Effective date: 20151012

TE4A Change of owner's address

Owner name: ZOETIS SERVICES LLC, PARSIPPANY, NEW JERSEY, US

Effective date: 20170314

MK4A Expiry of patent

Expiry date: 20191109