DK1131331T3 - 13-leddede azalider og deres anvendelse som antibiotiske midler - Google Patents

13-leddede azalider og deres anvendelse som antibiotiske midler

Info

Publication number
DK1131331T3
DK1131331T3 DK99954277T DK99954277T DK1131331T3 DK 1131331 T3 DK1131331 T3 DK 1131331T3 DK 99954277 T DK99954277 T DK 99954277T DK 99954277 T DK99954277 T DK 99954277T DK 1131331 T3 DK1131331 T3 DK 1131331T3
Authority
DK
Denmark
Prior art keywords
antibiotics
membered azalides
azalides
membered
Prior art date
Application number
DK99954277T
Other languages
English (en)
Inventor
Robert John Rafka
Barry James Morton
Colman Brendan Ragan
Peter Bertinato
John Philip Dirlam
Alan Elwood Blize
Carl Bernard Ziegler
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22327457&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1131331(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Application granted granted Critical
Publication of DK1131331T3 publication Critical patent/DK1131331T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Pyrane Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pyridine Compounds (AREA)
DK99954277T 1998-11-20 1999-11-09 13-leddede azalider og deres anvendelse som antibiotiske midler DK1131331T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10939998P 1998-11-20 1998-11-20
PCT/IB1999/001803 WO2000031097A1 (en) 1998-11-20 1999-11-09 13-membered azalides and their use as antibiotic agents

Publications (1)

Publication Number Publication Date
DK1131331T3 true DK1131331T3 (da) 2004-06-14

Family

ID=22327457

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99954277T DK1131331T3 (da) 1998-11-20 1999-11-09 13-leddede azalider og deres anvendelse som antibiotiske midler

Country Status (46)

Country Link
US (1) US6329345B1 (da)
EP (1) EP1131331B1 (da)
JP (1) JP3842973B2 (da)
KR (1) KR100477774B1 (da)
CN (2) CN1326460A (da)
AP (1) AP2001002142A0 (da)
AR (3) AR019496A1 (da)
AT (1) ATE260927T1 (da)
AU (1) AU766106B2 (da)
BG (1) BG65107B1 (da)
BR (2) BRPI9915480B1 (da)
CA (1) CA2351429C (da)
CO (1) CO5380019A1 (da)
CZ (1) CZ303099B6 (da)
DE (1) DE69915336T2 (da)
DK (1) DK1131331T3 (da)
DZ (1) DZ2944A1 (da)
EA (2) EA009729B1 (da)
EG (1) EG23823A (da)
ES (1) ES2216581T3 (da)
GT (1) GT199900198A (da)
HK (1) HK1041269A1 (da)
HR (1) HRP20010374B1 (da)
HU (1) HU229008B1 (da)
ID (1) ID28548A (da)
IL (3) IL142631A0 (da)
IS (1) IS2350B (da)
MA (1) MA26707A1 (da)
ME (1) ME00467B (da)
MY (1) MY122353A (da)
NO (3) NO319796B1 (da)
NZ (1) NZ511199A (da)
OA (1) OA11713A (da)
PA (1) PA8485601A1 (da)
PE (1) PE20001378A1 (da)
PL (1) PL198580B1 (da)
PT (1) PT1131331E (da)
RS (1) RS50302B (da)
SI (1) SI1131331T1 (da)
SK (1) SK284607B6 (da)
TN (1) TNSN99214A1 (da)
TW (2) TWI243825B (da)
UA (1) UA70972C2 (da)
UY (1) UY25805A1 (da)
WO (1) WO2000031097A1 (da)
ZA (1) ZA200104019B (da)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HN1998000086A (es) 1997-06-11 1999-03-08 Pfizer Prod Inc Derivados de 9 - desofo - 9 aza - 9a - homoeritromicina a - c - 4 sustituidos.
AP9801420A0 (en) * 1998-01-02 1998-12-31 Pfizer Prod Inc Novel macrolides.
UA70972C2 (uk) * 1998-11-20 2004-11-15 Пфайзер Продактс Інк. 13-членні азаліди і їх застосування як антибіотиків
EE200100613A (et) * 1999-05-24 2003-02-17 Pfizer Products Inc. 13-metüülerütromütsiini derivaadid
US6465437B1 (en) * 1999-06-30 2002-10-15 Pfizer Inc. Diphosphate salt of a 4″-substituted-9-deoxo-9A-AZA-9A- homoerythromycin derivative and its pharmaceutical composition
EP1276747A1 (en) * 2000-04-27 2003-01-22 Pfizer Products Inc. The use of azalide antibiotic compositions for treating or preventing a bacterial or protozoal infection in mammals
EP1383780A1 (en) * 2001-04-27 2004-01-28 Pfizer Products Inc. Process for preparing 4"-substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives
WO2003014136A1 (en) * 2001-08-08 2003-02-20 Taisho Pharmaceutical Co., Ltd. 11a-AZALIDE COMPOUNDS AND PROCESS FOR PRODUCING THE SAME
EP2772254A3 (en) * 2003-03-10 2015-03-11 Optimer Pharmaceuticals, Inc. Novel Antibacterial Agents
WO2004108744A2 (en) * 2003-05-19 2004-12-16 Prasad K Deshpande Azalides and azaketolides having antimicrobial activity
KR100785601B1 (ko) * 2003-11-21 2007-12-14 화이자 프로덕츠 인크. 백신 아쥬반트로서의 항생제의 용도
WO2007091393A1 (ja) * 2006-02-07 2007-08-16 Taisho Pharmaceutical Co., Ltd. １０ａ－アザライド化合物
EP2177526A4 (en) * 2007-08-06 2012-08-22 Taisho Pharmaceutical Co Ltd 10A-AZALIDE COMPOUND CROSS-LINKED IN POSITION 10A AND POSITION 12
JPWO2009139181A1 (ja) * 2008-05-15 2011-09-15 大正製薬株式会社 ４員環構造を有する１０ａ−アザライド化合物
US8940880B2 (en) 2010-09-20 2015-01-27 Novartis Ag Process for the preparation of 9-deoxo-9a-homoerythromycin A, modified in the C-4″ of the cladinose ring by an epoxide group
CN102295672B (zh) * 2011-07-13 2014-06-04 武汉回盛生物科技有限公司 一种泰拉菌素的合成方法
EP2736915A1 (en) 2011-07-27 2014-06-04 Farma GRS, d.o.o. New crystalline forms of tulathromycin
CN102786569B (zh) * 2012-09-07 2016-12-07 安徽中升药业有限公司 泰拉霉素中间体及其制备方法与泰拉霉素的制备方法
WO2015014907A1 (en) * 2013-07-31 2015-02-05 Farma Grs, D.O.O. Process for preparation of tulathromycin
CN109748942A (zh) * 2014-05-16 2019-05-14 普莱柯生物工程股份有限公司 一种大环内酯类化合物
CN104725446B (zh) * 2015-03-26 2017-10-27 宁夏泰瑞制药股份有限公司 一种从泰拉霉素粗品中分离泰拉霉素a和泰拉霉素b的方法
IL310280A (en) * 2018-11-19 2024-03-01 Zikani Therapeutics Inc Macrolides with 13 members converted to C10-cyclic and their uses
CN113573779A (zh) * 2018-11-19 2021-10-29 齐卡尼治疗股份有限公司 C10-亚烷基取代的13元大环内酯及其用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU43116B (en) 1979-04-02 1989-04-30 Pliva Pharm & Chem Works Process for preparing 11-aza-4-o-cladinosyl-6-o-desosaminyl-15-ethyl-7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl-oxacyclopentadecane-2-one(11-aza-10-deox
YU43006B (en) * 1981-03-06 1989-02-28 Pliva Pharm & Chem Works Process for preparing n-methyl-11-aza-10-deoxo-10-dihydro erythromycin and derivatives thereof
US4474768A (en) * 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
YU44599B (en) * 1986-09-12 1990-10-31 Pliva Pharm & Chem Works Process for preparing complex of n-methyl-11-aza-10-deoxo-10-dihydroeritromicine a and 11-aza-10-deoxo-10-dihydroeritromicine a with metals
US5106961A (en) 1987-05-26 1992-04-21 Eli Lilly And Company Erythromycin ring-contracted derivatives
SI9011409A (en) 1990-07-18 1995-10-31 Pliva Pharm & Chem Works O-methyl azitromycin derivates, methods and intermediates for their preparation and methods for preparation of pharmaceuticals products which comprise them
HRP931480B1 (en) * 1993-12-08 1997-08-31 Sour Pliva 9a-N-(N'-CARBAMONYL) and 9a-N-(N'-THIOCARBAMONYL) DERIVATES OF 9-DEOXO-9a-HOMOERYTHROMYCIN A
GB2327084A (en) * 1997-07-08 1999-01-13 Merck & Co Inc 9a-Aza-3-ketolide antibiotics
UA70972C2 (uk) * 1998-11-20 2004-11-15 Пфайзер Продактс Інк. 13-членні азаліди і їх застосування як антибіотиків

Also Published As

Publication number Publication date
IS2350B (is) 2008-04-15
DZ2944A1 (fr) 2004-03-15
PT1131331E (pt) 2004-06-30
OA11713A (en) 2005-01-25
NO20050893L (no) 2001-07-17
JP3842973B2 (ja) 2006-11-08
EP1131331B1 (en) 2004-03-03
NZ511199A (en) 2003-08-29
BG105600A (en) 2001-12-29
AR059524A2 (es) 2008-04-09
US6329345B1 (en) 2001-12-11
HUP0104313A3 (en) 2003-12-29
IS5918A (is) 2001-04-17
HU229008B1 (en) 2013-07-29
CZ20011754A3 (cs) 2002-03-13
EG23823A (en) 2007-09-19
TNSN99214A1 (fr) 2005-11-10
UA70972C2 (uk) 2004-11-15
TWI243825B (en) 2005-11-21
KR100477774B1 (ko) 2005-03-21
EA009729B1 (ru) 2008-02-28
CN1326460A (zh) 2001-12-12
AR019496A1 (es) 2002-02-20
NO319796B1 (no) 2005-09-19
PA8485601A1 (es) 2000-09-29
AP2001002142A0 (en) 2001-05-09
JP2002530422A (ja) 2002-09-17
BR9915480A (pt) 2001-07-31
YU33401A (sh) 2004-05-12
TWI243824B (en) 2005-11-21
ME00467B (me) 2011-10-10
EP1131331A1 (en) 2001-09-12
PL347784A1 (en) 2002-04-22
UY25805A1 (es) 2001-08-27
HK1041269A1 (zh) 2002-07-05
IL189430A0 (en) 2008-06-05
MY122353A (en) 2006-04-29
BG65107B1 (bg) 2007-02-28
RS50302B (sr) 2009-09-08
IL142631A0 (en) 2002-03-10
HUP0104313A2 (hu) 2002-02-28
PE20001378A1 (es) 2000-12-14
IL189430A (en) 2010-05-31
BRPI9915480B1 (pt) 2015-12-29
ZA200104019B (en) 2002-06-17
TW200404077A (en) 2004-03-16
ATE260927T1 (de) 2004-03-15
NO329629B1 (no) 2010-11-22
ID28548A (id) 2001-05-31
NO20012464L (no) 2001-07-17
AU1068600A (en) 2000-06-13
CN101367853A (zh) 2009-02-18
MA26707A1 (fr) 2004-12-20
EA200100416A1 (ru) 2001-10-22
DE69915336D1 (de) 2004-04-08
HRP20010374A2 (en) 2002-06-30
SK284607B6 (sk) 2005-07-01
GT199900198A (es) 2001-05-11
NO20012464D0 (no) 2001-05-18
SK6632001A3 (en) 2002-07-02
KR20010086043A (ko) 2001-09-07
NO20050904L (no) 2001-07-17
CZ303099B6 (cs) 2012-04-04
ES2216581T3 (es) 2004-10-16
EA200400701A1 (ru) 2004-12-30
CA2351429A1 (en) 2000-06-02
NO330249B1 (no) 2011-03-14
BRPI9915480B8 (pt) 2022-05-10
AR059523A2 (es) 2008-04-09
DE69915336T2 (de) 2005-01-13
CA2351429C (en) 2005-07-12
PL198580B1 (pl) 2008-06-30
SI1131331T1 (en) 2004-08-31
CO5380019A1 (es) 2004-03-31
WO2000031097A1 (en) 2000-06-02
IL142631A (en) 2010-05-31
EA005156B1 (ru) 2004-12-30
AU766106B2 (en) 2003-10-09
HRP20010374B1 (en) 2006-09-30

Similar Documents

Publication Publication Date Title
NO20050904L (no) 13-leddete azalider og deres anvendelse som antibiotiske midler
NO20021253L (no) Kinolylpropylpiperidinderivater og deres anvendelse som antibakterielle midler
NO20020683D0 (no) Arylmetylkarbonylaminotiazolderivater og deres anvendelse som antitumormidler
DK0906292T3 (da) Triazolylmercaptider og deres anvendelse som mikrobicider
DK1198454T3 (da) Multilinderivater og deres anvendelse som antibakterielle midler
EE200200175A (et) Asendatud 2-tio-3,5-ditsüano-4-arüül-6-aminopüridiinid ja nende kasutamine
ATE256694T1 (de) Ketolid-antibiotika
NO20005146D0 (no) Tienylazolylalkoksyetanaminer, deres fremstilling og deres anvendelse som medikamenter
DK1095025T3 (da) Benzimidazoler, deres fremstilling og deres anvendelse som lægemidler
NO20014702D0 (no) Diarylderivater og deres anvendelse som medikamenter
EE200100245A (et) Uued makroliidsed antibiootikumid
NO984761D0 (no) Aminoisokinoliner og aminotienopyridinderivater og deres anvendelse som antiinflammatoriske midler
NO994510L (no) Substituerte isokinolin-derivater og deres anvendelse som antikonvulsanter
ID27775A (id) Antibiotik-antibiotik nokatiasin
NO995513D0 (no) N-triazolyl-2-indolkarboksamider og deres anvendelse som CCK-A agonister
NO985891D0 (no) Substituerte benzamid-derivater og deres anvendelse som antikonvulsjonsmidler
NO20004904D0 (no) C11 oksymyl og hydroksylaminoprostaglandiner anvendbare som medikamenter
DK1140068T3 (da) Doramectin formulations
DK1367055T3 (da) Isoquinolinylcarboxamider og deres anvendelse som krampestillende midler
NO996156L (no) Substituerte cykloheptener, deres fremstilling og anvendelse
DK1072266T3 (da) Thienylazolylalkoxyethanaminer, deres fremstilling og deres anvendelse som lægemidler