SK284353B6 - Referenčná zlúčenina na použitie v analýze šarží levosimendanu - Google Patents
Referenčná zlúčenina na použitie v analýze šarží levosimendanu Download PDFInfo
- Publication number
- SK284353B6 SK284353B6 SK1872-2000A SK18722000A SK284353B6 SK 284353 B6 SK284353 B6 SK 284353B6 SK 18722000 A SK18722000 A SK 18722000A SK 284353 B6 SK284353 B6 SK 284353B6
- Authority
- SK
- Slovakia
- Prior art keywords
- levosimendan
- compound
- batch
- solution
- samples
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
- C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N2030/042—Standards
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/145555—Hetero-N
- Y10T436/147777—Plural nitrogen in the same ring [e.g., barbituates, creatinine, etc.]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI981428A FI104718B (fi) | 1998-06-18 | 1998-06-18 | [[4-(2-atsido-3-metyyli-5-oksotetrahydrofuran-2-yyli)fenyyli]hydratsono]propaanidinitriili käytettäväksi referenssiaineena levosimendaanierien analyysissä |
| PCT/FI1999/000539 WO1999065888A2 (en) | 1998-06-18 | 1999-06-18 | A reference compound for use in the analysis of levosimendan batches |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SK18722000A3 SK18722000A3 (sk) | 2001-09-11 |
| SK284353B6 true SK284353B6 (sk) | 2005-02-04 |
Family
ID=8552039
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK1872-2000A SK284353B6 (sk) | 1998-06-18 | 1999-06-18 | Referenčná zlúčenina na použitie v analýze šarží levosimendanu |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US6340764B1 (no) |
| EP (1) | EP1087956B1 (no) |
| JP (1) | JP4550279B2 (no) |
| KR (1) | KR100661772B1 (no) |
| CN (1) | CN1129590C (no) |
| AR (1) | AR018879A1 (no) |
| AT (1) | ATE253566T1 (no) |
| AU (1) | AU755699B2 (no) |
| BR (1) | BR9911230A (no) |
| CA (1) | CA2334864C (no) |
| CZ (1) | CZ298659B6 (no) |
| DE (1) | DE69912604D1 (no) |
| EA (1) | EA002854B1 (no) |
| ES (1) | ES2211113T3 (no) |
| FI (1) | FI104718B (no) |
| HK (1) | HK1032779A1 (no) |
| HR (1) | HRP20000866B1 (no) |
| HU (1) | HU229582B1 (no) |
| ID (1) | ID29239A (no) |
| IL (1) | IL139964A (no) |
| MX (1) | MXPA00012436A (no) |
| NO (1) | NO325393B1 (no) |
| NZ (1) | NZ508557A (no) |
| PL (1) | PL201772B1 (no) |
| RS (1) | RS49929B (no) |
| SK (1) | SK284353B6 (no) |
| WO (1) | WO1999065888A2 (no) |
| ZA (1) | ZA200006993B (no) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2563776A1 (en) | 2004-04-21 | 2005-11-10 | Teva Pharmaceutical Industries Ltd. | Processes for preparing montelukast sodium |
| FR2877013A1 (fr) * | 2004-10-27 | 2006-04-28 | Assist Publ Hopitaux De Paris | Indentification d'une mutation de jak2 impliquee dans la polyglobulie de vaquez |
| ES2358923T3 (es) | 2005-07-05 | 2011-05-16 | Teva Pharmaceutical Industries, Ltd. | Purificación de montelukast. |
| CN104230816B (zh) * | 2014-09-19 | 2017-02-15 | 成都新恒创药业有限公司 | 一种左西孟旦潜在基因毒性杂质及其制备、检测方法 |
| CN104478809B (zh) * | 2014-11-14 | 2016-08-17 | 成都新恒创药业有限公司 | 一种左西孟旦杂质及其制备和检测方法 |
| CN105817632A (zh) * | 2015-01-09 | 2016-08-03 | 中国科学院宁波材料技术与工程研究所 | 片状粉末的制备装置及方法 |
| CN105784895B (zh) * | 2015-10-30 | 2018-05-22 | 成都欣捷高新技术开发有限公司 | 一种用高效液相色谱仪检测左西孟旦中杂质的方法 |
| CN111474289A (zh) * | 2019-10-31 | 2020-07-31 | 武汉嘉诺康医药技术有限公司 | 一种利用反相色谱分离分析左西孟旦中右西孟旦的方法 |
| CA3161960A1 (en) | 2019-12-16 | 2021-06-24 | Tenax Therapeutics, Inc. | Levosimendan for treating pulmonary hypertension with heart failure with preserved ejection fraction (ph-hfpef) |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB383449A (en) * | 1931-12-12 | 1932-11-17 | Percy Charles Barton | Improvements relating to masts, poles, or like supports and their manufacture |
| GB565546A (en) * | 1943-04-13 | 1944-11-15 | Leslie Frederick Reeve | A pneumatically operated pickup unit for use in electric organs and the like |
| FI894035A (fi) | 1988-09-07 | 1990-03-08 | Orion Yhtymae Oy | Foerfarande foer framstaellning av nya substituerade pyridazinoner. |
| GB8903130D0 (en) | 1989-02-11 | 1989-03-30 | Orion Yhtymae Oy | Substituted pyridazinones |
| GB2251615B (en) * | 1991-01-03 | 1995-02-08 | Orion Yhtymae Oy | (-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]hydrazono]pro panedinitrile |
| GB2266841A (en) * | 1992-05-06 | 1993-11-17 | Orion Yhtymae Oy | Compounds for use as anti-ischemic medicaments |
| GB9606474D0 (en) | 1996-03-27 | 1996-06-05 | Orion Yhytmo Oy | Method for obtaining pure enantiomers of a pyridazinone derivative |
| GB9614098D0 (en) * | 1996-07-05 | 1996-09-04 | Orion Yhtymae Oy | Transdermal delivery of levosimendan |
| GB9915179D0 (en) * | 1999-06-29 | 1999-09-01 | Orion Corp | A method for the treatment or prevention of coronary graft vasospasm |
-
1998
- 1998-06-18 FI FI981428A patent/FI104718B/fi not_active IP Right Cessation
-
1999
- 1999-06-16 AR ARP990102890A patent/AR018879A1/es active IP Right Grant
- 1999-06-18 MX MXPA00012436A patent/MXPA00012436A/es active IP Right Grant
- 1999-06-18 US US09/719,806 patent/US6340764B1/en not_active Expired - Lifetime
- 1999-06-18 EA EA200100055A patent/EA002854B1/ru not_active IP Right Cessation
- 1999-06-18 WO PCT/FI1999/000539 patent/WO1999065888A2/en active IP Right Grant
- 1999-06-18 KR KR1020007014413A patent/KR100661772B1/ko not_active IP Right Cessation
- 1999-06-18 CN CN99807544A patent/CN1129590C/zh not_active Expired - Lifetime
- 1999-06-18 CZ CZ20004555A patent/CZ298659B6/cs not_active IP Right Cessation
- 1999-06-18 HU HU0102020A patent/HU229582B1/hu unknown
- 1999-06-18 NZ NZ508557A patent/NZ508557A/en not_active IP Right Cessation
- 1999-06-18 PL PL347577A patent/PL201772B1/pl unknown
- 1999-06-18 IL IL13996499A patent/IL139964A/xx not_active IP Right Cessation
- 1999-06-18 JP JP2000554714A patent/JP4550279B2/ja not_active Expired - Lifetime
- 1999-06-18 AT AT99931312T patent/ATE253566T1/de not_active IP Right Cessation
- 1999-06-18 DE DE69912604T patent/DE69912604D1/de not_active Expired - Lifetime
- 1999-06-18 ID IDW20010086A patent/ID29239A/id unknown
- 1999-06-18 BR BR9911230-2A patent/BR9911230A/pt not_active Application Discontinuation
- 1999-06-18 ES ES99931312T patent/ES2211113T3/es not_active Expired - Lifetime
- 1999-06-18 RS YUP-767/00A patent/RS49929B/sr unknown
- 1999-06-18 SK SK1872-2000A patent/SK284353B6/sk not_active IP Right Cessation
- 1999-06-18 AU AU47863/99A patent/AU755699B2/en not_active Expired
- 1999-06-18 EP EP99931312A patent/EP1087956B1/en not_active Expired - Lifetime
- 1999-06-18 CA CA002334864A patent/CA2334864C/en not_active Expired - Lifetime
-
2000
- 2000-11-28 ZA ZA200006993A patent/ZA200006993B/en unknown
- 2000-12-15 HR HR20000866A patent/HRP20000866B1/xx not_active IP Right Cessation
- 2000-12-15 NO NO20006444A patent/NO325393B1/no not_active IP Right Cessation
-
2001
- 2001-05-05 HK HK01103183A patent/HK1032779A1/xx not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK4A | Expiry of patent |
Expiry date: 20190618 |