SK284353B6 - Referenčná zlúčenina na použitie v analýze šarží levosimendanu - Google Patents

Referenčná zlúčenina na použitie v analýze šarží levosimendanu Download PDF

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Publication number
SK284353B6
SK284353B6 SK1872-2000A SK18722000A SK284353B6 SK 284353 B6 SK284353 B6 SK 284353B6 SK 18722000 A SK18722000 A SK 18722000A SK 284353 B6 SK284353 B6 SK 284353B6
Authority
SK
Slovakia
Prior art keywords
levosimendan
compound
batch
solution
samples
Prior art date
Application number
SK1872-2000A
Other languages
English (en)
Slovak (sk)
Other versions
SK18722000A3 (sk
Inventor
Reijo B�CKSTR�M
Tuula Heinonen
Tuula Hauta-Aho
Original Assignee
Orion Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orion Corporation filed Critical Orion Corporation
Publication of SK18722000A3 publication Critical patent/SK18722000A3/sk
Publication of SK284353B6 publication Critical patent/SK284353B6/sk

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32Oxygen atoms
    • C07D307/33Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02Column chromatography
    • G01N30/04Preparation or injection of sample to be analysed
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02Column chromatography
    • G01N30/04Preparation or injection of sample to be analysed
    • G01N2030/042Standards
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/14Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222Hetero-O [e.g., ascorbic acid, etc.]
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/14Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/145555Hetero-N
    • Y10T436/147777Plural nitrogen in the same ring [e.g., barbituates, creatinine, etc.]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
SK1872-2000A 1998-06-18 1999-06-18 Referenčná zlúčenina na použitie v analýze šarží levosimendanu SK284353B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI981428A FI104718B (fi) 1998-06-18 1998-06-18 [[4-(2-atsido-3-metyyli-5-oksotetrahydrofuran-2-yyli)fenyyli]hydratsono]propaanidinitriili käytettäväksi referenssiaineena levosimendaanierien analyysissä
PCT/FI1999/000539 WO1999065888A2 (en) 1998-06-18 1999-06-18 A reference compound for use in the analysis of levosimendan batches

Publications (2)

Publication Number Publication Date
SK18722000A3 SK18722000A3 (sk) 2001-09-11
SK284353B6 true SK284353B6 (sk) 2005-02-04

Family

ID=8552039

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1872-2000A SK284353B6 (sk) 1998-06-18 1999-06-18 Referenčná zlúčenina na použitie v analýze šarží levosimendanu

Country Status (28)

Country Link
US (1) US6340764B1 (no)
EP (1) EP1087956B1 (no)
JP (1) JP4550279B2 (no)
KR (1) KR100661772B1 (no)
CN (1) CN1129590C (no)
AR (1) AR018879A1 (no)
AT (1) ATE253566T1 (no)
AU (1) AU755699B2 (no)
BR (1) BR9911230A (no)
CA (1) CA2334864C (no)
CZ (1) CZ298659B6 (no)
DE (1) DE69912604D1 (no)
EA (1) EA002854B1 (no)
ES (1) ES2211113T3 (no)
FI (1) FI104718B (no)
HK (1) HK1032779A1 (no)
HR (1) HRP20000866B1 (no)
HU (1) HU229582B1 (no)
ID (1) ID29239A (no)
IL (1) IL139964A (no)
MX (1) MXPA00012436A (no)
NO (1) NO325393B1 (no)
NZ (1) NZ508557A (no)
PL (1) PL201772B1 (no)
RS (1) RS49929B (no)
SK (1) SK284353B6 (no)
WO (1) WO1999065888A2 (no)
ZA (1) ZA200006993B (no)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2563776A1 (en) 2004-04-21 2005-11-10 Teva Pharmaceutical Industries Ltd. Processes for preparing montelukast sodium
FR2877013A1 (fr) * 2004-10-27 2006-04-28 Assist Publ Hopitaux De Paris Indentification d'une mutation de jak2 impliquee dans la polyglobulie de vaquez
ES2358923T3 (es) 2005-07-05 2011-05-16 Teva Pharmaceutical Industries, Ltd. Purificación de montelukast.
CN104230816B (zh) * 2014-09-19 2017-02-15 成都新恒创药业有限公司 一种左西孟旦潜在基因毒性杂质及其制备、检测方法
CN104478809B (zh) * 2014-11-14 2016-08-17 成都新恒创药业有限公司 一种左西孟旦杂质及其制备和检测方法
CN105817632A (zh) * 2015-01-09 2016-08-03 中国科学院宁波材料技术与工程研究所 片状粉末的制备装置及方法
CN105784895B (zh) * 2015-10-30 2018-05-22 成都欣捷高新技术开发有限公司 一种用高效液相色谱仪检测左西孟旦中杂质的方法
CN111474289A (zh) * 2019-10-31 2020-07-31 武汉嘉诺康医药技术有限公司 一种利用反相色谱分离分析左西孟旦中右西孟旦的方法
CA3161960A1 (en) 2019-12-16 2021-06-24 Tenax Therapeutics, Inc. Levosimendan for treating pulmonary hypertension with heart failure with preserved ejection fraction (ph-hfpef)

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB383449A (en) * 1931-12-12 1932-11-17 Percy Charles Barton Improvements relating to masts, poles, or like supports and their manufacture
GB565546A (en) * 1943-04-13 1944-11-15 Leslie Frederick Reeve A pneumatically operated pickup unit for use in electric organs and the like
FI894035A (fi) 1988-09-07 1990-03-08 Orion Yhtymae Oy Foerfarande foer framstaellning av nya substituerade pyridazinoner.
GB8903130D0 (en) 1989-02-11 1989-03-30 Orion Yhtymae Oy Substituted pyridazinones
GB2251615B (en) * 1991-01-03 1995-02-08 Orion Yhtymae Oy (-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]hydrazono]pro panedinitrile
GB2266841A (en) * 1992-05-06 1993-11-17 Orion Yhtymae Oy Compounds for use as anti-ischemic medicaments
GB9606474D0 (en) 1996-03-27 1996-06-05 Orion Yhytmo Oy Method for obtaining pure enantiomers of a pyridazinone derivative
GB9614098D0 (en) * 1996-07-05 1996-09-04 Orion Yhtymae Oy Transdermal delivery of levosimendan
GB9915179D0 (en) * 1999-06-29 1999-09-01 Orion Corp A method for the treatment or prevention of coronary graft vasospasm

Also Published As

Publication number Publication date
NZ508557A (en) 2002-05-31
PL201772B1 (pl) 2009-05-29
BR9911230A (pt) 2001-03-06
JP2002518383A (ja) 2002-06-25
ZA200006993B (en) 2002-02-28
CZ20004555A3 (en) 2001-05-16
NO325393B1 (no) 2008-04-21
IL139964A (en) 2003-07-06
MXPA00012436A (es) 2002-06-04
NO20006444D0 (no) 2000-12-15
HU229582B1 (en) 2014-02-28
KR20010072622A (ko) 2001-07-31
NO20006444L (no) 2000-12-15
AR018879A1 (es) 2001-12-12
HK1032779A1 (en) 2001-08-03
SK18722000A3 (sk) 2001-09-11
ATE253566T1 (de) 2003-11-15
FI981428A (fi) 1999-12-19
FI104718B (fi) 2000-03-31
EA002854B1 (ru) 2002-10-31
ES2211113T3 (es) 2004-07-01
YU76700A (sh) 2002-11-15
CA2334864C (en) 2008-01-15
IL139964A0 (en) 2002-02-10
WO1999065888A3 (en) 2000-01-27
EA200100055A1 (ru) 2001-06-25
EP1087956A2 (en) 2001-04-04
WO1999065888A2 (en) 1999-12-23
DE69912604D1 (de) 2003-12-11
AU755699B2 (en) 2002-12-19
CA2334864A1 (en) 1999-12-23
CN1129590C (zh) 2003-12-03
HUP0102020A3 (en) 2002-04-29
JP4550279B2 (ja) 2010-09-22
US6340764B1 (en) 2002-01-22
AU4786399A (en) 2000-01-05
HUP0102020A2 (hu) 2001-12-28
FI981428A0 (fi) 1998-06-18
PL347577A1 (en) 2002-04-08
CN1306527A (zh) 2001-08-01
ID29239A (id) 2001-08-16
HRP20000866A2 (en) 2001-12-31
CZ298659B6 (cs) 2007-12-12
RS49929B (sr) 2008-09-29
EP1087956B1 (en) 2003-11-05
KR100661772B1 (ko) 2006-12-28
HRP20000866B1 (en) 2009-02-28

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MK4A Expiry of patent

Expiry date: 20190618