SK283589B6 - Tieno[2,3-d]pyrimidíndióny, spôsoby ich prípravy, farmaceutické kompozície s ich obsahom a ich použitie - Google Patents

Tieno[2,3-d]pyrimidíndióny, spôsoby ich prípravy, farmaceutické kompozície s ich obsahom a ich použitie Download PDF

Info

Publication number
SK283589B6
SK283589B6 SK1513-99A SK151399A SK283589B6 SK 283589 B6 SK283589 B6 SK 283589B6 SK 151399 A SK151399 A SK 151399A SK 283589 B6 SK283589 B6 SK 283589B6
Authority
SK
Slovakia
Prior art keywords
methyl
methylpropyl
pyrimidine
thieno
dione
Prior art date
Application number
SK1513-99A
Other languages
English (en)
Slovak (sk)
Other versions
SK151399A3 (en
Inventor
David Cheshire
Andrew Cooke
Martin Cooper
David Donald
Mark Furber
Matthew Perry
Philip Thorne
Original Assignee
Astra Pharmaceuticals Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Pharmaceuticals Ltd. filed Critical Astra Pharmaceuticals Ltd.
Publication of SK151399A3 publication Critical patent/SK151399A3/sk
Publication of SK283589B6 publication Critical patent/SK283589B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Use Of Switch Circuits For Exchanges And Methods Of Control Of Multiplex Exchanges (AREA)
  • Valve-Gear Or Valve Arrangements (AREA)
  • Liquid Crystal (AREA)
SK1513-99A 1997-05-28 1998-05-18 Tieno[2,3-d]pyrimidíndióny, spôsoby ich prípravy, farmaceutické kompozície s ich obsahom a ich použitie SK283589B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9702001A SE9702001D0 (sv) 1997-05-28 1997-05-28 Novel compounds
PCT/SE1998/000935 WO1998054190A1 (en) 1997-05-28 1998-05-18 Novel compounds

Publications (2)

Publication Number Publication Date
SK151399A3 SK151399A3 (en) 2000-05-16
SK283589B6 true SK283589B6 (sk) 2003-10-07

Family

ID=20407123

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1513-99A SK283589B6 (sk) 1997-05-28 1998-05-18 Tieno[2,3-d]pyrimidíndióny, spôsoby ich prípravy, farmaceutické kompozície s ich obsahom a ich použitie

Country Status (28)

Country Link
US (2) US6180635B1 (zh)
EP (1) EP0991653B1 (zh)
JP (1) JP2002500666A (zh)
KR (1) KR100561988B1 (zh)
CN (1) CN1122037C (zh)
AT (1) ATE226205T1 (zh)
AU (1) AU723708B2 (zh)
BR (1) BR9809481A (zh)
CA (1) CA2289509C (zh)
CZ (1) CZ297536B6 (zh)
DE (1) DE69808765T2 (zh)
DK (1) DK0991653T3 (zh)
EE (1) EE04018B1 (zh)
ES (1) ES2184270T3 (zh)
HU (1) HU226627B1 (zh)
ID (1) ID28432A (zh)
IL (2) IL132763A0 (zh)
IS (1) IS1983B (zh)
NO (1) NO323752B1 (zh)
NZ (1) NZ500853A (zh)
PL (1) PL199567B1 (zh)
PT (1) PT991653E (zh)
RU (1) RU2225410C2 (zh)
SE (1) SE9702001D0 (zh)
SK (1) SK283589B6 (zh)
TR (1) TR199902904T2 (zh)
UA (1) UA61111C2 (zh)
WO (1) WO1998054190A1 (zh)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9801399D0 (sv) 1998-04-21 1998-04-21 Astra Pharma Prod Method and apparatus for filling containers
GB9819382D0 (en) 1998-09-04 1998-10-28 Cerebrus Ltd Chemical compounds I
GB9819384D0 (en) 1998-09-04 1998-10-28 Cerebrus Ltd Chemical compounds II
EP1280806B1 (en) * 2000-05-04 2004-08-04 AstraZeneca AB THIENO 2,3-d]PYRIMIDINEDIONES AND THEIR USE AS PHARMACEUTICALS
GB2361917A (en) * 2000-05-04 2001-11-07 Astrazeneca Ab Novel thieno[2,3-d]pyrimidinediones
GB2363377B (en) * 2000-06-14 2004-06-09 Astrazeneca Ab Novel thieno[2,3-d]pyrimidinediones and therapeutic uses thereof
MXPA03004926A (es) * 2001-02-14 2005-02-14 Warner Lambert Co Inhibidores de metaloproteinasas de matriz basados en pirimidinonas fusionadas.
GB0117583D0 (en) * 2001-07-19 2001-09-12 Astrazeneca Ab Novel compounds
GB0118479D0 (en) * 2001-07-28 2001-09-19 Astrazeneca Ab Novel compounds
CZ2004747A3 (cs) * 2001-12-21 2004-11-10 Novo Nordisk A/S Deriváty amidů jako GK aktivátory
MXPA05000130A (es) * 2002-06-27 2005-02-17 Novo Nordisk As Derivados de aril-carbonilo como agentes terapeuticos.
US6890923B2 (en) * 2002-12-16 2005-05-10 Astrazeneca Ab Compounds
NZ541218A (en) * 2003-01-17 2008-05-30 Astrazeneca Ab Thienopyrimidinediones and their use in modulation of autoimmune disease
SE0300117D0 (sv) * 2003-01-17 2003-01-17 Astrazeneca Ab Novel Compounds
SE0300120D0 (sv) * 2003-01-17 2003-01-17 Astrazeneca Ab Novel compounds
SE0300119D0 (sv) * 2003-01-17 2003-01-17 Astrazeneca Ab Novel compounds
CA2551324C (en) * 2004-01-06 2012-11-27 Novo Nordisk A/S Heteroaryl-ureas and their use as glucokinase activators
EP1904466A1 (en) * 2005-07-08 2008-04-02 Novo Nordisk A/S Dicycloalkyl urea glucokinase activators
WO2007006761A1 (en) * 2005-07-08 2007-01-18 Novo Nordisk A/S Dicycloalkylcarbamoyl ureas as glucokinase activators
JP4960355B2 (ja) 2005-07-14 2012-06-27 ノボ・ノルデイスク・エー／エス ウレア型グルコキナーゼ活性化剤
CA2644996A1 (en) * 2006-03-02 2007-09-13 Cv Therapeutics, Inc. A2a adenosine receptor antagonists
CN101186612B (zh) * 2006-11-15 2012-10-03 天津和美生物技术有限公司 可抑制细胞释放肿瘤坏死因子的吡咯啉衍生物及其制备和应用
CA2670788A1 (en) * 2006-12-01 2008-06-12 Cv Therapeutics, Inc. A2a adenosine receptor antagonists
WO2008084043A1 (en) * 2007-01-09 2008-07-17 Novo Nordisk A/S Urea glucokinase activators
US8318778B2 (en) 2007-01-11 2012-11-27 Novo Nordisk A/S Urea glucokinase activators
EP2008656A1 (en) 2007-06-28 2008-12-31 Bergen Teknologioverforing AS Compositions for the treatment of hyperphenylalaninemia
PL2411395T3 (pl) * 2009-03-23 2013-10-31 Glenmark Pharmaceuticals Sa Pochodne furopirymidynodionu jako modulatory TRPA1
CA2855372C (en) * 2011-11-11 2022-03-22 Nimbus Apollo, Inc. 2,4-dioxo-thieno[2,3-d]pyrimidinyl derivatives and pharmaceutical compositions thereof used as acc inhibitors
JP6268093B2 (ja) * 2012-09-14 2018-01-24 キッセイ薬品工業株式会社 縮合複素環誘導体の製造方法およびその製造中間体
CN105793267B (zh) * 2013-10-07 2018-02-06 拜耳制药股份公司 环状噻吩并尿嘧啶甲酰胺类及其用途
UY36586A (es) 2015-03-26 2016-10-31 Bayer Pharma AG Heterociclilmetiltienouracilos y uso de los mismos
AR106472A1 (es) 2015-10-26 2018-01-17 Gilead Apollo Llc Inhibidores de acc y usos de los mismos
KR20180082557A (ko) 2015-11-25 2018-07-18 길리어드 아폴로, 엘엘씨 트리아졸 acc 억제제 및 그의 용도
KR20180082556A (ko) 2015-11-25 2018-07-18 길리어드 아폴로, 엘엘씨 피라졸 acc 억제제 및 그의 용도
SI3379933T1 (sl) 2015-11-25 2023-07-31 Gilead Apollo, Llc Fungicidni sestavki, ki vsebujejo derivate 2,4-diokso-1,4-dihidrotieno (2,3-d)pirimidina
HUE053175T2 (hu) 2015-11-25 2021-06-28 Gilead Apollo Llc ACC-gátló észterek és azok alkalmazása
JP6944462B2 (ja) 2016-03-02 2021-10-06 ギリアド アポロ， エルエルシー チエノピリミジンジオンａｃｃ阻害剤の固体形態およびその生成のための方法
WO2018041771A1 (de) 2016-09-02 2018-03-08 Bayer Pharma Aktiengesellschaft (1-methylcyclopropyl)methyl-substituierte thienouracile und ihre verwendung
CA3037642A1 (en) * 2016-09-23 2018-03-29 Bayer Aktiengesellschaft N 3 -cyclically substituted thienouraciles and use thereof
CN110461328A (zh) 2017-03-28 2019-11-15 吉利德科学公司 治疗肝疾病的治疗组合
EP3806852A1 (en) 2018-06-12 2021-04-21 vTv Therapeutics LLC Therapeutic uses of glucokinase activators in combination with insulin or insulin analogs

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989002432A1 (en) * 1987-09-16 1989-03-23 Taiho Pharmaceutical Company, Limited Thienopyrimidine derivatives
TW276256B (zh) * 1993-08-26 1996-05-21 Takeda Pharm Industry Co Ltd
FR2750862B1 (fr) * 1996-07-12 1998-10-16 Dupin Jean Pierre Utilisation d'heterocycles diazotes fusionnes avec un systeme aromatique ou heteroaromatique pour le traitement des maladies thrombo-emboliques

Also Published As

Publication number Publication date
CZ297536B6 (cs) 2007-01-03
PL337126A1 (en) 2000-07-31
HU226627B1 (en) 2009-05-28
CN1264382A (zh) 2000-08-23
ATE226205T1 (de) 2002-11-15
IL132763A0 (en) 2001-03-19
PT991653E (pt) 2003-02-28
NZ500853A (en) 2001-05-25
NO323752B1 (no) 2007-07-02
IL132763A (en) 2007-03-08
US6342502B1 (en) 2002-01-29
EE9900539A (et) 2000-06-15
ID28432A (id) 2001-05-24
TR199902904T2 (xx) 2000-06-21
EP0991653A1 (en) 2000-04-12
KR100561988B1 (ko) 2006-03-17
EP0991653B1 (en) 2002-10-16
ES2184270T3 (es) 2003-04-01
JP2002500666A (ja) 2002-01-08
IS1983B (is) 2005-01-14
NO995810D0 (no) 1999-11-26
DE69808765D1 (de) 2002-11-21
HUP0003355A2 (hu) 2001-02-28
US6180635B1 (en) 2001-01-30
AU7680898A (en) 1998-12-30
PL199567B1 (pl) 2008-10-31
NO995810L (no) 2000-01-27
UA61111C2 (uk) 2003-11-17
DE69808765T2 (de) 2003-07-24
EE04018B1 (et) 2003-04-15
HUP0003355A3 (en) 2003-03-28
CA2289509C (en) 2007-10-02
IS5264A (is) 1999-11-23
SK151399A3 (en) 2000-05-16
SE9702001D0 (sv) 1997-05-28
CA2289509A1 (en) 1998-12-03
CN1122037C (zh) 2003-09-24
RU2225410C2 (ru) 2004-03-10
CZ420199A3 (cs) 2000-07-12
AU723708B2 (en) 2000-09-07
WO1998054190A1 (en) 1998-12-03
DK0991653T3 (da) 2003-01-06
KR20010013107A (ko) 2001-02-26
BR9809481A (pt) 2000-06-20

Similar Documents

Publication Publication Date Title
SK283589B6 (sk) Tieno[2,3-d]pyrimidíndióny, spôsoby ich prípravy, farmaceutické kompozície s ich obsahom a ich použitie
RU2685234C1 (ru) Конденсированные бициклические гетероароматические производные в качестве модуляторов активности tnf
AU2006330924B2 (en) Anti-viral compounds
ES2240449T3 (es) Moduladores receptores de adenosina.
EP2513114B1 (en) Pyrrolo[2,3-d]pyrimidine compounds
JP2002517396A (ja) 細胞接着阻害抗炎症性化合物
MXPA02003841A (es) Heterociclos de nitrogeno biciclicos alquilamino substituidos como inhibidores de proteina p38.
NO333586B1 (no) Krystallinsk clopidogrel og fremgangsmate for fremstilling derav
CA2776028A1 (en) Pyrrolo[2,3-d]pyrimidine compounds
NZ504452A (en) [3,4-d]Pyridazinones, process for their preparation and pharmaceutical compositions containing them
KR19990022327A (ko) Ｎ-헤테로아릴-피리딘설폰아미드 유도체 및 이의 엔도텔린 길항 물질로서의 용도
EP2054417A2 (en) Fused thiophene derivatives as mek inhibitors
WO2007072095A1 (en) New compounds
US6984644B2 (en) Treatment of skin disorders using thieno[2,3-D]pyrimidinediones
US6469014B1 (en) Thieno[2,3-d] pyrimidinediones, their preparation and use in therapy
AU2006221037A1 (en) 1,3-thiazole-5-carboxamides useful as cancer chemotherapeutic agents
MXPA99010911A (en) Novel compounds
JP3304086B2 (ja) 呼吸器官に対して抗炎症作用と抗喘息作用を有する［３Ｈ，７Ｈ］チアゾロ［３，４―ａ］ビリジン類
MX2011003961A (es) Tieno[2,3-d]pirimidinas sustituidas con fenilo y heteroarilo y su uso como antagonistas de receptores de adenosina a2a.

Legal Events

Date Code Title Description
MM4A Patent lapsed due to non-payment of maintenance fees

Effective date: 20100518