SK283300B6 - Piperidínové zlúčeniny s analgetickým účinkom, spôsob ich prípravy, medziprodukty na ich prípravu, ich použitie, diagnostické činidlo a farmaceutické kompozície s ich obsahom - Google Patents

Piperidínové zlúčeniny s analgetickým účinkom, spôsob ich prípravy, medziprodukty na ich prípravu, ich použitie, diagnostické činidlo a farmaceutické kompozície s ich obsahom Download PDF

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Publication number
SK283300B6
SK283300B6 SK763-99A SK76399A SK283300B6 SK 283300 B6 SK283300 B6 SK 283300B6 SK 76399 A SK76399 A SK 76399A SK 283300 B6 SK283300 B6 SK 283300B6
Authority
SK
Slovakia
Prior art keywords
formula
compound
group
mmol
mixture
Prior art date
Application number
SK763-99A
Other languages
English (en)
Slovak (sk)
Other versions
SK76399A3 (en
Inventor
Benjamin Pelcman
Edward Roberts
Original Assignee
Astra Pharma Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Pharma Inc. filed Critical Astra Pharma Inc.
Publication of SK76399A3 publication Critical patent/SK76399A3/sk
Publication of SK283300B6 publication Critical patent/SK283300B6/sk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0446—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SK763-99A 1996-12-20 1997-12-09 Piperidínové zlúčeniny s analgetickým účinkom, spôsob ich prípravy, medziprodukty na ich prípravu, ich použitie, diagnostické činidlo a farmaceutické kompozície s ich obsahom SK283300B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9604786A SE9604786D0 (sv) 1996-12-20 1996-12-20 New compounds
PCT/SE1997/002051 WO1998028270A1 (en) 1996-12-20 1997-12-09 Novel compounds with analgesic effect

Publications (2)

Publication Number Publication Date
SK76399A3 SK76399A3 (en) 2000-01-18
SK283300B6 true SK283300B6 (sk) 2003-05-02

Family

ID=20405139

Family Applications (1)

Application Number Title Priority Date Filing Date
SK763-99A SK283300B6 (sk) 1996-12-20 1997-12-09 Piperidínové zlúčeniny s analgetickým účinkom, spôsob ich prípravy, medziprodukty na ich prípravu, ich použitie, diagnostické činidlo a farmaceutické kompozície s ich obsahom

Country Status (32)

Country Link
US (3) US6153626A (zh)
EP (2) EP0946510B1 (zh)
JP (1) JP2001507021A (zh)
KR (1) KR20000069600A (zh)
CN (2) CN1539824A (zh)
AR (1) AR010378A1 (zh)
AT (1) ATE266638T1 (zh)
AU (1) AU738002B2 (zh)
BR (1) BR9713785A (zh)
CA (1) CA2274117A1 (zh)
CZ (1) CZ220099A3 (zh)
DE (1) DE69729115T2 (zh)
DK (1) DK0946510T3 (zh)
EE (1) EE03966B1 (zh)
ES (1) ES2219783T3 (zh)
HK (2) HK1022910A1 (zh)
HU (1) HUP0000613A3 (zh)
ID (1) ID21662A (zh)
IL (1) IL130536A0 (zh)
IS (1) IS5078A (zh)
MY (1) MY132705A (zh)
NO (1) NO313632B1 (zh)
NZ (1) NZ336028A (zh)
PL (1) PL188945B1 (zh)
PT (1) PT946510E (zh)
RU (1) RU2193030C2 (zh)
SE (1) SE9604786D0 (zh)
SK (1) SK283300B6 (zh)
TR (1) TR199901411T2 (zh)
UA (1) UA54481C2 (zh)
WO (1) WO1998028270A1 (zh)
ZA (1) ZA9711049B (zh)

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US6974825B1 (en) 1996-12-20 2005-12-13 Astrazeneca Canada Inc. Compounds with analgesic effect
AU2003220725B2 (en) * 1997-12-24 2006-06-01 Ortho-Mcneil Pharmaceutical, Inc. 4-[aryl(piperidin-4-yl)] aminobenzamides which bind to the delta-opioid receptor
AU2009799A (en) * 1997-12-24 1999-07-19 Ortho-Mcneil Pharmaceutical, Inc. 4-(aryl(piperidin-4-yl)) aminobenzamides which bind to the delta-opioid receptor
US6900228B1 (en) 1998-03-10 2005-05-31 Research Triangle Institute Opiate compounds, methods of making and methods of use
AU756983B2 (en) * 1998-03-10 2003-01-30 Research Triangle Institute Novel opiate compounds, methods of making and methods of use
US6436959B1 (en) 1998-12-23 2002-08-20 Ortho-Mcneil Pharmaceutical, Inc. 4-[aryl(piperidin-4-yl)]aminobenzamides
SE9904673D0 (sv) * 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
SE9904675D0 (sv) 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
SE9904674D0 (sv) * 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
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ES2248281T3 (es) * 2000-02-18 2006-03-16 Meiji Seika Kaisha, Ltd. Derivados de fenoxialquilamina utiles como agonistas del receptor opioide delta.
AU2001241676A1 (en) 2000-03-03 2001-09-17 Ortho-Mcneil Pharmaceutical, Inc. 3-(diarylmethylene)-8-azabicyclo(3.2.1)octane derivatives
EP1277737A4 (en) 2000-03-24 2003-05-07 Meiji Seika Kaisha DIPHENYLALKYLAMINE DERIVATIVES AS AGONISTS OF THE OPIOID -g (d) RECEPTOR
SE0001209D0 (sv) 2000-04-04 2000-04-04 Astrazeneca Canada Inc Novel compounds
AU2002234010A1 (en) 2000-12-14 2002-06-24 Ortho-Mcneil Pharmaceutical, Inc. Benzamidine derivatives
BR0116129A (pt) * 2000-12-15 2003-11-04 Astrazeneca Ab Processo para a preparação de composto de diaril-4-aminopiperidinil-1substituìdo, e, composto
SE0101773D0 (sv) * 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
SI1395567T1 (sl) 2001-05-18 2009-04-30 Astrazeneca Ab 4-(fenil-piperazinil-metil)benzamidni derivati in njihova uporaba za zdravljenje bolečine, tesnobe ali gastrointestinalnih motenj
SE0101770D0 (sv) 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
SE0101769D0 (sv) 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
SE0101771D0 (sv) * 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
CA2462953C (en) 2001-10-15 2011-01-04 Janssen Pharmaceutica N.V. Substituted 4-phenyl-4-[1h-imidazol-2-yl]-piperidine derivatives and their use as selective non-peptide delta opioid agonists
EP1485099B1 (en) * 2002-03-13 2010-07-07 Janssen Pharmaceutica N.V. Inhibitors of histone deacetylase
CA2784937A1 (en) 2002-05-24 2003-12-04 Millennium Pharmaceuticals, Inc. Ccr9 inhibitors and methods of use thereof
SE0203302D0 (sv) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
SE0203300D0 (sv) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
SE0203303D0 (sv) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
US7420055B2 (en) 2002-11-18 2008-09-02 Chemocentryx, Inc. Aryl sulfonamides
US7227035B2 (en) 2002-11-18 2007-06-05 Chemocentryx Bis-aryl sulfonamides
EP1798223B2 (en) 2002-11-18 2014-07-30 ChemoCentryx, Inc. Aryl sulfonamides
US7741519B2 (en) 2007-04-23 2010-06-22 Chemocentryx, Inc. Bis-aryl sulfonamides
CA2530444C (en) 2003-06-27 2012-03-13 Janssen Pharmaceutica, N.V. Tricyclic .delta. opioid modulators
EP1737853A1 (en) 2004-02-03 2007-01-03 Janssen Pharmaceutica N.V. 3-(diheteroarylmethylene)-8-azabicyclo¬3.2.1|octane and 3-((aryl)(heteroaryl)methylene)-8-azabicyclo¬3.2.1|octane derivatives
DK1781631T3 (da) 2004-08-02 2012-05-14 Astrazeneca Ab Diarylmethylpiperazinderivater, præparater dermed og anvendelser deraf
KR20080027216A (ko) * 2004-08-05 2008-03-26 얀센 파마슈티카 엔.브이. 트리사이클릭 δ-오피오이드 조절자
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Also Published As

Publication number Publication date
NO993023L (no) 1999-08-12
IS5078A (is) 1999-06-11
ZA9711049B (en) 1998-06-22
NO313632B1 (no) 2002-11-04
EE9900261A (et) 2000-02-15
AR010378A1 (es) 2000-06-07
EP0946510B1 (en) 2004-05-12
HK1022910A1 (en) 2000-08-25
NZ336028A (en) 2001-03-30
JP2001507021A (ja) 2001-05-29
RU2193030C2 (ru) 2002-11-20
CA2274117A1 (en) 1998-07-02
IL130536A0 (en) 2000-06-01
SK76399A3 (en) 2000-01-18
EE03966B1 (et) 2003-02-17
ATE266638T1 (de) 2004-05-15
MY132705A (en) 2007-10-31
BR9713785A (pt) 2000-02-08
CN1154635C (zh) 2004-06-23
US20030055045A1 (en) 2003-03-20
PL188945B1 (pl) 2005-05-31
CN1539824A (zh) 2004-10-27
HK1023996A1 (en) 2000-09-29
DE69729115D1 (de) 2004-06-17
AU5351398A (en) 1998-07-17
US6710179B2 (en) 2004-03-23
ID21662A (id) 1999-07-08
PT946510E (pt) 2004-08-31
EP1428821A8 (en) 2005-01-26
CN1241178A (zh) 2000-01-12
HUP0000613A3 (en) 2002-10-28
SE9604786D0 (sv) 1996-12-20
CZ220099A3 (cs) 1999-11-17
ES2219783T3 (es) 2004-12-01
EP1428821A1 (en) 2004-06-16
US6153626A (en) 2000-11-28
TR199901411T2 (xx) 1999-09-21
WO1998028270A1 (en) 1998-07-02
AU738002B2 (en) 2001-09-06
NO993023D0 (no) 1999-06-18
KR20000069600A (ko) 2000-11-25
EP0946510A1 (en) 1999-10-06
US6399635B1 (en) 2002-06-04
UA54481C2 (uk) 2003-03-17
HUP0000613A2 (hu) 2000-09-28
DK0946510T3 (da) 2004-08-09
DE69729115T2 (de) 2005-04-28
PL334370A1 (en) 2000-02-28

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