EE03966B1 - Valuvaigistava toimega ühendid ja nende valmistamise meetod - Google Patents

Valuvaigistava toimega ühendid ja nende valmistamise meetod

Info

Publication number
EE03966B1
EE03966B1 EEP199900261A EE9900261A EE03966B1 EE 03966 B1 EE03966 B1 EE 03966B1 EE P199900261 A EEP199900261 A EE P199900261A EE 9900261 A EE9900261 A EE 9900261A EE 03966 B1 EE03966 B1 EE 03966B1
Authority
EE
Estonia
Prior art keywords
compounds
preparation
analgesic activity
analgesic
activity
Prior art date
Application number
EEP199900261A
Other languages
English (en)
Estonian (et)
Other versions
EE9900261A (et
Inventor
Pelcman Benjamin
Roberts Edward
Original Assignee
Astra Pharma Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Pharma Inc. filed Critical Astra Pharma Inc.
Publication of EE9900261A publication Critical patent/EE9900261A/xx
Publication of EE03966B1 publication Critical patent/EE03966B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0446—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EEP199900261A 1996-12-20 1997-12-09 Valuvaigistava toimega ühendid ja nende valmistamise meetod EE03966B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9604786A SE9604786D0 (sv) 1996-12-20 1996-12-20 New compounds
PCT/SE1997/002051 WO1998028270A1 (en) 1996-12-20 1997-12-09 Novel compounds with analgesic effect

Publications (2)

Publication Number Publication Date
EE9900261A EE9900261A (et) 2000-02-15
EE03966B1 true EE03966B1 (et) 2003-02-17

Family

ID=20405139

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP199900261A EE03966B1 (et) 1996-12-20 1997-12-09 Valuvaigistava toimega ühendid ja nende valmistamise meetod

Country Status (32)

Country Link
US (3) US6153626A (zh)
EP (2) EP0946510B1 (zh)
JP (1) JP2001507021A (zh)
KR (1) KR20000069600A (zh)
CN (2) CN1539824A (zh)
AR (1) AR010378A1 (zh)
AT (1) ATE266638T1 (zh)
AU (1) AU738002B2 (zh)
BR (1) BR9713785A (zh)
CA (1) CA2274117A1 (zh)
CZ (1) CZ220099A3 (zh)
DE (1) DE69729115T2 (zh)
DK (1) DK0946510T3 (zh)
EE (1) EE03966B1 (zh)
ES (1) ES2219783T3 (zh)
HK (2) HK1022910A1 (zh)
HU (1) HUP0000613A3 (zh)
ID (1) ID21662A (zh)
IL (1) IL130536A0 (zh)
IS (1) IS5078A (zh)
MY (1) MY132705A (zh)
NO (1) NO313632B1 (zh)
NZ (1) NZ336028A (zh)
PL (1) PL188945B1 (zh)
PT (1) PT946510E (zh)
RU (1) RU2193030C2 (zh)
SE (1) SE9604786D0 (zh)
SK (1) SK283300B6 (zh)
TR (1) TR199901411T2 (zh)
UA (1) UA54481C2 (zh)
WO (1) WO1998028270A1 (zh)
ZA (1) ZA9711049B (zh)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9504661D0 (sv) 1995-12-22 1995-12-22 Astra Pharma Inc New compounds
SE9604786D0 (sv) * 1996-12-20 1996-12-20 Astra Pharma Inc New compounds
TW548271B (en) * 1996-12-20 2003-08-21 Astra Pharma Inc Novel piperidine derivatives having an exocyclic double bond with analgesic effects
US6974825B1 (en) 1996-12-20 2005-12-13 Astrazeneca Canada Inc. Compounds with analgesic effect
AU2003220725B2 (en) * 1997-12-24 2006-06-01 Ortho-Mcneil Pharmaceutical, Inc. 4-[aryl(piperidin-4-yl)] aminobenzamides which bind to the delta-opioid receptor
AU2009799A (en) * 1997-12-24 1999-07-19 Ortho-Mcneil Pharmaceutical, Inc. 4-(aryl(piperidin-4-yl)) aminobenzamides which bind to the delta-opioid receptor
US6900228B1 (en) 1998-03-10 2005-05-31 Research Triangle Institute Opiate compounds, methods of making and methods of use
AU756983B2 (en) * 1998-03-10 2003-01-30 Research Triangle Institute Novel opiate compounds, methods of making and methods of use
US6436959B1 (en) 1998-12-23 2002-08-20 Ortho-Mcneil Pharmaceutical, Inc. 4-[aryl(piperidin-4-yl)]aminobenzamides
SE9904673D0 (sv) * 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
SE9904675D0 (sv) 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
SE9904674D0 (sv) * 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
CA2395471A1 (en) * 1999-12-22 2001-06-28 Ortho-Mcneil Pharmaceutical, Inc. 4-[aryl(8-azabicyclo[3.2.1]octan-3-yl)]aminobenzoic acid derivatives
ES2248281T3 (es) * 2000-02-18 2006-03-16 Meiji Seika Kaisha, Ltd. Derivados de fenoxialquilamina utiles como agonistas del receptor opioide delta.
AU2001241676A1 (en) 2000-03-03 2001-09-17 Ortho-Mcneil Pharmaceutical, Inc. 3-(diarylmethylene)-8-azabicyclo(3.2.1)octane derivatives
EP1277737A4 (en) 2000-03-24 2003-05-07 Meiji Seika Kaisha DIPHENYLALKYLAMINE DERIVATIVES AS AGONISTS OF THE OPIOID -g (d) RECEPTOR
SE0001209D0 (sv) 2000-04-04 2000-04-04 Astrazeneca Canada Inc Novel compounds
AU2002234010A1 (en) 2000-12-14 2002-06-24 Ortho-Mcneil Pharmaceutical, Inc. Benzamidine derivatives
BR0116129A (pt) * 2000-12-15 2003-11-04 Astrazeneca Ab Processo para a preparação de composto de diaril-4-aminopiperidinil-1substituìdo, e, composto
SE0101773D0 (sv) * 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
SI1395567T1 (sl) 2001-05-18 2009-04-30 Astrazeneca Ab 4-(fenil-piperazinil-metil)benzamidni derivati in njihova uporaba za zdravljenje bolečine, tesnobe ali gastrointestinalnih motenj
SE0101770D0 (sv) 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
SE0101769D0 (sv) 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
SE0101771D0 (sv) * 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
CA2462953C (en) 2001-10-15 2011-01-04 Janssen Pharmaceutica N.V. Substituted 4-phenyl-4-[1h-imidazol-2-yl]-piperidine derivatives and their use as selective non-peptide delta opioid agonists
EP1485099B1 (en) * 2002-03-13 2010-07-07 Janssen Pharmaceutica N.V. Inhibitors of histone deacetylase
CA2784937A1 (en) 2002-05-24 2003-12-04 Millennium Pharmaceuticals, Inc. Ccr9 inhibitors and methods of use thereof
SE0203302D0 (sv) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
SE0203300D0 (sv) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
SE0203303D0 (sv) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
US7420055B2 (en) 2002-11-18 2008-09-02 Chemocentryx, Inc. Aryl sulfonamides
US7227035B2 (en) 2002-11-18 2007-06-05 Chemocentryx Bis-aryl sulfonamides
EP1798223B2 (en) 2002-11-18 2014-07-30 ChemoCentryx, Inc. Aryl sulfonamides
US7741519B2 (en) 2007-04-23 2010-06-22 Chemocentryx, Inc. Bis-aryl sulfonamides
CA2530444C (en) 2003-06-27 2012-03-13 Janssen Pharmaceutica, N.V. Tricyclic .delta. opioid modulators
EP1737853A1 (en) 2004-02-03 2007-01-03 Janssen Pharmaceutica N.V. 3-(diheteroarylmethylene)-8-azabicyclo¬3.2.1|octane and 3-((aryl)(heteroaryl)methylene)-8-azabicyclo¬3.2.1|octane derivatives
DK1781631T3 (da) 2004-08-02 2012-05-14 Astrazeneca Ab Diarylmethylpiperazinderivater, præparater dermed og anvendelser deraf
KR20080027216A (ko) * 2004-08-05 2008-03-26 얀센 파마슈티카 엔.브이. 트리사이클릭 δ-오피오이드 조절자
CA2592462A1 (en) * 2004-12-22 2006-06-29 Janssen Pharmaceutica N.V. Tricyclic delta-opioid modulators
EP1833826B1 (en) 2004-12-22 2009-05-27 Janssen Pharmaceutica N.V. Tricyclic delta-opioid modulators
EP1833825A1 (en) * 2004-12-22 2007-09-19 Janssen Pharmaceutica N.V. Tricyclic delta-opioid modulators
CN101128460A (zh) * 2005-01-06 2008-02-20 詹森药业有限公司 三环的δ-阿片样物质调节剂
TWI449692B (zh) 2005-05-13 2014-08-21 Otsuka Pharma Co Ltd 吡咯烷化合物（三）
CA2612491A1 (en) * 2005-06-16 2006-12-28 Janssen Pharmaceutica N.V. Tricyclic opioid modulators
JP5219465B2 (ja) * 2006-11-10 2013-06-26 大塚製薬株式会社 医薬

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4091096A (en) * 1976-03-19 1978-05-23 Eli Lilly And Company Dinitroanilines for the control of phytopathogens
EG12406A (en) * 1976-08-12 1979-03-31 Janssen Pharmaceutica Nv Process for preparing of novel n-aryl-n-(1-l-4-piperidinyl)-arylacetamides
SE441448B (sv) * 1977-05-23 1985-10-07 Pfizer Sett att framstella hexahydro-gamma-karbolinforeningar
DE3200304A1 (de) * 1981-01-16 1982-08-26 Sandoz-Patent-GmbH, 7850 Lörrach 3-aminopropoxyaryl-derivate, ihre herstellung und sie enthaltende arzneimittel
DE3563964D1 (en) * 1984-10-16 1988-09-01 Synthelabo Piperidine derivatives, their preparation and their therapeutical application
YU150489A (sh) 1989-08-10 1992-12-21 W.L. Gore & Co. Gmbh. Uređaj za ispitivanje odevnih predmeta na nepromočivost
KR940003491B1 (ko) 1989-08-10 1994-04-23 리히터 게데온 베기에스제티 기아르 알.티 4,4-이중 치환된 피페리딘 유도체와 그 제조방법 및 상기 화합물을 함유하는 약제학적 조성물
GB9202238D0 (en) * 1992-02-03 1992-03-18 Wellcome Found Compounds
US5854245A (en) * 1996-06-28 1998-12-29 Merck & Co., Inc. Fibrinogen receptor antagonists
SE9604786D0 (sv) 1996-12-20 1996-12-20 Astra Pharma Inc New compounds
TW548271B (en) * 1996-12-20 2003-08-21 Astra Pharma Inc Novel piperidine derivatives having an exocyclic double bond with analgesic effects
AU2009799A (en) * 1997-12-24 1999-07-19 Ortho-Mcneil Pharmaceutical, Inc. 4-(aryl(piperidin-4-yl)) aminobenzamides which bind to the delta-opioid receptor
AU756983B2 (en) 1998-03-10 2003-01-30 Research Triangle Institute Novel opiate compounds, methods of making and methods of use
US6436959B1 (en) 1998-12-23 2002-08-20 Ortho-Mcneil Pharmaceutical, Inc. 4-[aryl(piperidin-4-yl)]aminobenzamides

Also Published As

Publication number Publication date
NO993023L (no) 1999-08-12
IS5078A (is) 1999-06-11
ZA9711049B (en) 1998-06-22
NO313632B1 (no) 2002-11-04
EE9900261A (et) 2000-02-15
AR010378A1 (es) 2000-06-07
EP0946510B1 (en) 2004-05-12
HK1022910A1 (en) 2000-08-25
NZ336028A (en) 2001-03-30
JP2001507021A (ja) 2001-05-29
RU2193030C2 (ru) 2002-11-20
CA2274117A1 (en) 1998-07-02
IL130536A0 (en) 2000-06-01
SK76399A3 (en) 2000-01-18
ATE266638T1 (de) 2004-05-15
MY132705A (en) 2007-10-31
BR9713785A (pt) 2000-02-08
CN1154635C (zh) 2004-06-23
US20030055045A1 (en) 2003-03-20
PL188945B1 (pl) 2005-05-31
CN1539824A (zh) 2004-10-27
HK1023996A1 (en) 2000-09-29
DE69729115D1 (de) 2004-06-17
AU5351398A (en) 1998-07-17
US6710179B2 (en) 2004-03-23
ID21662A (id) 1999-07-08
PT946510E (pt) 2004-08-31
EP1428821A8 (en) 2005-01-26
CN1241178A (zh) 2000-01-12
HUP0000613A3 (en) 2002-10-28
SE9604786D0 (sv) 1996-12-20
CZ220099A3 (cs) 1999-11-17
ES2219783T3 (es) 2004-12-01
EP1428821A1 (en) 2004-06-16
US6153626A (en) 2000-11-28
TR199901411T2 (xx) 1999-09-21
WO1998028270A1 (en) 1998-07-02
AU738002B2 (en) 2001-09-06
NO993023D0 (no) 1999-06-18
KR20000069600A (ko) 2000-11-25
EP0946510A1 (en) 1999-10-06
SK283300B6 (sk) 2003-05-02
US6399635B1 (en) 2002-06-04
UA54481C2 (uk) 2003-03-17
HUP0000613A2 (hu) 2000-09-28
DK0946510T3 (da) 2004-08-09
DE69729115T2 (de) 2005-04-28
PL334370A1 (en) 2000-02-28

Similar Documents

Publication Publication Date Title
EE03966B1 (et) Valuvaigistava toimega ühendid ja nende valmistamise meetod
FI955051A0 (fi) Heterosyklisiä yhdisteitä ja niiden valmistus ja käyttö
EE03976B1 (et) Erütromütsiinid ja nende valmistamise meetod
FI941137A (fi) 2-debentsoyyli-2-asyylitaksolijohdannaisia ja menetelmiä niiden valmistamiseksi
FI973750A0 (fi) 2-metyylitienobentsodiatsepiinin valmistus ja kiteiset muodot
EE9900454A (et) Varjestuskest ja varjestuskesta valmistamismeetod
FI972165A (fi) Aerogeelipitoinen komposiittimateriaali, menetelmä sen valmistamiseksi ja sen käyttö
EE9800459A (et) Spiro-piperidiini derivaadid ja nende kasutamine terapeutiliste toimeainetena
EE04540B1 (et) Meetod bioloogiliselt sobivate biodegradeeruvate mikroosakeste valmistamiseks ja mikroosakeste kasutamine
FI953479A0 (fi) 1-aryylipyrimidiinijohdannaiset ja niiden farmaseuttinen käyttö
DE69831755D1 (de) Optoakustische kontrastmittel und anwendungsverfahren
EE9700039A (et) Teraapias kasutatavad spiro-asabitsüklilised ühendid ja nende valmistamise protsess
FI945166A0 (fi) Katalyttejä, niiden käyttömenetelmä ja menetelmä niiden valmistamiseksi
NO975831D0 (no) Nytt farmasöytisk preparat med anestetisk virkning
NO982913D0 (no) Kinolin- og kinazolinforbindelser nyttige i terapi
FI971495A0 (fi) Vaahdonestokoostumus ja sen käyttömenetelmä
FI962908A (fi) Mikrobinvastainen koostumus, sen valmistusmenetelmä ja sen käyttö
FI980246A (fi) Menetelmä keittimen käyttämiseksi ja keitin
NO972477D0 (no) Meso-mono-jod substituerte tetramakrocykliske forbindelser og fremgangsmåter for fremstilling og anvendelse
FI103463B1 (fi) Tietokone ja menetelmä tietokoneen käyttämiseksi
EE200200105A (et) Radiofarmatseutilised saadused ja nende valmistamise meetod
EE9900141A (et) Keerdotstega suletav pakend ja meetod pakendamiseks
FI964267A (fi) Porfosyaniini ja CNC-laajennetut porfyriinit
NO964190D0 (no) Terapeutisk smertestillende middel samt fremgangsmåte ved fremstilling derav
FI945427A0 (fi) Dynemisiinianalogien enantiomeerit, niiden valmistus ja käyttö

Legal Events

Date Code Title Description
KB4A Valid patent at the end of a year

Effective date: 20031231

KB4A Valid patent at the end of a year

Effective date: 20041231

KB4A Valid patent at the end of a year

Effective date: 20051231

MM4A Lapsed by not paying the annual fees

Effective date: 20051209