FI945427A0 - Dynemisiinianalogien enantiomeerit, niiden valmistus ja käyttö - Google Patents
Dynemisiinianalogien enantiomeerit, niiden valmistus ja käyttöInfo
- Publication number
- FI945427A0 FI945427A0 FI945427A FI945427A FI945427A0 FI 945427 A0 FI945427 A0 FI 945427A0 FI 945427 A FI945427 A FI 945427A FI 945427 A FI945427 A FI 945427A FI 945427 A0 FI945427 A0 FI 945427A0
- Authority
- FI
- Finland
- Prior art keywords
- dynemisin
- enantiomers
- analogues
- preparation
- dynemisin analogues
- Prior art date
Links
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/886,984 US5276159A (en) | 1990-08-01 | 1992-05-21 | Dynemicin analogs: syntheses, methods of preparation and use |
US07/939,104 US5281710A (en) | 1990-08-01 | 1992-09-01 | Dynemicin analogs: synthesis, methods of preparation and use |
PCT/US1993/004708 WO1993023046A1 (en) | 1992-05-21 | 1993-05-18 | Enantiomeric cynemicin analogs, preparation and use thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
FI945427A0 true FI945427A0 (fi) | 1994-11-18 |
FI945427A FI945427A (fi) | 1995-01-18 |
Family
ID=27128819
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI945427A FI945427A (fi) | 1992-05-21 | 1994-11-18 | Dynemisiinianalogien enantiomeerit, niiden valmistus ja käyttö |
Country Status (7)
Country | Link |
---|---|
US (2) | US5281710A (fi) |
EP (1) | EP0641207A4 (fi) |
JP (1) | JPH07508037A (fi) |
AU (1) | AU680418B2 (fi) |
CA (1) | CA2136234A1 (fi) |
FI (1) | FI945427A (fi) |
WO (1) | WO1993023046A1 (fi) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5770736A (en) * | 1994-06-21 | 1998-06-23 | Northeastern University | Reagents for cleavage or crosslinking of biomolecules using nondiffusible reactive intermediates |
WO1996003124A1 (en) * | 1994-07-27 | 1996-02-08 | California Institute Of Technology | Dynemicin analogs |
US5622958A (en) * | 1994-12-01 | 1997-04-22 | Sloan-Kettering Institute For Cancer Research | Enediyne quinone imines and methods of preparation and use thereof |
GB9517001D0 (en) * | 1995-08-18 | 1995-10-18 | Denny William | Enediyne compounds |
US6248539B1 (en) * | 1997-09-05 | 2001-06-19 | The Scripps Research Institute | Porous semiconductor-based optical interferometric sensor |
US7105491B2 (en) * | 1999-01-06 | 2006-09-12 | Wisconsin Alumni Research Foundation (Warf) | Biosynthesis of enediyne compounds by manipulation of C-1027 gene pathway |
PT1627645T (pt) * | 2003-05-26 | 2017-11-23 | Maeda Hiroshi | Agente antitumoral e processo para a sua produção |
US7122353B2 (en) * | 2003-08-05 | 2006-10-17 | Wisconsin Alumni Research Foundation | Targeted carrier fusions for delivery of chemotherapeutic agents |
US20080148906A1 (en) * | 2006-12-21 | 2008-06-26 | Proxene Tools Co., Ltd. | Driving surface configuration for hand tools |
WO2008141130A1 (en) * | 2007-05-11 | 2008-11-20 | Kosan Biosciences, Inc. | Process for the preparation of epothilones |
US8030503B2 (en) * | 2007-05-11 | 2011-10-04 | Kosan Biosciences Incorporated | Process for the preparation of epothilones |
JP6113194B2 (ja) * | 2012-02-13 | 2017-04-12 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | エンジイン化合物、その抱合体、ならびにその使用および方法 |
CA2921401A1 (en) | 2013-08-14 | 2015-02-19 | William Marsh Rice University | Derivatives of uncialamycin, methods of synthesis and their use as antitumor agents |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3892850A (en) * | 1956-03-13 | 1975-07-01 | Gist Brocades Nv | Pimaricin and process of producing same |
GB846933A (en) * | 1956-07-23 | 1960-09-07 | American Cyanamid Co | New antifungal substance, pimaricin, and method of producing same |
GB1509866A (en) * | 1975-06-10 | 1978-05-04 | Johnson & Johnson | Enteric coated digestive enzyme compositions |
US4167450A (en) * | 1977-07-13 | 1979-09-11 | University Of New Hampshire | Method and apparatus for the production of secondary metabolites by the maintenance-state cultivation of microorganisms |
US4349528A (en) * | 1979-11-21 | 1982-09-14 | The Wistar Institute | Monocolonal hybridoma antibody specific for high molecular weight carcinoembryonic antigen |
US4311796A (en) * | 1980-07-14 | 1982-01-19 | Standard Oil Company (Indiana) | Method for improving specific xanthan productivity during continuous fermentation |
US4471057A (en) * | 1981-06-30 | 1984-09-11 | The Wistar Institute | Detection of colorectal carcinoma |
US4522918A (en) * | 1981-12-15 | 1985-06-11 | Jeffery Schlom | Process for producing monoclonal antibodies reactive with human breast cancer |
US4507391A (en) * | 1982-04-02 | 1985-03-26 | Sloan-Kettering Institute For Cancer Research | Method for detecting the presence of GD3 ganglioside |
JPS58201994A (ja) * | 1982-05-21 | 1983-11-25 | Hideaki Hagiwara | 抗原特異的ヒト免疫グロブリンの生産方法 |
ATE56046T1 (de) * | 1983-03-04 | 1990-09-15 | Health Research Inc | Monoklonale antikoerper gegen humane brustkarzinomzellen und ihre verwendung in der diagnose und therapie. |
US4579827A (en) * | 1983-03-11 | 1986-04-01 | Sloan-Kettering Institute For Cancer Research | Monoclonal antibodies to human gastrointestinal cancers and hybridoma method of production of the monoclonal antibodies |
US4643971A (en) * | 1983-03-11 | 1987-02-17 | Sloan-Kettering Institute | Monoclonal antibodies to human bladder and ureter cancers and method |
NZ210867A (en) * | 1984-01-31 | 1989-01-06 | Litton Bionetics Inc | Tumour-specific monoclonal antibodies, production thereof and use |
US4675287A (en) * | 1984-07-26 | 1987-06-23 | Scripps Clinic And Research Foundation | Monoclonal antibody directed to human ganglioside GD2 |
DE3620645A1 (de) * | 1985-12-20 | 1987-07-02 | Bayer Ag | 3-amino-4,5-dihydroxypiperidine, verfahren zu ihrer herstellung und ihre verwendung |
US4837206A (en) * | 1987-04-29 | 1989-06-06 | Bristol-Myers Company | Esperamicin derivatives |
WO1992002522A1 (en) * | 1990-08-01 | 1992-02-20 | Scripps Clinic And Research Foundation | Dynemicin analogs: syntheses, methods of preparation and use |
IE66159B1 (en) * | 1990-08-01 | 1995-12-13 | Scripps Research Inst | Dynemicin analogs: synthesis methods of preparation and use |
-
1992
- 1992-09-01 US US07/939,104 patent/US5281710A/en not_active Expired - Lifetime
-
1993
- 1993-05-18 AU AU43807/93A patent/AU680418B2/en not_active Expired - Fee Related
- 1993-05-18 JP JP6503816A patent/JPH07508037A/ja not_active Withdrawn
- 1993-05-18 WO PCT/US1993/004708 patent/WO1993023046A1/en not_active Application Discontinuation
- 1993-05-18 EP EP93913966A patent/EP0641207A4/en not_active Withdrawn
- 1993-05-18 CA CA002136234A patent/CA2136234A1/en not_active Abandoned
-
1994
- 1994-01-21 US US08/184,580 patent/US5527805A/en not_active Expired - Fee Related
- 1994-11-18 FI FI945427A patent/FI945427A/fi unknown
Also Published As
Publication number | Publication date |
---|---|
WO1993023046A1 (en) | 1993-11-25 |
AU680418B2 (en) | 1997-07-31 |
AU4380793A (en) | 1993-12-13 |
US5281710A (en) | 1994-01-25 |
JPH07508037A (ja) | 1995-09-07 |
CA2136234A1 (en) | 1993-11-25 |
EP0641207A1 (en) | 1995-03-08 |
FI945427A (fi) | 1995-01-18 |
EP0641207A4 (en) | 1996-08-14 |
US5527805A (en) | 1996-06-18 |
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