FI945427A0 - Enantiomerer av dynemicinanaloger, framställning och användning därav - Google Patents

Enantiomerer av dynemicinanaloger, framställning och användning därav

Info

Publication number
FI945427A0
FI945427A0 FI945427A FI945427A FI945427A0 FI 945427 A0 FI945427 A0 FI 945427A0 FI 945427 A FI945427 A FI 945427A FI 945427 A FI945427 A FI 945427A FI 945427 A0 FI945427 A0 FI 945427A0
Authority
FI
Finland
Prior art keywords
dynemisin
enantiomers
analogues
preparation
dynemisin analogues
Prior art date
Application number
FI945427A
Other languages
English (en)
Finnish (fi)
Other versions
FI945427A (sv
Inventor
Adrian L Smith
Chan-Kou Hwang
Sebastian V Wendeborn
Kyriacos C Nicolaou
Erwin P Schreiner
Wilhelm Stahl
Wei-Min Dai
Peter E Maligres
Toshio Susuki
Original Assignee
Scripps Research Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/886,984 external-priority patent/US5276159A/en
Application filed by Scripps Research Inst filed Critical Scripps Research Inst
Publication of FI945427A0 publication Critical patent/FI945427A0/sv
Publication of FI945427A publication Critical patent/FI945427A/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FI945427A 1992-05-21 1994-11-18 Enantiomerer av dynemicinanaloger, framställning och användning därav FI945427A (sv)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/886,984 US5276159A (en) 1990-08-01 1992-05-21 Dynemicin analogs: syntheses, methods of preparation and use
US07/939,104 US5281710A (en) 1990-08-01 1992-09-01 Dynemicin analogs: synthesis, methods of preparation and use
PCT/US1993/004708 WO1993023046A1 (en) 1992-05-21 1993-05-18 Enantiomeric cynemicin analogs, preparation and use thereof

Publications (2)

Publication Number Publication Date
FI945427A0 true FI945427A0 (sv) 1994-11-18
FI945427A FI945427A (sv) 1995-01-18

Family

ID=27128819

Family Applications (1)

Application Number Title Priority Date Filing Date
FI945427A FI945427A (sv) 1992-05-21 1994-11-18 Enantiomerer av dynemicinanaloger, framställning och användning därav

Country Status (7)

Country Link
US (2) US5281710A (sv)
EP (1) EP0641207A4 (sv)
JP (1) JPH07508037A (sv)
AU (1) AU680418B2 (sv)
CA (1) CA2136234A1 (sv)
FI (1) FI945427A (sv)
WO (1) WO1993023046A1 (sv)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5770736A (en) * 1994-06-21 1998-06-23 Northeastern University Reagents for cleavage or crosslinking of biomolecules using nondiffusible reactive intermediates
WO1996003124A1 (en) * 1994-07-27 1996-02-08 California Institute Of Technology Dynemicin analogs
US5622958A (en) * 1994-12-01 1997-04-22 Sloan-Kettering Institute For Cancer Research Enediyne quinone imines and methods of preparation and use thereof
GB9517001D0 (en) * 1995-08-18 1995-10-18 Denny William Enediyne compounds
US6248539B1 (en) 1997-09-05 2001-06-19 The Scripps Research Institute Porous semiconductor-based optical interferometric sensor
US7105491B2 (en) * 1999-01-06 2006-09-12 Wisconsin Alumni Research Foundation (Warf) Biosynthesis of enediyne compounds by manipulation of C-1027 gene pathway
JP4669393B2 (ja) * 2003-05-26 2011-04-13 浩 前田 抗腫瘍剤及びその製造方法
WO2005014823A2 (en) * 2003-08-05 2005-02-17 Wisconsin Alumni Research Foundation Targeted carrier fusions for delivery of chemotherapeutic agents
US20080148906A1 (en) * 2006-12-21 2008-06-26 Proxene Tools Co., Ltd. Driving surface configuration for hand tools
US8030503B2 (en) * 2007-05-11 2011-10-04 Kosan Biosciences Incorporated Process for the preparation of epothilones
US7955824B2 (en) * 2007-05-11 2011-06-07 Kosan Biosciences Incorporated Methods of making epothilones
EP2814829B1 (en) 2012-02-13 2016-12-07 Bristol-Myers Squibb Company Enediyne compounds, conjugates thereof, and uses and methods therefor
EA201690388A1 (ru) 2013-08-14 2016-07-29 Уильям Марш Райс Юниверсити Новые производные унциаламицина, способы их синтеза и их применение в качестве противоопухолевых агентов

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3892850A (en) * 1956-03-13 1975-07-01 Gist Brocades Nv Pimaricin and process of producing same
GB846933A (en) * 1956-07-23 1960-09-07 American Cyanamid Co New antifungal substance, pimaricin, and method of producing same
GB1509866A (en) * 1975-06-10 1978-05-04 Johnson & Johnson Enteric coated digestive enzyme compositions
US4167450A (en) * 1977-07-13 1979-09-11 University Of New Hampshire Method and apparatus for the production of secondary metabolites by the maintenance-state cultivation of microorganisms
US4349528A (en) * 1979-11-21 1982-09-14 The Wistar Institute Monocolonal hybridoma antibody specific for high molecular weight carcinoembryonic antigen
US4311796A (en) * 1980-07-14 1982-01-19 Standard Oil Company (Indiana) Method for improving specific xanthan productivity during continuous fermentation
US4471057A (en) * 1981-06-30 1984-09-11 The Wistar Institute Detection of colorectal carcinoma
US4522918A (en) * 1981-12-15 1985-06-11 Jeffery Schlom Process for producing monoclonal antibodies reactive with human breast cancer
US4507391A (en) * 1982-04-02 1985-03-26 Sloan-Kettering Institute For Cancer Research Method for detecting the presence of GD3 ganglioside
JPS58201994A (ja) * 1982-05-21 1983-11-25 Hideaki Hagiwara 抗原特異的ヒト免疫グロブリンの生産方法
CA1215331A (en) * 1983-03-04 1986-12-16 Tsann M. Chu Monoclonal antibodies to human breast carcinoma cells and their use in diagnosis and therapy
US4643971A (en) * 1983-03-11 1987-02-17 Sloan-Kettering Institute Monoclonal antibodies to human bladder and ureter cancers and method
US4579827A (en) * 1983-03-11 1986-04-01 Sloan-Kettering Institute For Cancer Research Monoclonal antibodies to human gastrointestinal cancers and hybridoma method of production of the monoclonal antibodies
NZ210867A (en) * 1984-01-31 1989-01-06 Litton Bionetics Inc Tumour-specific monoclonal antibodies, production thereof and use
US4675287A (en) * 1984-07-26 1987-06-23 Scripps Clinic And Research Foundation Monoclonal antibody directed to human ganglioside GD2
DE3620645A1 (de) * 1985-12-20 1987-07-02 Bayer Ag 3-amino-4,5-dihydroxypiperidine, verfahren zu ihrer herstellung und ihre verwendung
US4837206A (en) * 1987-04-29 1989-06-06 Bristol-Myers Company Esperamicin derivatives
IE66159B1 (en) * 1990-08-01 1995-12-13 Scripps Research Inst Dynemicin analogs: synthesis methods of preparation and use
WO1992002522A1 (en) * 1990-08-01 1992-02-20 Scripps Clinic And Research Foundation Dynemicin analogs: syntheses, methods of preparation and use

Also Published As

Publication number Publication date
US5281710A (en) 1994-01-25
AU680418B2 (en) 1997-07-31
CA2136234A1 (en) 1993-11-25
EP0641207A4 (en) 1996-08-14
EP0641207A1 (en) 1995-03-08
AU4380793A (en) 1993-12-13
US5527805A (en) 1996-06-18
FI945427A (sv) 1995-01-18
JPH07508037A (ja) 1995-09-07
WO1993023046A1 (en) 1993-11-25

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