UA26853C2 - Спосіб одержаhhя стабільhого соматотропіhу, стабільhий соматотропіh і композиція стабільhого соматотропіhу - Google Patents
Спосіб одержаhhя стабільhого соматотропіhу, стабільhий соматотропіh і композиція стабільhого соматотропіhуInfo
- Publication number
- UA26853C2 UA26853C2 UA4895049A UA4895049A UA26853C2 UA 26853 C2 UA26853 C2 UA 26853C2 UA 4895049 A UA4895049 A UA 4895049A UA 4895049 A UA4895049 A UA 4895049A UA 26853 C2 UA26853 C2 UA 26853C2
- Authority
- UA
- Ukraine
- Prior art keywords
- somatotropics
- stable
- composition
- obtaining
- obtaining stable
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/242,542 US5079230A (en) | 1988-09-12 | 1988-09-12 | Stable bioactive somatotropins |
PCT/US1989/003871 WO1990002758A1 (en) | 1988-09-12 | 1989-09-07 | Stable bioactive somatotropins |
Publications (1)
Publication Number | Publication Date |
---|---|
UA26853C2 true UA26853C2 (uk) | 1999-12-29 |
Family
ID=22915193
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UA4895049A UA26853C2 (uk) | 1988-09-12 | 1989-09-07 | Спосіб одержаhhя стабільhого соматотропіhу, стабільhий соматотропіh і композиція стабільhого соматотропіhу |
Country Status (16)
Country | Link |
---|---|
US (1) | US5079230A (uk) |
EP (1) | EP0433395A1 (uk) |
JP (1) | JPH04500519A (uk) |
CN (1) | CN1037845C (uk) |
AU (1) | AU4330889A (uk) |
CA (1) | CA1339759C (uk) |
DD (1) | DD289544A5 (uk) |
ES (1) | ES2018397A6 (uk) |
GR (1) | GR1002144B (uk) |
HU (2) | HU206375B (uk) |
NZ (1) | NZ230610A (uk) |
PL (1) | PL162822B1 (uk) |
RU (1) | RU2073686C1 (uk) |
UA (1) | UA26853C2 (uk) |
WO (1) | WO1990002758A1 (uk) |
ZA (1) | ZA896914B (uk) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE68929273T2 (de) * | 1988-08-24 | 2001-07-05 | American Cyanamid Co., Wayne | Stabilisierung von Somatotropinen durch Modifikation von Cystein-Resten durch orts-spezifische Mutagenese oder chemische Derivatisierung |
US5849694A (en) * | 1990-07-16 | 1998-12-15 | Synenki; Richard M. | Stable and bioactive modified porcine somatotropin and pharmaceutical compositions thereof |
US5169834A (en) * | 1990-11-30 | 1992-12-08 | American Cyanamid Company | Compositions and method for reducing vial breakage during lyophilization |
ZA94169B (en) * | 1993-01-26 | 1994-09-07 | Lilly Co Eli | Non-denaturing potency assay for bovine somatotropin |
US5567620A (en) * | 1993-01-26 | 1996-10-22 | Eli Lilly And Company | Non-denaturing potency assay for somatotropin |
DE4303744A1 (de) * | 1993-02-09 | 1994-08-11 | Univ Autonoma De Nuevo Leon Mo | Hundewachstumshormon |
DK44593D0 (da) * | 1993-04-20 | 1993-04-20 | Novo Nordisk As | Fremgangsmaade til fremstilling af et polypeptid |
ZA9711731B (en) * | 1996-12-31 | 1998-07-01 | Monsanto Co | Aqueous glycerol formulations of somatotropin |
AU7493198A (en) * | 1997-05-15 | 1998-12-08 | Geoffrey J Schmidt | Method of reducing immunological tolerance to malignancy |
KR100706469B1 (ko) * | 1997-06-25 | 2007-04-10 | 어플라이드 리서치 시스템스 에이알에스 홀딩 엔.브이. | 이황화결합으로 연결된 당단백질 호르몬 유사체, 이의제조방법 및 이의 용도 |
IL154118A0 (en) * | 2000-09-08 | 2003-07-31 | Gryphon Therapeutics Inc | "pseudo"-native chemical ligation |
US6811777B2 (en) * | 2002-04-13 | 2004-11-02 | Allan Mishra | Compositions and minimally invasive methods for treating incomplete connective tissue repair |
ES2343518T3 (es) * | 2002-09-09 | 2010-08-03 | Hanall Biopharma Co., Ltd. | Polipeptidos interferon alfa modificados resistentes a proteasas. |
US7998930B2 (en) | 2004-11-04 | 2011-08-16 | Hanall Biopharma Co., Ltd. | Modified growth hormones |
EP2386571B1 (en) | 2005-04-08 | 2016-06-01 | ratiopharm GmbH | Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants |
BR112012018116B1 (pt) * | 2010-01-22 | 2022-06-21 | Novo Nordisk Health Care Ag | Conjugados de hormônio do crescimento com eficácia in vivo prolongada |
EP2446898A1 (en) | 2010-09-30 | 2012-05-02 | Laboratorios Del. Dr. Esteve, S.A. | Use of growth hormone to enhance the immune response in immunosuppressed patients |
EP2981282B1 (en) | 2013-04-05 | 2020-11-04 | Novo Nordisk Health Care AG | Growth hormone compound formulation |
CN108828237B (zh) * | 2018-08-24 | 2021-04-02 | 浙江理工大学 | 一种分析羊毛角蛋白中氨基酸键合折叠分布的方法 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3853832A (en) * | 1971-04-27 | 1974-12-10 | Harmone Res Foundation | Synthetic human pituitary growth hormone and method of producing it |
US4342832A (en) * | 1979-07-05 | 1982-08-03 | Genentech, Inc. | Method of constructing a replicable cloning vehicle having quasi-synthetic genes |
JPS5630925A (en) * | 1979-08-21 | 1981-03-28 | Sumitomo Chem Co Ltd | Purification of human growth hormone |
EP0103395A3 (en) * | 1982-08-17 | 1985-05-22 | Biogen N.V. | Dna sequences, recombinant dna molecules and processes for producing bovine growth hormone-like polypeptides in high yield |
CA1341012C (en) * | 1982-09-27 | 2000-06-06 | Biogen, Inc. | Dna sequences, recombinant dna molecules and processes for producing swine growth hormone-like polypeptides |
FI82266C (fi) * | 1982-10-19 | 1991-02-11 | Cetus Corp | Foerfarande foer framstaellning av il-2 -mutein. |
US4620948A (en) * | 1982-12-22 | 1986-11-04 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
DE3685424D1 (de) * | 1985-06-26 | 1992-06-25 | Upjohn Co | Solubilisation und oxidation von somatotropin aus transformierten mikroorganismen. |
US4766205A (en) * | 1985-11-13 | 1988-08-23 | Beatrice Companies, Inc. | Method for isolation of recombinant polypeptides in biologically active forms |
US4816568A (en) * | 1986-05-16 | 1989-03-28 | International Minerals & Chemical Corp. | Stabilization of growth hormones |
DE68929273T2 (de) * | 1988-08-24 | 2001-07-05 | American Cyanamid Co., Wayne | Stabilisierung von Somatotropinen durch Modifikation von Cystein-Resten durch orts-spezifische Mutagenese oder chemische Derivatisierung |
-
1988
- 1988-09-12 US US07/242,542 patent/US5079230A/en not_active Expired - Lifetime
-
1989
- 1989-08-09 CA CA000607863A patent/CA1339759C/en not_active Expired - Fee Related
- 1989-09-07 WO PCT/US1989/003871 patent/WO1990002758A1/en not_active Application Discontinuation
- 1989-09-07 RU SU4895049/04A patent/RU2073686C1/ru not_active IP Right Cessation
- 1989-09-07 AU AU43308/89A patent/AU4330889A/en not_active Abandoned
- 1989-09-07 EP EP89911168A patent/EP0433395A1/en not_active Withdrawn
- 1989-09-07 HU HU895729A patent/HU206375B/hu not_active IP Right Cessation
- 1989-09-07 JP JP1510357A patent/JPH04500519A/ja active Pending
- 1989-09-07 UA UA4895049A patent/UA26853C2/uk unknown
- 1989-09-08 GR GR890100562A patent/GR1002144B/el not_active IP Right Cessation
- 1989-09-11 NZ NZ230610A patent/NZ230610A/en unknown
- 1989-09-11 DD DD89332530A patent/DD289544A5/de unknown
- 1989-09-11 ZA ZA896914A patent/ZA896914B/xx unknown
- 1989-09-11 CN CN89107230A patent/CN1037845C/zh not_active Expired - Fee Related
- 1989-09-12 PL PL28138089A patent/PL162822B1/pl not_active IP Right Cessation
- 1989-09-12 ES ES8903103A patent/ES2018397A6/es not_active Expired - Fee Related
-
1991
- 1991-03-26 HU HU91787A patent/HU910787D0/hu unknown
Also Published As
Publication number | Publication date |
---|---|
WO1990002758A1 (en) | 1990-03-22 |
ES2018397A6 (es) | 1991-04-01 |
HUT56856A (en) | 1991-10-28 |
DD289544A5 (de) | 1991-05-02 |
CN1037845C (zh) | 1998-03-25 |
PL162822B1 (pl) | 1994-01-31 |
RU2073686C1 (ru) | 1997-02-20 |
AU4330889A (en) | 1990-04-02 |
GR890100562A (el) | 1990-10-31 |
JPH04500519A (ja) | 1992-01-30 |
GR1002144B (en) | 1996-02-16 |
EP0433395A1 (en) | 1991-06-26 |
CA1339759C (en) | 1998-03-17 |
ZA896914B (en) | 1990-10-31 |
US5079230A (en) | 1992-01-07 |
HU206375B (en) | 1992-10-28 |
NZ230610A (en) | 1991-12-23 |
HU910787D0 (en) | 1991-09-30 |
CN1041160A (zh) | 1990-04-11 |
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