SK283128B6 - Spôsob vytvárania mikročastíc materiálu - Google Patents

Spôsob vytvárania mikročastíc materiálu Download PDF

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Publication number
SK283128B6
SK283128B6 SK1537-97A SK153797A SK283128B6 SK 283128 B6 SK283128 B6 SK 283128B6 SK 153797 A SK153797 A SK 153797A SK 283128 B6 SK283128 B6 SK 283128B6
Authority
SK
Slovakia
Prior art keywords
extraction
solvent
freezing
liquefied gas
microdroplets
Prior art date
Application number
SK1537-97A
Other languages
English (en)
Slovak (sk)
Other versions
SK153797A3 (en
Inventor
Paul F. Herbert
Michael S. Healy
Original Assignee
Alkermes Controlled Therapeutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alkermes Controlled Therapeutics, Inc. filed Critical Alkermes Controlled Therapeutics, Inc.
Publication of SK153797A3 publication Critical patent/SK153797A3/sk
Publication of SK283128B6 publication Critical patent/SK283128B6/sk

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29B—PREPARATION OR PRETREATMENT OF THE MATERIAL TO BE SHAPED; MAKING GRANULES OR PREFORMS; RECOVERY OF PLASTICS OR OTHER CONSTITUENTS OF WASTE MATERIAL CONTAINING PLASTICS
    • B29B9/00—Making granules
    • B29B9/12—Making granules characterised by structure or composition
    • B29B2009/125—Micropellets, microgranules, microparticles

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Extraction Or Liquid Replacement (AREA)
SK1537-97A 1995-05-18 1996-05-15 Spôsob vytvárania mikročastíc materiálu SK283128B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/443,726 US5922253A (en) 1995-05-18 1995-05-18 Production scale method of forming microparticles
PCT/US1996/006889 WO1996036317A1 (en) 1995-05-18 1996-05-15 Production scale method of forming microparticles

Publications (2)

Publication Number Publication Date
SK153797A3 SK153797A3 (en) 1998-09-09
SK283128B6 true SK283128B6 (sk) 2003-02-04

Family

ID=23761943

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1537-97A SK283128B6 (sk) 1995-05-18 1996-05-15 Spôsob vytvárania mikročastíc materiálu

Country Status (23)

Country Link
US (5) US5922253A (zh)
EP (1) EP0827396B1 (zh)
JP (1) JP4226649B2 (zh)
KR (1) KR100475476B1 (zh)
CN (1) CN1153567C (zh)
AT (1) ATE236618T1 (zh)
AU (1) AU701992B2 (zh)
BR (1) BR9608370A (zh)
CA (1) CA2221496C (zh)
CZ (1) CZ292969B6 (zh)
DE (1) DE69627320T2 (zh)
DK (1) DK0827396T3 (zh)
ES (1) ES2197239T3 (zh)
HK (1) HK1008937A1 (zh)
HU (1) HU224194B1 (zh)
MX (1) MX9708777A (zh)
NO (1) NO318237B1 (zh)
NZ (1) NZ308763A (zh)
PL (1) PL184484B1 (zh)
PT (1) PT827396E (zh)
RU (1) RU2159148C2 (zh)
SK (1) SK283128B6 (zh)
WO (1) WO1996036317A1 (zh)

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EP0827396A1 (en) 1998-03-11
US20040253316A1 (en) 2004-12-16
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WO1996036317A1 (en) 1996-11-21
PL184484B1 (pl) 2002-11-29
CZ292969B6 (cs) 2004-01-14
KR100475476B1 (ko) 2006-03-27
US6153129A (en) 2000-11-28
BR9608370A (pt) 1999-08-17
HUP9802489A2 (hu) 1999-07-28
AU5859296A (en) 1996-11-29
CN1153567C (zh) 2004-06-16
ATE236618T1 (de) 2003-04-15
HU224194B1 (hu) 2005-06-28
CA2221496C (en) 2008-01-15
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HUP9802489A3 (en) 2000-06-28
US6358443B1 (en) 2002-03-19
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