SK282789B6 - Spôsob výroby fenylheterocyklických zlúčenín a medziprodukt - Google Patents
Spôsob výroby fenylheterocyklických zlúčenín a medziprodukt Download PDFInfo
- Publication number
- SK282789B6 SK282789B6 SK316-97A SK31697A SK282789B6 SK 282789 B6 SK282789 B6 SK 282789B6 SK 31697 A SK31697 A SK 31697A SK 282789 B6 SK282789 B6 SK 282789B6
- Authority
- SK
- Slovakia
- Prior art keywords
- compound
- formula
- solvent
- carried out
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
- C07C69/675—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids of saturated hydroxy-carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/58—One oxygen atom, e.g. butenolide
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Oncology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Hospice & Palliative Care (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/307,972 US5585504A (en) | 1994-09-16 | 1994-09-16 | Process of making cox-2 inhibitors having a lactone bridge |
PCT/US1995/011539 WO1996008482A1 (en) | 1994-09-16 | 1995-09-12 | Process for making phenyl heterocycles useful as cox-2 inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
SK31697A3 SK31697A3 (en) | 1997-10-08 |
SK282789B6 true SK282789B6 (sk) | 2002-12-03 |
Family
ID=23191976
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SK316-97A SK282789B6 (sk) | 1994-09-16 | 1995-09-12 | Spôsob výroby fenylheterocyklických zlúčenín a medziprodukt |
Country Status (12)
Country | Link |
---|---|
US (1) | US5585504A (fi) |
CN (1) | CN1065533C (fi) |
AU (1) | AU3510595A (fi) |
BR (1) | BR9508927A (fi) |
CZ (1) | CZ288797B6 (fi) |
FI (1) | FI106376B (fi) |
RO (1) | RO118585B1 (fi) |
RU (1) | RU2160257C2 (fi) |
SK (1) | SK282789B6 (fi) |
TW (1) | TW325468B (fi) |
UA (1) | UA49809C2 (fi) |
WO (1) | WO1996008482A1 (fi) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5807873A (en) * | 1996-04-04 | 1998-09-15 | Laboratories Upsa | Diarylmethylidenefuran derivatives and their uses in therapeutics |
FR2747123B1 (fr) * | 1996-04-04 | 1998-06-26 | Union Pharma Scient Appl | Nouveaux derives diarylmethylidene tetrahydrofurane, leurs procedes de preparation, et leurs utilisations en therapeutique |
US6180651B1 (en) | 1996-04-04 | 2001-01-30 | Bristol-Myers Squibb | Diarylmethylidenefuran derivatives, processes for their preparation and their uses in therapeutics |
HRP970289A2 (en) * | 1996-05-31 | 1998-04-30 | Merck & Co Inc | Process for preparing phenyl heterocycles useful as cox-2 inhibitors |
US5883267A (en) * | 1996-05-31 | 1999-03-16 | Merck & Co., Inc. | Process for making phenyl heterocycles useful as cox-2 inhibitors |
US5985930A (en) * | 1996-11-21 | 1999-11-16 | Pasinetti; Giulio M. | Treatment of neurodegenerative conditions with nimesulide |
WO1998037235A1 (en) | 1997-02-24 | 1998-08-27 | Cornell Research Foundation, Inc. | Method of screening agents as candidates for drugs or sources of drugs |
US6071954A (en) * | 1997-03-14 | 2000-06-06 | Merk Frosst Canada, Inc. | (methylsulfonyl)phenyl-2-(5H)-furanones with oxygen link as COX-2 inhibitors |
ES2201466T3 (es) * | 1997-03-14 | 2004-03-16 | MERCK FROSST CANADA & CO. | `(metilsulfonil)fenil-2-(5h)-furanonas con enlace con oxigeno como inhibidores de cox-2`. |
US6727238B2 (en) * | 1998-06-11 | 2004-04-27 | Pfizer Inc. | Sulfonylbenzene compounds as anti-inflammatory/analgesic agents |
TNSN99111A1 (fr) * | 1998-06-11 | 2005-11-10 | Pfizer | Derives de sulfonylbenzene nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant. |
US6294558B1 (en) * | 1999-05-31 | 2001-09-25 | Pfizer Inc. | Sulfonylbenzene compounds as anti-inflammatory/analgesic agents |
DE60023119T2 (de) * | 1999-03-10 | 2006-07-20 | G.D. Searle Llc | Zusammensetzungen zur verabreichung eines cyclooxygenase-2-hemmers an tiere |
PT1104758E (pt) | 1999-12-03 | 2003-12-31 | Pfizer Prod Inc | Derivados de acetileno como agentes anti-inflamatorios/analgesicos |
CN1423646A (zh) | 1999-12-03 | 2003-06-11 | 辉瑞产品公司 | 作为抗炎/镇痛剂的杂环-烷基磺酰基吡唑衍生物 |
EP1104759B1 (en) | 1999-12-03 | 2003-10-22 | Pfizer Products Inc. | Heteroaryl phenyl pyrazole compounds as anti-inflammatory/analgesic agents |
DE60001623T2 (de) | 1999-12-03 | 2003-12-18 | Pfizer Products Inc., Groton | Sulfamoylheteroarylpyrazolverbindungen zur Verwendung als analgetisches/entzündungshemmendes Mittel |
BR0008060A (pt) | 1999-12-08 | 2002-02-05 | Pharmacia Corp | Composições inibidoras de ciclooxigenase-2 tendo rápido inìcio de eficácia terapêutica |
DE10012825B4 (de) | 2000-03-16 | 2004-04-15 | Bayer Corp. | Verfahren zur Herstellung von spirocyclischen Tetronsäurederivaten |
CN1102586C (zh) * | 2000-04-07 | 2003-03-05 | 中国科学院上海有机化学研究所 | β位含有芳基取代基的γ-丁烯酸内酯及其固相合成法 |
AU5754701A (en) * | 2000-07-13 | 2002-01-30 | Pharmacia Corp | Method of using cox-2 inhibitors in the treatment and prevention of ocular cox-2mediated disorders |
US8680081B2 (en) * | 2000-08-29 | 2014-03-25 | Peter Van Patten | Prophylactic treatment of migraine |
US7115565B2 (en) * | 2001-01-18 | 2006-10-03 | Pharmacia & Upjohn Company | Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability |
MY137736A (en) | 2001-04-03 | 2009-03-31 | Pharmacia Corp | Reconstitutable parenteral composition |
ATE298749T1 (de) | 2001-07-05 | 2005-07-15 | Pfizer Prod Inc | Heterocyclo-alkylsulfonyl pyrazole als entzündungshemmende/analgetische mittel |
UA80682C2 (en) * | 2001-08-06 | 2007-10-25 | Pharmacia Corp | Orally deliverable stabilized oral suspension formulation and process for the incresaing physical stability of thixotropic pharmaceutical composition |
GT200200183A (es) | 2001-09-28 | 2003-05-23 | Procedimiento para preparar derivados de heterocicloalquilsulfonil pirazol | |
WO2003037336A1 (en) | 2001-11-02 | 2003-05-08 | Pfizer Products Inc. | 1-(5-sulfonyl-pyridin-2-yl)-5-(methylidene-cycloalkylmethoxy)-1h-pyrazole-4-carbonitrile derivatives and other compounds as cyclooxygenase inhibitors for the treatment of arthritis, neurodegeneration and colon cancer |
ES2213485B1 (es) | 2003-02-13 | 2005-12-16 | Almirall Prodesfarma, S.A. | Derivados de la 2-fenilpiran-4-ona. |
PL1534305T3 (pl) * | 2003-05-07 | 2007-03-30 | Osteologix As | Leczenie zaburzeń chrząstek i kości solami strontu rozpuszczalnymi w wodzie |
PL1622630T3 (pl) * | 2003-05-07 | 2013-01-31 | Osteologix As | Połączenia strontu w profilaktyce/leczeniu schorzeń tkanki chrzęstnej i/lub kostnej |
AU2003263582A1 (en) * | 2003-08-14 | 2005-03-07 | Shasun Chemicals And Drugs Limited | Process for the manufacture of rofecoxib |
WO2005044227A1 (en) * | 2003-11-05 | 2005-05-19 | Glenmark Pharmaceuticals Limited | Topical pharmaceutical compositions |
US20050100594A1 (en) * | 2003-11-12 | 2005-05-12 | Nilendu Sen | Pharmaceutical formulation containing muscle relaxant and COX-II inhibitor |
CA3119728A1 (en) | 2018-11-21 | 2020-05-28 | Tremeau Pharmaceuticals, Inc. | Purified forms of rofecoxib, methods of manufacture and use |
US10945992B1 (en) | 2019-11-13 | 2021-03-16 | Tremeau Pharmaceuticals, Inc. | Dosage forms of rofecoxib and related methods |
US11161833B1 (en) | 2021-04-09 | 2021-11-02 | Tremeau Pharmaceuticals, Inc. | Deuterated etoricoxib, methods of manufacture, and use thereof |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2243199C (en) * | 1993-01-15 | 2005-08-02 | G.D. Searle & Co. | Novel 3,4-diaryl thiophenes and analogs thereof having use as antiinflammatory agents |
US5462939A (en) * | 1993-05-07 | 1995-10-31 | Sterling Winthrop Inc. | Peptidic ketones as interleukin-1β-converting enzyme inhibitors |
JP2788677B2 (ja) * | 1994-01-10 | 1998-08-20 | メルク フロスト カナダ インコーポレーテツド | Cox−2阻害剤としてのフェニル複素環 |
-
1994
- 1994-09-16 US US08/307,972 patent/US5585504A/en not_active Expired - Fee Related
-
1995
- 1995-09-08 TW TW084109387A patent/TW325468B/zh active
- 1995-09-12 BR BR9508927A patent/BR9508927A/pt not_active Application Discontinuation
- 1995-09-12 CN CN95195075A patent/CN1065533C/zh not_active Expired - Fee Related
- 1995-09-12 UA UA97041788A patent/UA49809C2/uk unknown
- 1995-09-12 WO PCT/US1995/011539 patent/WO1996008482A1/en active Search and Examination
- 1995-09-12 CZ CZ1997792A patent/CZ288797B6/cs not_active IP Right Cessation
- 1995-09-12 SK SK316-97A patent/SK282789B6/sk unknown
- 1995-09-12 RU RU97106093/04A patent/RU2160257C2/ru not_active IP Right Cessation
- 1995-09-12 AU AU35105/95A patent/AU3510595A/en not_active Abandoned
- 1995-09-12 RO RO97-00484A patent/RO118585B1/ro unknown
-
1997
- 1997-03-14 FI FI971104A patent/FI106376B/fi not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
WO1996008482A1 (en) | 1996-03-21 |
FI106376B (fi) | 2001-01-31 |
CZ288797B6 (cs) | 2001-09-12 |
FI971104A (fi) | 1997-03-14 |
SK31697A3 (en) | 1997-10-08 |
CZ79297A3 (en) | 1997-07-16 |
CN1159191A (zh) | 1997-09-10 |
RU2160257C2 (ru) | 2000-12-10 |
CN1065533C (zh) | 2001-05-09 |
BR9508927A (pt) | 1997-12-30 |
AU3510595A (en) | 1996-03-29 |
UA49809C2 (uk) | 2002-10-15 |
FI971104A0 (fi) | 1997-03-14 |
TW325468B (en) | 1998-01-21 |
RO118585B1 (ro) | 2003-07-30 |
US5585504A (en) | 1996-12-17 |
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