SK282789B6 - Spôsob výroby fenylheterocyklických zlúčenín a medziprodukt - Google Patents

Spôsob výroby fenylheterocyklických zlúčenín a medziprodukt Download PDF

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Publication number
SK282789B6
SK282789B6 SK316-97A SK31697A SK282789B6 SK 282789 B6 SK282789 B6 SK 282789B6 SK 31697 A SK31697 A SK 31697A SK 282789 B6 SK282789 B6 SK 282789B6
Authority
SK
Slovakia
Prior art keywords
compound
formula
solvent
carried out
alkyl
Prior art date
Application number
SK316-97A
Other languages
English (en)
Slovak (sk)
Other versions
SK31697A3 (en
Inventor
Richard Desmond
Ulf H. Dolling
Ben Marcune
Richard D. Tillyer
David M. Tschaen
Original Assignee
Merck & Co., Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co., Inc. filed Critical Merck & Co., Inc.
Publication of SK31697A3 publication Critical patent/SK31697A3/sk
Publication of SK282789B6 publication Critical patent/SK282789B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/675—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids of saturated hydroxy-carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/58—One oxygen atom, e.g. butenolide

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Oncology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
SK316-97A 1994-09-16 1995-09-12 Spôsob výroby fenylheterocyklických zlúčenín a medziprodukt SK282789B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/307,972 US5585504A (en) 1994-09-16 1994-09-16 Process of making cox-2 inhibitors having a lactone bridge
PCT/US1995/011539 WO1996008482A1 (en) 1994-09-16 1995-09-12 Process for making phenyl heterocycles useful as cox-2 inhibitors

Publications (2)

Publication Number Publication Date
SK31697A3 SK31697A3 (en) 1997-10-08
SK282789B6 true SK282789B6 (sk) 2002-12-03

Family

ID=23191976

Family Applications (1)

Application Number Title Priority Date Filing Date
SK316-97A SK282789B6 (sk) 1994-09-16 1995-09-12 Spôsob výroby fenylheterocyklických zlúčenín a medziprodukt

Country Status (12)

Country Link
US (1) US5585504A (fi)
CN (1) CN1065533C (fi)
AU (1) AU3510595A (fi)
BR (1) BR9508927A (fi)
CZ (1) CZ288797B6 (fi)
FI (1) FI106376B (fi)
RO (1) RO118585B1 (fi)
RU (1) RU2160257C2 (fi)
SK (1) SK282789B6 (fi)
TW (1) TW325468B (fi)
UA (1) UA49809C2 (fi)
WO (1) WO1996008482A1 (fi)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5807873A (en) * 1996-04-04 1998-09-15 Laboratories Upsa Diarylmethylidenefuran derivatives and their uses in therapeutics
FR2747123B1 (fr) * 1996-04-04 1998-06-26 Union Pharma Scient Appl Nouveaux derives diarylmethylidene tetrahydrofurane, leurs procedes de preparation, et leurs utilisations en therapeutique
US6180651B1 (en) 1996-04-04 2001-01-30 Bristol-Myers Squibb Diarylmethylidenefuran derivatives, processes for their preparation and their uses in therapeutics
HRP970289A2 (en) * 1996-05-31 1998-04-30 Merck & Co Inc Process for preparing phenyl heterocycles useful as cox-2 inhibitors
US5883267A (en) * 1996-05-31 1999-03-16 Merck & Co., Inc. Process for making phenyl heterocycles useful as cox-2 inhibitors
US5985930A (en) * 1996-11-21 1999-11-16 Pasinetti; Giulio M. Treatment of neurodegenerative conditions with nimesulide
WO1998037235A1 (en) 1997-02-24 1998-08-27 Cornell Research Foundation, Inc. Method of screening agents as candidates for drugs or sources of drugs
US6071954A (en) * 1997-03-14 2000-06-06 Merk Frosst Canada, Inc. (methylsulfonyl)phenyl-2-(5H)-furanones with oxygen link as COX-2 inhibitors
ES2201466T3 (es) * 1997-03-14 2004-03-16 MERCK FROSST CANADA & CO. `(metilsulfonil)fenil-2-(5h)-furanonas con enlace con oxigeno como inhibidores de cox-2`.
US6727238B2 (en) * 1998-06-11 2004-04-27 Pfizer Inc. Sulfonylbenzene compounds as anti-inflammatory/analgesic agents
TNSN99111A1 (fr) * 1998-06-11 2005-11-10 Pfizer Derives de sulfonylbenzene nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant.
US6294558B1 (en) * 1999-05-31 2001-09-25 Pfizer Inc. Sulfonylbenzene compounds as anti-inflammatory/analgesic agents
DE60023119T2 (de) * 1999-03-10 2006-07-20 G.D. Searle Llc Zusammensetzungen zur verabreichung eines cyclooxygenase-2-hemmers an tiere
PT1104758E (pt) 1999-12-03 2003-12-31 Pfizer Prod Inc Derivados de acetileno como agentes anti-inflamatorios/analgesicos
CN1423646A (zh) 1999-12-03 2003-06-11 辉瑞产品公司 作为抗炎/镇痛剂的杂环－烷基磺酰基吡唑衍生物
EP1104759B1 (en) 1999-12-03 2003-10-22 Pfizer Products Inc. Heteroaryl phenyl pyrazole compounds as anti-inflammatory/analgesic agents
DE60001623T2 (de) 1999-12-03 2003-12-18 Pfizer Products Inc., Groton Sulfamoylheteroarylpyrazolverbindungen zur Verwendung als analgetisches/entzündungshemmendes Mittel
BR0008060A (pt) 1999-12-08 2002-02-05 Pharmacia Corp Composições inibidoras de ciclooxigenase-2 tendo rápido inìcio de eficácia terapêutica
DE10012825B4 (de) 2000-03-16 2004-04-15 Bayer Corp. Verfahren zur Herstellung von spirocyclischen Tetronsäurederivaten
CN1102586C (zh) * 2000-04-07 2003-03-05 中国科学院上海有机化学研究所 β位含有芳基取代基的γ－丁烯酸内酯及其固相合成法
AU5754701A (en) * 2000-07-13 2002-01-30 Pharmacia Corp Method of using cox-2 inhibitors in the treatment and prevention of ocular cox-2mediated disorders
US8680081B2 (en) * 2000-08-29 2014-03-25 Peter Van Patten Prophylactic treatment of migraine
US7115565B2 (en) * 2001-01-18 2006-10-03 Pharmacia & Upjohn Company Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability
MY137736A (en) 2001-04-03 2009-03-31 Pharmacia Corp Reconstitutable parenteral composition
ATE298749T1 (de) 2001-07-05 2005-07-15 Pfizer Prod Inc Heterocyclo-alkylsulfonyl pyrazole als entzündungshemmende/analgetische mittel
UA80682C2 (en) * 2001-08-06 2007-10-25 Pharmacia Corp Orally deliverable stabilized oral suspension formulation and process for the incresaing physical stability of thixotropic pharmaceutical composition
GT200200183A (es) 2001-09-28 2003-05-23 Procedimiento para preparar derivados de heterocicloalquilsulfonil pirazol
WO2003037336A1 (en) 2001-11-02 2003-05-08 Pfizer Products Inc. 1-(5-sulfonyl-pyridin-2-yl)-5-(methylidene-cycloalkylmethoxy)-1h-pyrazole-4-carbonitrile derivatives and other compounds as cyclooxygenase inhibitors for the treatment of arthritis, neurodegeneration and colon cancer
ES2213485B1 (es) 2003-02-13 2005-12-16 Almirall Prodesfarma, S.A. Derivados de la 2-fenilpiran-4-ona.
PL1534305T3 (pl) * 2003-05-07 2007-03-30 Osteologix As Leczenie zaburzeń chrząstek i kości solami strontu rozpuszczalnymi w wodzie
PL1622630T3 (pl) * 2003-05-07 2013-01-31 Osteologix As Połączenia strontu w profilaktyce/leczeniu schorzeń tkanki chrzęstnej i/lub kostnej
AU2003263582A1 (en) * 2003-08-14 2005-03-07 Shasun Chemicals And Drugs Limited Process for the manufacture of rofecoxib
WO2005044227A1 (en) * 2003-11-05 2005-05-19 Glenmark Pharmaceuticals Limited Topical pharmaceutical compositions
US20050100594A1 (en) * 2003-11-12 2005-05-12 Nilendu Sen Pharmaceutical formulation containing muscle relaxant and COX-II inhibitor
CA3119728A1 (en) 2018-11-21 2020-05-28 Tremeau Pharmaceuticals, Inc. Purified forms of rofecoxib, methods of manufacture and use
US10945992B1 (en) 2019-11-13 2021-03-16 Tremeau Pharmaceuticals, Inc. Dosage forms of rofecoxib and related methods
US11161833B1 (en) 2021-04-09 2021-11-02 Tremeau Pharmaceuticals, Inc. Deuterated etoricoxib, methods of manufacture, and use thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2243199C (en) * 1993-01-15 2005-08-02 G.D. Searle & Co. Novel 3,4-diaryl thiophenes and analogs thereof having use as antiinflammatory agents
US5462939A (en) * 1993-05-07 1995-10-31 Sterling Winthrop Inc. Peptidic ketones as interleukin-1β-converting enzyme inhibitors
JP2788677B2 (ja) * 1994-01-10 1998-08-20 メルク フロスト カナダ インコーポレーテツド Ｃｏｘ−２阻害剤としてのフェニル複素環

Also Published As

Publication number Publication date
WO1996008482A1 (en) 1996-03-21
FI106376B (fi) 2001-01-31
CZ288797B6 (cs) 2001-09-12
FI971104A (fi) 1997-03-14
SK31697A3 (en) 1997-10-08
CZ79297A3 (en) 1997-07-16
CN1159191A (zh) 1997-09-10
RU2160257C2 (ru) 2000-12-10
CN1065533C (zh) 2001-05-09
BR9508927A (pt) 1997-12-30
AU3510595A (en) 1996-03-29
UA49809C2 (uk) 2002-10-15
FI971104A0 (fi) 1997-03-14
TW325468B (en) 1998-01-21
RO118585B1 (ro) 2003-07-30
US5585504A (en) 1996-12-17

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