FI971104A - Menetelmä COX-inhibiittoreina käyttökelpoisten fenyyliheterosyklien valmistamiseksi - Google Patents
Menetelmä COX-inhibiittoreina käyttökelpoisten fenyyliheterosyklien valmistamiseksi Download PDFInfo
- Publication number
- FI971104A FI971104A FI971104A FI971104A FI971104A FI 971104 A FI971104 A FI 971104A FI 971104 A FI971104 A FI 971104A FI 971104 A FI971104 A FI 971104A FI 971104 A FI971104 A FI 971104A
- Authority
- FI
- Finland
- Prior art keywords
- preparation
- cox inhibitors
- phenyl heterocycles
- heterocycles useful
- useful
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
- C07C69/675—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids of saturated hydroxy-carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/58—One oxygen atom, e.g. butenolide
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Neurology (AREA)
- Oncology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Hospice & Palliative Care (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30797294 | 1994-09-16 | ||
US08/307,972 US5585504A (en) | 1994-09-16 | 1994-09-16 | Process of making cox-2 inhibitors having a lactone bridge |
PCT/US1995/011539 WO1996008482A1 (en) | 1994-09-16 | 1995-09-12 | Process for making phenyl heterocycles useful as cox-2 inhibitors |
US9511539 | 1995-09-12 |
Publications (3)
Publication Number | Publication Date |
---|---|
FI971104A0 FI971104A0 (fi) | 1997-03-14 |
FI971104A true FI971104A (fi) | 1997-03-14 |
FI106376B FI106376B (fi) | 2001-01-31 |
Family
ID=23191976
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI971104A FI106376B (fi) | 1994-09-16 | 1997-03-14 | Menetelmä COX-inhibiittoreina käyttökelpoisten fenyyliheterosyklien valmistamiseksi |
Country Status (12)
Country | Link |
---|---|
US (1) | US5585504A (fi) |
CN (1) | CN1065533C (fi) |
AU (1) | AU3510595A (fi) |
BR (1) | BR9508927A (fi) |
CZ (1) | CZ288797B6 (fi) |
FI (1) | FI106376B (fi) |
RO (1) | RO118585B1 (fi) |
RU (1) | RU2160257C2 (fi) |
SK (1) | SK282789B6 (fi) |
TW (1) | TW325468B (fi) |
UA (1) | UA49809C2 (fi) |
WO (1) | WO1996008482A1 (fi) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2747123B1 (fr) * | 1996-04-04 | 1998-06-26 | Union Pharma Scient Appl | Nouveaux derives diarylmethylidene tetrahydrofurane, leurs procedes de preparation, et leurs utilisations en therapeutique |
US5807873A (en) * | 1996-04-04 | 1998-09-15 | Laboratories Upsa | Diarylmethylidenefuran derivatives and their uses in therapeutics |
US6180651B1 (en) | 1996-04-04 | 2001-01-30 | Bristol-Myers Squibb | Diarylmethylidenefuran derivatives, processes for their preparation and their uses in therapeutics |
US5883267A (en) * | 1996-05-31 | 1999-03-16 | Merck & Co., Inc. | Process for making phenyl heterocycles useful as cox-2 inhibitors |
HRP970289A2 (en) * | 1996-05-31 | 1998-04-30 | Merck & Co Inc | Process for preparing phenyl heterocycles useful as cox-2 inhibitors |
US5985930A (en) | 1996-11-21 | 1999-11-16 | Pasinetti; Giulio M. | Treatment of neurodegenerative conditions with nimesulide |
WO1998037235A1 (en) | 1997-02-24 | 1998-08-27 | Cornell Research Foundation, Inc. | Method of screening agents as candidates for drugs or sources of drugs |
US6071954A (en) * | 1997-03-14 | 2000-06-06 | Merk Frosst Canada, Inc. | (methylsulfonyl)phenyl-2-(5H)-furanones with oxygen link as COX-2 inhibitors |
EP0970067B1 (en) * | 1997-03-14 | 2003-07-02 | Merck Frosst Canada & Co. | (methylsulfonyl)phenyl-2-(5h)-furanones with oxygen link as cox-2 inhibitors |
US6294558B1 (en) * | 1999-05-31 | 2001-09-25 | Pfizer Inc. | Sulfonylbenzene compounds as anti-inflammatory/analgesic agents |
TNSN99111A1 (fr) * | 1998-06-11 | 2005-11-10 | Pfizer | Derives de sulfonylbenzene nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant. |
US6727238B2 (en) * | 1998-06-11 | 2004-04-27 | Pfizer Inc. | Sulfonylbenzene compounds as anti-inflammatory/analgesic agents |
DE60023119T2 (de) * | 1999-03-10 | 2006-07-20 | G.D. Searle Llc | Zusammensetzungen zur verabreichung eines cyclooxygenase-2-hemmers an tiere |
TR200302047T4 (tr) | 1999-12-03 | 2004-01-21 | Pfizer Products Inc. | Anti-iltihabik / analjezik maddeler olarak heteroaril fenil pirazol bileşikleri. |
DK1104760T3 (da) | 1999-12-03 | 2003-06-30 | Pfizer Prod Inc | Sulfamoylheteroarylpyrazolforbindelser som anti-inflammatoriske/analgetiske midler |
ES2200787T3 (es) | 1999-12-03 | 2004-03-16 | Pfizer Products Inc. | Derivados de acetileno como agentes antiinflamatorios/analgesicos. |
WO2001040216A1 (en) | 1999-12-03 | 2001-06-07 | Pfizer Products Inc. | Heterocyclo-alkylsulfonyl pyrazole derivatives as anti-inflammatory/analgesic agents |
ATE283048T1 (de) | 1999-12-08 | 2004-12-15 | Pharmacia Corp | Cyclooxygenase-2 hemmer enthaltende zusammensetzungen mit schnellem wirkungseintritt |
DE10012825B4 (de) * | 2000-03-16 | 2004-04-15 | Bayer Corp. | Verfahren zur Herstellung von spirocyclischen Tetronsäurederivaten |
CN1102586C (zh) * | 2000-04-07 | 2003-03-05 | 中国科学院上海有机化学研究所 | β位含有芳基取代基的γ-丁烯酸内酯及其固相合成法 |
CA2414674A1 (en) * | 2000-07-13 | 2002-01-24 | Pharmacia Corporation | Use of cox-2 inhibitors in the treatment and prevention of ocular cox-2 mediated disorders |
AU2001285334A1 (en) * | 2000-08-29 | 2002-03-13 | Peter Van Patten | Combination for the treatment of migraine comprising a cyclooxygenase-2 inhibitor and acetylsalicylic acid |
US7115565B2 (en) * | 2001-01-18 | 2006-10-03 | Pharmacia & Upjohn Company | Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability |
US7695736B2 (en) | 2001-04-03 | 2010-04-13 | Pfizer Inc. | Reconstitutable parenteral composition |
EP1273582B1 (en) | 2001-07-05 | 2005-06-29 | Pfizer Products Inc. | Heterocyclo-alkylsulfonyl pyrazoles as anti-inflammatory/analgesic agents |
UA80682C2 (en) * | 2001-08-06 | 2007-10-25 | Pharmacia Corp | Orally deliverable stabilized oral suspension formulation and process for the incresaing physical stability of thixotropic pharmaceutical composition |
GT200200183A (es) | 2001-09-28 | 2003-05-23 | Procedimiento para preparar derivados de heterocicloalquilsulfonil pirazol | |
WO2003037336A1 (en) | 2001-11-02 | 2003-05-08 | Pfizer Products Inc. | 1-(5-sulfonyl-pyridin-2-yl)-5-(methylidene-cycloalkylmethoxy)-1h-pyrazole-4-carbonitrile derivatives and other compounds as cyclooxygenase inhibitors for the treatment of arthritis, neurodegeneration and colon cancer |
ES2213485B1 (es) | 2003-02-13 | 2005-12-16 | Almirall Prodesfarma, S.A. | Derivados de la 2-fenilpiran-4-ona. |
DK1622630T3 (da) * | 2003-05-07 | 2012-12-17 | Osteologix As | P009368epdk1 |
ES2275218T3 (es) * | 2003-05-07 | 2007-06-01 | Osteologix A/S | Sales de estroncio hidrosolubles para el tratamiento de afecciones de cartilagos y/o huesos. |
AU2003263582A1 (en) * | 2003-08-14 | 2005-03-07 | Shasun Chemicals And Drugs Limited | Process for the manufacture of rofecoxib |
WO2005044227A1 (en) * | 2003-11-05 | 2005-05-19 | Glenmark Pharmaceuticals Limited | Topical pharmaceutical compositions |
US20050100594A1 (en) * | 2003-11-12 | 2005-05-12 | Nilendu Sen | Pharmaceutical formulation containing muscle relaxant and COX-II inhibitor |
JP7291220B2 (ja) | 2018-11-21 | 2023-06-14 | トレモ― ファーマシューティカルズ,インコーポレーテッド | ロフェコキシブの精製形態、製造方法および使用 |
US10945992B1 (en) | 2019-11-13 | 2021-03-16 | Tremeau Pharmaceuticals, Inc. | Dosage forms of rofecoxib and related methods |
US11161833B1 (en) | 2021-04-09 | 2021-11-02 | Tremeau Pharmaceuticals, Inc. | Deuterated etoricoxib, methods of manufacture, and use thereof |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2152792C (en) * | 1993-01-15 | 2000-02-15 | Stephen R. Bertenshaw | Novel 3,4-diaryl thiophenes and analogs thereof having use as antiinflammatory agents |
US5462939A (en) * | 1993-05-07 | 1995-10-31 | Sterling Winthrop Inc. | Peptidic ketones as interleukin-1β-converting enzyme inhibitors |
CA2180651A1 (en) * | 1994-01-10 | 1995-07-13 | Yves Ducharme | Phenyl heterocycles as cox-2 inhibitors |
-
1994
- 1994-09-16 US US08/307,972 patent/US5585504A/en not_active Expired - Fee Related
-
1995
- 1995-09-08 TW TW084109387A patent/TW325468B/zh active
- 1995-09-12 RU RU97106093/04A patent/RU2160257C2/ru not_active IP Right Cessation
- 1995-09-12 CN CN95195075A patent/CN1065533C/zh not_active Expired - Fee Related
- 1995-09-12 CZ CZ1997792A patent/CZ288797B6/cs not_active IP Right Cessation
- 1995-09-12 RO RO97-00484A patent/RO118585B1/ro unknown
- 1995-09-12 UA UA97041788A patent/UA49809C2/uk unknown
- 1995-09-12 AU AU35105/95A patent/AU3510595A/en not_active Abandoned
- 1995-09-12 BR BR9508927A patent/BR9508927A/pt not_active Application Discontinuation
- 1995-09-12 WO PCT/US1995/011539 patent/WO1996008482A1/en active Search and Examination
- 1995-09-12 SK SK316-97A patent/SK282789B6/sk unknown
-
1997
- 1997-03-14 FI FI971104A patent/FI106376B/fi not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
BR9508927A (pt) | 1997-12-30 |
UA49809C2 (uk) | 2002-10-15 |
FI971104A0 (fi) | 1997-03-14 |
SK282789B6 (sk) | 2002-12-03 |
CZ79297A3 (en) | 1997-07-16 |
RO118585B1 (ro) | 2003-07-30 |
WO1996008482A1 (en) | 1996-03-21 |
FI106376B (fi) | 2001-01-31 |
US5585504A (en) | 1996-12-17 |
CN1065533C (zh) | 2001-05-09 |
SK31697A3 (en) | 1997-10-08 |
CZ288797B6 (cs) | 2001-09-12 |
AU3510595A (en) | 1996-03-29 |
TW325468B (en) | 1998-01-21 |
RU2160257C2 (ru) | 2000-12-10 |
CN1159191A (zh) | 1997-09-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
FI971104A (fi) | Menetelmä COX-inhibiittoreina käyttökelpoisten fenyyliheterosyklien valmistamiseksi | |
FI962800A (fi) | Fenyyliheterosyklisiä yhdisteitä COX-2 inhibiittoreina | |
FI20090217A (fi) | Menetelmä elintarvikekoostumuksen valmistamiseksi | |
EE9900259A (et) | Ühendi uus vorm | |
DK0818448T3 (da) | Cycloalkanopyridiner som CETP-inhibitorer | |
NO985874D0 (no) | Bestemte fosfinylderivater nyttige som naaladase inhibitorer | |
DK1007520T3 (da) | 2-aminopyridiner som indeholder sammensluttede ringsubstituenter som NOS inhibitorer | |
NO992725D0 (no) | 6-Fenylpyridyl-2-amin-derivater anvendelige som NOS-inhibitorer | |
DK0797542T3 (da) | Fremgangsmåde til fremstilling af aluminosilikatderivater | |
DK0912537T3 (da) | Fremgangsmåde til fremstilling af phenylheterocykliske forbindelser, der er anvendelige som cox-2-inhibitorer | |
FI972495A (fi) | Menetelmä orgaanisia yhdisteitä hajottavien mikroorganismien valmistamiseksi | |
NO20031319D0 (no) | Fremgangsmåte for fremstilling av N-(substituert fenyl)-3- alkyl-, aryl- ogheteroaryl-sulfonyl-2-hydroksy-2-alkyl- oghalogenalkylpropanamidforbindelser | |
FI972065A (fi) | Menetelmä N-fosfonometyyliglysiinin valmistamiseksi | |
NO911459D0 (no) | Anvendelse av metallion-komplekser som belegginhibitorer. | |
FI942102A0 (fi) | Menetelmä alumiinioksaanien valmistamiseksi | |
NO993949L (no) | FremgangsmÕte for fremstilling av substituert tiazolidindion | |
FI990509A0 (fi) | Häiriönpoistomenetelmä | |
FI940992A0 (fi) | Cylindergrupp med enkelt viradrag i torkningspartiet av en pappersmaskin och torkningsparti i pappersmaskin som innehaoller dessa | |
FI956058A (fi) | Menetelmä glutaaridialdehydin valmistamiseksi | |
FI970793A (fi) | Menetelmä kytkentöjen purkamiseksi | |
FI982623A0 (fi) | Menetelmä alkyyliketeenidimeerien valmistamiseksi | |
DK0944601T3 (da) | Heterocykliske quanidinylaminoforbindelser som alfa-2-adrenoceptoragonister | |
FI932743A (fi) | Substituerade (bensotiazolyl- och kinoxalylmetoxi)fenyl-aettiksyraderivat | |
FI972694A0 (fi) | Uusi menetelmä sameridiinin valmistamiseksi | |
NO930739D0 (no) | Substituerte fenylkinazolinderivater |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MA | Patent expired |