FI971104A - Förfarande för framställning av fenylheterocykler användbara som COX-inhibitorer - Google Patents

Förfarande för framställning av fenylheterocykler användbara som COX-inhibitorer Download PDF

Info

Publication number
FI971104A
FI971104A FI971104A FI971104A FI971104A FI 971104 A FI971104 A FI 971104A FI 971104 A FI971104 A FI 971104A FI 971104 A FI971104 A FI 971104A FI 971104 A FI971104 A FI 971104A
Authority
FI
Finland
Prior art keywords
preparation
cox inhibitors
phenyl heterocycles
heterocycles useful
useful
Prior art date
Application number
FI971104A
Other languages
English (en)
Finnish (fi)
Other versions
FI106376B (sv
FI971104A0 (sv
Inventor
Richard Desmond
Ulf Dolling
Ben Marcune
Richard Tillyer
David Tschaen
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of FI971104A0 publication Critical patent/FI971104A0/sv
Publication of FI971104A publication Critical patent/FI971104A/sv
Application granted granted Critical
Publication of FI106376B publication Critical patent/FI106376B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/675—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids of saturated hydroxy-carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/58—One oxygen atom, e.g. butenolide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Oncology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
FI971104A 1994-09-16 1997-03-14 Förfarande för framställning av fenylheterocykler användbara som COX-inhibitorer FI106376B (sv)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/307,972 US5585504A (en) 1994-09-16 1994-09-16 Process of making cox-2 inhibitors having a lactone bridge
US30797294 1994-09-16
US9511539 1995-09-12
PCT/US1995/011539 WO1996008482A1 (en) 1994-09-16 1995-09-12 Process for making phenyl heterocycles useful as cox-2 inhibitors

Publications (3)

Publication Number Publication Date
FI971104A0 FI971104A0 (sv) 1997-03-14
FI971104A true FI971104A (sv) 1997-03-14
FI106376B FI106376B (sv) 2001-01-31

Family

ID=23191976

Family Applications (1)

Application Number Title Priority Date Filing Date
FI971104A FI106376B (sv) 1994-09-16 1997-03-14 Förfarande för framställning av fenylheterocykler användbara som COX-inhibitorer

Country Status (12)

Country Link
US (1) US5585504A (sv)
CN (1) CN1065533C (sv)
AU (1) AU3510595A (sv)
BR (1) BR9508927A (sv)
CZ (1) CZ288797B6 (sv)
FI (1) FI106376B (sv)
RO (1) RO118585B1 (sv)
RU (1) RU2160257C2 (sv)
SK (1) SK282789B6 (sv)
TW (1) TW325468B (sv)
UA (1) UA49809C2 (sv)
WO (1) WO1996008482A1 (sv)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2747123B1 (fr) * 1996-04-04 1998-06-26 Union Pharma Scient Appl Nouveaux derives diarylmethylidene tetrahydrofurane, leurs procedes de preparation, et leurs utilisations en therapeutique
US6180651B1 (en) * 1996-04-04 2001-01-30 Bristol-Myers Squibb Diarylmethylidenefuran derivatives, processes for their preparation and their uses in therapeutics
US5807873A (en) * 1996-04-04 1998-09-15 Laboratories Upsa Diarylmethylidenefuran derivatives and their uses in therapeutics
US5883267A (en) * 1996-05-31 1999-03-16 Merck & Co., Inc. Process for making phenyl heterocycles useful as cox-2 inhibitors
HRP970289A2 (en) * 1996-05-31 1998-04-30 Merck & Co Inc Process for preparing phenyl heterocycles useful as cox-2 inhibitors
US5985930A (en) 1996-11-21 1999-11-16 Pasinetti; Giulio M. Treatment of neurodegenerative conditions with nimesulide
AU6015098A (en) 1997-02-24 1998-09-09 Cornell Research Foundation Inc. Method of screening agents as candidates for drugs or sources of drugs
US6071954A (en) * 1997-03-14 2000-06-06 Merk Frosst Canada, Inc. (methylsulfonyl)phenyl-2-(5H)-furanones with oxygen link as COX-2 inhibitors
ES2201466T3 (es) * 1997-03-14 2004-03-16 MERCK FROSST CANADA & CO. `(metilsulfonil)fenil-2-(5h)-furanonas con enlace con oxigeno como inhibidores de cox-2`.
US6294558B1 (en) * 1999-05-31 2001-09-25 Pfizer Inc. Sulfonylbenzene compounds as anti-inflammatory/analgesic agents
TNSN99111A1 (fr) * 1998-06-11 2005-11-10 Pfizer Derives de sulfonylbenzene nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant.
US6727238B2 (en) 1998-06-11 2004-04-27 Pfizer Inc. Sulfonylbenzene compounds as anti-inflammatory/analgesic agents
WO2000053149A2 (en) * 1999-03-10 2000-09-14 G.D. Searle & Co. Method and composition for administering a cyclooxygenase-2 inhibitor
ATE252576T1 (de) 1999-12-03 2003-11-15 Pfizer Prod Inc Heteroarylphenylpyrazolverbindungen zur verwendung als analgetisches/entzündungshemmendes mittel
CA2326970C (en) 1999-12-03 2004-11-23 Pfizer Products Inc. Acetylene derivatives as anti-inflammatory/analgesic agents
JP2003517475A (ja) 1999-12-03 2003-05-27 ファイザー・プロダクツ・インク 抗炎症／鎮痛薬としてのヘテロシクロ−アルキルスルホニルピラゾール誘導体
EP1104760B1 (en) 1999-12-03 2003-03-12 Pfizer Products Inc. Sulfamoylheteroaryl pyrazole compounds as anti-inflammatory/analgesic agents
BR0008060A (pt) 1999-12-08 2002-02-05 Pharmacia Corp Composições inibidoras de ciclooxigenase-2 tendo rápido inìcio de eficácia terapêutica
DE10012825B4 (de) 2000-03-16 2004-04-15 Bayer Corp. Verfahren zur Herstellung von spirocyclischen Tetronsäurederivaten
CN1102586C (zh) * 2000-04-07 2003-03-05 中国科学院上海有机化学研究所 β位含有芳基取代基的γ－丁烯酸内酯及其固相合成法
WO2002005848A2 (en) * 2000-07-13 2002-01-24 Pharmacia Corporation Use of cox-2 inhibitors in the treatment and prevention of ocular cox-2 mediated disorders
US8680081B2 (en) * 2000-08-29 2014-03-25 Peter Van Patten Prophylactic treatment of migraine
US7115565B2 (en) * 2001-01-18 2006-10-03 Pharmacia & Upjohn Company Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability
PE20021017A1 (es) 2001-04-03 2002-11-24 Pharmacia Corp Composicion parenteral reconstituible
ATE298749T1 (de) 2001-07-05 2005-07-15 Pfizer Prod Inc Heterocyclo-alkylsulfonyl pyrazole als entzündungshemmende/analgetische mittel
UA80682C2 (en) * 2001-08-06 2007-10-25 Pharmacia Corp Orally deliverable stabilized oral suspension formulation and process for the incresaing physical stability of thixotropic pharmaceutical composition
GT200200183A (es) 2001-09-28 2003-05-23 Procedimiento para preparar derivados de heterocicloalquilsulfonil pirazol
WO2003037336A1 (en) 2001-11-02 2003-05-08 Pfizer Products Inc. 1-(5-sulfonyl-pyridin-2-yl)-5-(methylidene-cycloalkylmethoxy)-1h-pyrazole-4-carbonitrile derivatives and other compounds as cyclooxygenase inhibitors for the treatment of arthritis, neurodegeneration and colon cancer
ES2213485B1 (es) 2003-02-13 2005-12-16 Almirall Prodesfarma, S.A. Derivados de la 2-fenilpiran-4-ona.
DE602004002832T2 (de) * 2003-05-07 2007-06-06 Osteologix A/S Behandlung von knorpel/knochen-erkrankungen mit wasserlöslichen strontiumsalzen
DK2266584T3 (da) * 2003-05-07 2013-01-02 Osteologix As Sammensætning med strontium og D-vitamin til profylakse og/eller behandling af brusk- og knogletilstande
AU2003263582A1 (en) * 2003-08-14 2005-03-07 Shasun Chemicals And Drugs Limited Process for the manufacture of rofecoxib
WO2005044227A1 (en) * 2003-11-05 2005-05-19 Glenmark Pharmaceuticals Limited Topical pharmaceutical compositions
US20050100594A1 (en) * 2003-11-12 2005-05-12 Nilendu Sen Pharmaceutical formulation containing muscle relaxant and COX-II inhibitor
KR20210124188A (ko) 2018-11-21 2021-10-14 트루모 파마슈티칼스, 인크. 정제된 형태의 로페콕시브, 제조 및 사용 방법
US10945992B1 (en) 2019-11-13 2021-03-16 Tremeau Pharmaceuticals, Inc. Dosage forms of rofecoxib and related methods
US11161833B1 (en) 2021-04-09 2021-11-02 Tremeau Pharmaceuticals, Inc. Deuterated etoricoxib, methods of manufacture, and use thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE160345T1 (de) * 1993-01-15 1997-12-15 Searle & Co 3,4-diarylthiophene und analoga davon, sowie deren verwendung als entzündungshemmende mittel
US5462939A (en) * 1993-05-07 1995-10-31 Sterling Winthrop Inc. Peptidic ketones as interleukin-1β-converting enzyme inhibitors
SG43841A1 (en) * 1994-01-10 1997-11-14 Merck Frosst Canada Inc Phenyl heterocycles as cox-2 inhibitors

Also Published As

Publication number Publication date
CZ79297A3 (en) 1997-07-16
UA49809C2 (uk) 2002-10-15
WO1996008482A1 (en) 1996-03-21
BR9508927A (pt) 1997-12-30
RU2160257C2 (ru) 2000-12-10
CN1159191A (zh) 1997-09-10
US5585504A (en) 1996-12-17
TW325468B (en) 1998-01-21
FI106376B (sv) 2001-01-31
CN1065533C (zh) 2001-05-09
SK31697A3 (en) 1997-10-08
RO118585B1 (ro) 2003-07-30
CZ288797B6 (cs) 2001-09-12
SK282789B6 (sk) 2002-12-03
FI971104A0 (sv) 1997-03-14
AU3510595A (en) 1996-03-29

Similar Documents

Publication Publication Date Title
FI971104A0 (sv) Förfarande för framställning av fenylheterocykler användbara som COX-inhibitorer
FI962800A (sv) Fenylheterocykliska föreningar som COX-2 inhibitorer
FI20090217A (sv) Förfarande för framställning av livsmedelskompositioner
EE9900259A (et) Ühendi uus vorm
DK0818448T3 (da) Cycloalkanopyridiner som CETP-inhibitorer
NO985874D0 (no) Bestemte fosfinylderivater nyttige som naaladase inhibitorer
FI944804A0 (sv) Pyrimidinylacetamide som elastasinhibitorer
DK1007520T3 (da) 2-aminopyridiner som indeholder sammensluttede ringsubstituenter som NOS inhibitorer
DK0606248T3 (da) Heteroarylaminer som hidtil ukendte acetylcholinesteraseinhibitorer
NO991384D0 (no) Substituerte heterocykler som anti-tumormidler
FI972495A (sv) Förfarande för framställning av mikroorganismer, som nedbryter organiska föreningar
FI972065A (sv) Förfarande för framställning av N-fosfonometylglycin
NO911459D0 (no) Anvendelse av metallion-komplekser som belegginhibitorer.
FI942102A (sv) Förfarande för framställning av aluminoxaner
FI990509A (sv) Förfarande för eliminering av störningar
FI940992A0 (fi) Cylindergrupp med enkelt viradrag i torkningspartiet av en pappersmaskin och torkningsparti i pappersmaskin som innehaoller dessa
FI956058A (sv) Förfarande för framställning av glutardialdehyd
FI972440A0 (sv) Förfarande för framställning av mellanprodukter, som är användbara i syntes av cefalosporiner
FI970793A (sv) Förfarande för desaktivering av kopplingar
FI982623A0 (sv) Förfarande för framställning av alkylketendimerer
DK0944601T3 (da) Heterocykliske quanidinylaminoforbindelser som alfa-2-adrenoceptoragonister
FI972694A0 (sv) Nytt förfarande för framställning av sameridin
NO930739D0 (no) Substituerte fenylkinazolinderivater
FI971964A0 (sv) Förfarande för framställning av 1-halo-3-trialkylsilanylbensenderivat
FI951441A (sv) Förfarande för framställning av 5-formylamino-pyrimidiner

Legal Events

Date Code Title Description
MA Patent expired