SK282727B6 - 1,3-Disubstituované močoviny - inhibítory ACAT a spôsob ich prípravy - Google Patents
1,3-Disubstituované močoviny - inhibítory ACAT a spôsob ich prípravy Download PDFInfo
- Publication number
- SK282727B6 SK282727B6 SK1751-97A SK175197A SK282727B6 SK 282727 B6 SK282727 B6 SK 282727B6 SK 175197 A SK175197 A SK 175197A SK 282727 B6 SK282727 B6 SK 282727B6
- Authority
- SK
- Slovakia
- Prior art keywords
- phenyl
- dichlorophenyl
- urea
- yield
- analysis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
- C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C275/36—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with at least one of the oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. N-aryloxyphenylureas
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C07C323/43—Y being a hetero atom
- C07C323/44—X or Y being nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Enzymes And Modification Thereof (AREA)
Priority Applications (19)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SK1751-97A SK282727B6 (sk) | 1997-12-19 | 1997-12-19 | 1,3-Disubstituované močoviny - inhibítory ACAT a spôsob ich prípravy |
DE69811949T DE69811949T2 (de) | 1997-12-19 | 1998-12-16 | 1,3-disubstituierte harnstoffe als acat-inhibitoren, sowie verfahren zu deren herstellung |
YU35100A YU35100A (sh) | 1997-12-19 | 1998-12-16 | 1,3-disupstituisane uree kao inhibitori enzima holesterol aciltransferaze (acat), i postupak za njihovo dobijanje |
PCT/SK1998/000019 WO1999032437A1 (en) | 1997-12-19 | 1998-12-16 | 1,3-disubstituted ureas as acat inhibitors, and method of preparing thereof |
PL98341235A PL341235A1 (en) | 1997-12-19 | 1998-12-16 | 1,3-disubstituted ureas as inhibitors of acat and method of obtaining them |
HU0004332A HUP0004332A3 (en) | 1997-12-19 | 1998-12-16 | 1,3-disubstituted ureas as acat inhibitors, and method of preparing thereof |
EP98961715A EP1042278B1 (en) | 1997-12-19 | 1998-12-16 | 1,3-disubstituted ureas as acat inhibitors, and method of preparing thereof |
ES98961715T ES2194379T3 (es) | 1997-12-19 | 1998-12-16 | Ureas 1,3-disustituidas como inhibidores de acat, y metodo de preparacion de las mismas. |
JP2000525374A JP2001526259A (ja) | 1997-12-19 | 1998-12-16 | Acat阻害剤としての1,3位二置換尿素およびその製造法 |
PT98961715T PT1042278E (pt) | 1997-12-19 | 1998-12-16 | Ureias di-substituidas nas posicoes 1 e 3, utilizadas como inibidores de acat e o seu processo de preparacao |
US09/581,821 US6444691B1 (en) | 1997-12-19 | 1998-12-16 | 1,3-disubstituted ureas as ACAT inhibitors, and method of preparing thereof |
SI9830419T SI1042278T1 (en) | 1997-12-19 | 1998-12-16 | 1,3-disubstituted ureas as acat inhibitors, and method of preparing thereof |
RU2000119612/04A RU2216536C2 (ru) | 1997-12-19 | 1998-12-16 | 1,3-дизамещенные мочевины в качестве ингибиторов холестерол-ацилтрансферазы и способ их получения |
DK98961715T DK1042278T3 (da) | 1997-12-19 | 1998-12-16 | 1,3-disubstituerede urinstoffer som ACAT inhibitorer samt fremgangsmåde til fremstilling deraf |
CZ20002297A CZ299695B6 (cs) | 1997-12-19 | 1998-12-16 | 1,3-Disubstituované mocoviny jako inhibitory ACATa zpusob jejich prípravy |
AT98961715T ATE233727T1 (de) | 1997-12-19 | 1998-12-16 | 1,3-disubstituierte harnstoffe als acat- inhibitoren, sowie verfahren zu deren herstellung |
AU16976/99A AU1697699A (en) | 1997-12-19 | 1998-12-16 | 1,3-disubstituted ureas as acat inhibitors, and method of preparing thereof |
HR20000351A HRP20000351B1 (en) | 1997-12-19 | 2000-05-26 | 1,3-disubstituted ureas as acat inhibitors, and method of preparing thereof |
BG104537A BG104537A (en) | 1997-12-19 | 2000-06-15 | 1,3-doublesubstituted carbamides as acat inhibitors and method for their preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SK1751-97A SK282727B6 (sk) | 1997-12-19 | 1997-12-19 | 1,3-Disubstituované močoviny - inhibítory ACAT a spôsob ich prípravy |
Publications (2)
Publication Number | Publication Date |
---|---|
SK175197A3 SK175197A3 (en) | 1999-07-12 |
SK282727B6 true SK282727B6 (sk) | 2002-11-06 |
Family
ID=20434795
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SK1751-97A SK282727B6 (sk) | 1997-12-19 | 1997-12-19 | 1,3-Disubstituované močoviny - inhibítory ACAT a spôsob ich prípravy |
Country Status (18)
Country | Link |
---|---|
US (1) | US6444691B1 (da) |
EP (1) | EP1042278B1 (da) |
JP (1) | JP2001526259A (da) |
AT (1) | ATE233727T1 (da) |
AU (1) | AU1697699A (da) |
BG (1) | BG104537A (da) |
CZ (1) | CZ299695B6 (da) |
DE (1) | DE69811949T2 (da) |
DK (1) | DK1042278T3 (da) |
ES (1) | ES2194379T3 (da) |
HR (1) | HRP20000351B1 (da) |
HU (1) | HUP0004332A3 (da) |
PL (1) | PL341235A1 (da) |
PT (1) | PT1042278E (da) |
RU (1) | RU2216536C2 (da) |
SK (1) | SK282727B6 (da) |
WO (1) | WO1999032437A1 (da) |
YU (1) | YU35100A (da) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2298311B1 (en) | 1999-01-13 | 2012-05-09 | Bayer HealthCare LLC | w-Carboxy aryl substituted diphenyl ureas as p38 kinase inhibitors |
US7928239B2 (en) * | 1999-01-13 | 2011-04-19 | Bayer Healthcare Llc | Inhibition of RAF kinase using quinolyl, isoquinolyl or pyridyl ureas |
US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
DK1580188T3 (da) | 2002-02-11 | 2012-02-06 | Bayer Healthcare Llc | Forbindelser af arylurea som kinaseinhibitorer |
WO2003068228A1 (en) | 2002-02-11 | 2003-08-21 | Bayer Pharmaceuticals Corporation | Aryl ureas with angiogenesis inhibiting activity |
UY28213A1 (es) | 2003-02-28 | 2004-09-30 | Bayer Pharmaceuticals Corp | Nuevos derivados de cianopiridina útiles en el tratamiento de cáncer y otros trastornos. |
AU2004228028B2 (en) | 2003-04-03 | 2009-12-10 | The Regents Of The University Of California | Improved inhibitors for the soluble epoxide hydrolase |
EP1636585B2 (en) | 2003-05-20 | 2012-06-13 | Bayer HealthCare LLC | Diaryl ureas with kinase inhibiting activity |
ME00294B (me) | 2003-07-23 | 2011-05-10 | Bayer Pharmaceuticals Corp | Fluoro supstituisana omega-karaboksiaril difenil urea za liječenje i prevenciju bolesti i stanja bolesti |
WO2005068420A1 (en) * | 2003-12-23 | 2005-07-28 | Esperion Therapeutics, Inc. | Urea and thiourea compounds and compositions for cholesterol management and related uses |
US20090018092A1 (en) | 2004-03-16 | 2009-01-15 | The Regents Of The University Of California | Reducing Nephropathy with Inhibitors of Soluble Epoxide Hydrolase and Epoxyeicosanoids |
US7662910B2 (en) * | 2004-10-20 | 2010-02-16 | The Regents Of The University Of California | Inhibitors for the soluble epoxide hydrolase |
SK287385B6 (sk) | 2007-11-27 | 2010-08-09 | Hameln-Rds, A. S. | 1,3-Disubstituované močoviny, spôsob ich prípravy a použitia |
HRP20090186A2 (hr) | 2009-03-31 | 2010-10-31 | Institut Ruđer Bošković | Adamantanski bisureidni derivati, metoda priprave i primjena u detekciji aniona |
US8912184B1 (en) | 2010-03-01 | 2014-12-16 | Alzheimer's Institute Of America, Inc. | Therapeutic and diagnostic methods |
WO2011109441A1 (en) * | 2010-03-01 | 2011-09-09 | Myrexis, Inc. | Compounds and therapeutic uses thereof |
RU2486893C1 (ru) * | 2012-06-13 | 2013-07-10 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Волгоградский государственный технический университет" (ВолгГТУ) | Способ получения бис[3-метил(адамант-1-ил)]мочевин |
CN107417478B (zh) * | 2017-06-05 | 2020-05-05 | 南京师范大学 | 一种催化氧化羰基化合成不对称二取代脲的方法 |
CN115677660B (zh) * | 2022-10-27 | 2024-05-03 | 中国药科大学 | 苯基脲类化合物及其制备方法、用途和药物组合物 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3284433A (en) * | 1963-07-17 | 1966-11-08 | Merck & Co Inc | 4-phenoxy-carbanilides |
FR1593586A (da) * | 1967-10-17 | 1970-06-01 | ||
DE2246109A1 (de) * | 1972-09-20 | 1974-03-28 | Bayer Ag | 1-(4-phenoxy-phenyl)-1,3,5-triazinderivate, ein verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
JP2720053B2 (ja) * | 1988-11-09 | 1998-02-25 | チッソ株式会社 | 新規なジアミノ化合物、ジニトロ化合物、ジオール化合物および製造方法 |
FR2674522B1 (fr) | 1991-03-26 | 1993-07-16 | Lipha | Nouveaux derives de l'indole, procedes de preparation et medicaments les contenant. |
JP3668266B2 (ja) | 1994-02-01 | 2005-07-06 | 株式会社日清製粉グループ本社 | 尿素誘導体 |
US5576335A (en) | 1994-02-01 | 1996-11-19 | Nisshin Flour Milling Co., Ltd. | Urea derivatives and their use as ACAT inhibitors |
CA2161376C (en) * | 1994-10-27 | 2005-01-11 | Toshiaki Minami | Reversible multi-color thermal recording medium |
-
1997
- 1997-12-19 SK SK1751-97A patent/SK282727B6/sk unknown
-
1998
- 1998-12-16 HU HU0004332A patent/HUP0004332A3/hu unknown
- 1998-12-16 YU YU35100A patent/YU35100A/sh unknown
- 1998-12-16 US US09/581,821 patent/US6444691B1/en not_active Expired - Fee Related
- 1998-12-16 DE DE69811949T patent/DE69811949T2/de not_active Expired - Fee Related
- 1998-12-16 PT PT98961715T patent/PT1042278E/pt unknown
- 1998-12-16 PL PL98341235A patent/PL341235A1/xx not_active Application Discontinuation
- 1998-12-16 WO PCT/SK1998/000019 patent/WO1999032437A1/en active IP Right Grant
- 1998-12-16 AT AT98961715T patent/ATE233727T1/de not_active IP Right Cessation
- 1998-12-16 ES ES98961715T patent/ES2194379T3/es not_active Expired - Lifetime
- 1998-12-16 DK DK98961715T patent/DK1042278T3/da active
- 1998-12-16 JP JP2000525374A patent/JP2001526259A/ja active Pending
- 1998-12-16 AU AU16976/99A patent/AU1697699A/en not_active Abandoned
- 1998-12-16 CZ CZ20002297A patent/CZ299695B6/cs not_active IP Right Cessation
- 1998-12-16 RU RU2000119612/04A patent/RU2216536C2/ru not_active IP Right Cessation
- 1998-12-16 EP EP98961715A patent/EP1042278B1/en not_active Expired - Lifetime
-
2000
- 2000-05-26 HR HR20000351A patent/HRP20000351B1/xx not_active IP Right Cessation
- 2000-06-15 BG BG104537A patent/BG104537A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
YU35100A (sh) | 2002-10-18 |
ATE233727T1 (de) | 2003-03-15 |
DE69811949D1 (de) | 2003-04-10 |
WO1999032437A1 (en) | 1999-07-01 |
EP1042278A1 (en) | 2000-10-11 |
DE69811949T2 (de) | 2004-03-04 |
AU1697699A (en) | 1999-07-12 |
HUP0004332A3 (en) | 2002-11-28 |
RU2216536C2 (ru) | 2003-11-20 |
HRP20000351B1 (en) | 2003-10-31 |
PT1042278E (pt) | 2003-07-31 |
CZ20002297A3 (cs) | 2000-11-15 |
HRP20000351A2 (en) | 2000-12-31 |
ES2194379T3 (es) | 2003-11-16 |
JP2001526259A (ja) | 2001-12-18 |
PL341235A1 (en) | 2001-03-26 |
HUP0004332A2 (hu) | 2001-05-28 |
EP1042278B1 (en) | 2003-03-05 |
CZ299695B6 (cs) | 2008-10-22 |
US6444691B1 (en) | 2002-09-03 |
BG104537A (en) | 2000-12-29 |
DK1042278T3 (da) | 2003-06-30 |
SK175197A3 (en) | 1999-07-12 |
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