DK1042278T3 - 1,3-disubstituerede urinstoffer som ACAT inhibitorer samt fremgangsmåde til fremstilling deraf - Google Patents
1,3-disubstituerede urinstoffer som ACAT inhibitorer samt fremgangsmåde til fremstilling derafInfo
- Publication number
- DK1042278T3 DK1042278T3 DK98961715T DK98961715T DK1042278T3 DK 1042278 T3 DK1042278 T3 DK 1042278T3 DK 98961715 T DK98961715 T DK 98961715T DK 98961715 T DK98961715 T DK 98961715T DK 1042278 T3 DK1042278 T3 DK 1042278T3
- Authority
- DK
- Denmark
- Prior art keywords
- disubstituted ureas
- preparation
- acat inhibitors
- isocyanates
- enzyme
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
- C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C275/36—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with at least one of the oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. N-aryloxyphenylureas
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C07C323/43—Y being a hetero atom
- C07C323/44—X or Y being nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SK1751-97A SK282727B6 (sk) | 1997-12-19 | 1997-12-19 | 1,3-Disubstituované močoviny - inhibítory ACAT a spôsob ich prípravy |
| PCT/SK1998/000019 WO1999032437A1 (en) | 1997-12-19 | 1998-12-16 | 1,3-disubstituted ureas as acat inhibitors, and method of preparing thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1042278T3 true DK1042278T3 (da) | 2003-06-30 |
Family
ID=20434795
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK98961715T DK1042278T3 (da) | 1997-12-19 | 1998-12-16 | 1,3-disubstituerede urinstoffer som ACAT inhibitorer samt fremgangsmåde til fremstilling deraf |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6444691B1 (da) |
| EP (1) | EP1042278B1 (da) |
| JP (1) | JP2001526259A (da) |
| AT (1) | ATE233727T1 (da) |
| AU (1) | AU1697699A (da) |
| BG (1) | BG104537A (da) |
| CZ (1) | CZ299695B6 (da) |
| DE (1) | DE69811949T2 (da) |
| DK (1) | DK1042278T3 (da) |
| ES (1) | ES2194379T3 (da) |
| HR (1) | HRP20000351B1 (da) |
| HU (1) | HUP0004332A3 (da) |
| PL (1) | PL341235A1 (da) |
| PT (1) | PT1042278E (da) |
| RU (1) | RU2216536C2 (da) |
| SK (1) | SK282727B6 (da) |
| WO (1) | WO1999032437A1 (da) |
| YU (1) | YU35100A (da) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE556713T1 (de) | 1999-01-13 | 2012-05-15 | Bayer Healthcare Llc | Omega-carboxyarylsubstituierte-diphenyl- harnstoffe als p38-kinasehemmer |
| US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
| US7928239B2 (en) * | 1999-01-13 | 2011-04-19 | Bayer Healthcare Llc | Inhibition of RAF kinase using quinolyl, isoquinolyl or pyridyl ureas |
| ATE529406T1 (de) | 2002-02-11 | 2011-11-15 | Bayer Healthcare Llc | Aryl-harnstoffe als kinase inhibitoren |
| AU2003209116A1 (en) | 2002-02-11 | 2003-09-04 | Bayer Pharmaceuticals Corporation | Aryl ureas with angiogenesis inhibiting activity |
| US7557129B2 (en) | 2003-02-28 | 2009-07-07 | Bayer Healthcare Llc | Cyanopyridine derivatives useful in the treatment of cancer and other disorders |
| JP4943837B2 (ja) | 2003-04-03 | 2012-05-30 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 可溶性エポキシド加水分解酵素の改良インヒビター |
| JP4860474B2 (ja) | 2003-05-20 | 2012-01-25 | バイエル、ファーマシューテイカルズ、コーポレイション | Ｐｄｇｆｒによって仲介される病気のためのジアリール尿素 |
| DK1663978T3 (da) | 2003-07-23 | 2008-04-07 | Bayer Pharmaceuticals Corp | Fluorsubstitueret omega-carboxyaryl-diphenylurinstof til behandling og forebyggelse af sygdomme og lidelser |
| WO2005068420A1 (en) * | 2003-12-23 | 2005-07-28 | Esperion Therapeutics, Inc. | Urea and thiourea compounds and compositions for cholesterol management and related uses |
| US20090018092A1 (en) | 2004-03-16 | 2009-01-15 | The Regents Of The University Of California | Reducing Nephropathy with Inhibitors of Soluble Epoxide Hydrolase and Epoxyeicosanoids |
| WO2006045119A2 (en) * | 2004-10-20 | 2006-04-27 | The Regents Of The University Of California | Improved inhibitors for the soluble epoxide hydrolase |
| SK287385B6 (sk) | 2007-11-27 | 2010-08-09 | Hameln-Rds, A. S. | 1,3-Disubstituované močoviny, spôsob ich prípravy a použitia |
| HRP20090186A2 (hr) | 2009-03-31 | 2010-10-31 | Institut Ruđer Bošković | Adamantanski bisureidni derivati, metoda priprave i primjena u detekciji aniona |
| EP2542086A4 (en) * | 2010-03-01 | 2013-09-04 | Myrexis Inc | COMPOUNDS AND ITS THERAPEUTIC USE |
| US8912184B1 (en) | 2010-03-01 | 2014-12-16 | Alzheimer's Institute Of America, Inc. | Therapeutic and diagnostic methods |
| RU2486893C1 (ru) * | 2012-06-13 | 2013-07-10 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Волгоградский государственный технический университет" (ВолгГТУ) | Способ получения бис[3-метил(адамант-1-ил)]мочевин |
| CN107417478B (zh) * | 2017-06-05 | 2020-05-05 | 南京师范大学 | 一种催化氧化羰基化合成不对称二取代脲的方法 |
| CN115677660B (zh) * | 2022-10-27 | 2024-05-03 | 中国药科大学 | 苯基脲类化合物及其制备方法、用途和药物组合物 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3284433A (en) * | 1963-07-17 | 1966-11-08 | Merck & Co Inc | 4-phenoxy-carbanilides |
| FR1593586A (da) * | 1967-10-17 | 1970-06-01 | ||
| DE2246109A1 (de) * | 1972-09-20 | 1974-03-28 | Bayer Ag | 1-(4-phenoxy-phenyl)-1,3,5-triazinderivate, ein verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| JP2720053B2 (ja) * | 1988-11-09 | 1998-02-25 | チッソ株式会社 | 新規なジアミノ化合物、ジニトロ化合物、ジオール化合物および製造方法 |
| FR2674522B1 (fr) | 1991-03-26 | 1993-07-16 | Lipha | Nouveaux derives de l'indole, procedes de preparation et medicaments les contenant. |
| US5576335A (en) | 1994-02-01 | 1996-11-19 | Nisshin Flour Milling Co., Ltd. | Urea derivatives and their use as ACAT inhibitors |
| JP3668266B2 (ja) | 1994-02-01 | 2005-07-06 | 株式会社日清製粉グループ本社 | 尿素誘導体 |
| CA2161376C (en) * | 1994-10-27 | 2005-01-11 | Toshiaki Minami | Reversible multi-color thermal recording medium |
-
1997
- 1997-12-19 SK SK1751-97A patent/SK282727B6/sk unknown
-
1998
- 1998-12-16 AT AT98961715T patent/ATE233727T1/de not_active IP Right Cessation
- 1998-12-16 PT PT98961715T patent/PT1042278E/pt unknown
- 1998-12-16 YU YU35100A patent/YU35100A/sh unknown
- 1998-12-16 HU HU0004332A patent/HUP0004332A3/hu unknown
- 1998-12-16 EP EP98961715A patent/EP1042278B1/en not_active Expired - Lifetime
- 1998-12-16 AU AU16976/99A patent/AU1697699A/en not_active Abandoned
- 1998-12-16 RU RU2000119612/04A patent/RU2216536C2/ru not_active IP Right Cessation
- 1998-12-16 WO PCT/SK1998/000019 patent/WO1999032437A1/en active IP Right Grant
- 1998-12-16 JP JP2000525374A patent/JP2001526259A/ja active Pending
- 1998-12-16 DK DK98961715T patent/DK1042278T3/da active
- 1998-12-16 PL PL98341235A patent/PL341235A1/xx not_active Application Discontinuation
- 1998-12-16 CZ CZ20002297A patent/CZ299695B6/cs not_active IP Right Cessation
- 1998-12-16 US US09/581,821 patent/US6444691B1/en not_active Expired - Fee Related
- 1998-12-16 ES ES98961715T patent/ES2194379T3/es not_active Expired - Lifetime
- 1998-12-16 DE DE69811949T patent/DE69811949T2/de not_active Expired - Fee Related
-
2000
- 2000-05-26 HR HR20000351A patent/HRP20000351B1/xx not_active IP Right Cessation
- 2000-06-15 BG BG104537A patent/BG104537A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1042278B1 (en) | 2003-03-05 |
| YU35100A (sh) | 2002-10-18 |
| CZ20002297A3 (cs) | 2000-11-15 |
| RU2216536C2 (ru) | 2003-11-20 |
| WO1999032437A1 (en) | 1999-07-01 |
| US6444691B1 (en) | 2002-09-03 |
| DE69811949T2 (de) | 2004-03-04 |
| HUP0004332A2 (hu) | 2001-05-28 |
| BG104537A (en) | 2000-12-29 |
| ES2194379T3 (es) | 2003-11-16 |
| SK282727B6 (sk) | 2002-11-06 |
| CZ299695B6 (cs) | 2008-10-22 |
| DE69811949D1 (de) | 2003-04-10 |
| EP1042278A1 (en) | 2000-10-11 |
| ATE233727T1 (de) | 2003-03-15 |
| SK175197A3 (en) | 1999-07-12 |
| JP2001526259A (ja) | 2001-12-18 |
| AU1697699A (en) | 1999-07-12 |
| PL341235A1 (en) | 2001-03-26 |
| PT1042278E (pt) | 2003-07-31 |
| HRP20000351A2 (en) | 2000-12-31 |
| HUP0004332A3 (en) | 2002-11-28 |
| HRP20000351B1 (en) | 2003-10-31 |
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