SK282628B6 - Orto-substituované benzoylguanidíny, spôsob ich výroby, ich použitie ako liečiv alebo diagnostík, ako aj liečivo, ktoré ich obsahuje - Google Patents

Orto-substituované benzoylguanidíny, spôsob ich výroby, ich použitie ako liečiv alebo diagnostík, ako aj liečivo, ktoré ich obsahuje Download PDF

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Publication number
SK282628B6
SK282628B6 SK696-97A SK69697A SK282628B6 SK 282628 B6 SK282628 B6 SK 282628B6 SK 69697 A SK69697 A SK 69697A SK 282628 B6 SK282628 B6 SK 282628B6
Authority
SK
Slovakia
Prior art keywords
group
carbon atoms
formula
phenyl
hydrogen
Prior art date
Application number
SK696-97A
Other languages
English (en)
Slovak (sk)
Other versions
SK69697A3 (en
Inventor
Andreas Weichert
Joachim Brendel
Heinz-Werner Kleemann
Hans Jochen Lang
Jan-Robert Schwark
Udo Albus
Wolfgang Scholz
Original Assignee
Hoechst Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Aktiengesellschaft filed Critical Hoechst Aktiengesellschaft
Publication of SK69697A3 publication Critical patent/SK69697A3/sk
Publication of SK282628B6 publication Critical patent/SK282628B6/sk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pyridine Compounds (AREA)
SK696-97A 1996-06-04 1997-06-02 Orto-substituované benzoylguanidíny, spôsob ich výroby, ich použitie ako liečiv alebo diagnostík, ako aj liečivo, ktoré ich obsahuje SK282628B6 (sk)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19622370A DE19622370A1 (de) 1996-06-04 1996-06-04 Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Publications (2)

Publication Number Publication Date
SK69697A3 SK69697A3 (en) 1998-01-14
SK282628B6 true SK282628B6 (sk) 2002-10-08

Family

ID=7796095

Family Applications (1)

Application Number Title Priority Date Filing Date
SK696-97A SK282628B6 (sk) 1996-06-04 1997-06-02 Orto-substituované benzoylguanidíny, spôsob ich výroby, ich použitie ako liečiv alebo diagnostík, ako aj liečivo, ktoré ich obsahuje

Country Status (29)

Country Link
US (1) US6011063A (zh)
EP (1) EP0811610B1 (zh)
JP (1) JP4101904B2 (zh)
KR (1) KR980002019A (zh)
CN (1) CN1064956C (zh)
AR (1) AR008761A1 (zh)
AT (1) ATE209630T1 (zh)
AU (1) AU723665B2 (zh)
BR (1) BR9703440A (zh)
CA (1) CA2206758C (zh)
CZ (1) CZ289411B6 (zh)
DE (2) DE19622370A1 (zh)
DK (1) DK0811610T3 (zh)
ES (1) ES2166487T3 (zh)
HR (1) HRP970304B1 (zh)
HU (1) HUP9700989A3 (zh)
ID (1) ID17038A (zh)
IL (1) IL120988A0 (zh)
MX (1) MX9704094A (zh)
NO (1) NO310188B1 (zh)
NZ (1) NZ314973A (zh)
PL (1) PL185757B1 (zh)
PT (1) PT811610E (zh)
RU (1) RU2214397C2 (zh)
SI (1) SI0811610T1 (zh)
SK (1) SK282628B6 (zh)
TR (1) TR199700453A2 (zh)
TW (1) TW429243B (zh)
ZA (1) ZA974869B (zh)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6410563B1 (en) 1999-12-22 2002-06-25 Merck Frosst Canada & Co. Substituted 8-arylquinoline phosphodiesterase-4 inhibitors
MY123585A (en) 2000-03-23 2006-05-31 Merck Canada Inc Tri-aryl-substituted-ethane pde4 inhibitors.
US6639077B2 (en) 2000-03-23 2003-10-28 Merck Frosst Canada & Co. Tri-aryl-substituted-ethane PDE4 inhibitors
CA2407780A1 (en) 2000-05-25 2001-11-29 Merck Frosst Canada & Co./Merck Frosst Canada & Cie Fluoroalkoxy-substituted benzamide dichloropyridinyl n-oxide pde4 inhibitor
US6740666B2 (en) 2000-12-20 2004-05-25 Merck & Co., Inc. Substituted 8-arylquinoline phosphodiesterase-4 inhibitors
ES2247325T3 (es) 2001-05-24 2006-03-01 MERCK FROSST CANADA & CO. Inhibidores de 1-biaril-1,8-naftiridin-4-ona fosfodiesterasa-4.
JO2311B1 (en) 2001-08-29 2005-09-12 ميرك فروست كندا ليمتد Alkyl inhibitors Ariel phosphodiesterase-4
CA2478799C (en) 2002-03-12 2009-12-29 Merck & Co., Inc. Di-aryl substituted tetrazole modulators of metabotropic glutamate receptor-5
GB0916163D0 (en) * 2009-09-15 2009-10-28 Shire Llc Prodrugs of guanfacine

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE157351T1 (de) * 1993-02-20 1997-09-15 Hoechst Ag Substituierte benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament, als inhibitoren des zellulären na+/h+-austauschs oder als diagnostikum sowie sie enthaltendes medikament
DE4318756A1 (de) * 1993-06-05 1994-12-08 Hoechst Ag Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE4422685A1 (de) * 1994-06-29 1996-01-04 Hoechst Ag Ortho-amino-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Also Published As

Publication number Publication date
CN1064956C (zh) 2001-04-25
CN1175572A (zh) 1998-03-11
CA2206758C (en) 2007-08-14
HUP9700989A3 (en) 1998-04-28
RU2214397C2 (ru) 2003-10-20
DK0811610T3 (da) 2002-03-25
ES2166487T3 (es) 2002-04-16
HRP970304A2 (en) 1998-04-30
PL320327A1 (en) 1997-12-08
JPH1067731A (ja) 1998-03-10
AU723665B2 (en) 2000-08-31
ATE209630T1 (de) 2001-12-15
NO310188B1 (no) 2001-06-05
IL120988A0 (en) 1997-11-20
HRP970304B1 (en) 2002-10-31
JP4101904B2 (ja) 2008-06-18
SK69697A3 (en) 1998-01-14
US6011063A (en) 2000-01-04
TR199700453A2 (xx) 1997-12-21
CZ169697A3 (en) 1997-12-17
EP0811610B1 (de) 2001-11-28
AU2465097A (en) 1997-12-11
DE59705495D1 (de) 2002-01-10
EP0811610A1 (de) 1997-12-10
CA2206758A1 (en) 1997-12-04
KR980002019A (ko) 1998-03-30
BR9703440A (pt) 1998-09-29
PT811610E (pt) 2002-05-31
ID17038A (id) 1997-12-04
AR008761A1 (es) 2000-02-23
ZA974869B (en) 1997-12-04
NZ314973A (en) 1998-09-24
HU9700989D0 (en) 1997-07-28
CZ289411B6 (cs) 2002-01-16
MX9704094A (es) 1997-12-31
TW429243B (en) 2001-04-11
DE19622370A1 (de) 1997-12-11
PL185757B1 (pl) 2003-07-31
NO972527L (no) 1997-12-05
NO972527D0 (no) 1997-06-03
HUP9700989A2 (en) 1997-12-29
SI0811610T1 (en) 2002-04-30

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