SK282044B6 - (r)-5-bróm-n-(1-etyl-4-metylhexahydro-1h-1,4-diazepin-6-yl)-2- metoxy-6-metylamino-3-pyridínkarboxamid, spôsob prípravy, medziprodukt a farmaceutický prostriedok, ktorý ho obsahuje - Google Patents
(r)-5-bróm-n-(1-etyl-4-metylhexahydro-1h-1,4-diazepin-6-yl)-2- metoxy-6-metylamino-3-pyridínkarboxamid, spôsob prípravy, medziprodukt a farmaceutický prostriedok, ktorý ho obsahuje Download PDFInfo
- Publication number
- SK282044B6 SK282044B6 SK93-98A SK9398A SK282044B6 SK 282044 B6 SK282044 B6 SK 282044B6 SK 9398 A SK9398 A SK 9398A SK 282044 B6 SK282044 B6 SK 282044B6
- Authority
- SK
- Slovakia
- Prior art keywords
- compound
- formula
- ethyl
- methylhexahydro
- methoxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP07212495 | 1995-07-28 | ||
| PCT/JP1996/002053 WO1997005129A1 (fr) | 1995-07-28 | 1996-07-23 | (r)-5-bromo-n-(1-ethyl-4-methylhexahydro-1h-1,4-diazepin-6-yl)-2-methoxy-6-methylamino-3-pyridine-carboxamide, son procede d'obtention et medicament le contenant |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SK9398A3 SK9398A3 (en) | 1998-08-05 |
| SK282044B6 true SK282044B6 (sk) | 2001-10-08 |
Family
ID=16623612
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK93-98A SK282044B6 (sk) | 1995-07-28 | 1996-07-23 | (r)-5-bróm-n-(1-etyl-4-metylhexahydro-1h-1,4-diazepin-6-yl)-2- metoxy-6-metylamino-3-pyridínkarboxamid, spôsob prípravy, medziprodukt a farmaceutický prostriedok, ktorý ho obsahuje |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US5945415A (de) |
| EP (1) | EP0855397B1 (de) |
| KR (1) | KR19990028395A (de) |
| CN (1) | CN1096459C (de) |
| AT (1) | ATE201021T1 (de) |
| AU (1) | AU700635B2 (de) |
| BR (1) | BR9609691A (de) |
| CA (1) | CA2228056A1 (de) |
| CZ (1) | CZ290442B6 (de) |
| DE (1) | DE69612753T2 (de) |
| DK (1) | DK0855397T3 (de) |
| ES (1) | ES2156616T3 (de) |
| GR (1) | GR3036089T3 (de) |
| HK (1) | HK1018049A1 (de) |
| HU (1) | HUP9901208A3 (de) |
| IL (1) | IL122753A (de) |
| MX (1) | MX9800620A (de) |
| NO (1) | NO312964B1 (de) |
| NZ (1) | NZ312799A (de) |
| PL (1) | PL184073B1 (de) |
| PT (1) | PT855397E (de) |
| RU (1) | RU2156248C2 (de) |
| SK (1) | SK282044B6 (de) |
| TR (1) | TR199800165T1 (de) |
| WO (1) | WO1997005129A1 (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19650778C2 (de) * | 1996-12-06 | 2001-01-04 | Asta Medica Ag | Verwendung von Dopaminrezeptor-Antagonisten in der palliativen Tumortherapie |
| GB0216027D0 (en) * | 2002-07-10 | 2002-08-21 | Arachnova Therapeutics Ltd | New therapeutic use |
| US20040048874A1 (en) * | 2001-05-22 | 2004-03-11 | Bardsley Hazel Judith | New therapeutic use of 4-(2-fluorophenyl)-6-methyl-2-(1-piperazinyl)thieno[2,3-D]pyrimidine |
| ITBO20020198A1 (it) * | 2002-04-12 | 2003-10-13 | Univ Bologna | Derivati 2 , 5 bis diammino 1 , 4 benzochenionici utili per il trattamento della malattia di alzheimer , metodo per la loro preparazione ed |
| BRPI0406749A (pt) * | 2003-01-13 | 2005-12-20 | Dynogen Pharmaceuticals Inc | Métodos relacionados ao tratamento de distúrbios fincionais do intestino e composição farmacêutica |
| ATE359079T1 (de) * | 2003-01-13 | 2007-05-15 | Dynogen Pharmaceuticals Inc | Verfahren zur behandlung von übelkeit, erbrechen, würgereiz oder jede kombination daraus |
| ATE365554T1 (de) * | 2003-04-04 | 2007-07-15 | Dynogen Pharmaceuticals Inc | Methode zur behandlung von erkrankungen der unteren harnwege |
| US20060293309A1 (en) * | 2005-03-28 | 2006-12-28 | Dynogen Pharmaceuticals, Inc. | Method of treating disorders and conditions using peripherally-restricted antagonists and inhibitors |
| AU2010231439A1 (en) | 2009-03-31 | 2011-10-27 | Zeria Pharmaceutical Co., Ltd. | Method for manufacturing 1,5-benzodiazepine derivative |
| US9045460B2 (en) | 2010-08-26 | 2015-06-02 | Kowa Co., Ltd. | Production method for isoquinoline derivatives and salts thereof |
| EP3102565B1 (de) * | 2014-02-03 | 2019-01-02 | Mylan Laboratories Ltd. | Verfahren zur herstellung von raltegravir-intermediaten |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5166341A (en) * | 1988-07-29 | 1992-11-24 | Dainippon Pharmaceutical Co., Ltd. | 6-amino-1,4-hexahydro-1H-diazepine derivatives |
| US5017573A (en) * | 1988-07-29 | 1991-05-21 | Dainippon Pharmaceutical Co., Ltd. | Indazole-3-carboxylic acid derivatives |
| JPH04210970A (ja) * | 1990-01-26 | 1992-08-03 | Dainippon Pharmaceut Co Ltd | ベンズアミド誘導体及びその中間体 |
| JPH03223265A (ja) * | 1990-01-26 | 1991-10-02 | Dainippon Pharmaceut Co Ltd | 環状ジアミン誘導体 |
| MX9206075A (es) * | 1991-10-24 | 1993-04-01 | Smithkline Beecham Plc | Nuevos compuestos antagonistas del receptor 5-hidroxitriptamina y composiciones farmaceuticas que los contienen |
-
1996
- 1996-07-23 MX MX9800620A patent/MX9800620A/es not_active IP Right Cessation
- 1996-07-23 WO PCT/JP1996/002053 patent/WO1997005129A1/ja not_active Application Discontinuation
- 1996-07-23 CA CA002228056A patent/CA2228056A1/en not_active Abandoned
- 1996-07-23 US US09/000,468 patent/US5945415A/en not_active Expired - Fee Related
- 1996-07-23 AU AU64717/96A patent/AU700635B2/en not_active Ceased
- 1996-07-23 CN CN96195988A patent/CN1096459C/zh not_active Expired - Fee Related
- 1996-07-23 BR BR9609691A patent/BR9609691A/pt not_active Application Discontinuation
- 1996-07-23 HU HU9901208A patent/HUP9901208A3/hu unknown
- 1996-07-23 RU RU98103388/04A patent/RU2156248C2/ru not_active IP Right Cessation
- 1996-07-23 NZ NZ312799A patent/NZ312799A/en unknown
- 1996-07-23 DK DK96924189T patent/DK0855397T3/da active
- 1996-07-23 AT AT96924189T patent/ATE201021T1/de not_active IP Right Cessation
- 1996-07-23 EP EP96924189A patent/EP0855397B1/de not_active Expired - Lifetime
- 1996-07-23 PL PL96324749A patent/PL184073B1/pl unknown
- 1996-07-23 ES ES96924189T patent/ES2156616T3/es not_active Expired - Lifetime
- 1996-07-23 TR TR1998/00165T patent/TR199800165T1/xx unknown
- 1996-07-23 PT PT96924189T patent/PT855397E/pt unknown
- 1996-07-23 SK SK93-98A patent/SK282044B6/sk unknown
- 1996-07-23 KR KR1019970709711A patent/KR19990028395A/ko not_active Application Discontinuation
- 1996-07-23 IL IL12275396A patent/IL122753A/xx not_active IP Right Cessation
- 1996-07-23 DE DE69612753T patent/DE69612753T2/de not_active Expired - Fee Related
- 1996-07-23 CZ CZ1998230A patent/CZ290442B6/cs not_active IP Right Cessation
-
1998
- 1998-01-26 NO NO19980333A patent/NO312964B1/no not_active IP Right Cessation
- 1998-12-08 HK HK98112940A patent/HK1018049A1/xx not_active IP Right Cessation
-
2001
- 2001-06-19 GR GR20010400934T patent/GR3036089T3/el not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2434851C1 (ru) | Циклические n, n'-диарилтиомочевины или n, n'-диарилмочевины - антагонисты андрогенных рецепторов, противораковое средство, способ получения и применения | |
| US6696468B2 (en) | (s)-4-amino-5-chloro-2-methoxy-n-[1-[1-(2-tetrahydrofuryl-carbonyl)-4-piperidinylmethyl]-4-piperidinyl]benzamide, process for the preparation thereof, pharmaceutical composition containing the same, and intermediate therefor | |
| SK282044B6 (sk) | (r)-5-bróm-n-(1-etyl-4-metylhexahydro-1h-1,4-diazepin-6-yl)-2- metoxy-6-metylamino-3-pyridínkarboxamid, spôsob prípravy, medziprodukt a farmaceutický prostriedok, ktorý ho obsahuje | |
| PT1529041E (pt) | Novos pró-fármacos de ( n-2-piridil-n-2-hidroxicarboniletil )-amida do ácido 1-metil-2-( 4-amidinofenilaminometil )-benzimidazol-5-il-carboxílico, sua preparação e sua utilização como medicamentos | |
| EP1988075A1 (de) | Pyrrolderivat oder salz davon | |
| MXPA98000620A (en) | (r) -5-bromo-n- (1-ethyl-4-methylhexahidro-1h-1,4-diazepin-6-il) -2-metoxy-6-methylamin-3-pyridincarboxamide, process for preparation of the same and pharmaceutical composition containing such compue | |
| SK284802B6 (sk) | Deriváty N-triazolylmetylpiperazínu s antagonistickou aktivitou k neurokinínovým receptorom, spôsob ich výroby, medziprodukt a liečivá s ich obsahom | |
| KR101586507B1 (ko) | 아미드 유도체 및 이를 함유하는 약학적 조성물 | |
| JP2004277319A (ja) | １−（４−ピペリジニルメチル）ピペリジニルアミド誘導体およびそれを含有する医薬組成物 | |
| JPH10203987A (ja) | （ｒ）−１−エチル−４−メチルヘキサヒドロ−１ｈ−１，４−ジアゼピン誘導体を有効成分とするモルヒネ様薬剤誘発嘔吐抑制剤 | |
| JP2990073B2 (ja) | （ｒ）−１−エチル−４−メチルヘキサヒドロ−１ｈ−１，４−ジアゼピン誘導体及びそれを含有する医薬 | |
| JP2001122784A (ja) | １−［（１−置換−４−ピペリジニル）メチル］−４−ピペリジン誘導体からなる医薬 | |
| US6303608B1 (en) | 2-{4-[4-(4,5-dichloro-2-methylimidazol-1-yl)butyl]-1-piperazinyl}-5-fluoropyrimidine, its preparation and its therapeutic use | |
| JP2000080081A (ja) | １―〔（１―置換―４―ピペリジニル）メチル〕―４―ピペリジン誘導体及びそれを含有する医薬組成物 | |
| JPH09118669A (ja) | ５−クロロ−２−メトキシ−４−メチルアミノベンズアミド誘導体及びそれを含有する医薬組成物 | |
| CN116535390A (zh) | pH敏感型4-酰胺哌啶类衍生物、药物组合物及其制备方法和应用 | |
| JP2005170933A (ja) | （ｓ）−４−アミノ−５−クロロ−２−メトキシ−ｎ−［１−［１−（２−テトラヒドロフリルカルボニル）−４−ピペリジニルメチル］−４−ピペリジニル］ベンズアミドからなる医薬 | |
| CA2340168A1 (en) | N-substituted azabicycloheptane derivatives, production and use thereof |