SK281974B6 - 9-[(substituované glycyl)amido)]-6-demetyl-6-deoxytetracyklínové zlúčeniny, ich použitie, medziprodukty na ich výrobu a prípravky na ich báze - Google Patents

9-[(substituované glycyl)amido)]-6-demetyl-6-deoxytetracyklínové zlúčeniny, ich použitie, medziprodukty na ich výrobu a prípravky na ich báze Download PDF

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Publication number
SK281974B6
SK281974B6 SK848-93A SK84893A SK281974B6 SK 281974 B6 SK281974 B6 SK 281974B6 SK 84893 A SK84893 A SK 84893A SK 281974 B6 SK281974 B6 SK 281974B6
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SK
Slovakia
Prior art keywords
amino
dimethylamino
tetrahydroxy
dioxo
octahydro
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Application number
SK848-93A
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English (en)
Slovak (sk)
Other versions
SK84893A3 (en
Inventor
Phaik-Eng Sum
Ving J. Lee
Raymond T. Testa
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American Cyanamid Company
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Publication date
Application filed by American Cyanamid Company filed Critical American Cyanamid Company
Publication of SK84893A3 publication Critical patent/SK84893A3/sk
Publication of SK281974B6 publication Critical patent/SK281974B6/sk

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40Acylated substituent nitrogen atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C239/00Compounds containing nitrogen-to-halogen bonds; Hydroxylamino compounds or ethers or esters thereof
    • C07C239/08Hydroxylamino compounds or their ethers or esters
    • C07C239/18Hydroxylamino compounds or their ethers or esters having nitrogen atoms of hydroxylamino groups further bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C239/00Compounds containing nitrogen-to-halogen bonds; Hydroxylamino compounds or ethers or esters thereof
    • C07C239/08Hydroxylamino compounds or their ethers or esters
    • C07C239/20Hydroxylamino compounds or their ethers or esters having oxygen atoms of hydroxylamino groups etherified
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06Esters of carbamic acids
    • C07C271/08Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215Radicals derived from nitrogen analogues of carbonic acid
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/24Oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00Systems containing at least three condensed rings
    • C07C2603/02Ortho- or ortho- and peri-condensed systems
    • C07C2603/40Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/461,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Seasonings (AREA)
  • Pyrrole Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Luminescent Compositions (AREA)
  • Tires In General (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
SK848-93A 1992-08-13 1993-08-06 9-[(substituované glycyl)amido)]-6-demetyl-6-deoxytetracyklínové zlúčeniny, ich použitie, medziprodukty na ich výrobu a prípravky na ich báze SK281974B6 (sk)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/928,590 US5442059A (en) 1992-08-13 1992-08-13 9-[(substituted glycyl)amido)]-6-demethyl-6-deoxytetracyclines

Publications (2)

Publication Number Publication Date
SK84893A3 SK84893A3 (en) 1994-06-08
SK281974B6 true SK281974B6 (sk) 2001-09-11

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
SK848-93A SK281974B6 (sk) 1992-08-13 1993-08-06 9-[(substituované glycyl)amido)]-6-demetyl-6-deoxytetracyklínové zlúčeniny, ich použitie, medziprodukty na ich výrobu a prípravky na ich báze

Country Status (28)

Country Link
US (3) US5442059A (de)
EP (1) EP0582829B1 (de)
JP (1) JP3633640B2 (de)
KR (1) KR100309541B1 (de)
CN (1) CN1033971C (de)
AT (1) ATE205472T1 (de)
AU (1) AU680616B2 (de)
BR (1) BR1100987A (de)
CA (1) CA2103845C (de)
CZ (1) CZ288174B6 (de)
DE (1) DE69330733T2 (de)
DK (1) DK0582829T3 (de)
ES (1) ES2161220T3 (de)
FI (1) FI116055B (de)
HK (1) HK1009960A1 (de)
HU (3) HU212265B (de)
IL (3) IL119698A (de)
MX (1) MX9304756A (de)
NO (1) NO304884B1 (de)
NZ (1) NZ248342A (de)
PH (1) PH30006A (de)
PL (3) PL174073B1 (de)
PT (1) PT582829E (de)
RU (1) RU2123999C1 (de)
SG (1) SG52326A1 (de)
SK (1) SK281974B6 (de)
TW (1) TW269678B (de)
ZA (1) ZA935890B (de)

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US5371076A (en) * 1993-04-02 1994-12-06 American Cyanamid Company 9-[(substituted glycyl)amido]-6-(substituted)-5-hydroxy-6-deoxytetracyclines

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FI933568A0 (fi) 1993-08-12
AU680616B2 (en) 1997-08-07
RU2123999C1 (ru) 1998-12-27
ES2161220T3 (es) 2001-12-01
EP0582829B1 (de) 2001-09-12
NZ248342A (en) 1995-07-26
NO932873L (no) 1994-02-14
HUT71594A (en) 1996-01-29
US5495030A (en) 1996-02-27
HU215445B (hu) 2000-12-28
NO932873D0 (no) 1993-08-12
CZ288174B6 (en) 2001-05-16
KR940003908A (ko) 1994-03-14
DE69330733T2 (de) 2002-07-04
DE69330733D1 (de) 2001-10-18
JP3633640B2 (ja) 2005-03-30
ATE205472T1 (de) 2001-09-15
IL119698A (en) 1998-09-24
ZA935890B (en) 1994-03-11
IL106672A0 (en) 1993-12-08
MX9304756A (es) 1994-02-28
JPH06199758A (ja) 1994-07-19
FI933568A (fi) 1994-02-14
HUT66660A (en) 1994-12-28
HU212265B (en) 1996-04-29
PL300068A1 (en) 1994-02-21
CN1033971C (zh) 1997-02-05
KR100309541B1 (ko) 2002-08-31
NO304884B1 (no) 1999-03-01
US5442059A (en) 1995-08-15
SG52326A1 (en) 1998-09-28
SK84893A3 (en) 1994-06-08
EP0582829A1 (de) 1994-02-16
PH30006A (en) 1996-10-29
HU9302335D0 (en) 1993-10-28
CZ157493A3 (en) 1994-03-16
IL106672A (en) 1998-02-22
HK1009960A1 (en) 1999-06-11
HU9401974D0 (en) 1994-09-28
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US5567692A (en) 1996-10-22
CN1087899A (zh) 1994-06-15
PL174073B1 (pl) 1998-06-30
CA2103845C (en) 2005-05-17
PL173448B1 (pl) 1998-03-31
PL174108B1 (pl) 1998-06-30
DK0582829T3 (da) 2001-10-15
FI116055B (fi) 2005-09-15
BR1100987A (pt) 1999-12-07
PT582829E (pt) 2002-01-30
TW269678B (de) 1996-02-01
AU4461193A (en) 1994-02-17
CA2103845A1 (en) 1994-02-14
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