SK281418B6 - Deriváty piperazínu, spôsob ich prípravy, medziprodukt na ich prípravu, ich použitie ako 5ht1a antagonistov a farmaceutický prípravok s ich obsahom - Google Patents
Deriváty piperazínu, spôsob ich prípravy, medziprodukt na ich prípravu, ich použitie ako 5ht1a antagonistov a farmaceutický prípravok s ich obsahom Download PDFInfo
- Publication number
- SK281418B6 SK281418B6 SK1541-96A SK154196A SK281418B6 SK 281418 B6 SK281418 B6 SK 281418B6 SK 154196 A SK154196 A SK 154196A SK 281418 B6 SK281418 B6 SK 281418B6
- Authority
- SK
- Slovakia
- Prior art keywords
- methyl
- formula
- hydrogen
- compounds
- pyridyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9411099A GB9411099D0 (en) | 1994-06-03 | 1994-06-03 | Piperazine derivatives |
| PCT/GB1995/001263 WO1995033743A1 (en) | 1994-06-03 | 1995-06-01 | Piperazine derivatives as 5ht1a antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SK154196A3 SK154196A3 (en) | 1997-08-06 |
| SK281418B6 true SK281418B6 (sk) | 2001-03-12 |
Family
ID=10756114
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK1541-96A SK281418B6 (sk) | 1994-06-03 | 1995-06-01 | Deriváty piperazínu, spôsob ich prípravy, medziprodukt na ich prípravu, ich použitie ako 5ht1a antagonistov a farmaceutický prípravok s ich obsahom |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US5723464A (pt) |
| EP (1) | EP0763031B1 (pt) |
| JP (1) | JPH10500989A (pt) |
| KR (1) | KR100359393B1 (pt) |
| CN (2) | CN1048985C (pt) |
| AT (1) | ATE192744T1 (pt) |
| AU (1) | AU680147B2 (pt) |
| BR (1) | BR9507910A (pt) |
| CA (1) | CA2191871C (pt) |
| CZ (1) | CZ287381B6 (pt) |
| DE (1) | DE69516867T2 (pt) |
| DK (1) | DK0763031T3 (pt) |
| ES (1) | ES2145275T3 (pt) |
| FI (1) | FI114985B (pt) |
| GB (1) | GB9411099D0 (pt) |
| GR (1) | GR3033449T3 (pt) |
| HU (1) | HUT76466A (pt) |
| IL (1) | IL113967A (pt) |
| MX (1) | MX9605915A (pt) |
| NZ (2) | NZ287498A (pt) |
| PT (1) | PT763031E (pt) |
| RU (1) | RU2165933C2 (pt) |
| SK (1) | SK281418B6 (pt) |
| WO (1) | WO1995033743A1 (pt) |
| ZA (1) | ZA954525B (pt) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL101722A (en) * | 1991-05-02 | 1996-05-14 | Wyeth John & Brother Ltd | History of piperazine, their preparation and pharmaceutical preparations containing them |
| WO1995033725A1 (en) * | 1994-06-03 | 1995-12-14 | John Wyeth & Brother Limited | Novel processes and intermediates for the preparation of piperazine derivatives |
| MX9700693A (es) * | 1994-07-26 | 1997-04-30 | Pfizer | Derivados del 4-indol. |
| US5519025A (en) * | 1995-04-10 | 1996-05-21 | American Home Products Corporation | 4-indolylpiperazinyl derivatives |
| US5486518A (en) * | 1995-04-10 | 1996-01-23 | American Home Products Corporation | 4-indolylpiperazinyl derivatives |
| US5990114A (en) * | 1996-02-28 | 1999-11-23 | Recordati, S.A., Chemical And Pharmaceutical Company | Use of 5-HT1A receptor antagonists for the treatment of urinary incontinence |
| IT1282705B1 (it) * | 1996-02-28 | 1998-03-31 | Recordati Chem Pharm | Uso di antagonisti del recettore serotoninergico 5-ht|a per il trattamento dell'incontinenza urinaria |
| DE19615232A1 (de) * | 1996-04-18 | 1997-10-23 | Merck Patent Gmbh | Neue Carbamoylderivate und deren Verwendung als 5-HT ¶1¶¶A¶-Antagonisten |
| DE19725664A1 (de) * | 1997-06-18 | 1998-12-24 | Merck Patent Gmbh | 3-Benzylpiperidine |
| US6271234B1 (en) | 1997-08-01 | 2001-08-07 | Recordati S.A., Chemical And Pharmaceutical Company | 1,4-disubstituted piperazines |
| IT1293804B1 (it) | 1997-08-01 | 1999-03-10 | Recordati Chem Pharm | Diarilalchilpiperazine attive sulle basse vie urinarie |
| AU9256498A (en) * | 1997-08-01 | 1999-02-22 | Recordati S.A. Chemical And Pharmaceutical Company | 1,4-disubstituted piperazines |
| US6399614B1 (en) | 1997-08-01 | 2002-06-04 | Recordati S.A. Chemical And Pharmaceutical Company | 1-(N-phenylaminoalkyl)piperazine derivatives substituted at position 2 of the phenyl ring |
| IT1293807B1 (it) * | 1997-08-01 | 1999-03-10 | Recordati Chem Pharm | Derivati 1- (n-fenilaminoalchil) piperazinici sostituiti alla posizione 2 dell'anello fenilico |
| CN1312802A (zh) * | 1998-06-15 | 2001-09-12 | 美国家用产品公司 | 作为5－羟色胺能药物的环烷基取代的芳基哌嗪、哌啶和四氢吡啶 |
| US6376494B1 (en) | 1998-06-15 | 2002-04-23 | American Home Products Corporation | Cycloalkyl-substituted aryl-piperazines, piperidines and tetrahydropyridines as serotonergic agents |
| US20060223824A1 (en) * | 2000-11-28 | 2006-10-05 | Wyeth | Serotonergic agents |
| US20060287335A1 (en) | 2000-11-28 | 2006-12-21 | Wyeth | Serotonergic agents for treating sexual dysfunction |
| WO2002070482A1 (fr) * | 2001-02-27 | 2002-09-12 | Kaneka Corporation | Procede de production de derives de n-aryl-1-amino-2-propanol optiquement actifs |
| US7091349B2 (en) | 2002-03-12 | 2006-08-15 | Wyeth | Process for synthesizing N-aryl piperazines with chiral N′-1-[benzoyl(2-pyridyl)amino]-2-propane substitution |
| WO2003078417A1 (en) * | 2002-03-12 | 2003-09-25 | Wyeth, A Corporation Of The State Of Delaware | Process for synthesizing chiral n-aryl piperazines |
| AU2003220122A1 (en) | 2002-03-12 | 2003-09-29 | Wyeth | Preparation of n1-(2'-pyridyl)-1,2-propanediamine sulfamic acid and its use in the synthesis of biologically active piperazines |
| US7361773B2 (en) | 2002-03-12 | 2008-04-22 | Wyeth | Preparation of N1-(2'-pyridyl)-1,2-propanediamine sulfamic acid and its use in the synthesis of biologically active piperazines |
| KR20040091119A (ko) | 2002-03-12 | 2004-10-27 | 와이어쓰 | 키랄 1,4-이치환된 피페라진의 제조방법 |
| US7179813B2 (en) * | 2003-06-11 | 2007-02-20 | Wyeth | Bicyclic indolyl derivatives and methods for their use as serotonergic agents |
| CN100436448C (zh) * | 2003-06-11 | 2008-11-26 | 惠氏公司 | 二环吲哚基衍生物以及其作为5-羟色胺能活性剂的应用 |
| TW200800959A (en) | 2005-06-10 | 2008-01-01 | Wyeth Corp | Piperazine-piperidine antagonists and agonists of the 5-HT1a receptor |
| CN101466365A (zh) * | 2006-06-09 | 2009-06-24 | 惠氏公司 | 增强认知功能的方法 |
| CN106535884A (zh) | 2014-06-06 | 2017-03-22 | 弗雷克萨斯生物科学公司 | 免疫调节剂 |
| UY36390A (es) * | 2014-11-05 | 2016-06-01 | Flexus Biosciences Inc | Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido), sus métodos de síntesis y composiciones farmacéuticas que los contienen |
| WO2016073738A2 (en) | 2014-11-05 | 2016-05-12 | Flexus Biosciences, Inc. | Immunoregulatory agents |
| AR102537A1 (es) | 2014-11-05 | 2017-03-08 | Flexus Biosciences Inc | Agentes inmunomoduladores |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8909209D0 (en) * | 1989-04-22 | 1989-06-07 | Wyeth John & Brother Ltd | Piperazine derivatives |
| DD297968A5 (de) * | 1989-04-22 | 1992-01-30 | �����@��������@�K@�����������@�������k�� | Neue piperazine, ihre herstellung und verwendung in pharmazeutischen mitteln |
| GB9021535D0 (en) * | 1990-10-03 | 1990-11-14 | Wyeth John & Brother Ltd | Piperazine derivatives |
| IL101722A (en) * | 1991-05-02 | 1996-05-14 | Wyeth John & Brother Ltd | History of piperazine, their preparation and pharmaceutical preparations containing them |
| SE9201138D0 (sv) * | 1992-04-09 | 1992-04-09 | Astra Ab | Novel phthalimidoalkylpiperazines |
| GB9300195D0 (en) * | 1993-01-06 | 1993-03-03 | Wyeth John & Brother Ltd | Piperazine derivatives |
-
1994
- 1994-06-03 GB GB9411099A patent/GB9411099D0/en active Pending
-
1995
- 1995-06-01 WO PCT/GB1995/001263 patent/WO1995033743A1/en active IP Right Grant
- 1995-06-01 AU AU26230/95A patent/AU680147B2/en not_active Ceased
- 1995-06-01 HU HU9603315A patent/HUT76466A/hu unknown
- 1995-06-01 NZ NZ287498A patent/NZ287498A/xx unknown
- 1995-06-01 RU RU97100151/04A patent/RU2165933C2/ru not_active IP Right Cessation
- 1995-06-01 PT PT95921017T patent/PT763031E/pt unknown
- 1995-06-01 NZ NZ331452A patent/NZ331452A/xx unknown
- 1995-06-01 BR BR9507910A patent/BR9507910A/pt not_active Application Discontinuation
- 1995-06-01 KR KR1019960706880A patent/KR100359393B1/ko not_active IP Right Cessation
- 1995-06-01 DK DK95921017T patent/DK0763031T3/da active
- 1995-06-01 ES ES95921017T patent/ES2145275T3/es not_active Expired - Lifetime
- 1995-06-01 ZA ZA954525A patent/ZA954525B/xx unknown
- 1995-06-01 AT AT95921017T patent/ATE192744T1/de not_active IP Right Cessation
- 1995-06-01 DE DE69516867T patent/DE69516867T2/de not_active Expired - Fee Related
- 1995-06-01 IL IL11396795A patent/IL113967A/xx not_active IP Right Cessation
- 1995-06-01 CA CA002191871A patent/CA2191871C/en not_active Expired - Fee Related
- 1995-06-01 JP JP8500531A patent/JPH10500989A/ja not_active Withdrawn
- 1995-06-01 CZ CZ19963507A patent/CZ287381B6/cs not_active IP Right Cessation
- 1995-06-01 SK SK1541-96A patent/SK281418B6/sk unknown
- 1995-06-01 CN CN95193383A patent/CN1048985C/zh not_active Expired - Fee Related
- 1995-06-01 MX MX9605915A patent/MX9605915A/es not_active IP Right Cessation
- 1995-06-01 EP EP95921017A patent/EP0763031B1/en not_active Expired - Lifetime
- 1995-06-02 US US08/459,205 patent/US5723464A/en not_active Expired - Lifetime
-
1996
- 1996-12-02 FI FI964815A patent/FI114985B/fi active IP Right Grant
-
1998
- 1998-11-10 CN CN98122461A patent/CN1093122C/zh not_active Expired - Fee Related
-
2000
- 2000-05-19 GR GR20000401137T patent/GR3033449T3/el not_active IP Right Cessation
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