SK280833B6 - Racemický alebo opticky aktívny 5-(1-hydroxy-2- -piperidínopropyl)-2-(1h,3h)-indolový derivát, 5-(1-oxo-2- -piperidínopropyl)-2-(1h,3h)-indol ako medziprodukt na jeho prípravu, farmaceutický prostriedok s jeho obsahom a ich použitie - Google Patents

Racemický alebo opticky aktívny 5-(1-hydroxy-2- -piperidínopropyl)-2-(1h,3h)-indolový derivát, 5-(1-oxo-2- -piperidínopropyl)-2-(1h,3h)-indol ako medziprodukt na jeho prípravu, farmaceutický prostriedok s jeho obsahom a ich použitie Download PDF

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Publication number
SK280833B6
SK280833B6 SK1354-91A SK135491A SK280833B6 SK 280833 B6 SK280833 B6 SK 280833B6 SK 135491 A SK135491 A SK 135491A SK 280833 B6 SK280833 B6 SK 280833B6
Authority
SK
Slovakia
Prior art keywords
hydroxy
piperidinopropyl
racemic
optically active
indole derivative
Prior art date
Application number
SK1354-91A
Other languages
English (en)
Slovak (sk)
Inventor
Bertrand Leo Chenard
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of SK280833B6 publication Critical patent/SK280833B6/sk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
SK1354-91A 1990-05-10 1991-05-08 Racemický alebo opticky aktívny 5-(1-hydroxy-2- -piperidínopropyl)-2-(1h,3h)-indolový derivát, 5-(1-oxo-2- -piperidínopropyl)-2-(1h,3h)-indol ako medziprodukt na jeho prípravu, farmaceutický prostriedok s jeho obsahom a ich použitie SK280833B6 (sk)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US52233290A 1990-05-10 1990-05-10

Publications (1)

Publication Number Publication Date
SK280833B6 true SK280833B6 (sk) 2000-08-14

Family

ID=24080448

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1354-91A SK280833B6 (sk) 1990-05-10 1991-05-08 Racemický alebo opticky aktívny 5-(1-hydroxy-2- -piperidínopropyl)-2-(1h,3h)-indolový derivát, 5-(1-oxo-2- -piperidínopropyl)-2-(1h,3h)-indol ako medziprodukt na jeho prípravu, farmaceutický prostriedok s jeho obsahom a ich použitie

Country Status (30)

Country Link
US (1) US5306723A (sh)
EP (1) EP0554247B1 (sh)
JP (1) JPH0699423B2 (sh)
KR (1) KR0163355B1 (sh)
CN (1) CN1037439C (sh)
AT (1) ATE192149T1 (sh)
AU (1) AU642994B2 (sh)
BR (1) BR9106432A (sh)
CA (1) CA2080475C (sh)
CZ (1) CZ280560B6 (sh)
DE (1) DE69132141T2 (sh)
DK (1) DK0554247T3 (sh)
EG (1) EG19647A (sh)
ES (1) ES2146578T3 (sh)
FI (1) FI109121B (sh)
GR (1) GR3034005T3 (sh)
HU (1) HU221193B1 (sh)
IE (1) IE911569A1 (sh)
IL (1) IL98056A (sh)
MY (1) MY107799A (sh)
NO (1) NO301979B1 (sh)
PH (1) PH29902A (sh)
PL (1) PL169267B1 (sh)
PT (1) PT97602B (sh)
RU (1) RU2068414C1 (sh)
SK (1) SK280833B6 (sh)
TW (1) TW198720B (sh)
WO (1) WO1991017156A1 (sh)
YU (1) YU48528B (sh)
ZA (1) ZA913494B (sh)

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US6255322B1 (en) 1992-06-19 2001-07-03 Pfizer Inc. 2-(4-hydroxypiperidino)-1-alkanol derivatives as antiischemic agents
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ZA9610741B (en) 1995-12-22 1997-06-24 Warner Lambert Co 4-Substituted piperidine analogs and their use as subtype selective nmda receptor antagonists
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US6316474B1 (en) 1999-10-29 2001-11-13 Merck & Co., Inc. 2-benzyl and 2-heteroaryl benzimidazole NMDA/NR2B antagonists
US6476041B1 (en) 1999-10-29 2002-11-05 Merck & Co., Inc. 1,4 substituted piperidinyl NMDA/NR2B antagonists
US6495561B2 (en) 1999-10-29 2002-12-17 Merck & Co., Inc. 2-cyclohexyl imidazopyridine NMDA/NR2B antagonists
US6489477B1 (en) 1999-10-29 2002-12-03 Merck & Co., Inc. 2-aza-bicyclo[2.2.2]octane NMDA/NR2B antigonists
US6432976B1 (en) 1999-10-29 2002-08-13 Merck & Co., Inc. 8-aza-bicyclo[3.2.1]octane NMDA/NR2B antagonists
US6291499B1 (en) 1999-10-29 2001-09-18 Merck & Co., Inc. 2-cyclohexyl benzimidazole NMDA/NR2B antagonists
US6369076B1 (en) 1999-10-29 2002-04-09 Merck & Co. Inc. 5-benzyl-octahydroindole and 6-benzyl-decahydroquinoline NMDA/NR2B antagonists
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Also Published As

Publication number Publication date
FI925069A (fi) 1992-11-09
NO924310D0 (no) 1992-11-09
CS135491A3 (en) 1992-05-13
CZ280560B6 (cs) 1996-02-14
ES2146578T3 (es) 2000-08-16
EP0554247A1 (en) 1993-08-11
BR9106432A (pt) 1993-05-04
DE69132141T2 (de) 2000-09-21
NO924310L (no) 1992-11-09
WO1991017156A1 (en) 1991-11-14
YU48528B (sh) 1998-11-05
AU7456591A (en) 1991-11-27
IE911569A1 (en) 1991-11-20
HU9203515D0 (en) 1993-01-28
NO301979B1 (no) 1998-01-05
MY107799A (en) 1996-06-29
PL169267B1 (pl) 1996-06-28
TW198720B (sh) 1993-01-21
CA2080475A1 (en) 1991-11-11
AU642994B2 (en) 1993-11-04
DE69132141D1 (de) 2000-05-31
US5306723A (en) 1994-04-26
YU81091A (sh) 1993-11-16
JPH0699423B2 (ja) 1994-12-07
PT97602A (pt) 1992-02-28
KR930700482A (ko) 1993-03-15
CN1056497A (zh) 1991-11-27
ATE192149T1 (de) 2000-05-15
GR3034005T3 (en) 2000-11-30
PH29902A (en) 1996-09-16
RU2068414C1 (ru) 1996-10-27
CN1037439C (zh) 1998-02-18
HU221193B1 (en) 2002-08-28
EG19647A (en) 1995-08-30
JPH05506433A (ja) 1993-09-22
HUT62879A (en) 1993-06-28
KR0163355B1 (ko) 1998-12-01
FI109121B (fi) 2002-05-31
IL98056A (en) 1995-11-27
ZA913494B (en) 1992-12-30
IL98056A0 (en) 1992-06-21
PT97602B (pt) 1998-08-31
FI925069A0 (fi) 1992-11-09
DK0554247T3 (da) 2000-08-07
CA2080475C (en) 2001-04-17
EP0554247B1 (en) 2000-04-26

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