SK280578B6 - Derivát izatinoxímu, spôsob jeho prípravy, farmace - Google Patents
Derivát izatinoxímu, spôsob jeho prípravy, farmace Download PDFInfo
- Publication number
- SK280578B6 SK280578B6 SK238-94A SK23894A SK280578B6 SK 280578 B6 SK280578 B6 SK 280578B6 SK 23894 A SK23894 A SK 23894A SK 280578 B6 SK280578 B6 SK 280578B6
- Authority
- SK
- Slovakia
- Prior art keywords
- group
- isatinoxime
- branched
- formula
- derivative
- Prior art date
Links
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- 208000001286 intracranial vasospasm Diseases 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 208000028867 ischemia Diseases 0.000 description 1
- 125000000468 ketone group Chemical group 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- JZMJDSHXVKJFKW-UHFFFAOYSA-M methyl sulfate(1-) Chemical compound COS([O-])(=O)=O JZMJDSHXVKJFKW-UHFFFAOYSA-M 0.000 description 1
- 230000016273 neuron death Effects 0.000 description 1
- 239000002858 neurotransmitter agent Substances 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 229910052759 nickel Inorganic materials 0.000 description 1
- LQNUZADURLCDLV-UHFFFAOYSA-N nitrobenzene Substances [O-][N+](=O)C1=CC=CC=C1 LQNUZADURLCDLV-UHFFFAOYSA-N 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 150000002923 oximes Chemical class 0.000 description 1
- MUMZUERVLWJKNR-UHFFFAOYSA-N oxoplatinum Chemical compound [Pt]=O MUMZUERVLWJKNR-UHFFFAOYSA-N 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 229910003446 platinum oxide Inorganic materials 0.000 description 1
- 229920000137 polyphosphoric acid Polymers 0.000 description 1
- FYRHIOVKTDQVFC-UHFFFAOYSA-M potassium phthalimide Chemical compound [K+].C1=CC=C2C(=O)[N-]C(=O)C2=C1 FYRHIOVKTDQVFC-UHFFFAOYSA-M 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 238000000159 protein binding assay Methods 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 238000010898 silica gel chromatography Methods 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000008174 sterile solution Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 229960002317 succinimide Drugs 0.000 description 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- GJBRNHKUVLOCEB-UHFFFAOYSA-N tert-butyl benzenecarboperoxoate Chemical compound CC(C)(C)OOC(=O)C1=CC=CC=C1 GJBRNHKUVLOCEB-UHFFFAOYSA-N 0.000 description 1
- YBRBMKDOPFTVDT-UHFFFAOYSA-N tert-butylamine Chemical compound CC(C)(C)N YBRBMKDOPFTVDT-UHFFFAOYSA-N 0.000 description 1
- 230000009424 thromboembolic effect Effects 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 208000019553 vascular disease Diseases 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Medicinal Preparation (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75116591A | 1991-08-28 | 1991-08-28 | |
| US83185192A | 1992-02-05 | 1992-02-05 | |
| PCT/EP1992/001999 WO1993005043A1 (en) | 1991-08-28 | 1992-08-27 | Novel isatinoxime derivatives, their preparation and use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SK23894A3 SK23894A3 (en) | 1994-12-07 |
| SK280578B6 true SK280578B6 (sk) | 2000-04-10 |
Family
ID=27115380
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK238-94A SK280578B6 (sk) | 1991-08-28 | 1992-08-27 | Derivát izatinoxímu, spôsob jeho prípravy, farmace |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0529636B1 (cs) |
| JP (1) | JP3170584B2 (cs) |
| KR (1) | KR100277481B1 (cs) |
| AT (1) | ATE181552T1 (cs) |
| AU (1) | AU655672B2 (cs) |
| CA (1) | CA2076948C (cs) |
| CZ (1) | CZ282759B6 (cs) |
| DE (1) | DE69229461T2 (cs) |
| DK (1) | DK0529636T3 (cs) |
| FI (1) | FI107156B (cs) |
| GE (1) | GEP20002329B (cs) |
| HU (2) | HUT70753A (cs) |
| MX (1) | MX9204914A (cs) |
| NO (1) | NO301117B1 (cs) |
| PL (1) | PL170920B1 (cs) |
| RU (1) | RU2114827C1 (cs) |
| SK (1) | SK280578B6 (cs) |
| WO (1) | WO1993005043A1 (cs) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2109516T3 (es) | 1992-10-13 | 1998-01-16 | Warner Lambert Co | Derivados de quinoxalinodiona como antagonistas de aminoacidos excitadores. |
| US5843945A (en) * | 1993-05-13 | 1998-12-01 | Neurosearch A/S | AMPA antagonists and a method of treatment |
| AU679075B2 (en) * | 1993-05-13 | 1997-06-19 | Neurosearch A/S | Ampa antagonists and a method of treatment therewith |
| DK81593D0 (da) * | 1993-07-07 | 1993-07-07 | Neurosearch As | Nye isatinoximderivater, deres fremstilling og anvendelse |
| EP0781284B1 (en) * | 1994-09-14 | 2000-01-12 | Neurosearch A/S | Indole-2,3-dione-3-oxime derivatives, their preparation and use |
| NZ293266A (en) * | 1994-09-14 | 1998-01-26 | Neurosearch As | Fused indole and quinoxaline dione and dione oxime derivatives, preparation and pharmaceutical compositions |
| UA54403C2 (uk) * | 1996-10-01 | 2003-03-17 | Н'Юросерч А/С | Похідні індол-2,3-діон-3-оксиму, фармацевтична композиція, спосіб лікування розладу чи захворювання ссавців, у тому числі людини та спосіб одержання похідних індол-2,3-діон-3-оксиму |
| FR2768624B1 (fr) | 1997-09-25 | 1999-11-12 | Oreal | Utilisation d'un inhibiteur d'acides amines excitateurs dans une composition cosmetique ou dermatologique pour peaux sensibles et composition obtenue |
| ATE420636T1 (de) | 1999-05-19 | 2009-01-15 | Painceptor Pharma Corp | Hemmer der protonenabhängigen kationenkanäle und deren verwendung in der behandlung von ischemiebedingten erkrankungen |
| CN1298704C (zh) | 2000-01-24 | 2007-02-07 | 神经研究公司 | 具有神经营养活性的靛红衍生物 |
| US7250422B2 (en) | 2002-10-29 | 2007-07-31 | Sungkyunkwan University | Pharmaceutical composition containing berberine as effective ingredient for preventing and treating addiction or tolerance to morphine |
| EP1957486A4 (en) | 2005-11-23 | 2009-11-11 | Painceptor Pharma Corp | COMPOSITIONS AND METHODS FOR MODULATION OF IONIC CHANNELS |
| EP2935213B1 (en) * | 2012-12-19 | 2019-05-22 | Bayer CropScience Aktiengesellschaft | Difluoromethyl-nicotinic-indanyl carboxamides as fungicides |
| CN106061938B (zh) * | 2014-02-28 | 2019-04-12 | 住友化学株式会社 | 2-(卤代甲基)-3-甲基硝基苯的制造方法 |
| EA039557B1 (ru) | 2016-03-17 | 2022-02-10 | Фмк Корпорейшн | Способ превращения s-энантиомера в его рацемическую форму |
| CN109776451B (zh) * | 2017-11-15 | 2020-12-11 | 中山光禾医疗科技有限公司 | 光交联水凝胶材料的制备、原料、产品及应用 |
| CN108912127B (zh) * | 2018-08-27 | 2019-12-10 | 青岛农业大学 | 一种基于靛红骨架的苯并[b,e]氮杂卓化合物及其制备方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE69677B1 (en) * | 1989-12-11 | 1996-10-02 | Neurosearch As | Isatine derivatives their preparation and use |
-
1992
- 1992-08-26 MX MX9204914A patent/MX9204914A/es not_active IP Right Cessation
- 1992-08-26 CA CA002076948A patent/CA2076948C/en not_active Expired - Fee Related
- 1992-08-27 CZ CZ94395A patent/CZ282759B6/cs not_active IP Right Cessation
- 1992-08-27 EP EP92114654A patent/EP0529636B1/en not_active Expired - Lifetime
- 1992-08-27 WO PCT/EP1992/001999 patent/WO1993005043A1/en not_active Ceased
- 1992-08-27 AU AU24820/92A patent/AU655672B2/en not_active Ceased
- 1992-08-27 GE GEAP19922683A patent/GEP20002329B/en unknown
- 1992-08-27 DK DK92114654T patent/DK0529636T3/da active
- 1992-08-27 SK SK238-94A patent/SK280578B6/sk unknown
- 1992-08-27 AT AT92114654T patent/ATE181552T1/de not_active IP Right Cessation
- 1992-08-27 KR KR1019940700676A patent/KR100277481B1/ko not_active Expired - Fee Related
- 1992-08-27 RU RU94019425/04A patent/RU2114827C1/ru not_active IP Right Cessation
- 1992-08-27 JP JP50493393A patent/JP3170584B2/ja not_active Expired - Fee Related
- 1992-08-27 PL PL92302584A patent/PL170920B1/pl unknown
- 1992-08-27 HU HU9400595A patent/HUT70753A/hu unknown
- 1992-08-27 DE DE69229461T patent/DE69229461T2/de not_active Expired - Lifetime
-
1994
- 1994-02-25 FI FI940889A patent/FI107156B/fi active
- 1994-02-25 NO NO940676A patent/NO301117B1/no unknown
-
1995
- 1995-06-21 HU HU95P/P00323P patent/HU211632A9/hu unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GEP20002329B (en) | 2000-12-25 |
| RU2114827C1 (ru) | 1998-07-10 |
| PL170920B1 (pl) | 1997-02-28 |
| DE69229461D1 (de) | 1999-07-29 |
| NO301117B1 (no) | 1997-09-15 |
| FI940889A7 (fi) | 1994-02-25 |
| ATE181552T1 (de) | 1999-07-15 |
| SK23894A3 (en) | 1994-12-07 |
| HU9400595D0 (en) | 1994-05-30 |
| JP3170584B2 (ja) | 2001-05-28 |
| CZ282759B6 (cs) | 1997-09-17 |
| HUT70753A (en) | 1995-10-30 |
| MX9204914A (es) | 1993-07-01 |
| AU2482092A (en) | 1993-04-05 |
| CA2076948C (en) | 2002-04-16 |
| WO1993005043A1 (en) | 1993-03-18 |
| DE69229461T2 (de) | 1999-10-21 |
| EP0529636B1 (en) | 1999-06-23 |
| CZ39594A3 (en) | 1994-11-16 |
| DK0529636T3 (da) | 1999-12-13 |
| AU655672B2 (en) | 1995-01-05 |
| HU211632A9 (en) | 1995-12-28 |
| CA2076948A1 (en) | 1993-03-01 |
| KR100277481B1 (ko) | 2001-02-01 |
| EP0529636A1 (en) | 1993-03-03 |
| NO940676L (cs) | 1994-04-27 |
| FI940889A0 (fi) | 1994-02-25 |
| JPH06510056A (ja) | 1994-11-10 |
| NO940676D0 (no) | 1994-02-25 |
| FI107156B (fi) | 2001-06-15 |
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