WO1992022653A1
(en)
|
1991-06-14 |
1992-12-23 |
Genentech, Inc. |
Method for making humanized antibodies
|
US6800738B1
(en)
|
1991-06-14 |
2004-10-05 |
Genentech, Inc. |
Method for making humanized antibodies
|
EP1745799B1
(en)
|
1998-03-04 |
2015-09-02 |
The Trustees of The University of Pennsylvania |
Compositions and methods of treating tumors
|
US6417168B1
(en)
|
1998-03-04 |
2002-07-09 |
The Trustees Of The University Of Pennsylvania |
Compositions and methods of treating tumors
|
US6706721B1
(en)
|
1998-04-29 |
2004-03-16 |
Osi Pharmaceuticals, Inc. |
N-(3-ethynylphenylamino)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine mesylate anhydrate and monohydrate
|
EP1206234A4
(en)
|
1999-06-03 |
2005-06-01 |
Jessie L S Au |
METHODS AND COMPOSITIONS FOR MODULATING PROLIFERATION AND CELL DEATH
|
GB9925958D0
(en)
*
|
1999-11-02 |
1999-12-29 |
Bundred Nigel J |
Therapeutic use
|
UA74803C2
(uk)
|
1999-11-11 |
2006-02-15 |
Осі Фармасьютікалз, Інк. |
Стійкий поліморф гідрохлориду n-(3-етинілфеніл)-6,7-біс(2-метоксіетокси)-4-хіназолінаміну, спосіб його одержання (варіанти) та фармацевтичне застосування
|
US7087613B2
(en)
|
1999-11-11 |
2006-08-08 |
Osi Pharmaceuticals, Inc. |
Treating abnormal cell growth with a stable polymorph of N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride
|
JP2004527456A
(ja)
*
|
2000-08-09 |
2004-09-09 |
イムクローン システムズ インコーポレイティド |
Egf受容体拮抗剤による過増殖性の疾患の治療
|
CU22979A1
(es)
*
|
2000-12-08 |
2004-09-09 |
Centro Inmunologia Molecular |
Combinación inmunoterapéutica para el tratamiento de tumores que sobre-expresan receptores con actividad quinasa en residuos de tirosina
|
AU2002239486A1
(en)
*
|
2000-12-08 |
2002-06-18 |
Uab Research Foundation |
Combination radiation therapy and chemotherapy in conjuction with administration of growth factor receptor antibody
|
US7081454B2
(en)
|
2001-03-28 |
2006-07-25 |
Bristol-Myers Squibb Co. |
Tyrosine kinase inhibitors
|
ES2362931T3
(es)
|
2002-03-04 |
2011-07-15 |
Imclone Llc |
Anticuerpos humanos específicos contra kdr y usos de los mismos.
|
CA2481005C
(en)
*
|
2002-04-02 |
2009-06-09 |
Pharmacia Italia S.P.A. |
Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and radiotherapy
|
IL165256A0
(en)
|
2002-05-24 |
2005-12-18 |
Schering Corp |
Neutralizing human anti-igfr antibody
|
CA2524305C
(en)
|
2003-05-01 |
2015-12-08 |
Imclone Systems Incorporated |
Fully human antibodies directed against the human insulin-like growth factor-1 receptor
|
CN101966338A
(zh)
|
2003-06-09 |
2011-02-09 |
塞缪尔·瓦克萨尔 |
用胞外拮抗物和胞内拮抗物抑制受体酪氨酸激酶的方法
|
US7312215B2
(en)
|
2003-07-29 |
2007-12-25 |
Bristol-Myers Squibb Company |
Benzimidazole C-2 heterocycles as kinase inhibitors
|
UA85058C2
(ru)
|
2003-08-13 |
2008-12-25 |
Пфайзер Продактс Инк. |
Модифицированное моноклональное антитело человека, которое специфически связывается с рецептором подобного к инсулину фактора роста i человека (igf-ir)
|
JP2007510434A
(ja)
|
2003-11-12 |
2007-04-26 |
シェーリング コーポレイション |
多重遺伝子発現のためのプラスミドシステム
|
AR046639A1
(es)
|
2003-11-21 |
2005-12-14 |
Schering Corp |
Combinaciones terapeuticas de anticuerpo anti- igfr1
|
US7598350B2
(en)
*
|
2004-03-19 |
2009-10-06 |
Imclone Llc |
Human anti-epidermal growth factor receptor antibody
|
AU2005249206A1
(en)
|
2004-06-03 |
2005-12-15 |
F. Hoffmann-La Roche Ag |
Treatment with cisplatin and an EGFR-inhibitor
|
ATE493442T1
(de)
|
2004-12-03 |
2011-01-15 |
Schering Corp |
Biologische marker zur vorauswahl von patienten für die anti-igf1r-therapie
|
MY146381A
(en)
|
2004-12-22 |
2012-08-15 |
Amgen Inc |
Compositions and methods relating relating to anti-igf-1 receptor antibodies
|
ES2452115T3
(es)
|
2005-06-17 |
2014-03-31 |
Imclone Llc |
Un anticuerpo anti-PDGFRalfa para su uso en el tratamiento de cáncer de huesos metastásico
|
ES2374450T3
(es)
|
2005-09-20 |
2012-02-16 |
OSI Pharmaceuticals, LLC |
Marcadores biológicos predictivos de respuesta anticancerígena para inhibidores de cinasa del receptor del factor de crecimiento 1 similar a insulina.
|
EP3178850B1
(en)
|
2005-10-11 |
2021-01-13 |
Amgen Research (Munich) GmbH |
Compositions comprising cross-species-specific antibodies and uses thereof
|
TW200812615A
(en)
|
2006-03-22 |
2008-03-16 |
Hoffmann La Roche |
Tumor therapy with an antibody for vascular endothelial growth factor and an antibody for human epithelial growth factor receptor type 2
|
US20080050385A1
(en)
|
2006-08-21 |
2008-02-28 |
Thomas Friess |
Tumor therapy with an anti-vegf antibody
|
RS53042B
(en)
|
2007-02-16 |
2014-04-30 |
Merrimack Pharmaceuticals Inc. |
ANTIBODIES AGAINST ERBB3 AND THEIR USES
|
US20100183615A1
(en)
*
|
2007-04-03 |
2010-07-22 |
Micromet Ag |
Cross-species-specific bispecific binders
|
CN101821292B
(zh)
|
2007-09-05 |
2014-03-26 |
霍夫曼-拉罗奇有限公司 |
Ⅰ型和ⅱ型抗-cd20抗体的组合疗法
|
US20090098118A1
(en)
|
2007-10-15 |
2009-04-16 |
Thomas Friess |
Combination therapy of a type ii anti-cd20 antibody with an anti-bcl-2 active agent
|
AR071891A1
(es)
|
2008-05-30 |
2010-07-21 |
Imclone Llc |
Anticuerpos humanos anti-flt3 (receptor tirosina cinasa 3 tipo fms humano)
|
US8623592B2
(en)
|
2008-08-15 |
2014-01-07 |
Merrimack Pharmaceuticals, Inc. |
Methods and systems for predicting response of cells to a therapeutic agent
|
JP2012518657A
(ja)
|
2009-02-25 |
2012-08-16 |
オーエスアイ・ファーマシューティカルズ,エルエルシー |
併用抗癌治療
|
JP2012519170A
(ja)
|
2009-02-26 |
2012-08-23 |
オーエスアイ・ファーマシューティカルズ,エルエルシー |
生体内の腫瘍細胞のemtステータスをモニターするためのinsitu法
|
EP2408479A1
(en)
|
2009-03-18 |
2012-01-25 |
OSI Pharmaceuticals, LLC |
Combination cancer therapy comprising administration of an egfr inhibitor and an igf-1r inhibitor
|
CN102356092B
(zh)
|
2009-03-20 |
2014-11-05 |
霍夫曼-拉罗奇有限公司 |
双特异性抗-her抗体
|
EP2236139A1
(en)
|
2009-03-31 |
2010-10-06 |
F. Hoffmann-La Roche AG |
Combination therapy of erlotinib with an anti-IGF-1R antibody, which does not inhibit binding of insulin to the insulin receptor
|
US20100247484A1
(en)
|
2009-03-31 |
2010-09-30 |
Heinrich Barchet |
Combination therapy of an afucosylated antibody and one or more of the cytokines gm csf, m csf and/or il3
|
JP2013501741A
(ja)
|
2009-08-14 |
2013-01-17 |
ロシュ グリクアート アーゲー |
アフコシル化cd20抗体とフルダラビン及び/又はミトキサントロンの併用療法
|
TWI409079B
(zh)
|
2009-08-14 |
2013-09-21 |
Roche Glycart Ag |
非典型岩藻醣化cd20抗體與苯達莫斯汀(bendamustine)之組合療法
|
AR078161A1
(es)
|
2009-09-11 |
2011-10-19 |
Hoffmann La Roche |
Formulaciones farmaceuticas muy concentradas de un anticuerpo anti cd20. uso de la formulacion. metodo de tratamiento.
|
US20110275644A1
(en)
|
2010-03-03 |
2011-11-10 |
Buck Elizabeth A |
Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors
|
WO2011109584A2
(en)
|
2010-03-03 |
2011-09-09 |
OSI Pharmaceuticals, LLC |
Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors
|
SG183532A1
(en)
|
2010-03-11 |
2012-09-27 |
Merrimack Pharmaceuticals Inc |
Use of erbb3 inhibitors in the treatment of triple negative and basal-like breast cancers
|
EP2563391B1
(en)
|
2010-04-27 |
2020-08-26 |
Roche Glycart AG |
Combination therapy of an afucosylated cd20 antibody with a mtor inhibitor
|
AR082693A1
(es)
|
2010-08-17 |
2012-12-26 |
Roche Glycart Ag |
Terapia de combinacion de un anticuerpo anti-cd20 afucosilado con un anticuerpo anti-vegf
|
TW201302793A
(zh)
|
2010-09-03 |
2013-01-16 |
Glaxo Group Ltd |
新穎之抗原結合蛋白
|
MX2013006739A
(es)
|
2010-12-16 |
2013-07-17 |
Roche Glycart Ag |
Terapia combinada de anticuerpo cd20 afucosilado con inhibidor de mdm2.
|
AU2012212075A1
(en)
|
2011-02-02 |
2013-07-18 |
Amgen Inc. |
Methods and compositons relating to inhibition of IGF-1R
|
WO2012116040A1
(en)
|
2011-02-22 |
2012-08-30 |
OSI Pharmaceuticals, LLC |
Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors in hepatocellular carcinoma
|
WO2012129145A1
(en)
|
2011-03-18 |
2012-09-27 |
OSI Pharmaceuticals, LLC |
Nscle combination therapy
|
US8628773B2
(en)
|
2011-04-07 |
2014-01-14 |
Amgen Inc. |
Antigen binding proteins
|
WO2012149014A1
(en)
|
2011-04-25 |
2012-11-01 |
OSI Pharmaceuticals, LLC |
Use of emt gene signatures in cancer drug discovery, diagnostics, and treatment
|
US9700619B2
(en)
|
2011-11-11 |
2017-07-11 |
Duke University |
Combination drug therapy for the treatment of solid tumors
|
US20130302274A1
(en)
|
2011-11-25 |
2013-11-14 |
Roche Glycart Ag |
Combination therapy
|
WO2013124419A1
(en)
|
2012-02-23 |
2013-08-29 |
U3 Pharma Gmbh |
Her3 inhibitor for modulating radiosensitivity
|
AR090263A1
(es)
|
2012-03-08 |
2014-10-29 |
Hoffmann La Roche |
Terapia combinada de anticuerpos contra el csf-1r humano y las utilizaciones de la misma
|
WO2013152252A1
(en)
|
2012-04-06 |
2013-10-10 |
OSI Pharmaceuticals, LLC |
Combination anti-cancer therapy
|
RU2648476C2
(ru)
|
2012-09-07 |
2018-03-26 |
Дженентек, Инк. |
Комбинированная терапия с использованием антитела против cd20 типа ii и селективного ингибитора bcl-2
|
US9180185B2
(en)
|
2013-01-11 |
2015-11-10 |
Hoffman-La Roche Inc. |
Combination therapy of anti-HER3 antibodies
|
WO2015100459A2
(en)
|
2013-12-27 |
2015-07-02 |
Merrimack Pharmaceuticals, Inc. |
Biomarker profiles for predicting outcomes of cancer therapy with erbb3 inhibitors and/or chemotherapies
|
RU2016141385A
(ru)
|
2014-03-24 |
2018-04-28 |
Дженентек, Инк. |
Лечение рака антагонистами с-мет и их корреляция с экспрессией hgf
|
US10184006B2
(en)
|
2015-06-04 |
2019-01-22 |
Merrimack Pharmaceuticals, Inc. |
Biomarkers for predicting outcomes of cancer therapy with ErbB3 inhibitors
|
HUE044139T2
(hu)
|
2015-07-07 |
2019-09-30 |
Hoffmann La Roche |
Kombinált terápia egy HER2-ellenes antitest-gyógyszer konjugátummal és bcl-2 inhibitorral
|
EP3383375A1
(en)
|
2015-12-03 |
2018-10-10 |
Agios Pharmaceuticals, Inc. |
Mat2a inhibitors for treating mtap null cancer
|
WO2017125429A1
(en)
|
2016-01-18 |
2017-07-27 |
Institut National De La Santé Et De La Recherche Médicale (Inserm) |
The use of a temporary inhibitor of p53 for preventing or reducing cancer relapse
|
WO2017205465A2
(en)
|
2016-05-24 |
2017-11-30 |
Griswold Karl Edwin |
Antibodies and methods of making same
|
CN110891608A
(zh)
|
2017-07-26 |
2020-03-17 |
豪夫迈·罗氏有限公司 |
用BET抑制剂和Bcl-2抑制剂进行的组合疗法
|
EP3658584A1
(en)
|
2017-07-26 |
2020-06-03 |
H. Hoffnabb-La Roche Ag |
Combination therapy with a bet inhibitor, a bcl-2 inhibitor and an anti-cd20 antibody
|
US20200354460A1
(en)
*
|
2017-09-29 |
2020-11-12 |
Wuxi Biologics Ireland Limited. |
Bispecific antibodies against EGFR and PD-1
|
CN111989092A
(zh)
|
2018-04-18 |
2020-11-24 |
豪夫迈·罗氏有限公司 |
Bet抑制剂和蛋白酶体抑制剂的联合治疗
|
WO2020234445A1
(en)
|
2019-05-23 |
2020-11-26 |
F. Hoffmann-La Roche Ag |
Combination therapy with a bet inhibitor and a bcl-2 inhibitor
|
WO2021155006A1
(en)
|
2020-01-31 |
2021-08-05 |
Les Laboratoires Servier Sas |
Inhibitors of cyclin-dependent kinases and uses thereof
|