SK14762001A3 - Ligandy receptora estrogénu beta - Google Patents

Ligandy receptora estrogénu beta Download PDF

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Publication number
SK14762001A3
SK14762001A3 SK1476-2001A SK14762001A SK14762001A3 SK 14762001 A3 SK14762001 A3 SK 14762001A3 SK 14762001 A SK14762001 A SK 14762001A SK 14762001 A3 SK14762001 A3 SK 14762001A3
Authority
SK
Slovakia
Prior art keywords
hydrogen
disease
hydroxyphenyl
use according
estrogen
Prior art date
Application number
SK1476-2001A
Other languages
English (en)
Slovak (sk)
Inventor
Bernard Christophe Barlaam
Timothy Martin Piser
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of SK14762001A3 publication Critical patent/SK14762001A3/sk

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A61K31/37—Coumarins, e.g. psoralen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
SK1476-2001A 1999-04-16 2000-04-11 Ligandy receptora estrogénu beta SK14762001A3 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12990199P 1999-04-16 1999-04-16
PCT/GB2000/001380 WO2000062765A2 (fr) 1999-04-16 2000-04-11 β-LIGANDS DE RECEPTEURS D'OESTROGENE

Publications (1)

Publication Number Publication Date
SK14762001A3 true SK14762001A3 (sk) 2002-10-08

Family

ID=22442124

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1476-2001A SK14762001A3 (sk) 1999-04-16 2000-04-11 Ligandy receptora estrogénu beta

Country Status (22)

Country Link
US (1) US6518301B1 (fr)
EP (1) EP1173164A2 (fr)
JP (1) JP2002542187A (fr)
KR (1) KR20010108509A (fr)
CN (1) CN1358091A (fr)
AR (1) AR043085A1 (fr)
AU (1) AU4128800A (fr)
BG (1) BG106103A (fr)
BR (1) BR0009814A (fr)
CA (1) CA2370126A1 (fr)
CZ (1) CZ20013714A3 (fr)
EE (1) EE200100526A (fr)
HU (1) HUP0200740A3 (fr)
IL (1) IL145839A0 (fr)
IS (1) IS6108A (fr)
MX (1) MXPA01010423A (fr)
NO (1) NO20015015L (fr)
PL (1) PL351314A1 (fr)
SK (1) SK14762001A3 (fr)
TR (2) TR200201762T2 (fr)
WO (1) WO2000062765A2 (fr)
ZA (1) ZA200108409B (fr)

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GB2361642A (en) * 2000-10-24 2001-10-31 Karobio Ab Estrogen receptor beta (ERbeta) agonists for use in cancer treatment
WO2002046164A1 (fr) * 2000-12-07 2002-06-13 Astrazeneca Ab Composes therapeutiques
WO2002046168A1 (fr) * 2000-12-07 2002-06-13 Astrazeneca Ab Composes therapeutiques de benzimidazole
US6559177B2 (en) 2001-04-19 2003-05-06 Wyeth 5, 11-Dioxa-benzo[b]fluoren-10-one and 5-oxa-11-thia-benzo[b]fluoren-10-ones as estrogenic agents
IL161325A0 (en) 2001-11-19 2004-09-27 Lilly Co Eli Substituted benzopyrans as selective estrogen receptor-beta agonists
UA83620C2 (ru) 2001-12-05 2008-08-11 Уайт Замещенные бензоксазолы и их аналоги как эстрогенные агенты
US6914074B2 (en) * 2001-12-13 2005-07-05 Wyeth Substituted phenyl naphthalenes as estrogenic agents
TW200301107A (en) 2001-12-13 2003-07-01 Wyeth Corp Substituted 6H-dibenzo[c,h]chromenes as estrogenic agents
US6835745B2 (en) 2002-01-15 2004-12-28 Wyeth Phenyl substituted thiophenes as estrogenic agents
US7235539B2 (en) 2002-01-23 2007-06-26 Wyeth 6-Hydroxyequilenins as estrogenic agents
AU2003212856A1 (en) * 2002-03-01 2003-09-16 Eli Lilly And Company Substituted benzopyrans as selective estrogen receptor-beta agonists
EP1545206B1 (fr) 2002-07-24 2020-03-04 Children's Hospital Medical Center Compositions et produits contenant de l'equol enantiomere, et procedes de fabrication
US8668914B2 (en) 2002-07-24 2014-03-11 Brigham Young University Use of equol for treating skin diseases
WO2004039327A2 (fr) 2002-10-29 2004-05-13 Colorado State University Research Foundation Utilisation d'equol dans le traitement de maladies d'origine androgenique
US7468445B2 (en) 2002-08-07 2008-12-23 University Of Mississippi Antigiardial agents and use thereof
US8580846B2 (en) 2002-10-29 2013-11-12 Brigham Young University Use of equol for ameliorating or preventing neuropsychiatric and neurodegenerative diseases or disorders
US7674783B2 (en) * 2002-11-22 2010-03-09 Dimera Inc. Estrogen beta receptor agonists to prevent or reduce the severity of cardiovascular disease
DE602004016150D1 (de) * 2003-04-21 2008-10-09 Lilly Co Eli Substituierte benzopyrane als selektive antagonisten am östrogenrezeptor-beta
EP2305272A1 (fr) * 2004-04-28 2011-04-06 Brigham Young University Utilisation de l'equol dans le traitement des maladies de la peau
PE20060503A1 (es) * 2004-08-26 2006-07-20 Wyeth Corp Prodroga de benzoxazoles substituidos como agentes estrogenicos
EP1789420A2 (fr) 2004-09-07 2007-05-30 Wyeth, A Corporation of the State of Delaware 6h-[1]benzopyrano[4,3-b]quinolines et leur utilisation comme agents oestrogenes
US20060135574A1 (en) * 2004-12-17 2006-06-22 Wyeth Novel uses for estrogen beta agonists
WO2006088716A1 (fr) * 2005-02-15 2006-08-24 Eli Lilly And Company Tetralines substituees utilisees comme antagonistes selectifs du recepteur d'oestrogenes beta
CN101203219B (zh) * 2005-03-24 2011-06-15 诺沃根研究控股有限公司 消炎用药程式
US8546451B2 (en) * 2005-11-28 2013-10-01 Gtx, Inc. Estrogen receptor ligands and methods of use thereof
US9409856B2 (en) 2005-11-28 2016-08-09 Gtx, Inc. Estrogen receptor ligands and methods of use thereof
EA201500845A1 (ru) * 2005-11-28 2016-04-29 Джи Ти Икс, ИНК. Агенты, связывающиеся с ядерными рецепторами
US8158828B2 (en) * 2005-11-28 2012-04-17 Gtx, Inc. Nuclear receptor binding agents
US8637706B2 (en) 2005-11-28 2014-01-28 Gtx, Inc. Nuclear receptor binding agents
TWI366565B (en) 2007-06-06 2012-06-21 Otsuka Pharma Co Ltd Quinolone compound and pharmaceutical composition
WO2009026657A1 (fr) * 2007-08-29 2009-03-05 The University Of Sydney Agonistes flavonoïdes de ppar
US8592007B2 (en) * 2008-10-29 2013-11-26 Merck Patent Gmbh Liquid-crystal display
TWI492943B (zh) 2008-12-05 2015-07-21 大塚製藥股份有限公司 喹啉酮化合物及藥學組成物（二）
ES2343347B2 (es) * 2009-01-27 2011-12-07 Universidade De Santiago De Compostela Uso de derivados de 3-fenilcumarinas 6-sustituidas y preparacion de nuevos derivados.
US9624161B2 (en) 2009-02-23 2017-04-18 Gtx, Inc. Estrogen receptor ligands and methods of use thereof
US9427418B2 (en) 2009-02-23 2016-08-30 Gtx, Inc. Estrogen receptor ligands and methods of use thereof
CN101863867B (zh) * 2009-04-14 2012-07-18 清华大学深圳研究生院 黄酮类化合物的衍生物及其制备方法与应用
WO2012147102A1 (fr) * 2011-04-25 2012-11-01 Council Of Scientific & Industrial Research Fractions et composés bioactifs issus de dalbergia sissoo pour prévenir ou traiter les troubles d'origine ostéopathique
CN103450134B (zh) * 2012-05-31 2017-12-22 中国医学科学院药物研究所 香豆素衍生物的制备及其在防治脑部重大疾病中的应用
US9718799B2 (en) * 2015-05-11 2017-08-01 University Of Kentucky Research Foundation 3-aryl-4H-chromene-4-ones as antineoplastic agents for the treatment of cancer
EP3597187A1 (fr) * 2018-07-16 2020-01-22 Centre National De La Recherche Scientifique Inhibiteurs de brag2 et applications associées
CN112574177B (zh) * 2020-12-21 2023-01-31 陕西师范大学 一类嘧啶衍生物及其制备抗肿瘤药物的应用
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Also Published As

Publication number Publication date
HUP0200740A3 (en) 2004-08-30
KR20010108509A (ko) 2001-12-07
JP2002542187A (ja) 2002-12-10
AU4128800A (en) 2000-11-02
IL145839A0 (en) 2002-07-25
HUP0200740A2 (hu) 2002-07-29
BG106103A (en) 2002-05-31
AR043085A1 (es) 2005-07-20
CZ20013714A3 (cs) 2002-08-14
CA2370126A1 (fr) 2000-10-26
EP1173164A2 (fr) 2002-01-23
IS6108A (is) 2001-10-15
PL351314A1 (en) 2003-04-07
NO20015015L (no) 2001-12-17
US6518301B1 (en) 2003-02-11
BR0009814A (pt) 2002-01-08
NO20015015D0 (no) 2001-10-15
TR200102992T2 (tr) 2004-12-21
MXPA01010423A (es) 2002-03-27
EE200100526A (et) 2002-12-16
CN1358091A (zh) 2002-07-10
ZA200108409B (en) 2003-03-26
WO2000062765A2 (fr) 2000-10-26
TR200201762T2 (tr) 2002-10-21
WO2000062765A3 (fr) 2001-09-07

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