TR200102992T2 - ß östrojen reseptörü ligandları. - Google Patents

ß östrojen reseptörü ligandları.

Info

Publication number
TR200102992T2
TR200102992T2 TR2001/02992T TR200102992T TR200102992T2 TR 200102992 T2 TR200102992 T2 TR 200102992T2 TR 2001/02992 T TR2001/02992 T TR 2001/02992T TR 200102992 T TR200102992 T TR 200102992T TR 200102992 T2 TR200102992 T2 TR 200102992T2
Authority
TR
Turkey
Prior art keywords
estrogen receptor
receptor ligands
ligands
estrogen
kiae
Prior art date
Application number
TR2001/02992T
Other languages
English (en)
Inventor
Christophe Barlaam Bernard
Martin Piser Timothy
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of TR200102992T2 publication Critical patent/TR200102992T2/tr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A61K31/37—Coumarins, e.g. psoralen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychiatry (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

(KiaA/Ki A)/(KiaE/Ki E)>1 esitsizligini saglayan, istege bagli olarak genel yapi (I)'i tasiyan bir bilesigin terapötik olarak etkili bir miktarinin uygulanmasi asamasindan olusan, östrojen reseptörü- ile iliskili bir yöntemin tedavisi için bir yöntem.
TR2001/02992T 1999-04-16 2000-04-11 ß östrojen reseptörü ligandları. TR200102992T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12990199P 1999-04-16 1999-04-16

Publications (1)

Publication Number Publication Date
TR200102992T2 true TR200102992T2 (tr) 2004-12-21

Family

ID=22442124

Family Applications (2)

Application Number Title Priority Date Filing Date
TR2001/02992T TR200102992T2 (tr) 1999-04-16 2000-04-11 ß östrojen reseptörü ligandları.
TR2002/01762T TR200201762T2 (tr) 1999-04-16 2000-04-11 B östrojen reseptörü ligandları.

Family Applications After (1)

Application Number Title Priority Date Filing Date
TR2002/01762T TR200201762T2 (tr) 1999-04-16 2000-04-11 B östrojen reseptörü ligandları.

Country Status (22)

Country Link
US (1) US6518301B1 (tr)
EP (1) EP1173164A2 (tr)
JP (1) JP2002542187A (tr)
KR (1) KR20010108509A (tr)
CN (1) CN1358091A (tr)
AR (1) AR043085A1 (tr)
AU (1) AU4128800A (tr)
BG (1) BG106103A (tr)
BR (1) BR0009814A (tr)
CA (1) CA2370126A1 (tr)
CZ (1) CZ20013714A3 (tr)
EE (1) EE200100526A (tr)
HU (1) HUP0200740A3 (tr)
IL (1) IL145839A0 (tr)
IS (1) IS6108A (tr)
MX (1) MXPA01010423A (tr)
NO (1) NO20015015L (tr)
PL (1) PL351314A1 (tr)
SK (1) SK14762001A3 (tr)
TR (2) TR200102992T2 (tr)
WO (1) WO2000062765A2 (tr)
ZA (1) ZA200108409B (tr)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPQ266199A0 (en) * 1999-09-06 1999-09-30 Novogen Research Pty Ltd Compositions and therapeutic methods involving isoflavones and analogues thereof
US7226945B2 (en) 2000-10-13 2007-06-05 Astrazeneca Ab Estrogen receptor-β ligands
GB2361642A (en) * 2000-10-24 2001-10-31 Karobio Ab Estrogen receptor beta (ERbeta) agonists for use in cancer treatment
AU2002222853A1 (en) * 2000-12-07 2002-06-18 Astrazeneca Ab Therapeutic compounds
US20070004713A1 (en) * 2000-12-07 2007-01-04 Bernard Barlaam Therapeutic benimidazole compounds
US6559177B2 (en) 2001-04-19 2003-05-06 Wyeth 5, 11-Dioxa-benzo[b]fluoren-10-one and 5-oxa-11-thia-benzo[b]fluoren-10-ones as estrogenic agents
WO2003044006A1 (en) 2001-11-19 2003-05-30 Eli Lilly And Company Substituted benzopyrans as selective estrogen receptor-beta agonists
UA83620C2 (ru) 2001-12-05 2008-08-11 Уайт Замещенные бензоксазолы и их аналоги как эстрогенные агенты
TW200301107A (en) 2001-12-13 2003-07-01 Wyeth Corp Substituted 6H-dibenzo[c,h]chromenes as estrogenic agents
TWI306450B (en) 2001-12-13 2009-02-21 Wyeth Corp Substituted phenyl naphthalenes as estrogenic agents
US6835745B2 (en) 2002-01-15 2004-12-28 Wyeth Phenyl substituted thiophenes as estrogenic agents
US7235539B2 (en) 2002-01-23 2007-06-26 Wyeth 6-Hydroxyequilenins as estrogenic agents
WO2003074044A1 (en) * 2002-03-01 2003-09-12 Eli Lilly And Company Substituted benzopyrans as selective estrogen receptor-beta agonists
WO2004039327A2 (en) * 2002-10-29 2004-05-13 Colorado State University Research Foundation Use of equol for treating androgen mediated diseases
US20050245492A1 (en) * 2004-04-28 2005-11-03 Lephart Edwin D Use of equol for treating skin diseases
US8668914B2 (en) * 2002-07-24 2014-03-11 Brigham Young University Use of equol for treating skin diseases
JP2006504409A (ja) * 2002-07-24 2006-02-09 チルドレンズ　ホスピタル　メディカル　センター 鏡像異性のエクオールを含有する組成物および製品、およびその製造方法
WO2004014886A1 (en) * 2002-08-07 2004-02-19 University Of Mississippi Antigiardial agents and use thereof
US8580846B2 (en) 2002-10-29 2013-11-12 Brigham Young University Use of equol for ameliorating or preventing neuropsychiatric and neurodegenerative diseases or disorders
US7674783B2 (en) * 2002-11-22 2010-03-09 Dimera Inc. Estrogen beta receptor agonists to prevent or reduce the severity of cardiovascular disease
MXPA05011243A (es) * 2003-04-21 2005-12-15 Lilly Co Eli Benzopiranos substituidos como agonistas selectivos del receptor beta de estrogeno.
EP1781628A2 (en) * 2004-08-26 2007-05-09 Wyeth a Corporation of the State of Delaware Prodrug substituted benzoxazoles as estrogenic agents
BRPI0514974A (pt) 2004-09-07 2008-07-01 Wyeth Corp composto, composição, métodos de tratar ou inibir uma doença ou condição, estados de doença induzidos por radical livre em um mamìfero, dano à junta secundário aos procedimentos artroscópicos ou cirúrgicos em um mamìfero, infertilidade em um mamìfero, de diminuir os nìveis de colesterol, triglicerìdeos, lp(a), ou ldl, de fornecer realce na cognição ou neuroproteção, de contracepção em um mamìfero, e para preparar um composto, e, produto
AU2005316561A1 (en) * 2004-12-17 2006-06-22 Wyeth The uses of estrogen beta agonists to treat cognitive diseases
US8093302B2 (en) * 2005-02-15 2012-01-10 Eli Lilly And Company Substituted tetralins as selective estrogen receptor-β agonists
ATE496921T1 (de) * 2005-03-24 2011-02-15 Novogen Res Pty Ltd Isoflavonoiddimere
US8637706B2 (en) 2005-11-28 2014-01-28 Gtx, Inc. Nuclear receptor binding agents
US9409856B2 (en) 2005-11-28 2016-08-09 Gtx, Inc. Estrogen receptor ligands and methods of use thereof
EA018066B1 (ru) * 2005-11-28 2013-05-30 Джи Ти Икс, ИНК. Агент, связывающийся с ядерными рецепторами
US8546451B2 (en) * 2005-11-28 2013-10-01 Gtx, Inc. Estrogen receptor ligands and methods of use thereof
US8158828B2 (en) * 2005-11-28 2012-04-17 Gtx, Inc. Nuclear receptor binding agents
TWI366565B (en) 2007-06-06 2012-06-21 Otsuka Pharma Co Ltd Quinolone compound and pharmaceutical composition
WO2009026657A1 (en) * 2007-08-29 2009-03-05 The University Of Sydney Flavonoid ppar agonists
DE102009043436A1 (de) * 2008-10-29 2010-05-06 Merck Patent Gmbh Flüssigkristallanzeige
TWI472525B (zh) 2008-12-05 2015-02-11 Otsuka Pharma Co Ltd 喹啉酮化合物及藥學組成物
ES2343347B2 (es) * 2009-01-27 2011-12-07 Universidade De Santiago De Compostela Uso de derivados de 3-fenilcumarinas 6-sustituidas y preparacion de nuevos derivados.
US9427418B2 (en) 2009-02-23 2016-08-30 Gtx, Inc. Estrogen receptor ligands and methods of use thereof
US9624161B2 (en) 2009-02-23 2017-04-18 Gtx, Inc. Estrogen receptor ligands and methods of use thereof
CN101863867B (zh) * 2009-04-14 2012-07-18 清华大学深圳研究生院 黄酮类化合物的衍生物及其制备方法与应用
EP2705047B1 (en) 2011-04-25 2015-08-05 Council of Scientific & Industrial Research Bioactive fractions and compounds from dalbergia sissoo for the prevention or treatment of osteo-health related disorders
CN103450134B (zh) * 2012-05-31 2017-12-22 中国医学科学院药物研究所 香豆素衍生物的制备及其在防治脑部重大疾病中的应用
US9718799B2 (en) * 2015-05-11 2017-08-01 University Of Kentucky Research Foundation 3-aryl-4H-chromene-4-ones as antineoplastic agents for the treatment of cancer
EP3796905A4 (en) * 2018-05-23 2022-02-16 The Board of Trustees of the University of Illinois ESTROGEN RECEPTOR BETA LIGANDS FOR THE PREVENTION AND TREATMENT OF MULTIPLE SCLEROSIS (MS) AND OTHER DEMYELINIZING, INFLAMMATORY AND NEURODEGENERATIVE DISEASES
EP3597187A1 (en) * 2018-07-16 2020-01-22 Centre National De La Recherche Scientifique Brag2 inhibitors and applications thereof
CN112574177B (zh) * 2020-12-21 2023-01-31 陕西师范大学 一类嘧啶衍生物及其制备抗肿瘤药物的应用
CN115322198A (zh) * 2022-06-13 2022-11-11 上海工程技术大学 基于喹诺里西啶类衍生物的药物化合物及其制备方法和应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4954371A (tr) * 1972-09-28 1974-05-27
GB1495189A (en) * 1975-09-12 1977-12-14 Pfizer Ltd 4-oxo-4h-benzopyran derivatives and process for their preparation
JPS6048924A (ja) * 1983-08-24 1985-03-16 Takeda Chem Ind Ltd 骨粗鬆症治療剤
ZA873745B (en) * 1986-06-04 1988-10-26 Daiichi Seiyaku Co Benzopyran derivatives
JP3085464B2 (ja) * 1990-05-24 2000-09-11 コニカ株式会社 感熱拡散転写材料
US5204369A (en) * 1991-07-01 1993-04-20 The Endowment For Research In Human Biology Method for the inhibition of aldh-i useful in the treatment of alcohol dependence or alcohol abuse
JPH05112552A (ja) * 1991-10-17 1993-05-07 Tanabe Seiyaku Co Ltd ベンゾピラン誘導体及びその製法
JP3166093B2 (ja) * 1993-08-13 2001-05-14 森永乳業株式会社 クマリン誘導体及びそれらの用途
JPH06321752A (ja) * 1993-05-07 1994-11-22 Kao Corp 美白剤
JP3522754B2 (ja) * 1993-12-16 2004-04-26 マリンクロッド・インコーポレイテッド 多価フェノール化合物類
US5998401A (en) 1995-02-28 1999-12-07 Eli Lilly And Company Naphthyl compounds, intermediates, compositions, and methods
JP3786447B2 (ja) * 1995-03-31 2006-06-14 エーザイ株式会社 Ｃ型肝炎の予防・治療剤
AUPO203996A0 (en) * 1996-08-30 1996-09-26 Novogen Research Pty Ltd Therapeutic uses
US5916916A (en) * 1996-10-10 1999-06-29 Eli Lilly And Company 1-aryloxy-2-arylnaphthyl compounds, intermediates, compositions, and methods
US5733926A (en) * 1996-12-13 1998-03-31 Gorbach; Sherwood L. Isoflavonoids for treatment and prevention of alzheimer dementia and reduced cognitive functions
GB9707013D0 (en) * 1997-04-07 1997-05-28 Univ Strathclyde Halo and/or nitro-substituted flavonoids
EP0979074A4 (en) * 1997-05-01 2003-07-09 Novogen Inc TREATMENT OR PREVENTION CLIMATE ACTION SYMPTOMS AND OSTEOPOROSIS

Also Published As

Publication number Publication date
TR200201762T2 (tr) 2002-10-21
BR0009814A (pt) 2002-01-08
CN1358091A (zh) 2002-07-10
IL145839A0 (en) 2002-07-25
HUP0200740A2 (hu) 2002-07-29
HUP0200740A3 (en) 2004-08-30
CA2370126A1 (en) 2000-10-26
IS6108A (is) 2001-10-15
BG106103A (en) 2002-05-31
EP1173164A2 (en) 2002-01-23
EE200100526A (et) 2002-12-16
SK14762001A3 (sk) 2002-10-08
NO20015015D0 (no) 2001-10-15
PL351314A1 (en) 2003-04-07
ZA200108409B (en) 2003-03-26
CZ20013714A3 (cs) 2002-08-14
AU4128800A (en) 2000-11-02
KR20010108509A (ko) 2001-12-07
WO2000062765A3 (en) 2001-09-07
NO20015015L (no) 2001-12-17
WO2000062765A2 (en) 2000-10-26
MXPA01010423A (es) 2002-03-27
US6518301B1 (en) 2003-02-11
JP2002542187A (ja) 2002-12-10
AR043085A1 (es) 2005-07-20

Similar Documents

Publication Publication Date Title
TR200102992T2 (tr) ß östrojen reseptörü ligandları.
GB2344265B (en) Network accounting and billing system and method
IS5888A (is) Efnameðferð við krabbameini með asetýldínalíni blönduðu gemsítabíni, kapesítabíni eða sisplatíni
BR9904850A (pt) Porta-ferramenta
FR2797599B1 (fr) Forets a lame a langue d'aspic, lame correspondante et procedes de formation de tels forets et lame
DE69932738D1 (de) 3-azabicyclo(3.1.0)hexanderivate als opiat rezeptoren liganden
AU3771699A (en) Cycle planner for an earthmoving machine
ZA200002398B (en) A work flow management system.
ES2175989T3 (es) Derivado de testosterona.
BR0007922A (pt) Compostos calcilìticos
TR199902929T2 (tr) Yeni proses.
DE69905162D1 (de) 3-[2-oxo-(1,3')bipyrrolidinyl-3-yliden-methyl]-cephemderivate
HK1029524A1 (en) Base for suppository.
ATE234837T1 (de) 3-bicycloindole als liganden des 5-ht 1d rezeptors
ES2180998T3 (es) Compuestos heterociclicos.
GB2377060A (en) System for ranking financial underwriters
ZA995029B (en) Estrogen agonists/antagonists.
IT1303585B1 (it) Supporto metallico per un catalizzatore.
ZA200004547B (en) Lip for an excavation bucket.
NL1013875A1 (nl) Postuitwisselingsinrichting.
DZ3193A1 (fr) Méthode d'encryptage multi-modules.
Kim Reforming Rural Planning System Based on Localization
ES1043504Y (es) Adaptador telefonico.
ES1041131U (es) Gancho de amarre, perfeccionado.
JO2054B1 (en) Zubaydah bath