SK119997A3 - New cryptophycins from synthesis - Google Patents

New cryptophycins from synthesis Download PDF

Info

Publication number
SK119997A3
SK119997A3 SK1199-97A SK119997A SK119997A3 SK 119997 A3 SK119997 A3 SK 119997A3 SK 119997 A SK119997 A SK 119997A SK 119997 A3 SK119997 A3 SK 119997A3
Authority
SK
Slovakia
Prior art keywords
cryptophycin
taken together
methyl
chloro
formula
Prior art date
Application number
SK1199-97A
Other languages
English (en)
Slovak (sk)
Inventor
Richard E Moore
Marcus A Tius
Russell A Barrow
Jian Liang
Thomas H Corbett
Frederick A Valeriote
Thomas K Hemscheidt
Galakoti Trimurtulu
Original Assignee
Univ Hawaii
Univ Wayne State
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/400,057 external-priority patent/US6013626A/en
Priority claimed from US08/482,141 external-priority patent/US5952298A/en
Application filed by Univ Hawaii, Univ Wayne State filed Critical Univ Hawaii
Publication of SK119997A3 publication Critical patent/SK119997A3/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Reproductive Health (AREA)
  • Psychology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
SK1199-97A 1995-03-07 1996-03-07 New cryptophycins from synthesis SK119997A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/400,057 US6013626A (en) 1993-12-21 1995-03-07 Cryptophycins from synthesis
US08/482,141 US5952298A (en) 1993-12-21 1995-06-07 Cryptophycins
PCT/US1996/003246 WO1996040184A1 (en) 1995-03-07 1996-03-07 New cryptophycins from synthesis

Publications (1)

Publication Number Publication Date
SK119997A3 true SK119997A3 (en) 1998-12-02

Family

ID=27016884

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1199-97A SK119997A3 (en) 1995-03-07 1996-03-07 New cryptophycins from synthesis

Country Status (23)

Country Link
EP (1) EP0830136B1 (pl)
JP (1) JP4181632B2 (pl)
CN (1) CN1165337C (pl)
AP (1) AP737A (pl)
AT (1) ATE279935T1 (pl)
AU (1) AU723652B2 (pl)
BG (1) BG63289B1 (pl)
CZ (1) CZ278197A3 (pl)
DE (1) DE69633667T2 (pl)
ES (1) ES2230561T3 (pl)
FI (1) FI973591A0 (pl)
GE (1) GEP20002206B (pl)
HK (1) HK1009747A1 (pl)
HU (1) HU225041B1 (pl)
MD (1) MD2196B2 (pl)
NO (1) NO326685B1 (pl)
NZ (1) NZ305571A (pl)
OA (1) OA10614A (pl)
PL (1) PL185949B1 (pl)
RO (1) RO118931B1 (pl)
SK (1) SK119997A3 (pl)
TJ (1) TJ347B (pl)
WO (1) WO1996040184A1 (pl)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6904896A (en) * 1995-08-30 1997-03-19 Eli Lilly And Company Pharmaceutical compounds
EP0934065B1 (en) * 1996-08-30 2006-06-07 University Of Hawaii Novel cryptophycin derivatives as anti-neoplastic agents
US6680311B1 (en) 1996-08-30 2004-01-20 Eli Lilly And Company Cryptophycin compounds
US5977387A (en) * 1996-08-30 1999-11-02 Eli Lilly And Company Process for preparing pharmaceutical compounds
JP2001500496A (ja) * 1996-09-06 2001-01-16 イーライ・リリー・アンド・カンパニー 医薬化合物の製造方法
AU4335297A (en) * 1996-09-06 1998-03-26 Eli Lilly And Company Process and novel intermediates
WO1998009601A2 (en) * 1996-09-06 1998-03-12 Eli Lilly And Company Process to prepare pharmaceutical compounds
JP2002513403A (ja) * 1997-02-26 2002-05-08 イーライ・リリー・アンド・カンパニー 医薬品化合物を製造するための選択的なエポキシ化方法
WO1998038178A1 (en) * 1997-02-26 1998-09-03 Eli Lilly And Company Tripeptide and tetrapeptide pharmaceutical compounds
EP0870501A1 (en) * 1997-04-11 1998-10-14 Eli Lilly And Company Use of specific cryptophycin derivatives for the manufacture of a medicament in the treatment of fungal infections
EP0870510A3 (en) * 1997-04-11 1999-09-15 Eli Lilly And Company Synergistic combination comprising cryptophycin derivatives and microtubule synergizing agents
EP0870506A1 (en) * 1997-04-11 1998-10-14 Eli Lilly And Company Compositions comprising a cryptophycin compound in combination with a synchronizing or activating agent for treating cancer
US6376230B1 (en) 1998-10-16 2002-04-23 Eli Lilly And Company Stereoselective process for producing intermediates of cryptophycins
US6103913A (en) * 1998-10-16 2000-08-15 Eli Lilly And Company Process for preparing enollactone derivatives
EP1127055A2 (en) * 1998-10-16 2001-08-29 Eli Lilly And Company Stereoselective process for producing cryptophycins
WO2000034252A2 (en) * 1998-12-07 2000-06-15 Eli Lilly And Company Process for the preparation of cryptophycin derivatives
US6372936B1 (en) * 1999-06-09 2002-04-16 Eli Lilly And Company Optical resolution of aminoisobobutyric acid
FR2947269B1 (fr) 2009-06-29 2013-01-18 Sanofi Aventis Nouveaux composes anticancereux

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4868208A (en) * 1988-07-15 1989-09-19 Merck & Co., Inc. Antifungal agent and method
US4946835A (en) * 1988-07-15 1990-08-07 Merck & Co., Inc. Antifungal fermentation product and method
US4845085A (en) * 1988-08-09 1989-07-04 Merck & Co., Inc. Antifungal agent
US4845086A (en) * 1988-08-09 1989-07-04 Merck & Co., Inc. Antifungal agent
AU695873B2 (en) * 1993-12-21 1998-08-27 University Of Hawaii New cryptophycins

Also Published As

Publication number Publication date
NO974105D0 (no) 1997-09-05
AP737A (en) 1999-03-15
CN1183726A (zh) 1998-06-03
JP4181632B2 (ja) 2008-11-19
ATE279935T1 (de) 2004-11-15
HK1009747A1 (en) 1999-06-11
EP0830136B1 (en) 2004-10-20
BG63289B1 (bg) 2001-09-28
EP0830136A1 (en) 1998-03-25
MD2196B2 (ro) 2003-06-30
HU225041B1 (en) 2006-05-29
HUP9801880A2 (hu) 1998-11-30
WO1996040184A1 (en) 1996-12-19
CZ278197A3 (cs) 1998-12-16
DE69633667T2 (de) 2006-03-02
EP0830136A4 (en) 2001-01-24
NO326685B1 (no) 2009-01-26
RO118931B1 (ro) 2004-01-30
FI973591A0 (fi) 1997-09-03
TJ347B (en) 2002-10-06
DE69633667D1 (en) 2004-11-25
PL322507A1 (en) 1998-02-02
OA10614A (en) 2001-03-15
NZ305571A (en) 1999-02-25
AU723652B2 (en) 2000-08-31
BG101875A (en) 1998-10-30
PL185949B1 (pl) 2003-09-30
GEP20002206B (en) 2000-08-25
MD970313A (en) 1999-06-30
JPH11510476A (ja) 1999-09-14
ES2230561T3 (es) 2005-05-01
AP9701069A0 (en) 1997-10-30
CN1165337C (zh) 2004-09-08
HUP9801880A3 (en) 1999-08-30
NO974105L (no) 1997-11-05
AU5360396A (en) 1996-12-30

Similar Documents

Publication Publication Date Title
US6013626A (en) Cryptophycins from synthesis
SK119997A3 (en) New cryptophycins from synthesis
KR100459527B1 (ko) 합성된신규한크립토파이신
JP4364944B2 (ja) 医薬化合物群
WO1996039829A9 (en) New cryptophycins
WO1998008506A1 (en) Pharmaceutical compounds
EP0792875B1 (en) Cryptophycin derivatives and their use as anti-microtubule agents
EP0712854B1 (en) Baccatin derivatives and processes for preparing the same
JP2000502351A (ja) 医薬化合物
EP0923564A1 (en) Pharmaceutical compounds
RU2195458C2 (ru) Криптофициновое соединение, фармацевтическая композиция, способ ингибирования пролиферации клеток и способ смягчения патологического состояния
US20020128185A1 (en) Pharmaceutical compounds
CA2214565C (en) New cryptophycins from synthesis
AU679687B2 (en) 4-oxa-1-azabicyclo (3,2,0) heptan-7-one derivatives as antitumor agents
AU716025B2 (en) New cryptophycins
KR100505779B1 (ko) 제약 화합물
JP2000505473A (ja) 医薬化合物
MXPA98001604A (en) Farmaceuti compounds