NO326685B1 - Kryptofyciner samt anvendelse derav og farmasoytisk blanding - Google Patents
Kryptofyciner samt anvendelse derav og farmasoytisk blanding Download PDFInfo
- Publication number
- NO326685B1 NO326685B1 NO19974105A NO974105A NO326685B1 NO 326685 B1 NO326685 B1 NO 326685B1 NO 19974105 A NO19974105 A NO 19974105A NO 974105 A NO974105 A NO 974105A NO 326685 B1 NO326685 B1 NO 326685B1
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- NO
- Norway
- Prior art keywords
- cryptophycin
- together form
- methyl
- isobutyl
- chloro
- Prior art date
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- 229960000485 methotrexate Drugs 0.000 description 1
- SIGOIUCRXKUEIG-UHFFFAOYSA-N methyl 2-dimethoxyphosphorylacetate Chemical compound COC(=O)CP(=O)(OC)OC SIGOIUCRXKUEIG-UHFFFAOYSA-N 0.000 description 1
- BXGDNKQFNQZCLG-UHFFFAOYSA-N methyl 3-amino-2-methylpropanoate Chemical compound COC(=O)C(C)CN BXGDNKQFNQZCLG-UHFFFAOYSA-N 0.000 description 1
- 125000004492 methyl ester group Chemical group 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 230000029115 microtubule polymerization Effects 0.000 description 1
- 210000003879 microtubule-organizing center Anatomy 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 239000003607 modifier Substances 0.000 description 1
- 230000009456 molecular mechanism Effects 0.000 description 1
- 125000002950 monocyclic group Chemical group 0.000 description 1
- 125000001624 naphthyl group Chemical group 0.000 description 1
- 201000011216 nasopharynx carcinoma Diseases 0.000 description 1
- 230000035407 negative regulation of cell proliferation Effects 0.000 description 1
- 210000004412 neuroendocrine cell Anatomy 0.000 description 1
- XWXYUMMDTVBTOU-UHFFFAOYSA-N nilutamide Chemical compound O=C1C(C)(C)NC(=O)N1C1=CC=C([N+]([O-])=O)C(C(F)(F)F)=C1 XWXYUMMDTVBTOU-UHFFFAOYSA-N 0.000 description 1
- 229960002653 nilutamide Drugs 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- 230000009871 nonspecific binding Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 210000004940 nucleus Anatomy 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 150000007530 organic bases Chemical class 0.000 description 1
- 239000012044 organic layer Substances 0.000 description 1
- 239000011368 organic material Substances 0.000 description 1
- 229960003552 other antineoplastic agent in atc Drugs 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000006174 pH buffer Substances 0.000 description 1
- 229940116369 pancreatic lipase Drugs 0.000 description 1
- 229920002866 paraformaldehyde Polymers 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 235000011007 phosphoric acid Nutrition 0.000 description 1
- 150000003016 phosphoric acids Chemical class 0.000 description 1
- 125000004437 phosphorous atom Chemical group 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 229960001298 polyestradiol phosphate Drugs 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 150000003138 primary alcohols Chemical class 0.000 description 1
- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
- 229960004919 procaine Drugs 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000005522 programmed cell death Effects 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- 210000005267 prostate cell Anatomy 0.000 description 1
- 238000000425 proton nuclear magnetic resonance spectrum Methods 0.000 description 1
- LVTJOONKWUXEFR-FZRMHRINSA-N protoneodioscin Natural products O(C[C@@H](CC[C@]1(O)[C@H](C)[C@@H]2[C@]3(C)[C@H]([C@H]4[C@@H]([C@]5(C)C(=CC4)C[C@@H](O[C@@H]4[C@H](O[C@H]6[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O6)[C@@H](O)[C@H](O[C@H]6[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O6)[C@H](CO)O4)CC5)CC3)C[C@@H]2O1)C)[C@H]1[C@H](O)[C@H](O)[C@H](O)[C@@H](CO)O1 LVTJOONKWUXEFR-FZRMHRINSA-N 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 125000004076 pyridyl group Chemical group 0.000 description 1
- 125000000168 pyrrolyl group Chemical group 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 230000008707 rearrangement Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000006894 reductive elimination reaction Methods 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 231100000916 relative toxicity Toxicity 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 229910001927 ruthenium tetroxide Inorganic materials 0.000 description 1
- BIXNGBXQRRXPLM-UHFFFAOYSA-K ruthenium(3+);trichloride;hydrate Chemical compound O.Cl[Ru](Cl)Cl BIXNGBXQRRXPLM-UHFFFAOYSA-K 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 210000000329 smooth muscle myocyte Anatomy 0.000 description 1
- 229910000033 sodium borohydride Inorganic materials 0.000 description 1
- 239000012279 sodium borohydride Substances 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000012258 stirred mixture Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- YBBRCQOCSYXUOC-UHFFFAOYSA-N sulfuryl dichloride Chemical compound ClS(Cl)(=O)=O YBBRCQOCSYXUOC-UHFFFAOYSA-N 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 229960001603 tamoxifen Drugs 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- KJTULOVPMGUBJS-UHFFFAOYSA-N tert-butyl-[tert-butyl(diphenyl)silyl]oxy-diphenylsilane Chemical compound C=1C=CC=CC=1[Si](C=1C=CC=CC=1)(C(C)(C)C)O[Si](C(C)(C)C)(C=1C=CC=CC=1)C1=CC=CC=C1 KJTULOVPMGUBJS-UHFFFAOYSA-N 0.000 description 1
- YHNNTRSKLGPWDV-UHFFFAOYSA-N tert-butyl-[tert-butyl(phenyl)silyl]oxy-phenylsilane Chemical compound C(C)(C)(C)[SiH](C1=CC=CC=C1)O[SiH](C(C)(C)C)C1=CC=CC=C1 YHNNTRSKLGPWDV-UHFFFAOYSA-N 0.000 description 1
- 125000001973 tert-pentyl group Chemical group [H]C([H])([H])C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 229960005353 testolactone Drugs 0.000 description 1
- BPEWUONYVDABNZ-DZBHQSCQSA-N testolactone Chemical compound O=C1C=C[C@]2(C)[C@H]3CC[C@](C)(OC(=O)CC4)[C@@H]4[C@@H]3CCC2=C1 BPEWUONYVDABNZ-DZBHQSCQSA-N 0.000 description 1
- 125000001544 thienyl group Chemical group 0.000 description 1
- 201000002510 thyroid cancer Diseases 0.000 description 1
- 125000006000 trichloroethyl group Chemical group 0.000 description 1
- VYNGFCUGSYEOOZ-UHFFFAOYSA-N triphenylphosphine sulfide Chemical compound C=1C=CC=CC=1P(C=1C=CC=CC=1)(=S)C1=CC=CC=C1 VYNGFCUGSYEOOZ-UHFFFAOYSA-N 0.000 description 1
- 210000003932 urinary bladder Anatomy 0.000 description 1
- 238000005292 vacuum distillation Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Psychology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Neurosurgery (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/400,057 US6013626A (en) | 1993-12-21 | 1995-03-07 | Cryptophycins from synthesis |
| US08/482,141 US5952298A (en) | 1993-12-21 | 1995-06-07 | Cryptophycins |
| PCT/US1996/003246 WO1996040184A1 (en) | 1995-03-07 | 1996-03-07 | New cryptophycins from synthesis |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO974105D0 NO974105D0 (no) | 1997-09-05 |
| NO974105L NO974105L (no) | 1997-11-05 |
| NO326685B1 true NO326685B1 (no) | 2009-01-26 |
Family
ID=27016884
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19974105A NO326685B1 (no) | 1995-03-07 | 1997-09-05 | Kryptofyciner samt anvendelse derav og farmasoytisk blanding |
Country Status (23)
| Country | Link |
|---|---|
| EP (1) | EP0830136B1 (pl) |
| JP (1) | JP4181632B2 (pl) |
| CN (1) | CN1165337C (pl) |
| AP (1) | AP737A (pl) |
| AT (1) | ATE279935T1 (pl) |
| AU (1) | AU723652B2 (pl) |
| BG (1) | BG63289B1 (pl) |
| CZ (1) | CZ278197A3 (pl) |
| DE (1) | DE69633667T2 (pl) |
| ES (1) | ES2230561T3 (pl) |
| FI (1) | FI973591A0 (pl) |
| GE (1) | GEP20002206B (pl) |
| HK (1) | HK1009747A1 (pl) |
| HU (1) | HU225041B1 (pl) |
| MD (1) | MD2196B2 (pl) |
| NO (1) | NO326685B1 (pl) |
| NZ (1) | NZ305571A (pl) |
| OA (1) | OA10614A (pl) |
| PL (1) | PL185949B1 (pl) |
| RO (1) | RO118931B1 (pl) |
| SK (1) | SK119997A3 (pl) |
| TJ (1) | TJ347B (pl) |
| WO (1) | WO1996040184A1 (pl) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000501067A (ja) * | 1995-08-30 | 2000-02-02 | イーライ・リリー・アンド・カンパニー | 医薬化合物 |
| EP0932601A4 (en) * | 1996-08-30 | 2000-02-02 | Lilly Co Eli | METHOD FOR PRODUCING PHARMACEUTICALS |
| US6680311B1 (en) | 1996-08-30 | 2004-01-20 | Eli Lilly And Company | Cryptophycin compounds |
| EA001913B1 (ru) * | 1996-08-30 | 2001-10-22 | Эли Лилли Энд Компани | Фармацевтические соединения |
| KR20010029475A (ko) * | 1996-09-06 | 2001-04-06 | 피터 지. 스트링거 | 약제학적 화합물의 제조 방법 |
| BR9712805A (pt) * | 1996-09-06 | 1999-11-23 | Lilly Co Eli | Processo para a preparação de compostos farmecêuticos |
| CA2263764A1 (en) * | 1996-09-06 | 1998-03-12 | Michael John Martinelli | Process and novel intermediates |
| EP0975610A4 (en) * | 1997-02-26 | 2000-05-17 | Lilly Co Eli | PHARMACEUTICAL COMPOUNDS BASED ON TRIPEPTIDES AND TETRAPEPTIDES |
| WO1998038158A1 (en) * | 1997-02-26 | 1998-09-03 | Eli Lilly And Company | Process for preparing pharmaceutical compounds |
| EP0870510A3 (en) * | 1997-04-11 | 1999-09-15 | Eli Lilly And Company | Synergistic combination comprising cryptophycin derivatives and microtubule synergizing agents |
| EP0870501A1 (en) * | 1997-04-11 | 1998-10-14 | Eli Lilly And Company | Use of specific cryptophycin derivatives for the manufacture of a medicament in the treatment of fungal infections |
| EP0870506A1 (en) * | 1997-04-11 | 1998-10-14 | Eli Lilly And Company | Compositions comprising a cryptophycin compound in combination with a synchronizing or activating agent for treating cancer |
| US6376230B1 (en) | 1998-10-16 | 2002-04-23 | Eli Lilly And Company | Stereoselective process for producing intermediates of cryptophycins |
| CA2347246A1 (en) * | 1998-10-16 | 2000-04-27 | James Abraham Aikins | Stereoselective process for producing cryptophycins |
| US6103913A (en) * | 1998-10-16 | 2000-08-15 | Eli Lilly And Company | Process for preparing enollactone derivatives |
| AU1930100A (en) * | 1998-12-07 | 2000-06-26 | Eli Lilly And Company | Crotylboration process to produce cryptophycin compounds |
| US6372936B1 (en) * | 1999-06-09 | 2002-04-16 | Eli Lilly And Company | Optical resolution of aminoisobobutyric acid |
| FR2947269B1 (fr) | 2009-06-29 | 2013-01-18 | Sanofi Aventis | Nouveaux composes anticancereux |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4868208A (en) * | 1988-07-15 | 1989-09-19 | Merck & Co., Inc. | Antifungal agent and method |
| US4946835A (en) * | 1988-07-15 | 1990-08-07 | Merck & Co., Inc. | Antifungal fermentation product and method |
| US4845086A (en) * | 1988-08-09 | 1989-07-04 | Merck & Co., Inc. | Antifungal agent |
| US4845085A (en) * | 1988-08-09 | 1989-07-04 | Merck & Co., Inc. | Antifungal agent |
| CA2179490A1 (en) * | 1993-12-21 | 1995-06-29 | Trimurtulu Golakoti | New cryptophycins |
-
1996
- 1996-03-07 SK SK1199-97A patent/SK119997A3/sk unknown
- 1996-03-07 TJ TJ97000493A patent/TJ347B/xx unknown
- 1996-03-07 JP JP50044097A patent/JP4181632B2/ja not_active Expired - Lifetime
- 1996-03-07 EP EP96910399A patent/EP0830136B1/en not_active Expired - Lifetime
- 1996-03-07 AU AU53603/96A patent/AU723652B2/en not_active Expired
- 1996-03-07 RO RO97-01693A patent/RO118931B1/ro unknown
- 1996-03-07 HU HU9801880A patent/HU225041B1/hu not_active IP Right Cessation
- 1996-03-07 AT AT96910399T patent/ATE279935T1/de not_active IP Right Cessation
- 1996-03-07 NZ NZ305571A patent/NZ305571A/xx not_active IP Right Cessation
- 1996-03-07 DE DE69633667T patent/DE69633667T2/de not_active Expired - Lifetime
- 1996-03-07 CZ CZ972781A patent/CZ278197A3/cs unknown
- 1996-03-07 WO PCT/US1996/003246 patent/WO1996040184A1/en active IP Right Grant
- 1996-03-07 CN CNB96193140XA patent/CN1165337C/zh not_active Expired - Lifetime
- 1996-03-07 PL PL96322507A patent/PL185949B1/pl unknown
- 1996-03-07 AP APAP/P/1997/001069A patent/AP737A/en active
- 1996-03-07 GE GEAP19963909A patent/GEP20002206B/en unknown
- 1996-03-07 ES ES96910399T patent/ES2230561T3/es not_active Expired - Lifetime
- 1996-03-07 MD MD97-0313A patent/MD2196B2/ro unknown
-
1997
- 1997-09-03 FI FI973591A patent/FI973591A0/fi not_active Application Discontinuation
- 1997-09-04 BG BG101875A patent/BG63289B1/bg unknown
- 1997-09-05 OA OA70070A patent/OA10614A/en unknown
- 1997-09-05 NO NO19974105A patent/NO326685B1/no not_active IP Right Cessation
-
1998
- 1998-09-17 HK HK98110673A patent/HK1009747A1/xx not_active IP Right Cessation
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK1K | Patent expired |