ATE279935T1 - Neue synthetische cryptophycine - Google Patents

Neue synthetische cryptophycine

Info

Publication number
ATE279935T1
ATE279935T1 AT96910399T AT96910399T ATE279935T1 AT E279935 T1 ATE279935 T1 AT E279935T1 AT 96910399 T AT96910399 T AT 96910399T AT 96910399 T AT96910399 T AT 96910399T AT E279935 T1 ATE279935 T1 AT E279935T1
Authority
AT
Austria
Prior art keywords
cryptophycins
new synthetic
synthetic
new
synthetic cryptophycins
Prior art date
Application number
AT96910399T
Other languages
English (en)
Inventor
Richard E Moore
Marcus A Tius
Russell A Barrow
Jian Liang
Thomas H Corbett
Frederick A Valeriote
Thomas K Hemscheidt
Trimurtulu Golakoti
Original Assignee
Univ Hawaii
Univ Wayne State
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/400,057 external-priority patent/US6013626A/en
Priority claimed from US08/482,141 external-priority patent/US5952298A/en
Application filed by Univ Hawaii, Univ Wayne State filed Critical Univ Hawaii
Application granted granted Critical
Publication of ATE279935T1 publication Critical patent/ATE279935T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Reproductive Health (AREA)
  • Psychology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT96910399T 1995-03-07 1996-03-07 Neue synthetische cryptophycine ATE279935T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/400,057 US6013626A (en) 1993-12-21 1995-03-07 Cryptophycins from synthesis
US08/482,141 US5952298A (en) 1993-12-21 1995-06-07 Cryptophycins
PCT/US1996/003246 WO1996040184A1 (en) 1995-03-07 1996-03-07 New cryptophycins from synthesis

Publications (1)

Publication Number Publication Date
ATE279935T1 true ATE279935T1 (de) 2004-11-15

Family

ID=27016884

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96910399T ATE279935T1 (de) 1995-03-07 1996-03-07 Neue synthetische cryptophycine

Country Status (23)

Country Link
EP (1) EP0830136B1 (de)
JP (1) JP4181632B2 (de)
CN (1) CN1165337C (de)
AP (1) AP737A (de)
AT (1) ATE279935T1 (de)
AU (1) AU723652B2 (de)
BG (1) BG63289B1 (de)
CZ (1) CZ278197A3 (de)
DE (1) DE69633667T2 (de)
ES (1) ES2230561T3 (de)
FI (1) FI973591A0 (de)
GE (1) GEP20002206B (de)
HK (1) HK1009747A1 (de)
HU (1) HU225041B1 (de)
MD (1) MD2196B2 (de)
NO (1) NO326685B1 (de)
NZ (1) NZ305571A (de)
OA (1) OA10614A (de)
PL (1) PL185949B1 (de)
RO (1) RO118931B1 (de)
SK (1) SK119997A3 (de)
TJ (1) TJ347B (de)
WO (1) WO1996040184A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0850057A4 (de) * 1995-08-30 2001-04-11 Lilly Co Eli Pharmazeutische zusammensetzungen
US6680311B1 (en) 1996-08-30 2004-01-20 Eli Lilly And Company Cryptophycin compounds
YU10899A (sh) * 1996-08-30 2002-03-18 Eli Lilli And Company Farmaceutska jedinjenja
WO1998008812A1 (en) * 1996-08-30 1998-03-05 Eli Lilly And Company Process for preparing pharmaceutical compounds
HUP0000212A3 (en) * 1996-09-06 2001-12-28 Wayne State University Detroit Process to prepare cryptophycin derivatives and intermediates thereof
IL128497A0 (en) * 1996-09-06 2000-01-31 Lilly Co Eli Process to prepare pharmaceuticals compounds
CA2263764A1 (en) * 1996-09-06 1998-03-12 Michael John Martinelli Process and novel intermediates
CA2281107A1 (en) * 1997-02-26 1998-09-03 Eli Lilly And Company Tripeptide and tetrapeptide pharmaceutical compounds
WO1998038158A1 (en) * 1997-02-26 1998-09-03 Eli Lilly And Company Process for preparing pharmaceutical compounds
EP0870501A1 (de) * 1997-04-11 1998-10-14 Eli Lilly And Company Verwendung von specifischen Cryptophycin Derivaten zur Herstellung eines Medikaments für die Behandlung von Pilzinfektionen
EP0870510A3 (de) * 1997-04-11 1999-09-15 Eli Lilly And Company Synergistische Zusammensetzung enthaltend Cryptophycinderivate und synergistische mikrotubuli Mitteln
EP0870506A1 (de) * 1997-04-11 1998-10-14 Eli Lilly And Company Zusammentsetzungen enthaltend ein Cryptophycin Derivat in Kombination mit einem synchronisierten Wirkstoff oder Aktivierungsmittel zur Behandlung von Krebs
CA2347246A1 (en) * 1998-10-16 2000-04-27 James Abraham Aikins Stereoselective process for producing cryptophycins
US6376230B1 (en) 1998-10-16 2002-04-23 Eli Lilly And Company Stereoselective process for producing intermediates of cryptophycins
US6103913A (en) * 1998-10-16 2000-08-15 Eli Lilly And Company Process for preparing enollactone derivatives
AU1930100A (en) * 1998-12-07 2000-06-26 Eli Lilly And Company Crotylboration process to produce cryptophycin compounds
US6372936B1 (en) * 1999-06-09 2002-04-16 Eli Lilly And Company Optical resolution of aminoisobobutyric acid
FR2947269B1 (fr) 2009-06-29 2013-01-18 Sanofi Aventis Nouveaux composes anticancereux

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4868208A (en) * 1988-07-15 1989-09-19 Merck & Co., Inc. Antifungal agent and method
US4946835A (en) * 1988-07-15 1990-08-07 Merck & Co., Inc. Antifungal fermentation product and method
US4845086A (en) * 1988-08-09 1989-07-04 Merck & Co., Inc. Antifungal agent
US4845085A (en) * 1988-08-09 1989-07-04 Merck & Co., Inc. Antifungal agent
CA2179490A1 (en) * 1993-12-21 1995-06-29 Trimurtulu Golakoti New cryptophycins

Also Published As

Publication number Publication date
MD970313A (en) 1999-06-30
TJ347B (en) 2002-10-06
FI973591A0 (fi) 1997-09-03
JP4181632B2 (ja) 2008-11-19
HUP9801880A3 (en) 1999-08-30
CN1183726A (zh) 1998-06-03
AU5360396A (en) 1996-12-30
DE69633667T2 (de) 2006-03-02
OA10614A (en) 2001-03-15
HUP9801880A2 (hu) 1998-11-30
GEP20002206B (en) 2000-08-25
SK119997A3 (en) 1998-12-02
AU723652B2 (en) 2000-08-31
NO974105D0 (no) 1997-09-05
PL322507A1 (en) 1998-02-02
ES2230561T3 (es) 2005-05-01
PL185949B1 (pl) 2003-09-30
EP0830136B1 (de) 2004-10-20
EP0830136A4 (de) 2001-01-24
NO326685B1 (no) 2009-01-26
HU225041B1 (en) 2006-05-29
BG63289B1 (bg) 2001-09-28
AP9701069A0 (en) 1997-10-30
MD2196B2 (ro) 2003-06-30
BG101875A (en) 1998-10-30
NO974105L (no) 1997-11-05
CZ278197A3 (cs) 1998-12-16
RO118931B1 (ro) 2004-01-30
HK1009747A1 (en) 1999-06-11
WO1996040184A1 (en) 1996-12-19
DE69633667D1 (en) 2004-11-25
NZ305571A (en) 1999-02-25
CN1165337C (zh) 2004-09-08
AP737A (en) 1999-03-15
JPH11510476A (ja) 1999-09-14
EP0830136A1 (de) 1998-03-25

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties