SK10432003A3 - Príprava kyseliny D-pantoténovej a/alebo jej solí ako prísad do krmív - Google Patents
Príprava kyseliny D-pantoténovej a/alebo jej solí ako prísad do krmív Download PDFInfo
- Publication number
- SK10432003A3 SK10432003A3 SK1043-2003A SK10432003A SK10432003A3 SK 10432003 A3 SK10432003 A3 SK 10432003A3 SK 10432003 A SK10432003 A SK 10432003A SK 10432003 A3 SK10432003 A3 SK 10432003A3
- Authority
- SK
- Slovakia
- Prior art keywords
- salts
- pantothenic acid
- polyvalent
- process according
- nanofiltration
- Prior art date
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- GHOKWGTUZJEAQD-UHFFFAOYSA-N pantothenic acid Chemical compound OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 title claims abstract description 159
- 150000003839 salts Chemical class 0.000 title claims abstract description 81
- 238000000034 method Methods 0.000 title claims abstract description 77
- 238000004519 manufacturing process Methods 0.000 title abstract description 16
- 241001465754 Metazoa Species 0.000 title abstract description 4
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 claims description 124
- 238000000855 fermentation Methods 0.000 claims description 71
- 230000004151 fermentation Effects 0.000 claims description 71
- 239000000243 solution Substances 0.000 claims description 66
- UCMIRNVEIXFBKS-UHFFFAOYSA-N beta-alanine Chemical compound NCCC(O)=O UCMIRNVEIXFBKS-UHFFFAOYSA-N 0.000 claims description 63
- 230000008569 process Effects 0.000 claims description 58
- 235000019161 pantothenic acid Nutrition 0.000 claims description 54
- 239000011713 pantothenic acid Substances 0.000 claims description 54
- 238000001728 nano-filtration Methods 0.000 claims description 46
- 229940055726 pantothenic acid Drugs 0.000 claims description 45
- 150000001768 cations Chemical class 0.000 claims description 44
- 239000012528 membrane Substances 0.000 claims description 39
- 239000000203 mixture Substances 0.000 claims description 34
- 229940000635 beta-alanine Drugs 0.000 claims description 26
- 239000002609 medium Substances 0.000 claims description 25
- 239000007864 aqueous solution Substances 0.000 claims description 22
- 239000011575 calcium Substances 0.000 claims description 21
- 238000001035 drying Methods 0.000 claims description 21
- 238000000926 separation method Methods 0.000 claims description 21
- 239000012465 retentate Substances 0.000 claims description 19
- 239000012466 permeate Substances 0.000 claims description 18
- 239000002253 acid Substances 0.000 claims description 17
- 239000001963 growth medium Substances 0.000 claims description 16
- 238000002360 preparation method Methods 0.000 claims description 16
- 238000000108 ultra-filtration Methods 0.000 claims description 16
- 241000193830 Bacillus <bacterium> Species 0.000 claims description 11
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 claims description 10
- 230000015572 biosynthetic process Effects 0.000 claims description 10
- 238000011026 diafiltration Methods 0.000 claims description 10
- 238000005374 membrane filtration Methods 0.000 claims description 10
- 244000005700 microbiome Species 0.000 claims description 10
- 238000009472 formulation Methods 0.000 claims description 9
- 239000007787 solid Substances 0.000 claims description 9
- 230000002074 deregulated effect Effects 0.000 claims description 8
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 7
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims description 7
- 239000003674 animal food additive Substances 0.000 claims description 7
- 229910052791 calcium Inorganic materials 0.000 claims description 7
- FAPWYRCQGJNNSJ-UBKPKTQASA-L calcium D-pantothenic acid Chemical compound [Ca+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-UBKPKTQASA-L 0.000 claims description 7
- 229910052749 magnesium Inorganic materials 0.000 claims description 6
- 239000011777 magnesium Substances 0.000 claims description 6
- 241000894006 Bacteria Species 0.000 claims description 5
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims description 5
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims description 5
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- 239000006052 feed supplement Substances 0.000 claims description 5
- 229960000310 isoleucine Drugs 0.000 claims description 5
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims description 5
- 229910001629 magnesium chloride Inorganic materials 0.000 claims description 5
- 239000004474 valine Substances 0.000 claims description 5
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims description 4
- 241000233866 Fungi Species 0.000 claims description 4
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 4
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 4
- 229910001414 potassium ion Inorganic materials 0.000 claims description 4
- 229910001415 sodium ion Inorganic materials 0.000 claims description 4
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- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims description 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-M Aminoacetate Chemical compound NCC([O-])=O DHMQDGOQFOQNFH-UHFFFAOYSA-M 0.000 claims description 3
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- 229910002651 NO3 Inorganic materials 0.000 claims description 3
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 claims description 3
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 3
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 claims description 3
- 239000011591 potassium Substances 0.000 claims description 3
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- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 10
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 10
- 229910052799 carbon Inorganic materials 0.000 description 10
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- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
- -1 calcium pentanothenate Chemical compound 0.000 description 9
- 101150079396 trpC2 gene Proteins 0.000 description 9
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- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 7
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- 239000013612 plasmid Substances 0.000 description 7
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- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 6
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 6
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 6
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- 239000001110 calcium chloride Substances 0.000 description 6
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- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- PXEDJBXQKAGXNJ-QTNFYWBSSA-L disodium L-glutamate Chemical compound [Na+].[Na+].[O-]C(=O)[C@@H](N)CCC([O-])=O PXEDJBXQKAGXNJ-QTNFYWBSSA-L 0.000 description 6
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- QHKABHOOEWYVLI-UHFFFAOYSA-N 3-methyl-2-oxobutanoic acid Chemical compound CC(C)C(=O)C(O)=O QHKABHOOEWYVLI-UHFFFAOYSA-N 0.000 description 5
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
- A23K10/12—Animal feeding-stuffs obtained by microbiological or biochemical processes by fermentation of natural products, e.g. of vegetable material, animal waste material or biomass
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/174—Vitamins
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82B—NANOSTRUCTURES FORMED BY MANIPULATION OF INDIVIDUAL ATOMS, MOLECULES, OR LIMITED COLLECTIONS OF ATOMS OR MOLECULES AS DISCRETE UNITS; MANUFACTURE OR TREATMENT THEREOF
- B82B3/00—Manufacture or treatment of nanostructures by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Health & Medical Sciences (AREA)
- Animal Husbandry (AREA)
- Food Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- General Health & Medical Sciences (AREA)
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- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physiology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Sustainable Development (AREA)
- Crystallography & Structural Chemistry (AREA)
- Nanotechnology (AREA)
- Manufacturing & Machinery (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Fodder In General (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10108226 | 2001-02-21 | ||
| PCT/EP2002/001754 WO2002066664A2 (de) | 2001-02-21 | 2002-02-20 | Verfahren zur herstellung von d-pantothensäure und/oder salze als zusatz zu tierfuttermitteln |
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|---|---|
| SK10432003A3 true SK10432003A3 (sk) | 2004-02-03 |
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| SK1043-2003A SK10432003A3 (sk) | 2001-02-21 | 2002-02-20 | Príprava kyseliny D-pantoténovej a/alebo jej solí ako prísad do krmív |
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| EP (1) | EP1385975B1 (zh) |
| JP (1) | JP2004524028A (zh) |
| KR (1) | KR20030075205A (zh) |
| CN (1) | CN1294271C (zh) |
| AT (1) | ATE350483T1 (zh) |
| AU (1) | AU2002308290A1 (zh) |
| BR (1) | BRPI0207477B1 (zh) |
| CA (1) | CA2438945A1 (zh) |
| CZ (1) | CZ20032245A3 (zh) |
| DE (1) | DE50209165D1 (zh) |
| EE (1) | EE200300407A (zh) |
| ES (1) | ES2278929T3 (zh) |
| HU (1) | HU230180B1 (zh) |
| IL (1) | IL157495A0 (zh) |
| IN (1) | IN2003CH01314A (zh) |
| MX (1) | MXPA03007455A (zh) |
| NO (1) | NO20033705L (zh) |
| PL (1) | PL364087A1 (zh) |
| RU (1) | RU2003128533A (zh) |
| SK (1) | SK10432003A3 (zh) |
| WO (1) | WO2002066664A2 (zh) |
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| DE10344200A1 (de) * | 2003-09-22 | 2005-05-04 | Basf Ag | Verfahren zur Herstellung eines D-Pantothensäure und/oder deren Salze enthaltendes Tierfuttersupplement |
| FI120590B (fi) * | 2005-10-28 | 2009-12-15 | Danisco Sweeteners Oy | Erotusmenetelmä |
| JP4615470B2 (ja) * | 2006-03-29 | 2011-01-19 | 卓郎 簑和田 | 大脳の認知力を用いた疾患治療・予防の方法および医薬 |
| DE102008031579A1 (de) * | 2008-07-03 | 2010-01-07 | Bayer Materialscience Ag | Ein hocheffizientes Gasphasenverfahren zur Modifizierung und Funktionalisierung von Kohlenstoff-Nanofasern mit Salpetersäuredampf |
| KR200449818Y1 (ko) * | 2008-07-11 | 2010-08-12 | (주)디에스피 | 의자용 허리받침대 |
| KR101105780B1 (ko) * | 2009-09-07 | 2012-01-17 | 김선환 | 요추받이가 구비된 의자용 등받이 |
| MY186792A (en) | 2016-02-04 | 2021-08-20 | Ind Tech Res Inst | Method for separating hydrolysis product of biomass |
| CN110035991B (zh) * | 2017-04-04 | 2022-06-17 | Nnb营养品美国有限公司 | 一步发酵制备(r)-3-羟基丁酸或其盐 |
| CN112592290B (zh) * | 2020-12-14 | 2023-08-11 | 广安摩珈生物科技有限公司 | 泛酸钙粗品纯化方法 |
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| GB526267A (en) | 1938-04-01 | 1940-09-13 | Goldschmidt Ag Th | Process of applying coatings of non-ferrous metals to cast iron |
| GB562267A (en) * | 1941-08-08 | 1944-06-26 | Hoffmann La Roche | Process for the manufacture of a crystallised, non-hygroscopic calcium salt of d-pantothenic acid |
| US4891208A (en) * | 1985-04-10 | 1990-01-02 | The Liposome Company, Inc. | Steroidal liposomes |
| DE3572491D1 (en) * | 1984-07-25 | 1989-09-28 | Ciba Geigy Ag | Phosphatidyl compounds, process for their preparation and their use |
| US5993823A (en) * | 1990-12-18 | 1999-11-30 | Institut Pasteur De Lille | Cytotoxic T lymphocyte-inducing lipopeptides and methods of use |
| EP0493060A3 (en) | 1990-12-25 | 1993-04-14 | Takeda Chemical Industries, Ltd. | Production method of d-pantothenic acid and plasmids and microorganisms thereof |
| JP3710497B2 (ja) * | 1992-09-25 | 2005-10-26 | ビーエーエスエフ アクチェンゲゼルシャフト | Ｄ−パント酸、ｄ−パントテン酸およびそれらの塩の製造法 |
| JPH06114948A (ja) | 1992-10-01 | 1994-04-26 | Shiimetsuto Kk | 未硬化液排出口付光硬化造形物とその造形法 |
| US5888821A (en) * | 1994-12-28 | 1999-03-30 | Max-Delbruck-Centrum Fur Molekulare Medizin | Cholesterol derivative for liposomal gene transfer |
| SK282858B6 (sk) * | 1995-04-21 | 2002-12-03 | Basf Aktiengesellschaft | Spôsob výroby D-pantotenátu vápenatého |
| CN1142997C (zh) | 1995-09-13 | 2004-03-24 | Basf公司 | 生产d-泛解酸和d-泛酸或其盐的方法 |
| US6063428A (en) * | 1996-02-26 | 2000-05-16 | The Procter & Gamble Company | Green tea extract subjected to cation exchange treatment and nanofiltration to improve clarity and color |
| US5814498A (en) * | 1996-04-29 | 1998-09-29 | Archer Daniels Midland Company | Process for the recovery of organic acids and ammonia from their salts |
| TW391881B (en) * | 1996-09-25 | 2000-06-01 | Baxter Int | Method and apparatus for filtering suspensions of medical and biological fluids or the like |
| US7267967B1 (en) | 1997-10-04 | 2007-09-11 | Forschungszentrum Julich Gmbh | Nucleic acid encoding pyruvate carboxylase from coryneform glutamicum |
| CA2311505A1 (en) | 1997-11-26 | 1999-06-03 | Novo Nordisk A/S | Enzymatic starch saccharification including a membrane separation step |
| AT407050B (de) | 1997-12-29 | 2000-11-27 | Chemie Linz Gmbh | Verfahren zur herstellung von l-asparaginsäure |
| DE19846499A1 (de) | 1998-10-09 | 2000-04-20 | Degussa | Verfahren zur Herstellung von Pantothensäure durch Verstärkung von für Ketopantoat-Reduktase kodierenden Nukleotidsequenzen |
| DE19855313A1 (de) * | 1998-12-01 | 2000-06-08 | Degussa | Verfahren zur fermentativen Herstellung von D-Pantothensäure durch Verstärkung des panD-Gens in Mikroorganismen |
| JP3236828B2 (ja) * | 1999-01-27 | 2001-12-10 | 雪印乳業株式会社 | 乳カルシウム組成物 |
| FR2791701B1 (fr) | 1999-04-02 | 2003-05-23 | Roquette Freres | Procede de fabrication d'un hydrolysat d'amidon a haute teneur en dextrose |
| PT1050219E (pt) * | 1999-05-05 | 2003-04-30 | Degussa | Aditivos alimentares para animais contendo acido d-pantotenico e/ou seus sais e processo para a sua preparacao |
| CA2385497A1 (en) | 1999-09-21 | 2001-03-29 | Basf Aktiengesellschaft | Methods and microorganisms for production of panto-compounds |
| WO2002005747A2 (en) | 2000-07-14 | 2002-01-24 | Cadila Pharmaceuticals Limited | The process of manufacturing pharmaceutical grade tannates |
| EP1318725A2 (de) | 2000-09-20 | 2003-06-18 | Basf Aktiengesellschaft | Tierfuttersupplement enthaltend d-pantothensäure und/oder deren salze, verbessertes verfahren zu dessen herstellung sowie dessen verwendung |
| EP1390519B1 (en) | 2001-01-19 | 2006-12-06 | BASF Aktiengesellschaft | Microorganisms and processes for enhanced production of pantothenate |
| EE200300438A (et) * | 2001-03-09 | 2003-12-15 | Basf Aktiengesellschaft | Pantoteenhappe võimendatud produktsiooni meetod |
-
2002
- 2002-02-20 EE EEP200300407A patent/EE200300407A/xx unknown
- 2002-02-20 WO PCT/EP2002/001754 patent/WO2002066664A2/de active IP Right Grant
- 2002-02-20 CA CA002438945A patent/CA2438945A1/en not_active Abandoned
- 2002-02-20 IL IL15749502A patent/IL157495A0/xx unknown
- 2002-02-20 JP JP2002566368A patent/JP2004524028A/ja active Pending
- 2002-02-20 HU HU0303299A patent/HU230180B1/hu not_active IP Right Cessation
- 2002-02-20 SK SK1043-2003A patent/SK10432003A3/sk unknown
- 2002-02-20 KR KR20037010982A patent/KR20030075205A/ko not_active Application Discontinuation
- 2002-02-20 US US10/468,564 patent/US7611872B2/en not_active Expired - Fee Related
- 2002-02-20 MX MXPA03007455A patent/MXPA03007455A/es unknown
- 2002-02-20 CZ CZ20032245A patent/CZ20032245A3/cs unknown
- 2002-02-20 EP EP02742430A patent/EP1385975B1/de not_active Expired - Lifetime
- 2002-02-20 DE DE50209165T patent/DE50209165D1/de not_active Expired - Lifetime
- 2002-02-20 AT AT02742430T patent/ATE350483T1/de not_active IP Right Cessation
- 2002-02-20 RU RU2003128533/13A patent/RU2003128533A/ru not_active Application Discontinuation
- 2002-02-20 PL PL02364087A patent/PL364087A1/xx not_active Application Discontinuation
- 2002-02-20 ES ES02742430T patent/ES2278929T3/es not_active Expired - Lifetime
- 2002-02-20 AU AU2002308290A patent/AU2002308290A1/en not_active Abandoned
- 2002-02-20 BR BRPI0207477-0A patent/BRPI0207477B1/pt not_active IP Right Cessation
- 2002-02-20 CN CNB028052749A patent/CN1294271C/zh not_active Expired - Fee Related
-
2003
- 2003-08-20 NO NO20033705A patent/NO20033705L/no not_active Application Discontinuation
- 2003-08-21 IN IN1314CH2003 patent/IN2003CH01314A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2438945A1 (en) | 2002-08-29 |
| ES2278929T3 (es) | 2007-08-16 |
| NO20033705L (no) | 2003-10-16 |
| HUP0303299A2 (hu) | 2004-01-28 |
| RU2003128533A (ru) | 2005-04-10 |
| MXPA03007455A (es) | 2004-07-30 |
| ATE350483T1 (de) | 2007-01-15 |
| WO2002066664A2 (de) | 2002-08-29 |
| WO2002066664A3 (de) | 2003-12-04 |
| EP1385975A2 (de) | 2004-02-04 |
| CN1492933A (zh) | 2004-04-28 |
| DE50209165D1 (de) | 2007-02-15 |
| AU2002308290A1 (en) | 2002-09-04 |
| NO20033705D0 (no) | 2003-08-20 |
| CZ20032245A3 (cs) | 2003-11-12 |
| EE200300407A (et) | 2003-12-15 |
| JP2004524028A (ja) | 2004-08-12 |
| HUP0303299A3 (en) | 2007-09-28 |
| BRPI0207477B1 (pt) | 2015-05-26 |
| PL364087A1 (en) | 2004-12-13 |
| US7611872B2 (en) | 2009-11-03 |
| US20040053374A1 (en) | 2004-03-18 |
| CN1294271C (zh) | 2007-01-10 |
| BR0207477A (pt) | 2004-08-10 |
| IL157495A0 (en) | 2004-03-28 |
| KR20030075205A (ko) | 2003-09-22 |
| HU230180B1 (hu) | 2015-09-28 |
| EP1385975B1 (de) | 2007-01-03 |
| IN2003CH01314A (en) | 2005-11-25 |
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