SI9520091B - Soli anti-migrenskega derivata indola - Google Patents

Soli anti-migrenskega derivata indola Download PDF

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Publication number
SI9520091B
SI9520091B SI9520091A SI9520091A SI9520091B SI 9520091 B SI9520091 B SI 9520091B SI 9520091 A SI9520091 A SI 9520091A SI 9520091 A SI9520091 A SI 9520091A SI 9520091 B SI9520091 B SI 9520091B
Authority
SI
Slovenia
Prior art keywords
compound
formula
polymorphic form
solvent
suitable solvent
Prior art date
Application number
SI9520091A
Other languages
English (en)
Slovenian (sl)
Other versions
SI9520091A (sl
Inventor
Valerie Denise Harding
Ross James Macrae
Ronald James Ogilvie
Original Assignee
Pfizer Research And Development Company, N.V./S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10760474&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI9520091(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Research And Development Company, N.V./S.A. filed Critical Pfizer Research And Development Company, N.V./S.A.
Publication of SI9520091A publication Critical patent/SI9520091A/sl
Publication of SI9520091B publication Critical patent/SI9520091B/sl

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Child & Adolescent Psychology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Toxicology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Nutrition Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Reciprocating, Oscillating Or Vibrating Motors (AREA)
SI9520091A 1994-08-27 1995-05-17 Soli anti-migrenskega derivata indola SI9520091B (sl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9417310A GB9417310D0 (en) 1994-08-27 1994-08-27 Therapeutic agents
PCT/EP1995/001914 WO1996006842A1 (en) 1994-08-27 1995-05-17 Salts of an anti-migraine indole derivative

Publications (2)

Publication Number Publication Date
SI9520091A SI9520091A (sl) 1998-02-28
SI9520091B true SI9520091B (sl) 2004-10-31

Family

ID=10760474

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9520091A SI9520091B (sl) 1994-08-27 1995-05-17 Soli anti-migrenskega derivata indola

Country Status (45)

Country Link
US (2) US6110940A (bg)
EP (1) EP0776323B1 (bg)
JP (1) JP2904588B2 (bg)
KR (1) KR100228952B1 (bg)
CN (1) CN1066727C (bg)
AP (1) AP576A (bg)
AT (1) ATE163182T1 (bg)
AU (1) AU691005B2 (bg)
BG (1) BG61840B1 (bg)
BR (1) BRPI9503812B1 (bg)
CA (1) CA2198599C (bg)
CO (1) CO4410334A1 (bg)
CZ (1) CZ287693B6 (bg)
DE (1) DE69501620T2 (bg)
DK (1) DK0776323T3 (bg)
DZ (1) DZ1923A1 (bg)
EG (1) EG23822A (bg)
ES (1) ES2112650T3 (bg)
FI (1) FI113768B (bg)
GB (1) GB9417310D0 (bg)
GR (1) GR3026475T3 (bg)
HR (1) HRP950460B1 (bg)
HU (1) HU227822B1 (bg)
IL (1) IL115013A (bg)
IS (1) IS1850B (bg)
LV (1) LV11800B (bg)
MA (1) MA23650A1 (bg)
MX (1) MX9701538A (bg)
MY (1) MY113733A (bg)
NO (1) NO311297B1 (bg)
NZ (1) NZ288210A (bg)
OA (1) OA10600A (bg)
PE (1) PE41596A1 (bg)
PL (1) PL180867B1 (bg)
RO (1) RO116400B1 (bg)
RU (1) RU2159241C2 (bg)
SA (1) SA95160156B1 (bg)
SI (1) SI9520091B (bg)
SK (1) SK282922B6 (bg)
TN (1) TNSN95092A1 (bg)
TR (1) TR199501061A2 (bg)
UA (1) UA45980C2 (bg)
WO (1) WO1996006842A1 (bg)
YU (1) YU49287B (bg)
ZA (1) ZA957142B (bg)

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GB9922963D0 (en) * 1999-09-28 1999-12-01 Pfizer Ltd Polymorphic salt
GB9915231D0 (en) 1999-06-29 1999-09-01 Pfizer Ltd Pharmaceutical complex
GB9923314D0 (en) 1999-10-01 1999-12-08 Pfizer Ltd Acylation process
CA2324116A1 (en) * 1999-10-25 2001-04-25 Susan Beth Sobolov-Jaynes Nk-1 receptor antagonists and eletriptan for the treatment of migraine
US7108970B2 (en) 2000-01-07 2006-09-19 Transform Pharmaceuticals, Inc. Rapid identification of conditions, compounds, or compositions that inhibit, prevent, induce, modify, or reverse transitions of physical state
US6977723B2 (en) 2000-01-07 2005-12-20 Transform Pharmaceuticals, Inc. Apparatus and method for high-throughput preparation and spectroscopic classification and characterization of compositions
GB0008563D0 (en) 2000-04-07 2000-05-24 Cambridge Discovery Chemistry Investigating different physical and/or chemical forms of materials
GB0018968D0 (en) * 2000-08-02 2000-09-20 Pfizer Ltd Particulate composition
US20030166704A1 (en) * 2000-12-20 2003-09-04 Pfizer Inc. New process
US6579898B2 (en) 2001-03-01 2003-06-17 Pfizer Inc. Compositions having improved bioavailability
BRPI0409127A (pt) 2003-04-11 2006-03-28 Pfizer combinação farmacêutica compreendendo eletriptano e bicarbonato de sódio
GB0312478D0 (en) * 2003-05-30 2003-07-09 Pfizer Ltd Improved process
US7132549B2 (en) 2003-05-30 2006-11-07 Pfizer Inc. Process
US6927296B2 (en) 2003-07-23 2005-08-09 Pfizer Inc. Process
GB0317229D0 (en) * 2003-07-23 2003-08-27 Pfizer Ltd Improved process
US7241805B2 (en) 2005-06-27 2007-07-10 Biovail Laboratories, Inc. Modified release formulations of a bupropion salt
BRPI0715579A2 (pt) * 2006-10-19 2015-05-26 Auspex Pharmaceuticals Inc "composto, composição farmacêutica e uso de um composto"
US20080139510A1 (en) * 2006-12-07 2008-06-12 Abe Rose Treatment of migraine headaches with sublingual amino acids
EP1956018A1 (de) * 2007-02-06 2008-08-13 Boehringer Ingelheim Pharma GmbH & Co. KG Verfahren zur Herstellung eines Benzimidazolderivats
US20080287519A1 (en) * 2007-05-01 2008-11-20 Marioara Mendelovici Amorphous eletriptan hydrobromide and process for preparing it and other forms of eletriptan hydrobromide
WO2008150500A1 (en) * 2007-05-29 2008-12-11 Plus Chemicals, S.A. A process for preparing 5-bromo-3-[(r)-1-methyl-pyrrolidin-2-ylmethyl]-1h-indole
US20100285075A1 (en) * 2007-12-17 2010-11-11 Actavis Group Ptc Ehf Novel Hemioxalate Salt of Eletriptan
US20090299077A1 (en) * 2008-05-22 2009-12-03 Vinod Kumar Kansal Salts of (R)-5-(2phenylsulphonylethenyl)-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole, 5-bromo-3-[(R)-1-methyl-pyrrolidin-2-ylmethyl]-1H-indole and of eletriptan
CA2731041C (en) * 2008-08-07 2016-09-06 Biovail Laboratories International Srl Bupropion hydrobromide polymorphs
US20120027816A1 (en) * 2009-02-25 2012-02-02 Actavis Group Ptc Ehf Highly pure eletriptan or a pharmaceutically acceptable salt thereof substantially free of eletriptan n-oxide impurity
WO2010116386A2 (en) * 2009-04-08 2010-10-14 Biophore India Pharmaceuticals Pvt. Ltd. Novel polymorph of eletriptan hydrobromide and process for the preparation thereof
IT1393700B1 (it) 2009-04-22 2012-05-08 F S I Fabbrica Italiana Sint Sintesi di 3-{[(2r)-1-metilpirrolidin-2-il]metil}-5-[2-(fenilsulfonil)etil]-1h-indolo
WO2011004391A2 (en) * 2009-06-25 2011-01-13 Matrix Laboratories Ltd An improved process for the preparation of eletriptan and its salt thereof
WO2011089614A1 (en) * 2010-01-19 2011-07-28 Sms Pharmaceuticals Limited PROCESS FOR PREPARING ELETRIPTAN HYDROBROMIDE HAVING α-FORM
WO2014063752A1 (en) 2012-10-26 2014-05-01 Synthon Bv Process for making crystalline form alpha of eletriptan hydrobromide
JP2019502761A (ja) 2016-01-21 2019-01-31 ラボラトリオス レヴィ エセエレ （（ｒ）−３−［（−１−メチルピロリジン−２−イル）メチル］−５−（２−フェニルスルホニルエチル）−１ｈ−インドールを作製する方法

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Also Published As

Publication number Publication date
IS1850B (is) 2003-02-07
DE69501620D1 (de) 1998-03-19
TNSN95092A1 (fr) 1996-02-06
SA95160156B1 (ar) 2005-05-30
BR9503812A (pt) 1996-04-16
NZ288210A (en) 1998-01-26
RO116400B1 (ro) 2001-01-30
LV11800B (en) 1997-10-20
PL180867B1 (pl) 2001-04-30
SK24897A3 (en) 1998-08-05
CA2198599C (en) 2000-06-06
NO970861D0 (no) 1997-02-26
US6380226B1 (en) 2002-04-30
HRP950460A2 (en) 1997-08-31
BG101250A (bg) 1997-09-30
MX9701538A (es) 1997-05-31
BRPI9503812B1 (pt) 2017-04-18
KR970705557A (ko) 1997-10-09
AP576A (en) 1997-03-20
HUT77310A (hu) 1998-03-30
IL115013A (en) 2000-11-21
AU691005B2 (en) 1998-05-07
CO4410334A1 (es) 1997-01-09
RU2159241C2 (ru) 2000-11-20
NO970861L (no) 1997-02-26
LV11800A (lv) 1997-06-20
AU2735295A (en) 1996-03-22
JP2904588B2 (ja) 1999-06-14
ZA957142B (en) 1997-02-25
CZ56397A3 (cs) 1998-05-13
TR199501061A2 (tr) 1996-06-21
MY113733A (en) 2002-05-31
US6110940A (en) 2000-08-29
CZ287693B6 (en) 2001-01-17
HU227822B1 (en) 2012-03-28
GB9417310D0 (en) 1994-10-19
AP9500754A0 (en) 1995-07-31
NO311297B1 (no) 2001-11-12
PL318319A1 (en) 1997-06-09
SI9520091A (sl) 1998-02-28
IL115013A0 (en) 1995-12-08
SK282922B6 (sk) 2003-01-09
IS4401A (is) 1996-12-19
FI113768B (fi) 2004-06-15
FI970800A (fi) 1997-02-26
UA45980C2 (uk) 2002-05-15
JPH09512283A (ja) 1997-12-09
MA23650A1 (fr) 1996-04-01
OA10600A (en) 2000-04-06
FI970800A0 (fi) 1997-02-26
DE69501620T2 (de) 1998-07-02
CA2198599A1 (en) 1996-03-07
ATE163182T1 (de) 1998-02-15
DK0776323T3 (da) 1998-03-30
PE41596A1 (es) 1996-10-12
KR100228952B1 (ko) 1999-11-01
EP0776323A1 (en) 1997-06-04
EG23822A (en) 2007-09-19
HRP950460B1 (en) 2000-02-29
CN1155886A (zh) 1997-07-30
YU49287B (sh) 2005-03-15
CN1066727C (zh) 2001-06-06
DZ1923A1 (fr) 2002-02-17
EP0776323B1 (en) 1998-02-11
ES2112650T3 (es) 1998-04-01
BG61840B1 (bg) 1998-07-31
GR3026475T3 (en) 1998-06-30
WO1996006842A1 (en) 1996-03-07
YU56995A (sh) 1998-07-10

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