CZ56397A3 - Soli derivátů indolu - Google Patents

Soli derivátů indolu

Info

Publication number
CZ56397A3
CZ56397A3 CZ97563A CZ56397A CZ56397A3 CZ 56397 A3 CZ56397 A3 CZ 56397A3 CZ 97563 A CZ97563 A CZ 97563A CZ 56397 A CZ56397 A CZ 56397A CZ 56397 A3 CZ56397 A3 CZ 56397A3
Authority
CZ
Czechia
Prior art keywords
salts
indole derivatives
indole
derivatives
Prior art date
Application number
CZ97563A
Other languages
English (en)
Other versions
CZ287693B6 (en
Inventor
Valerie Denise Harding
Ross James Macrae
Ronald James Ogilvie
Original Assignee
Pfizer Research And Development Company, N. V. /S. A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10760474&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CZ56397(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Research And Development Company, N. V. /S. A. filed Critical Pfizer Research And Development Company, N. V. /S. A.
Publication of CZ56397A3 publication Critical patent/CZ56397A3/cs
Publication of CZ287693B6 publication Critical patent/CZ287693B6/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Child & Adolescent Psychology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Toxicology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Nutrition Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Reciprocating, Oscillating Or Vibrating Motors (AREA)
CZ1997563A 1994-08-27 1995-05-17 Hydrobromide salt of 3-(N-methyl-2(R)pyrrolidinylmethyl)-5-(2-phenylsulfonylethyl)-1H-indole, process of its preparation, use and pharmaceutical preparation based thereon CZ287693B6 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9417310A GB9417310D0 (en) 1994-08-27 1994-08-27 Therapeutic agents

Publications (2)

Publication Number Publication Date
CZ56397A3 true CZ56397A3 (cs) 1998-05-13
CZ287693B6 CZ287693B6 (en) 2001-01-17

Family

ID=10760474

Family Applications (1)

Application Number Title Priority Date Filing Date
CZ1997563A CZ287693B6 (en) 1994-08-27 1995-05-17 Hydrobromide salt of 3-(N-methyl-2(R)pyrrolidinylmethyl)-5-(2-phenylsulfonylethyl)-1H-indole, process of its preparation, use and pharmaceutical preparation based thereon

Country Status (45)

Country Link
US (2) US6110940A (cs)
EP (1) EP0776323B1 (cs)
JP (1) JP2904588B2 (cs)
KR (1) KR100228952B1 (cs)
CN (1) CN1066727C (cs)
AP (1) AP576A (cs)
AT (1) ATE163182T1 (cs)
AU (1) AU691005B2 (cs)
BG (1) BG61840B1 (cs)
BR (1) BRPI9503812B1 (cs)
CA (1) CA2198599C (cs)
CO (1) CO4410334A1 (cs)
CZ (1) CZ287693B6 (cs)
DE (1) DE69501620T2 (cs)
DK (1) DK0776323T3 (cs)
DZ (1) DZ1923A1 (cs)
EG (1) EG23822A (cs)
ES (1) ES2112650T3 (cs)
FI (1) FI113768B (cs)
GB (1) GB9417310D0 (cs)
GR (1) GR3026475T3 (cs)
HR (1) HRP950460B1 (cs)
HU (1) HU227822B1 (cs)
IL (1) IL115013A (cs)
IS (1) IS1850B (cs)
LV (1) LV11800B (cs)
MA (1) MA23650A1 (cs)
MX (1) MX9701538A (cs)
MY (1) MY113733A (cs)
NO (1) NO311297B1 (cs)
NZ (1) NZ288210A (cs)
OA (1) OA10600A (cs)
PE (1) PE41596A1 (cs)
PL (1) PL180867B1 (cs)
RO (1) RO116400B1 (cs)
RU (1) RU2159241C2 (cs)
SA (1) SA95160156B1 (cs)
SI (1) SI9520091B (cs)
SK (1) SK282922B6 (cs)
TN (1) TNSN95092A1 (cs)
TR (1) TR199501061A2 (cs)
UA (1) UA45980C2 (cs)
WO (1) WO1996006842A1 (cs)
YU (1) YU49287B (cs)
ZA (1) ZA957142B (cs)

Families Citing this family (37)

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GB9420529D0 (en) 1994-10-12 1994-11-30 Pfizer Ltd Indoles
GB9706089D0 (en) * 1997-03-24 1997-05-14 Scherer Ltd R P Pharmaceutical composition
GB9714081D0 (en) * 1997-07-03 1997-09-10 Pfizer Ltd Pharmaceutical compositions
ID24528A (id) * 1997-07-03 2000-07-20 Pfizer Komposisi-komposisi obat farmasi yang mengandung eletriptan hemisulfat dan kafein
GB9816556D0 (en) * 1998-07-30 1998-09-30 Pfizer Ltd Therapy
GB9825988D0 (en) * 1998-11-27 1999-01-20 Pfizer Ltd Indole derivatives
GB9922963D0 (en) * 1999-09-28 1999-12-01 Pfizer Ltd Polymorphic salt
GB9915231D0 (en) 1999-06-29 1999-09-01 Pfizer Ltd Pharmaceutical complex
GB9923314D0 (en) 1999-10-01 1999-12-08 Pfizer Ltd Acylation process
JP2001172178A (ja) * 1999-10-25 2001-06-26 Pfizer Prod Inc 偏頭痛治療用のｎｋ−１レセプターアンタゴニスト及びエレトリプタン
US7108970B2 (en) 2000-01-07 2006-09-19 Transform Pharmaceuticals, Inc. Rapid identification of conditions, compounds, or compositions that inhibit, prevent, induce, modify, or reverse transitions of physical state
US6977723B2 (en) 2000-01-07 2005-12-20 Transform Pharmaceuticals, Inc. Apparatus and method for high-throughput preparation and spectroscopic classification and characterization of compositions
GB0008563D0 (en) 2000-04-07 2000-05-24 Cambridge Discovery Chemistry Investigating different physical and/or chemical forms of materials
GB0018968D0 (en) * 2000-08-02 2000-09-20 Pfizer Ltd Particulate composition
US20030166704A1 (en) * 2000-12-20 2003-09-04 Pfizer Inc. New process
US6579898B2 (en) 2001-03-01 2003-06-17 Pfizer Inc. Compositions having improved bioavailability
MXPA05010070A (es) 2003-04-11 2005-11-23 Pfizer Combinacion farmaceutica.
GB0312478D0 (en) * 2003-05-30 2003-07-09 Pfizer Ltd Improved process
US7132549B2 (en) 2003-05-30 2006-11-07 Pfizer Inc. Process
GB0317229D0 (en) * 2003-07-23 2003-08-27 Pfizer Ltd Improved process
US6927296B2 (en) 2003-07-23 2005-08-09 Pfizer Inc. Process
CA2578626C (en) 2005-06-27 2011-07-19 Biovail Laboratories International S.R.L. Modified-release formulations of a bupropion salt
EP2081893B1 (en) * 2006-10-19 2011-03-23 Auspex Pharmaceuticals, Inc. Substituted indoles
US20080139510A1 (en) * 2006-12-07 2008-06-12 Abe Rose Treatment of migraine headaches with sublingual amino acids
EP1956018A1 (de) * 2007-02-06 2008-08-13 Boehringer Ingelheim Pharma GmbH & Co. KG Verfahren zur Herstellung eines Benzimidazolderivats
EP2093225A1 (en) 2007-05-01 2009-08-26 Plus Chemicals B.V. Process for preparing crystalline eletriptan hydrobromide form ß
US20080319205A1 (en) * 2007-05-29 2008-12-25 Roman Bednar Process for preparing 5-bromo-3-[(R)-1-methyl-pyrrolidin-2-ylmethyl]-1H-indole
EP2225224A2 (en) * 2007-12-17 2010-09-08 Actavis Group PTC EHF Novel hemioxalate salt of eletriptan
US20090299077A1 (en) * 2008-05-22 2009-12-03 Vinod Kumar Kansal Salts of (R)-5-(2phenylsulphonylethenyl)-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole, 5-bromo-3-[(R)-1-methyl-pyrrolidin-2-ylmethyl]-1H-indole and of eletriptan
WO2010015692A2 (en) 2008-08-07 2010-02-11 Biovail Laboratories International Srl Bupropion hydrobromide polymorphs
US20120027816A1 (en) * 2009-02-25 2012-02-02 Actavis Group Ptc Ehf Highly pure eletriptan or a pharmaceutically acceptable salt thereof substantially free of eletriptan n-oxide impurity
WO2010116386A2 (en) * 2009-04-08 2010-10-14 Biophore India Pharmaceuticals Pvt. Ltd. Novel polymorph of eletriptan hydrobromide and process for the preparation thereof
IT1393700B1 (it) 2009-04-22 2012-05-08 F S I Fabbrica Italiana Sint Sintesi di 3-{[(2r)-1-metilpirrolidin-2-il]metil}-5-[2-(fenilsulfonil)etil]-1h-indolo
WO2011004391A2 (en) 2009-06-25 2011-01-13 Matrix Laboratories Ltd An improved process for the preparation of eletriptan and its salt thereof
US8754239B2 (en) 2010-01-19 2014-06-17 Sms Pharmaceuticals Limited Process for preparing eletriptan hydrobromide having α-form
WO2014063752A1 (en) 2012-10-26 2014-05-01 Synthon Bv Process for making crystalline form alpha of eletriptan hydrobromide
WO2017125351A1 (en) 2016-01-21 2017-07-27 Laboratorios Lesvi Sl Process for preparing (( r)-3-[(-1-methylpyrrolidin-2-yl)methyl]-5-(2-phenylsulfonylethyl)-1h-indole

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US3037031A (en) * 1959-08-04 1962-05-29 Warner Lambert Pharmaceutical Derivatives of 3-(2-aminoalkyl)-5-indolol and process therefor
GB893707A (en) * 1960-03-01 1962-04-11 Roche Products Ltd Novel tryptamine derivatives and a process for the manufacture thereof
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ZW19381A1 (en) * 1980-08-12 1983-03-09 Glaxo Group Ltd Heterocyclic compounds
US4803218A (en) * 1982-09-29 1989-02-07 Mcneilab, Inc. 3-aminoalkyl-1H-indole-5-urea and amide derivatives
GB8600397D0 (en) * 1986-01-08 1986-02-12 Glaxo Group Ltd Chemical compounds
DK158590D0 (da) * 1990-07-02 1990-07-02 Lundbeck & Co As H Indolderivater
US5559129A (en) * 1990-10-15 1996-09-24 Pfizer Inc Indole derivatives
US5559246A (en) * 1990-10-15 1996-09-24 Pfizer Inc. Indole derivatives
ATE157361T1 (de) * 1990-10-15 1997-09-15 Pfizer Indolderivate
US5545644A (en) * 1990-10-15 1996-08-13 Pfizer Inc. Indole derivatives
US5578612A (en) * 1990-10-15 1996-11-26 Pfizer Inc. Indole derivatives
US5208248A (en) * 1991-01-11 1993-05-04 Merck Sharpe & Dohme, Ltd. Indazole-substituted five-membered heteroaromatic compounds
SK278998B6 (sk) * 1991-02-01 1998-05-06 Merck Sharp & Dohme Limited Deriváty imidazolu, triazolu a tetrazolu, spôsob i
BR9206810A (pt) * 1991-11-25 1995-10-31 Pfizer Derivados de indol
GB9201038D0 (en) * 1992-01-16 1992-03-11 Glaxo Group Ltd Chemical compounds
US5409941A (en) * 1992-02-03 1995-04-25 Pfizer Inc. 5-heteroyl indole derivatives
TW288010B (cs) * 1992-03-05 1996-10-11 Pfizer
EP0635017A1 (en) * 1992-04-07 1995-01-25 Pfizer Inc. Indole derivatives as 5-ht1 agonists
AU670270B2 (en) * 1992-04-10 1996-07-11 Pfizer Inc. Acylaminoindole derivatives as 5-HT1 agonists
GB9207930D0 (en) * 1992-04-10 1992-05-27 Pfizer Ltd Indoles
GB9208161D0 (en) * 1992-04-14 1992-05-27 Pfizer Ltd Indoles
GB9210400D0 (en) * 1992-05-15 1992-07-01 Merck Sharp & Dohme Therapeutic agents
FR2701026B1 (fr) * 1993-02-02 1995-03-31 Adir Nouveaux dérivés de l'indole, de l'indazole et du benzisoxazole, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
US5607960A (en) * 1993-04-22 1997-03-04 Pfizer Inc. Indole derivatives as 5-HT1-like agonists for use in migraine
AP486A (en) * 1993-04-27 1996-04-16 Pfizer Indole derivatives.
DK0716649T3 (da) * 1993-08-31 1999-02-08 Pfizer 5-Arylindolderivater

Also Published As

Publication number Publication date
FI970800A0 (fi) 1997-02-26
CO4410334A1 (es) 1997-01-09
LV11800A (lv) 1997-06-20
MA23650A1 (fr) 1996-04-01
WO1996006842A1 (en) 1996-03-07
CN1155886A (zh) 1997-07-30
DE69501620T2 (de) 1998-07-02
PE41596A1 (es) 1996-10-12
FI113768B (fi) 2004-06-15
ZA957142B (en) 1997-02-25
KR100228952B1 (ko) 1999-11-01
YU49287B (sh) 2005-03-15
EP0776323B1 (en) 1998-02-11
BG61840B1 (bg) 1998-07-31
KR970705557A (ko) 1997-10-09
HU227822B1 (en) 2012-03-28
AP9500754A0 (en) 1995-07-31
CA2198599A1 (en) 1996-03-07
DK0776323T3 (da) 1998-03-30
AU2735295A (en) 1996-03-22
SA95160156B1 (ar) 2005-05-30
SK24897A3 (en) 1998-08-05
MX9701538A (es) 1997-05-31
IL115013A (en) 2000-11-21
US6110940A (en) 2000-08-29
YU56995A (sh) 1998-07-10
JPH09512283A (ja) 1997-12-09
JP2904588B2 (ja) 1999-06-14
SI9520091B (sl) 2004-10-31
EG23822A (en) 2007-09-19
MY113733A (en) 2002-05-31
HRP950460A2 (en) 1997-08-31
IL115013A0 (en) 1995-12-08
UA45980C2 (uk) 2002-05-15
TNSN95092A1 (fr) 1996-02-06
PL180867B1 (pl) 2001-04-30
ES2112650T3 (es) 1998-04-01
GB9417310D0 (en) 1994-10-19
CA2198599C (en) 2000-06-06
SI9520091A (sl) 1998-02-28
ATE163182T1 (de) 1998-02-15
NO970861L (no) 1997-02-26
AP576A (en) 1997-03-20
OA10600A (en) 2000-04-06
LV11800B (en) 1997-10-20
IS1850B (is) 2003-02-07
RU2159241C2 (ru) 2000-11-20
NO311297B1 (no) 2001-11-12
HRP950460B1 (en) 2000-02-29
BR9503812A (pt) 1996-04-16
DE69501620D1 (de) 1998-03-19
IS4401A (is) 1996-12-19
PL318319A1 (en) 1997-06-09
CZ287693B6 (en) 2001-01-17
DZ1923A1 (fr) 2002-02-17
SK282922B6 (sk) 2003-01-09
EP0776323A1 (en) 1997-06-04
HUT77310A (hu) 1998-03-30
US6380226B1 (en) 2002-04-30
NZ288210A (en) 1998-01-26
RO116400B1 (ro) 2001-01-30
AU691005B2 (en) 1998-05-07
CN1066727C (zh) 2001-06-06
FI970800A (fi) 1997-02-26
GR3026475T3 (en) 1998-06-30
BG101250A (en) 1997-09-30
NO970861D0 (no) 1997-02-26
BRPI9503812B1 (pt) 2017-04-18
TR199501061A2 (tr) 1996-06-21

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Legal Events

Date Code Title Description
PD00 Pending as of 2000-06-30 in czech republic
MK4A Patent expired

Effective date: 20150517

MK4A Patent expired

Effective date: 20151214