SI9400091A - Substituted pyrrolo(2,3-b)pyridine derivatives - Google Patents

Substituted pyrrolo(2,3-b)pyridine derivatives Download PDF

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Publication number
SI9400091A
SI9400091A SI9400091A SI9400091A SI9400091A SI 9400091 A SI9400091 A SI 9400091A SI 9400091 A SI9400091 A SI 9400091A SI 9400091 A SI9400091 A SI 9400091A SI 9400091 A SI9400091 A SI 9400091A
Authority
SI
Slovenia
Prior art keywords
methyl
pyrrolo
pyridine
piperazin
alkyl
Prior art date
Application number
SI9400091A
Other languages
English (en)
Slovenian (sl)
Inventor
Raymond Baker
Neil Roy Curtis
Janusz Jozef Kulagowski
Paul David Leeson
Mark Peter Ridgill
Adrian Leonard Smith
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939304111A external-priority patent/GB9304111D0/en
Priority claimed from GB939316275A external-priority patent/GB9316275D0/en
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of SI9400091A publication Critical patent/SI9400091A/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
SI9400091A 1993-03-01 1994-02-22 Substituted pyrrolo(2,3-b)pyridine derivatives SI9400091A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB939304111A GB9304111D0 (en) 1993-03-01 1993-03-01 Therapeutic agents
GB939316275A GB9316275D0 (en) 1993-08-05 1993-08-05 Therapeutic agents

Publications (1)

Publication Number Publication Date
SI9400091A true SI9400091A (en) 1994-12-31

Family

ID=26302519

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9400091A SI9400091A (en) 1993-03-01 1994-02-22 Substituted pyrrolo(2,3-b)pyridine derivatives

Country Status (20)

Country Link
US (1) US5432177A (zh)
EP (1) EP0623618A3 (zh)
JP (1) JP2710751B2 (zh)
KR (1) KR960701052A (zh)
CN (1) CN1118598A (zh)
AU (1) AU674373B2 (zh)
BG (1) BG99885A (zh)
BR (1) BR9406128A (zh)
CA (1) CA2116213A1 (zh)
CZ (1) CZ224195A3 (zh)
FI (1) FI954088A0 (zh)
HU (1) HUT71799A (zh)
IL (1) IL108729A0 (zh)
NO (1) NO953406L (zh)
NZ (1) NZ261593A (zh)
PL (1) PL310443A1 (zh)
SI (1) SI9400091A (zh)
SK (1) SK106395A3 (zh)
WO (1) WO1994020497A1 (zh)
YU (1) YU9194A (zh)

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GB9305641D0 (en) * 1993-03-18 1993-05-05 Merck Sharp & Dohme Therapeutic agents
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WO1994024105A1 (en) * 1993-04-15 1994-10-27 Merck Sharp & Dohme Limited Indole derivatives as dopamine d4 antagonists
EP0717623A1 (en) 1993-09-10 1996-06-26 Cytomed, Inc. Epibatidine and derivatives thereof as cholinergic receptor agonists and antagonists
US6117889A (en) * 1994-04-01 2000-09-12 University Of Virginia 7-Azabicyclo-[2.2.1]-heptane and -heptene derivatives as analgesics and anti-inflammatory agents
AU694226B2 (en) * 1994-05-19 1998-07-16 Merck Sharp & Dohme Limited Piperazine, piperidine and tetrahydropyridine derivatives ofindol-3-ylalkyl as 5-HT1D-alpha agonists
SK284341B6 (sk) * 1994-09-30 2005-02-04 Pfizer Inc. 2,7-Substituované oktahydro-1H-pyrido[1,2-a]pyrazínové deriváty a farmaceutické prostriedky na ich báze
GB9423460D0 (en) * 1994-11-21 1995-01-11 Merck Sharp & Dohme Therapeutic agents
JPH11500123A (ja) * 1995-02-15 1999-01-06 ファルマシア・アンド・アップジョン・カンパニー ＣＮＳおよび心臓病の治療のためのイミダゾ［１，２−ａ］ピリジン類
GB2298199A (en) * 1995-02-21 1996-08-28 Merck Sharp & Dohme Synthesis of azaindoles
GB9507291D0 (en) * 1995-04-07 1995-05-31 Merck Sharp & Dohme Therapeutic agents
US6187774B1 (en) * 1996-03-04 2001-02-13 Yoshitomi Pharmaceutical Industries, Ltd. Fused heterocyclic compounds and pharmaceutical applications thereof
US5725838A (en) * 1996-05-31 1998-03-10 Resolution Pharmaceuticals, Inc. Radiolabeled D4 receptor ligands
DE19637237A1 (de) 1996-09-13 1998-03-19 Merck Patent Gmbh Piperazin-Derivate
US5976497A (en) * 1997-08-04 1999-11-02 Resolution Pharmaceuticals, Inc. Dopamine D4 receptor ligands
AU8096798A (en) * 1997-06-27 1999-01-19 Resolution Pharmaceuticals Inc. Dopamine d4 receptor ligands
US6013654A (en) * 1997-08-14 2000-01-11 Pharmacia & Upjohn Company Imidazo[1,2-A]pyridines for the treatment of CNS and cardiac diseases
US6686374B1 (en) 1999-08-12 2004-02-03 Nps Allelix Corp. Azaindoles having serotonin receptor affinity
EP1204662B1 (en) * 1999-08-12 2004-06-02 NPS Allelix Corp. Azaindoles having serotonin receptor affinity
AR028945A1 (es) * 2000-06-19 2003-05-28 Lundbeck & Co As H Derivados de indol
CA2414115A1 (en) * 2000-06-29 2002-01-03 Jakob Felding Indole derivatives useful for the treatment of cns disorders
KR100539139B1 (ko) * 2000-07-31 2005-12-26 에프. 호프만-라 로슈 아게 피페라진 유도체
US7432304B2 (en) 2001-05-30 2008-10-07 The Regents Of The University Of Michigan Small molecule antagonists of Bcl-2 family proteins
CA2450315A1 (en) * 2001-06-13 2002-12-19 The Regents Of The University Of Michigan Dopamine receptor ligands and therapeutic methods based thereon
US7354928B2 (en) 2001-11-01 2008-04-08 The Regents Of The University Of Michigan Small molecule inhibitors targeted at Bcl-2
CN100347171C (zh) * 2002-02-08 2007-11-07 中国科学院上海原子核研究所 一种吡啶类化合物及其制备方法和作为多巴胺d4受体拮抗剂的应用
CN1305873C (zh) * 2002-07-12 2007-03-21 中国科学院上海原子核研究所 [18f]氟标记的吡啶类化合物及其制备方法和作为多巴胺d4受体显像剂的应用
JP2004123562A (ja) * 2002-09-30 2004-04-22 Japan Science & Technology Corp 神経細胞死抑制作用を有する化合物を用いた医薬
GB0314967D0 (en) * 2003-06-26 2003-07-30 Hoffmann La Roche Piperazine derivatives
DK1696920T3 (en) * 2003-12-19 2015-01-19 Plexxikon Inc RELATIONS AND PROCEDURES FOR THE DEVELOPMENT OF LAW MODULATORS
US20070066641A1 (en) * 2003-12-19 2007-03-22 Prabha Ibrahim Compounds and methods for development of RET modulators
CA2561303C (en) 2004-03-25 2011-01-18 The Regents Of The University Of Michigan Gossypol co-crystals and the use thereof
EP1755597A2 (en) * 2004-06-17 2007-02-28 Plexxikon, Inc. Azaindoles modulating c-kit activity and uses therefor
US7498342B2 (en) * 2004-06-17 2009-03-03 Plexxikon, Inc. Compounds modulating c-kit activity
DE102004054634A1 (de) * 2004-11-12 2006-05-18 Schwarz Pharma Ag Azaindolcarboxamide
JP2008545652A (ja) * 2005-05-17 2008-12-18 プレキシコン，インコーポレーテッド ｃ−ｋｉｔおよびｃ−ｆｍｓ活性を調節する化合物およびその用途
MY153898A (en) * 2005-06-22 2015-04-15 Plexxikon Inc Compounds and methods for kinase modulation, and indications therefor
US7544685B2 (en) 2005-08-17 2009-06-09 H. Lundbeck A/S 2,3-dihydroindole compounds
JP2010519171A (ja) 2006-02-17 2010-06-03 メモリー・ファーマシューティカルズ・コーポレイション ５−ｈｔ６受容体親和性を有する化合物
WO2008063888A2 (en) 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
WO2008079909A1 (en) * 2006-12-21 2008-07-03 Plexxikon, Inc. Pyrrolo [2,3-b] pyridines as kinase modulators
RU2009122670A (ru) 2006-12-21 2011-01-27 Плекссикон, Инк. (Us) Соединения и способы для модуляции киназ и показания к их применению
PE20081581A1 (es) * 2006-12-21 2008-11-12 Plexxikon Inc COMPUESTOS PIRROLO[2,3-b]PIRIDINAS COMO MODULADORES DE QUINASA
MX2010000617A (es) 2007-07-17 2010-05-17 Plexxikon Inc Compuestos y metodos para modulacion de cinasa, e indicaciones de estos.
NZ594398A (en) 2009-04-03 2014-03-28 Plexxikon Inc Propane-1-sulfonic acid (3-[5-(4-chloro-phenyl)-1h-pyrrol [2, 3-b] pyridine-3-carbonyl]-2,4-difluoro-phenyl} -amide compositions and uses thereof
US8546377B2 (en) * 2009-04-23 2013-10-01 Abbvie Inc. Modulators of 5-HT receptors and methods of use thereof
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US8329724B2 (en) 2009-08-03 2012-12-11 Hoffmann-La Roche Inc. Process for the manufacture of pharmaceutically active compounds
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BR112013012494A2 (pt) * 2010-12-02 2016-09-06 Lilly Co Eli compostos de 6-(piridinilmetóxi)-pirrolopiridina substitu-ídos em 3
US9624213B2 (en) 2011-02-07 2017-04-18 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
TWI558702B (zh) 2011-02-21 2016-11-21 普雷辛肯公司 醫藥活性物質的固態形式
US9150570B2 (en) 2012-05-31 2015-10-06 Plexxikon Inc. Synthesis of heterocyclic compounds
BR112015010620A2 (pt) * 2012-11-08 2017-07-11 Pfizer compostos heteroaromáticos e seus usos como ligantes de dopamina d1

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US3511841A (en) * 1967-05-29 1970-05-12 Sterling Drug Inc 1-((4-,5-,6-,and 7-azaindolyl)-lower-alkyl)- 4-substituted-piperazines
US5422265A (en) * 1990-12-07 1995-06-06 State Of Oregon, Acting By And Through The State Board Of Higher Education On Behalf Of The Oregon Health Sciences University DNA sequence for the human dopamine receptor D4 and expression thereof in mammalian cells

Also Published As

Publication number Publication date
FI954088A (fi) 1995-08-31
HU9501871D0 (en) 1995-08-28
EP0623618A3 (en) 1997-04-02
EP0623618A2 (en) 1994-11-09
NZ261593A (en) 1996-09-25
CZ224195A3 (en) 1996-03-13
JP2710751B2 (ja) 1998-02-10
HUT71799A (en) 1996-02-28
AU5647094A (en) 1994-09-08
WO1994020497A1 (en) 1994-09-15
PL310443A1 (en) 1995-12-11
CA2116213A1 (en) 1994-09-02
FI954088A0 (fi) 1995-08-31
CN1118598A (zh) 1996-03-13
US5432177A (en) 1995-07-11
JPH06279442A (ja) 1994-10-04
YU9194A (sh) 1997-08-22
AU674373B2 (en) 1996-12-19
IL108729A0 (en) 1994-05-30
KR960701052A (ko) 1996-02-24
BR9406128A (pt) 1996-02-27
SK106395A3 (en) 1995-12-06
BG99885A (en) 1996-02-29
NO953406L (no) 1995-10-31
NO953406D0 (no) 1995-08-30

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