IL108729A0 - Pyrrolo-pyridine derivatives, their preparation and pharmaceutical compositions containing them - Google Patents

Pyrrolo-pyridine derivatives, their preparation and pharmaceutical compositions containing them

Info

Publication number
IL108729A0
IL108729A0 IL10872994A IL10872994A IL108729A0 IL 108729 A0 IL108729 A0 IL 108729A0 IL 10872994 A IL10872994 A IL 10872994A IL 10872994 A IL10872994 A IL 10872994A IL 108729 A0 IL108729 A0 IL 108729A0
Authority
IL
Israel
Prior art keywords
pyrrolo
preparation
pharmaceutical compositions
compositions containing
pyridine derivatives
Prior art date
Application number
IL10872994A
Other languages
English (en)
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939304111A external-priority patent/GB9304111D0/en
Priority claimed from GB939316275A external-priority patent/GB9316275D0/en
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of IL108729A0 publication Critical patent/IL108729A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
IL10872994A 1993-03-01 1994-02-22 Pyrrolo-pyridine derivatives, their preparation and pharmaceutical compositions containing them IL108729A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB939304111A GB9304111D0 (en) 1993-03-01 1993-03-01 Therapeutic agents
GB939316275A GB9316275D0 (en) 1993-08-05 1993-08-05 Therapeutic agents

Publications (1)

Publication Number Publication Date
IL108729A0 true IL108729A0 (en) 1994-05-30

Family

ID=26302519

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10872994A IL108729A0 (en) 1993-03-01 1994-02-22 Pyrrolo-pyridine derivatives, their preparation and pharmaceutical compositions containing them

Country Status (20)

Country Link
US (1) US5432177A (zh)
EP (1) EP0623618A3 (zh)
JP (1) JP2710751B2 (zh)
KR (1) KR960701052A (zh)
CN (1) CN1118598A (zh)
AU (1) AU674373B2 (zh)
BG (1) BG99885A (zh)
BR (1) BR9406128A (zh)
CA (1) CA2116213A1 (zh)
CZ (1) CZ224195A3 (zh)
FI (1) FI954088A0 (zh)
HU (1) HUT71799A (zh)
IL (1) IL108729A0 (zh)
NO (1) NO953406L (zh)
NZ (1) NZ261593A (zh)
PL (1) PL310443A1 (zh)
SI (1) SI9400091A (zh)
SK (1) SK106395A3 (zh)
WO (1) WO1994020497A1 (zh)
YU (1) YU9194A (zh)

Families Citing this family (60)

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US5700809A (en) * 1993-03-01 1997-12-23 Merck Sharp & Dohme, Ltd. Pyrrolo-pyridine derivatives
US5622950A (en) * 1993-03-01 1997-04-22 Merck, Sharp & Dohme Ltd. Pyrrolo-pyridine derivatives
GB9305644D0 (en) * 1993-03-18 1993-05-05 Merck Sharp & Dohme Therapeutic agents
GB9305641D0 (en) * 1993-03-18 1993-05-05 Merck Sharp & Dohme Therapeutic agents
GB9305623D0 (en) * 1993-03-18 1993-05-05 Merck Sharp & Dohme Therapeutic agents
GB9306578D0 (en) * 1993-03-30 1993-05-26 Merck Sharp & Dohme Therapeutic agents
US6060473A (en) * 1993-04-01 2000-05-09 Ucb S.A. - Dtb 7-azabicyclo[2.2.1]-heptane and -heptene derivatives as cholinergic receptor ligands
US5817679A (en) 1993-04-01 1998-10-06 University Of Virginia 7-Azabicyclo 2.2.1!-heptane and -heptene derivatives as cholinergic receptor ligands
US5814644A (en) * 1993-04-15 1998-09-29 Merck Sharp & Dohme, Ltd. Indole derivatives as dopamine D4 antagonists
WO1995007078A1 (en) * 1993-09-10 1995-03-16 Cytomed, Inc. Epibatidine and derivatives thereof as cholinergic receptor agonists and antagonists
US6117889A (en) * 1994-04-01 2000-09-12 University Of Virginia 7-Azabicyclo-[2.2.1]-heptane and -heptene derivatives as analgesics and anti-inflammatory agents
AU694226B2 (en) * 1994-05-19 1998-07-16 Merck Sharp & Dohme Limited Piperazine, piperidine and tetrahydropyridine derivatives ofindol-3-ylalkyl as 5-HT1D-alpha agonists
JP3287574B2 (ja) * 1994-09-30 2002-06-04 ファイザー・インク ２，７−置換オクタヒドロ−１ｈ−ピリド［１，２−ａ］ピラジン誘導体
GB9423460D0 (en) * 1994-11-21 1995-01-11 Merck Sharp & Dohme Therapeutic agents
EP0809642A1 (en) * 1995-02-15 1997-12-03 PHARMACIA & UPJOHN COMPANY Imidazo 1,2-a]pyridines for the treatment of cns and cardiac diseases
GB2298199A (en) * 1995-02-21 1996-08-28 Merck Sharp & Dohme Synthesis of azaindoles
GB9507291D0 (en) * 1995-04-07 1995-05-31 Merck Sharp & Dohme Therapeutic agents
US6187774B1 (en) * 1996-03-04 2001-02-13 Yoshitomi Pharmaceutical Industries, Ltd. Fused heterocyclic compounds and pharmaceutical applications thereof
US5725838A (en) * 1996-05-31 1998-03-10 Resolution Pharmaceuticals, Inc. Radiolabeled D4 receptor ligands
DE19637237A1 (de) * 1996-09-13 1998-03-19 Merck Patent Gmbh Piperazin-Derivate
US5976497A (en) * 1997-08-04 1999-11-02 Resolution Pharmaceuticals, Inc. Dopamine D4 receptor ligands
AU8096798A (en) * 1997-06-27 1999-01-19 Resolution Pharmaceuticals Inc. Dopamine d4 receptor ligands
US6013654A (en) * 1997-08-14 2000-01-11 Pharmacia & Upjohn Company Imidazo[1,2-A]pyridines for the treatment of CNS and cardiac diseases
JP4969004B2 (ja) * 1999-08-12 2012-07-04 エヌピーエス ファーマシューティカルズ，インク． セロトニン受容体親和性を有するアザインドール
US6686374B1 (en) 1999-08-12 2004-02-03 Nps Allelix Corp. Azaindoles having serotonin receptor affinity
AR028945A1 (es) * 2000-06-19 2003-05-28 Lundbeck & Co As H Derivados de indol
IL153254A0 (en) * 2000-06-29 2003-07-06 Lundbeck & Co As H Indole derivatives useful for the treatment of cns disorders
AU8395501A (en) * 2000-07-31 2002-02-13 Hoffmann La Roche Piperazine derivatives
US7432304B2 (en) 2001-05-30 2008-10-07 The Regents Of The University Of Michigan Small molecule antagonists of Bcl-2 family proteins
CA2450315A1 (en) * 2001-06-13 2002-12-19 The Regents Of The University Of Michigan Dopamine receptor ligands and therapeutic methods based thereon
AU2002360335A1 (en) 2001-11-01 2003-05-12 The Regents Of The University Of Michigan Small molecule inhibitors targeted at bcl-2
CN100347171C (zh) * 2002-02-08 2007-11-07 中国科学院上海原子核研究所 一种吡啶类化合物及其制备方法和作为多巴胺d4受体拮抗剂的应用
CN1305873C (zh) * 2002-07-12 2007-03-21 中国科学院上海原子核研究所 [18f]氟标记的吡啶类化合物及其制备方法和作为多巴胺d4受体显像剂的应用
JP2004123562A (ja) * 2002-09-30 2004-04-22 Japan Science & Technology Corp 神経細胞死抑制作用を有する化合物を用いた医薬
GB0314967D0 (en) * 2003-06-26 2003-07-30 Hoffmann La Roche Piperazine derivatives
EP1696920B8 (en) 2003-12-19 2015-05-06 Plexxikon Inc. Compounds and methods for development of ret modulators
US20070066641A1 (en) * 2003-12-19 2007-03-22 Prabha Ibrahim Compounds and methods for development of RET modulators
CN1960719B (zh) 2004-03-25 2011-12-07 密执安州立大学董事会 棉酚共结晶及其应用
US7498342B2 (en) * 2004-06-17 2009-03-03 Plexxikon, Inc. Compounds modulating c-kit activity
JP2008503473A (ja) * 2004-06-17 2008-02-07 プレキシコン，インコーポレーテッド Ｃ−ｋｉｔ活性を調節する化合物
DE102004054634A1 (de) * 2004-11-12 2006-05-18 Schwarz Pharma Ag Azaindolcarboxamide
NZ563444A (en) * 2005-05-17 2011-04-29 Plexxikon Inc Pyrrolo(2,3-b)pyridine derivatives as protein kinase inhibitors
NZ565255A (en) * 2005-06-22 2010-04-30 Plexxikon Inc Pyrrolo[2,3-b] pyridine derivatives as protein kinase inhibitors
US7544685B2 (en) 2005-08-17 2009-06-09 H. Lundbeck A/S 2,3-dihydroindole compounds
CA2637531A1 (en) 2006-02-17 2007-08-30 Memory Pharmaceuticals Corporation Compounds having 5-ht6 receptor affinity
WO2008063888A2 (en) 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
PE20121126A1 (es) * 2006-12-21 2012-08-24 Plexxikon Inc Compuestos pirrolo [2,3-b] piridinas como moduladores de quinasa
WO2008079909A1 (en) * 2006-12-21 2008-07-03 Plexxikon, Inc. Pyrrolo [2,3-b] pyridines as kinase modulators
US7872018B2 (en) 2006-12-21 2011-01-18 Plexxikon, Inc. Compounds and methods for kinase modulation, and indications therefor
US20100190777A1 (en) 2007-07-17 2010-07-29 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
CN105237530A (zh) 2009-04-03 2016-01-13 豪夫迈罗氏公司 丙烷-1-磺酸{3-[5-(4-氯-苯基)-1H-吡咯并[2,3-b]吡啶-3-羰基]-2,4-二氟-苯基}-酰胺组合物及其用途
US8518933B2 (en) * 2009-04-23 2013-08-27 Abbvie Inc. Modulators of 5-HT receptors and methods of use thereof
US8546377B2 (en) * 2009-04-23 2013-10-01 Abbvie Inc. Modulators of 5-HT receptors and methods of use thereof
US8329724B2 (en) 2009-08-03 2012-12-11 Hoffmann-La Roche Inc. Process for the manufacture of pharmaceutically active compounds
WO2011057022A1 (en) 2009-11-06 2011-05-12 Plexxikon, Inc. Compounds and methods for kinase modulation, and indications therefor
US8778946B2 (en) * 2010-12-02 2014-07-15 Eli Lilly And Company 3-substituted-6-(pyridinylmethoxy)-pyrrolopyridine compounds
PT2672967T (pt) 2011-02-07 2018-12-07 Plexxikon Inc Compostos e métodos de modulação da quinase e suas indicações
TWI558702B (zh) 2011-02-21 2016-11-21 普雷辛肯公司 醫藥活性物質的固態形式
US9150570B2 (en) 2012-05-31 2015-10-06 Plexxikon Inc. Synthesis of heterocyclic compounds
EP3323821A1 (en) * 2012-11-08 2018-05-23 Pfizer Inc Heteroaromatic compounds and their use as dopamine d1 ligands

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Publication number Priority date Publication date Assignee Title
US3362956A (en) * 1965-08-19 1968-01-09 Sterling Drug Inc 1-[(heterocyclyl)-lower-alkyl]-4-substituted-piperazines
US3511841A (en) * 1967-05-29 1970-05-12 Sterling Drug Inc 1-((4-,5-,6-,and 7-azaindolyl)-lower-alkyl)- 4-substituted-piperazines
US5422265A (en) * 1990-12-07 1995-06-06 State Of Oregon, Acting By And Through The State Board Of Higher Education On Behalf Of The Oregon Health Sciences University DNA sequence for the human dopamine receptor D4 and expression thereof in mammalian cells

Also Published As

Publication number Publication date
FI954088A (fi) 1995-08-31
WO1994020497A1 (en) 1994-09-15
NO953406D0 (no) 1995-08-30
CZ224195A3 (en) 1996-03-13
SK106395A3 (en) 1995-12-06
PL310443A1 (en) 1995-12-11
JPH06279442A (ja) 1994-10-04
HU9501871D0 (en) 1995-08-28
JP2710751B2 (ja) 1998-02-10
SI9400091A (en) 1994-12-31
HUT71799A (en) 1996-02-28
EP0623618A2 (en) 1994-11-09
KR960701052A (ko) 1996-02-24
FI954088A0 (fi) 1995-08-31
BR9406128A (pt) 1996-02-27
US5432177A (en) 1995-07-11
CN1118598A (zh) 1996-03-13
BG99885A (en) 1996-02-29
YU9194A (sh) 1997-08-22
AU674373B2 (en) 1996-12-19
NZ261593A (en) 1996-09-25
NO953406L (no) 1995-10-31
EP0623618A3 (en) 1997-04-02
AU5647094A (en) 1994-09-08
CA2116213A1 (en) 1994-09-02

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