SI8711299A8 - Process for preparing new diphenylpropylamine derivatives - Google Patents

Process for preparing new diphenylpropylamine derivatives Download PDF

Info

Publication number
SI8711299A8
SI8711299A8 SI8711299A SI8711299A SI8711299A8 SI 8711299 A8 SI8711299 A8 SI 8711299A8 SI 8711299 A SI8711299 A SI 8711299A SI 8711299 A SI8711299 A SI 8711299A SI 8711299 A8 SI8711299 A8 SI 8711299A8
Authority
SI
Slovenia
Prior art keywords
hydrogen
general formula
methyl
group
chlorine
Prior art date
Application number
SI8711299A
Other languages
English (en)
Slovenian (sl)
Inventor
Dezso Korbonits
Pal Kiss
Laszlo Szekeres
Gyula Papp
Gabor Kovacs
Nee Csutor Andrea Santa
Sandor Virag
Eva Udvari
Imre Bata
Nee Kellner Katalin Marmarosi
Laszlo Tardos
Peter Kormoczy
Vera Gergely
Zoltan Vargai
Original Assignee
Chinoin Gyogyszer Es Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer Es Vegyeszet filed Critical Chinoin Gyogyszer Es Vegyeszet
Publication of SI8711299A8 publication Critical patent/SI8711299A8/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58—Radicals substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/16—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of a saturated carbon skeleton containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/29—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/58—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms with amino groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/42—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/43—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SI8711299A 1986-07-11 1987-07-10 Process for preparing new diphenylpropylamine derivatives SI8711299A8 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU862873A HU200591B (en) 1986-07-11 1986-07-11 Process for producing new diphenyl propylamine derivatives and pharmaceutical compositions comprising such compounds
YU129987A YU46559B (sh) 1986-07-11 1987-07-10 Postupak za dobivanje novih derivata difenilpropilamina

Publications (1)

Publication Number Publication Date
SI8711299A8 true SI8711299A8 (en) 1996-08-31

Family

ID=55982790

Family Applications (1)

Application Number Title Priority Date Filing Date
SI8711299A SI8711299A8 (en) 1986-07-11 1987-07-10 Process for preparing new diphenylpropylamine derivatives

Country Status (28)

Country Link
US (1) US4988730A (no)
EP (1) EP0253327B1 (no)
JP (1) JP2637737B2 (no)
KR (1) KR910000864B1 (no)
CN (1) CN1019571B (no)
AT (1) ATE75722T1 (no)
AU (1) AU599117B2 (no)
CA (1) CA1335104C (no)
CS (1) CS271343B2 (no)
DD (1) DD263980A5 (no)
DE (1) DE3778770D1 (no)
DK (1) DK360187A (no)
ES (1) ES2032778T3 (no)
FI (1) FI95128C (no)
GR (1) GR3004518T3 (no)
HR (1) HRP930508A2 (no)
HU (1) HU200591B (no)
IE (1) IE60028B1 (no)
IL (1) IL83044A (no)
NO (1) NO167658C (no)
NZ (1) NZ221036A (no)
PH (1) PH24514A (no)
PL (1) PL150887B1 (no)
PT (1) PT85304B (no)
SI (1) SI8711299A8 (no)
SU (2) SU1597096A3 (no)
YU (1) YU46559B (no)
ZA (1) ZA874812B (no)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1205124B (it) * 1987-06-05 1989-03-15 Simens Soteta Italiana Medicin Composto attivo nella terapia carciovascolare
GB8823203D0 (en) * 1988-10-04 1988-11-09 Pfizer Ltd Therapeutic agents
JPH04329415A (ja) * 1991-04-30 1992-11-18 Fujitsu Ltd カード型入出力インタフェース装置及びシステム
US5688938A (en) * 1991-08-23 1997-11-18 The Brigham & Women's Hospital, Inc. Calcium receptor-active molecules
US6031003A (en) * 1991-08-23 2000-02-29 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
EP0657029A4 (en) * 1991-08-23 1996-02-07 Nps Pharma Inc CALCIUM RECEPTORS INFLUENCING MOLECULES.
US6001884A (en) * 1991-08-23 1999-12-14 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US5858684A (en) * 1991-08-23 1999-01-12 The Brigham And Women's Hospital, Inc. Method of screening calcium receptor-active molecules
US5763569A (en) * 1991-08-23 1998-06-09 The Brigham And Women's Hospital, Inc Calcium receptor-active molecules
US6011068A (en) * 1991-08-23 2000-01-04 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US6313146B1 (en) 1991-08-23 2001-11-06 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US5198548A (en) * 1992-01-30 1993-03-30 Warner-Lambert Company Process for the preparation of D(-) and L(+)-3,3-diphenylalanine and D(-) and L(+)-substituted 3,3-diphenylalanines and derivatives thereof
US6071970A (en) * 1993-02-08 2000-06-06 Nps Pharmaceuticals, Inc. Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases
ATE267009T1 (de) * 1993-02-23 2004-06-15 Brigham & Womens Hospital Calciumrezeptoraktive moleküle
US5962314A (en) * 1993-02-23 1999-10-05 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US5492933A (en) * 1993-10-08 1996-02-20 Sepracor, Inc. Methods and compositions for treating urinary incontinence and other disorders using optically pure R-terodiline and hydroxylated derivatives thereof
DE69533948T2 (de) 1994-10-21 2005-12-15 NPS Pharmaceuticals, Inc., Salt Lake City Kalzium-Rezeptor aktive Verbindungen
ATE430123T1 (de) 1996-05-01 2009-05-15 Nps Pharma Inc Inorganische am ionen-rezeptor aktive verbindungen
SE9701144D0 (sv) * 1997-03-27 1997-03-27 Pharmacia & Upjohn Ab Novel compounds, their use and preparation
US6124507A (en) * 1997-12-10 2000-09-26 Union Carbide Chemicals & Plastics Technology Corporation Electron donors
EP0957073A1 (en) * 1998-05-12 1999-11-17 Schwarz Pharma Ag Novel derivatives of 3,3-diphenylpropylamines
DE10315917A1 (de) * 2003-04-08 2004-11-18 Schwarz Pharma Ag Hochreine Basen von 3,3-Diphenylpropylaminmonoestern
FR2902789A1 (fr) * 2006-06-21 2007-12-28 Genfit Sa Derives de 1,3-diphenylpropane substitues, preparations et utilisations

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH462189A (de) 1961-08-10 1968-09-15 Chinoin Gyogyszer Es Vegyeszet Verfahren zur Herstellung von substituierten Propylaminderivaten
DE1171930B (de) * 1961-08-10 1964-06-11 Chinoin Gyogyszer Es Vegyeszet Verfahren zur Herstellung von koronardilatent wirksamen substituierten Propylaminderivaten
GB1032650A (en) * 1962-05-24 1966-06-15 Chinoin Gyogyszer Es Vegyeszet Improvements in or relating to diphenyl-propylamine derivatives
DD122967A1 (de) * 1975-07-10 1976-11-12 Lothar Luecke Hylamin-derivate

Also Published As

Publication number Publication date
DE3778770D1 (de) 1992-06-11
EP0253327B1 (de) 1992-05-06
NO872880D0 (no) 1987-07-10
AU7552687A (en) 1988-01-14
FI873069A0 (fi) 1987-07-10
KR910000864B1 (ko) 1991-02-11
PT85304B (pt) 1990-03-30
KR880001573A (ko) 1988-04-25
US4988730A (en) 1991-01-29
NO167658B (no) 1991-08-19
NZ221036A (en) 1990-05-28
ATE75722T1 (de) 1992-05-15
YU129987A (en) 1988-06-30
CS271343B2 (en) 1990-09-12
HRP930508A2 (en) 1995-02-28
CS511987A2 (en) 1989-08-14
CN1019571B (zh) 1992-12-23
HUT46651A (en) 1988-11-28
IL83044A (en) 1991-09-16
AU599117B2 (en) 1990-07-12
ES2032778T3 (es) 1993-03-01
DK360187A (da) 1988-01-12
DK360187D0 (da) 1987-07-10
HU200591B (en) 1990-07-28
DD263980A5 (de) 1989-01-18
ZA874812B (en) 1988-10-26
PL266759A1 (en) 1988-09-01
NO167658C (no) 1991-11-27
PH24514A (en) 1990-07-18
IL83044A0 (en) 1987-12-31
IE60028B1 (en) 1994-05-18
JP2637737B2 (ja) 1997-08-06
FI95128C (fi) 1995-12-27
SU1597096A3 (ru) 1990-09-30
YU46559B (sh) 1993-11-16
NO872880L (no) 1988-01-12
FI873069A (fi) 1988-01-12
GR3004518T3 (no) 1993-04-28
CN87104753A (zh) 1988-06-15
EP0253327A2 (de) 1988-01-20
PL150887B1 (en) 1990-07-31
SU1588740A1 (ru) 1990-08-30
FI95128B (fi) 1995-09-15
IE871866L (en) 1988-01-11
CA1335104C (en) 1995-04-04
JPS6372657A (ja) 1988-04-02
EP0253327A3 (en) 1988-11-30
PT85304A (en) 1987-08-01

Similar Documents

Publication Publication Date Title
SI8711299A8 (en) Process for preparing new diphenylpropylamine derivatives
DE69013607T2 (de) Pyrazol-Derivate, Verfahren zu deren Herstellung und Anwendung.
EP0004920B1 (de) Carbazolyl-(4)-oxy-propanolamin-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
EP0496222B1 (de) Indolderivate
JPH06509820A (ja) 選択的ホスホジエステラーゼ■阻害剤としての三置換フェニル誘導体
EP0124476B1 (de) Carboxamide, Verfahren zur Herstellung und pharmazeutische Präparate, die diese enthalten
CS228532B2 (en) Production method of phenylpiperazine derivative
DE69418045T2 (de) Amidderivate als 5ht1d rezeptor antagonisten
CA2325587A1 (en) Imidazolone anorectic agents: ii. phenyl derivatives
DE3228990A1 (de) Thiazolidindion-derivate, herstellung dieser verbindungen und diese enthaltende pharmazeutische praeparate
DE60316683T2 (de) Phenylcyclohexylpropanolaminderivate, deren herstellung und therapeutsche anwendung
NZ225430A (en) N-aminobutyl-n-phenyl arylamides and pharmaceutical compositions
EP0104614B1 (en) Phenylpiperazine derivatives and process for producing the same
JP2569088B2 (ja) 塩基性置換フェニルアセトニトリル及びカルシウム拮抗作用を有する心血管系疾患の治療剤
AU621003B2 (en) 3-alkoxy-2-aminopropylamides
JPH0134226B2 (no)
KR100372312B1 (ko) 신규의히드록시믹산유도체,그를포함한약제학적조성물및그의제조방법
DE3923675A1 (de) Amonoalkylsubstituierte 2-aminothiazole und diese enthaltende therapeutische mittel
SK279199B6 (sk) Diamidy n,n'-bis-/alkoxyalkyl/-pyridín-2,4-dikarbo
DE68921198T2 (de) Benzothiadiazepin-derivate.
JP3145803B2 (ja) ３−シクロアルキル−２−プロペンアミド誘導体
DE3779813T2 (de) 1,4-dihydropyridinderivate.
JP7494224B2 (ja) ビアリールジアルキルホスフィンオキシドｆｐｒ２アゴニスト
JPH0471067B2 (no)
DE3228992A1 (de) Spirothiazolidindion-derivate, herstellung dieser verbindungen und diese enthaltende pharmazeutische praeparate