SI8510440A8 - Postopek za pridobivanje 2-oksindol-1-karboksamidnih spojin - Google Patents

Postopek za pridobivanje 2-oksindol-1-karboksamidnih spojin Download PDF

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Publication number
SI8510440A8
SI8510440A8 SI8510440A SI8510440A SI8510440A8 SI 8510440 A8 SI8510440 A8 SI 8510440A8 SI 8510440 A SI8510440 A SI 8510440A SI 8510440 A SI8510440 A SI 8510440A SI 8510440 A8 SI8510440 A8 SI 8510440A8
Authority
SI
Slovenia
Prior art keywords
oxindole
carbons
alkyl
formula
carboxamide
Prior art date
Application number
SI8510440A
Other languages
English (en)
Slovenian (sl)
Inventor
Bernard Saul Kadin
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of SI8510440A8 publication Critical patent/SI8510440A8/sl

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
SI8510440A 1984-03-19 1985-03-19 Postopek za pridobivanje 2-oksindol-1-karboksamidnih spojin SI8510440A8 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US59065984A 1984-03-19 1984-03-19
US06/684,634 US4556672A (en) 1984-03-19 1984-12-21 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents
YU440/85A YU43870B (en) 1984-03-19 1985-03-19 Process for obtaining 2-oxindole-1-carboxamidic compounds

Publications (1)

Publication Number Publication Date
SI8510440A8 true SI8510440A8 (sl) 1996-06-30

Family

ID=27080909

Family Applications (1)

Application Number Title Priority Date Filing Date
SI8510440A SI8510440A8 (sl) 1984-03-19 1985-03-19 Postopek za pridobivanje 2-oksindol-1-karboksamidnih spojin

Country Status (36)

Country Link
US (1) US4556672A (nl)
EP (1) EP0156603B1 (nl)
JP (1) JPH04235165A (nl)
KR (1) KR860001873B1 (nl)
AT (1) ATE45731T1 (nl)
AU (1) AU549927B2 (nl)
BG (1) BG60347B2 (nl)
CA (2) CA1251441A (nl)
CS (1) CS249539B2 (nl)
CY (1) CY1668A (nl)
DE (1) DE3572481D1 (nl)
DK (1) DK162090C (nl)
EG (1) EG17795A (nl)
ES (1) ES8603408A1 (nl)
FI (2) FI82042C (nl)
GR (1) GR850668B (nl)
HK (1) HK78392A (nl)
HU (1) HU196178B (nl)
IE (1) IE57743B1 (nl)
IL (3) IL85130A (nl)
LV (1) LV5618A3 (nl)
MA (1) MA20380A1 (nl)
MY (1) MY101987A (nl)
NL (1) NL940025I2 (nl)
NO (1) NO165799C (nl)
NZ (2) NZ211486A (nl)
OA (1) OA07966A (nl)
PH (2) PH21323A (nl)
PL (1) PL145951B1 (nl)
PT (1) PT80117B (nl)
RO (1) RO90952B (nl)
SI (1) SI8510440A8 (nl)
SU (1) SU1445556A3 (nl)
UA (1) UA6343A1 (nl)
YU (1) YU43870B (nl)
ZW (1) ZW4785A1 (nl)

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US4678802A (en) * 1985-07-09 1987-07-07 Pfizer Inc. 1-acylcarbamoyloxindole-3-carboxamides as antiinflammatory agents
ATE67185T1 (de) * 1985-07-09 1991-09-15 Pfizer Substituierte oxindol-3-carboxamine als entzuendungshemmendes und schmerzstillendes mittel.
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UA25898A1 (uk) * 1987-02-02 1999-02-26 Пфайзер Інк. Спосіб одержаhhя кристалічhої hатрієвої солі 5-хлор-3-(2-теhоїл)-2-оксііhдол-1-карбоксаміду
US4885370A (en) * 1987-03-11 1989-12-05 Pfizer Inc. Synthetic method for indol-2(3H)-ones
US4761485A (en) * 1987-03-11 1988-08-02 Pfizer Inc. Synthetic method for indol-2(3H)-ones
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DE3803775A1 (de) * 1988-02-09 1989-08-17 Boehringer Mannheim Gmbh Neue substituierte lactame, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten
US4861794A (en) * 1988-04-13 1989-08-29 Pfizer Inc. 3-substituted-2-oxindole-1-carboxamides as inhibitors of interleukin-1 biosynthesis
US4853409A (en) * 1988-04-13 1989-08-01 Pfizer Inc. 3-substituted-2-oxindole-1-carboxamides for suppressing T-cell function
DE68923673T2 (de) * 1988-10-18 1996-01-18 Pfizer Prodrogen von antiinflammatorischen 3-Acyl-2-oxindol-1-carboxamiden.
US5118703A (en) * 1988-10-18 1992-06-02 Pfizer Inc. Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides
WO1990008145A1 (en) * 1989-01-10 1990-07-26 Pfizer Inc. Anti-inflammatory 1-heteroaryl-3-acyl-2-oxindoles
US5300655A (en) * 1989-04-18 1994-04-05 Pfizer Inc. 2-carboxy-thiophene derivatives
US5047554A (en) 1989-04-18 1991-09-10 Pfizer Inc. 3-substituted-2-oxindole derivatives
US5059693A (en) * 1989-10-06 1991-10-22 Pfizer Inc. Process for making 3-aroyl-2-oxindole-1-carboxamides
IL95880A (en) * 1989-10-13 1995-12-31 Pfizer Use of 3-Transformed History of 2-Oxindole for the Preparation of Pharmaceuticals for Inhibition of Interlaukio-1 Biosynthesis
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US5008283A (en) * 1990-03-19 1991-04-16 Pfizer Inc. Use of tenidap to inhibit activation of collagenase and to inhibit the activity of myeloperoxidase
US5006547A (en) * 1990-03-19 1991-04-09 Pfizer Inc. Tenidap as an inhibitor of the release of elastase by neutrophils
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US5095031A (en) * 1990-08-20 1992-03-10 Abbott Laboratories Indole derivatives which inhibit leukotriene biosynthesis
US5122534A (en) * 1991-02-08 1992-06-16 Pfizer Inc. Use of tenidap to reduce total serum cholesterol, ldl cholesterol and triglycerides
DE4111306C2 (de) * 1991-04-08 1994-06-01 Mack Chem Pharm Pharmazeutische Zubereitungen, die ein 2-Oxindol-l-carboxamid-derivat enthalten und zur Injektion bestimmt sind
DE4111305C2 (de) * 1991-04-08 1994-12-01 Mack Chem Pharm Pharmazeutische Zubereitung zur rektalen Applikation, die ein 2-Oxindol-l-carboxamid-derivat enthält
US5166401A (en) * 1991-06-25 1992-11-24 Pfizer Inc Intermediates for 5-fluoro-6-chlorooxindole
US5210212A (en) * 1991-06-25 1993-05-11 Pfizer Inc Process for 5-fluoro-6-chlorooxindole
TW438798B (en) * 1992-10-07 2001-06-07 Pfizer 3-substituted 2-oxindole-1-carboxamide pharmaceutical compositions
US5288743A (en) * 1992-11-20 1994-02-22 Abbott Laboratories Indole carboxylate derivatives which inhibit leukotriene biosynthesis
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CN102458374A (zh) 2009-05-06 2012-05-16 实验室护肤股份有限公司 包含活性剂-磷酸钙颗粒复合物的皮肤递送组合物及其使用方法
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Also Published As

Publication number Publication date
SU1445556A3 (ru) 1988-12-15
EP0156603A2 (en) 1985-10-02
AU4005985A (en) 1985-09-26
BG60347B2 (bg) 1994-09-30
MA20380A1 (fr) 1985-10-01
IL74631A0 (en) 1985-06-30
NL940025I2 (nl) 2000-01-03
FI82449B (fi) 1990-11-30
IL85130A0 (en) 1988-06-30
ES541372A0 (es) 1985-12-16
RO90952A (ro) 1987-02-27
UA6343A1 (uk) 1994-12-29
NL940025I1 (nl) 1995-02-01
PL252434A1 (en) 1985-12-03
PT80117B (pt) 1987-10-20
DE3572481D1 (en) 1989-09-28
MY101987A (en) 1992-02-29
NZ224134A (en) 1988-10-28
IE57743B1 (en) 1993-03-24
DK162090B (da) 1991-09-16
FI894540A0 (fi) 1989-09-26
OA07966A (fr) 1987-01-31
ATE45731T1 (de) 1989-09-15
JPH04235165A (ja) 1992-08-24
PT80117A (en) 1985-04-01
IE850684L (en) 1985-09-19
CA1288422C (en) 1991-09-03
LV5618A3 (lv) 1994-05-10
FI82042C (fi) 1991-01-10
EP0156603B1 (en) 1989-08-23
ZW4785A1 (en) 1985-06-19
HK78392A (en) 1992-10-23
CS249539B2 (en) 1987-03-12
CA1251441A (en) 1989-03-21
EG17795A (en) 1990-08-30
YU43870B (en) 1989-12-31
FI851069A0 (fi) 1985-03-18
NZ211486A (en) 1988-10-28
ES8603408A1 (es) 1985-12-16
AU549927B2 (en) 1986-02-20
HUT37398A (en) 1985-12-28
IL74631A (en) 1988-07-31
DK121385D0 (da) 1985-03-18
HU196178B (en) 1988-10-28
NO165799C (no) 1991-04-10
PH21470A (en) 1987-10-28
PL145951B1 (en) 1988-12-31
DK162090C (da) 1992-02-24
RO90952B (ro) 1987-03-01
PH21323A (en) 1987-09-28
YU44085A (en) 1988-02-29
FI894540A (fi) 1989-09-26
EP0156603A3 (en) 1986-02-12
NO165799B (no) 1991-01-02
FI82449C (fi) 1991-03-11
JPH0561269B2 (nl) 1993-09-06
NO851054L (no) 1985-09-20
GR850668B (nl) 1985-07-16
KR860001873B1 (ko) 1986-10-24
KR850006173A (ko) 1985-10-02
DK121385A (da) 1985-09-20
US4556672A (en) 1985-12-03
IL85130A (en) 1988-07-31
FI82042B (fi) 1990-09-28
CY1668A (en) 1993-05-14
FI851069L (fi) 1985-09-20

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