SI3568475T1 - Raztopina za ohranjanje nukleinske kisline in načini uporabe - Google Patents

Raztopina za ohranjanje nukleinske kisline in načini uporabe

Info

Publication number
SI3568475T1
SI3568475T1 SI201830891T SI201830891T SI3568475T1 SI 3568475 T1 SI3568475 T1 SI 3568475T1 SI 201830891 T SI201830891 T SI 201830891T SI 201830891 T SI201830891 T SI 201830891T SI 3568475 T1 SI3568475 T1 SI 3568475T1
Authority
SI
Slovenia
Prior art keywords
methods
nucleic acid
preservation solution
acid preservation
solution
Prior art date
Application number
SI201830891T
Other languages
English (en)
Inventor
Federico Carlos Arejola Gaeta
Original Assignee
Spectrum Solutions L. L. C.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=62839045&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI3568475(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Spectrum Solutions L. L. C. filed Critical Spectrum Solutions L. L. C.
Publication of SI3568475T1 publication Critical patent/SI3568475T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
SI201830891T 2017-01-16 2018-01-16 Raztopina za ohranjanje nukleinske kisline in načini uporabe SI3568475T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762446818P 2017-01-16 2017-01-16
PCT/US2018/013862 WO2018132827A1 (en) 2017-01-16 2018-01-16 Nucleic acid preservation solution and methods of manufacture and use
EP18739053.9A EP3568475B1 (en) 2017-01-16 2018-01-16 Nucleic acid preservation solution and methods of use

Publications (1)

Publication Number Publication Date
SI3568475T1 true SI3568475T1 (sl) 2023-05-31

Family

ID=62839045

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201830891T SI3568475T1 (sl) 2017-01-16 2018-01-16 Raztopina za ohranjanje nukleinske kisline in načini uporabe

Country Status (17)

Country Link
US (4) US10174362B2 (sl)
EP (2) EP4177342B1 (sl)
JP (3) JP6652692B2 (sl)
CN (2) CN110072999B (sl)
CA (1) CA3042088A1 (sl)
CY (1) CY1126046T1 (sl)
DK (1) DK3568475T3 (sl)
ES (1) ES2942577T3 (sl)
FI (1) FI3568475T3 (sl)
HR (1) HRP20230345T1 (sl)
HU (1) HUE062204T2 (sl)
LT (1) LT3568475T (sl)
MX (2) MX2019006767A (sl)
PL (1) PL3568475T3 (sl)
PT (1) PT3568475T (sl)
SI (1) SI3568475T1 (sl)
WO (1) WO2018132827A1 (sl)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3568475T3 (da) * 2017-01-16 2023-04-17 Spectrum Solutions L L C Nukleinsyrekonserveringsopløsning og fremgangsmåder til anvendelse
MX2021005762A (es) * 2018-11-14 2021-08-11 Spectrum Solutions L L C Solución de preservación de rna y métodos de fabricación y uso.
CA3120708A1 (en) 2018-11-20 2020-05-28 Spectrum Solutions, Llc Sample collection system including sealing cap and valve
US11701094B2 (en) 2019-06-20 2023-07-18 Spectrum Solutions L.L.C. Sample collection system including valve and plug assemblies
EP4047089A4 (en) * 2019-09-18 2023-08-23 Technosuruga Laboratory Co.,Ltd. SAMPLE PRESERVATION SOLUTION AND ANALYZER AND METHOD OF ANALYSIS USING THE SAME
CN110747193B (zh) * 2019-09-25 2021-08-31 广州市达瑞生物技术股份有限公司 一种基于二代测序平台的肺癌多基因联合检测试剂盒质控品
CN110643679A (zh) * 2019-09-26 2020-01-03 李润成 一种水环境dna采集保存卡及其制作方法
CN113133996B (zh) * 2020-01-20 2023-07-04 山东威高宏瑞医学科技有限公司 乙酰半胱氨酸或其化学上可接受的盐/酯在制备结缔组织的分离制剂中的应用
CN111172239A (zh) * 2020-02-28 2020-05-19 上海思路迪医学检验所有限公司 一种病毒样本保存液、核酸提取试剂及病毒核酸提取方法
WO2021205470A1 (en) * 2020-04-06 2021-10-14 30M Genomics Private Limited Buffer composition for one step nucleic acid sample preparation and storage from biological samples
EP3996732A4 (en) * 2020-04-14 2022-08-24 Spectrum Solutions, LLC ASSAYS AND METHODS FOR DETECTION OF VIRAL NUCLEIC ACIDS
CN111218444B (zh) * 2020-04-24 2020-09-01 广州安必平医药科技股份有限公司 一种痰液保存液
CN111690640B (zh) * 2020-06-22 2023-10-03 广州东盛生物科技有限公司 一种高度兼容磁珠法病毒核酸提取试剂盒的病毒保存液
CN112280775A (zh) * 2020-08-10 2021-01-29 广州捷倍斯生物科技有限公司 一种生物样品核酸保护液及应用
JP2022040103A (ja) * 2020-08-28 2022-03-10 花王株式会社 Ｒｎａの保存方法
CN112029824A (zh) * 2020-09-15 2020-12-04 北京康美天鸿生物科技有限公司 一种通用于多种样本的核酸保存液
EP4213740A1 (en) * 2020-09-18 2023-07-26 Procomcure Biotech GmbH Kit for collecting saliva samples
AT18096U1 (de) * 2020-09-18 2024-01-15 Procomcure Biotech Gmbh Kit zur Entnahme von Speichelproben
CN112176025B (zh) * 2020-10-12 2022-05-24 广东南芯医疗科技有限公司 一种核酸保存液及其制备方法和应用
CN112760318B (zh) * 2020-12-30 2023-11-17 苏州白垩纪生物科技有限公司 一种用于稳定核酸分子的试剂组合物及其应用
CN113373031B (zh) * 2021-08-13 2021-11-16 北京健为医学检验实验室有限公司 一种喷雾型的游离dna样本保存管及应用
CN113736755B (zh) * 2021-08-18 2024-01-19 江苏默乐生物科技股份有限公司 一种可常温保存的灭活型病毒保存液及其制备方法
CN114235986A (zh) * 2021-11-25 2022-03-25 浙江艾兰得生物科技有限公司 维生素b1、b2、b6、烟酸、烟酰胺含量的高效液相色谱检测方法
CN116555248B (zh) * 2023-07-10 2023-10-20 北京凡知医学科技有限公司 一种细菌中高分子量dna提取试剂盒及提取方法
CN117165580B (zh) * 2023-11-03 2024-01-26 青岛金域医学检验实验室有限公司 一种用于稳定样本中核酸的组合物、制备方法及其应用

Family Cites Families (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4308264A (en) * 1981-01-28 1981-12-29 Abbott Laboratories Stabilized, dilute aqueous preparation of 1α,25-dihydroxycholecalciferol for neonatal administration
US5346999A (en) * 1985-01-18 1994-09-13 Applied Biosystems, Inc. Method of nucleic acid extraction
DE3689398T2 (de) 1985-01-18 1994-07-14 Applied Biosystems Verfahren zum Extrahieren von Nukleinsäuren aus Zellen.
US4925796A (en) * 1986-03-07 1990-05-15 Massachusetts Institute Of Technology Method for enhancing glycoprotein stability
CA1317860C (en) 1987-04-01 1993-05-18 Daniel Louis Kacian Techniques for preparing specimens for bacterial assays
US4808328A (en) * 1987-05-08 1989-02-28 Joseph N. Cooper Iodine-based antiseptic cleanser composition
US5110493A (en) * 1987-09-11 1992-05-05 Syntex (U.S.A.) Inc. Ophthalmic NSAID formulations containing a quaternary ammonium preservative and a nonionic surfactant
WO1989006704A1 (en) 1988-01-11 1989-07-27 Microprobe Corporation Oligonucleotide probes for detection of periodontal pathogens
US5128247A (en) 1989-08-14 1992-07-07 Board Of Regents, The University Of Texas System Methods for isolation of nucleic acids from eukaryotic and prokaryotic sources
US5747339A (en) * 1990-06-25 1998-05-05 Research Foundation For Microbial Diseases Of Osaka Non-A, non-B hepatitis virus genomic CDNA and antigen polypeptide
US5422241A (en) 1991-07-03 1995-06-06 Ambion, Inc. Methods for the recovery of nucleic acids from reaction mixtures
CA2115061A1 (en) * 1991-08-06 1993-02-18 David S. Sigman Method of isolation of dna
US5648215A (en) * 1992-05-13 1997-07-15 Board Of Regents, The University Of Texas System Telomerase diagnostic methods
GB9403423D0 (en) * 1994-02-23 1994-04-13 Unilever Plc Novel exo-(1-4)- beta-D galactanase
US5658749A (en) * 1994-04-05 1997-08-19 Corning Clinical Laboratories, Inc. Method for processing mycobacteria
CA2147593C (en) 1994-04-22 2008-07-29 Hyman C. Birnboim Dual purpose tissue fixative
US5643767A (en) 1994-05-02 1997-07-01 The Rockefeller University Process for isolating cellular components
US5945515A (en) * 1995-07-31 1999-08-31 Chomczynski; Piotr Product and process for isolating DNA, RNA and proteins
AU6589698A (en) 1997-03-28 1998-10-22 Epitope, Inc. Simultaneous collection of dna and non-nucleic analytes from oral fluids
US7569342B2 (en) 1997-12-10 2009-08-04 Sierra Molecular Corp. Removal of molecular assay interferences
JP2001526051A (ja) 1997-12-10 2001-12-18 シエラ ダイアグノスティクス，インク． 体液中のｄｎａを保存するための方法及び試薬
US20080064108A1 (en) 1997-12-10 2008-03-13 Tony Baker Urine Preservation System
US6204375B1 (en) 1998-07-31 2001-03-20 Ambion, Inc. Methods and reagents for preserving RNA in cell and tissue samples
DE19836559A1 (de) 1998-08-12 2000-03-23 Antigen Gmbh Gefäß zur Entnahme von Blut
WO2000077235A1 (en) 1999-06-16 2000-12-21 University Of Cincinnati Agent and process for isolation of extra-chromosomal nucleic acids
US6242188B1 (en) 1999-07-30 2001-06-05 Applied Gene Technologies, Inc. Sample processing to release nucleic acids for direct detection
AU1483601A (en) 1999-11-10 2001-06-06 Ligochem, Inc. Method for isolating dna from a proteinaceous medium and kit for performing method
DE10006662A1 (de) 2000-02-15 2001-08-23 Antigen Produktions Gmbh Gefäß zur Nukleinsäureanalytik
DE10031236A1 (de) 2000-06-27 2002-01-10 Qiagen Gmbh Verwendung von Carbonsäuren und anderen Additiven in Kombination mit kationischen Verbindungen zur Stabilisierung von Nukleinsäuren in biologischen Materialien
US6602718B1 (en) 2000-11-08 2003-08-05 Becton, Dickinson And Company Method and device for collecting and stabilizing a biological sample
US7029840B2 (en) 2000-11-15 2006-04-18 Becton, Dickinson And Company Method for preservation of cells and nucleic acid targets
US6503716B1 (en) 2000-11-28 2003-01-07 Pe Corporation (Ny) Compositions and methods for extracting a nucleic acid
US6911308B2 (en) 2001-01-05 2005-06-28 Exact Sciences Corporation Methods for detecting, grading or monitoring an H. pylori infection
US20100120078A1 (en) 2001-08-16 2010-05-13 Tony Baker Urine Stabilization System
US7148343B2 (en) * 2001-10-12 2006-12-12 Gentra Systems, Inc. Compositions and methods for using a solid support to purify RNA
JP2003235555A (ja) * 2002-02-08 2003-08-26 Jsr Corp 一本鎖核酸および／または二本鎖核酸の単離方法
CN100389880C (zh) * 2002-05-07 2008-05-28 贝克顿·迪金森公司 采集组件
US7482116B2 (en) 2002-06-07 2009-01-27 Dna Genotek Inc. Compositions and methods for obtaining nucleic acids from sputum
US20040101859A1 (en) 2002-11-25 2004-05-27 Cepheid Compositions, methods and kits for polynucleotide amplification reactions and microfluidic devices
ATE504660T1 (de) * 2003-05-07 2011-04-15 Coris Bioconcept Sprl Einstufige oligochromatographische vorrichtung und verfahren zu ihrer verwendung
ES2355899T3 (es) 2003-05-19 2011-04-01 Brandeis University Procedimientos, kits y dispositivos de tratamiento de ácidos nucleicos.
US20050042656A1 (en) * 2003-07-09 2005-02-24 Davis James C. Room temperature elution of nucleic acids
US20050059024A1 (en) 2003-07-25 2005-03-17 Ambion, Inc. Methods and compositions for isolating small RNA molecules
EP1654361B2 (en) 2003-07-25 2023-01-18 Life Technologies Corporation Methods and compositions for preparing rna from a fixed sample
AU2003257013A1 (en) * 2003-07-29 2005-03-07 Sigma Aldrich Co. Methods and compositions for amplification of dna
US7638309B2 (en) 2003-12-03 2009-12-29 Council Of Science And Industrial Research Method for detecting pathogenic mycobacteria in clinical specimens
EP1584923A3 (en) 2004-04-07 2006-01-04 Roche Diagnostics GmbH Stabilization of biomolecules in samples
EP1747271A4 (en) 2004-05-18 2008-09-03 Fujifilm Corp PROCESS FOR EXTRACTING NUCLEIC ACID AND APPARATUS FOR EXTRACTING NUCLEIC ACID
EP1758937B1 (en) * 2004-05-24 2009-09-02 Genvault Corporation Stable protein storage and stable nucleic acid storage in recoverable form
JP2006087394A (ja) * 2004-09-27 2006-04-06 Wako Pure Chem Ind Ltd 核酸抽出方法および核酸抽出キット
US20060078894A1 (en) * 2004-10-12 2006-04-13 Winkler Matthew M Methods and compositions for analyzing nucleic acids
TWI294460B (en) 2004-12-23 2008-03-11 Ind Tech Res Inst Method for stabilizing nucleic acids
WO2006096973A1 (en) 2005-03-16 2006-09-21 Dna Genotek Inc. Compositions and method for storage of nucleic acid from bodily fluids
WO2007049326A1 (ja) 2005-10-24 2007-05-03 Wako Pure Chemical Industries, Ltd. 核酸抽出方法および核酸抽出キット
US20070202511A1 (en) 2006-02-28 2007-08-30 Sigma-Aldrich Co. Methods and compositions for the rapid isolation of small RNA molecules
JP5479895B2 (ja) * 2006-07-25 2014-04-23 アジレント・テクノロジーズ・インク Ｄｎａポリメラーゼの保存及び使用のための両性イオン洗剤
US20080124728A1 (en) 2006-09-12 2008-05-29 Tony Baker Removal of Molecular Assay Interferences for Nucleic Acids Employing Buffered Solutions of Chaotropes
US8652782B2 (en) * 2006-09-12 2014-02-18 Longhorn Vaccines & Diagnostics, Llc Compositions and methods for detecting, identifying and quantitating mycobacterial-specific nucleic acids
US8080645B2 (en) 2007-10-01 2011-12-20 Longhorn Vaccines & Diagnostics Llc Biological specimen collection/transport compositions and methods
US20130260369A1 (en) * 2012-03-28 2013-10-03 Longhorn Vaccines And Diagnostics, Llc Compositions and Methods for the Collection and Isolation of Nucleic Acids from Biological Specimens
US8097419B2 (en) 2006-09-12 2012-01-17 Longhorn Vaccines & Diagnostics Llc Compositions and method for rapid, real-time detection of influenza A virus (H1N1) swine 2009
GB0701253D0 (en) 2007-01-23 2007-02-28 Diagnostics For The Real World Nucleic acid amplification and testing
US9683256B2 (en) * 2007-10-01 2017-06-20 Longhorn Vaccines And Diagnostics, Llc Biological specimen collection and transport system
ES2552858T3 (es) 2007-10-01 2015-12-02 Longhorn Vaccines And Diagnostics, Llc Recogida de muestras biológicas y sistema de transporte y métodos de uso
US20140038174A1 (en) * 2011-04-26 2014-02-06 Longhorn Vaccines And Diagnostics, Llc Compositions and Methods for Detecting and Identifying Nucleic Acid Sequences in Biological Samples
WO2009061864A1 (en) * 2007-11-06 2009-05-14 3M Innovative Properties Company Processing device tablet
US20100003748A1 (en) 2008-07-03 2010-01-07 Tony Baker Compositions, systems, and methods for stabilization of a cell and/or macromolecule
WO2010064628A1 (ja) * 2008-12-05 2010-06-10 オリンパス株式会社 核酸含有試料の調製方法、試料調製用溶液、及び核酸の解析方法
JP2012511317A (ja) * 2008-12-12 2012-05-24 ウロジャンテック、ソシエテ、アノニム 核酸増幅反応の特異性、感度および収量を改善するためのシクロデキストリンの使用
US20110256292A1 (en) 2010-04-16 2011-10-20 Purgatorio James C Device and method for making food items
WO2012018638A2 (en) 2010-07-26 2012-02-09 Biomatrica, Inc. Compositions for stabilizing dna, rna and proteins in blood and other biological samples during shipping and storage at ambient temperatures
US9845489B2 (en) 2010-07-26 2017-12-19 Biomatrica, Inc. Compositions for stabilizing DNA, RNA and proteins in saliva and other biological samples during shipping and storage at ambient temperatures
CA2779850C (en) 2011-06-17 2016-08-09 Norgen Biotek Corporation Methods, reagents and kits for preservation of nucleic acids in biological samples
CN103827301A (zh) * 2011-09-13 2014-05-28 恰根有限公司 从兽医学全血样品中分离核酸的方法
WO2013117967A1 (en) * 2012-02-10 2013-08-15 Reametrix Inc. Compositions and methods for sputum samples preparation, and kit
WO2013169861A1 (en) * 2012-05-09 2013-11-14 Bio-Rad Laboratories, Inc. Buffer for one-step dna extraction
US8861976B2 (en) * 2012-06-29 2014-10-14 Intel Corporation Transmit and receive MIMO protocols for light array communications
JP2014039481A (ja) * 2012-08-21 2014-03-06 Seiko Epson Corp Ｒｎａの抽出方法
ES2843202T3 (es) * 2012-09-28 2021-07-16 Cepheid Métodos para la extracción de ADN y ARN a partir de muestras de tejido fijado embebido en parafina
WO2014197090A2 (en) 2013-03-14 2014-12-11 Gentegra, Llc Preservation of biological materials in non-aqueous fluid media
SG11201607382TA (en) * 2014-03-07 2016-10-28 Agency Science Tech & Res Apparatus and methods for fractionation of biological products
AU2015302319B2 (en) * 2014-08-15 2017-04-13 Myriad Women’s Health, Inc. High-throughput sample processing systems and methods of use
JP2016067275A (ja) * 2014-09-30 2016-05-09 セイコーエプソン株式会社 核酸精製デバイス
WO2016094465A1 (en) * 2014-12-09 2016-06-16 Corning Incorporated Methods and kits for purifying plasmid dna
US9976136B2 (en) 2015-05-14 2018-05-22 Longhorn Vaccines And Diagnostics, Llc Rapid methods for the extraction of nucleic acids from biological samples
US20160348153A1 (en) 2015-05-29 2016-12-01 The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv Extraction and preservation of nucleic acid molecules from pathogens
DK3568475T3 (da) * 2017-01-16 2023-04-17 Spectrum Solutions L L C Nukleinsyrekonserveringsopløsning og fremgangsmåder til anvendelse

Also Published As

Publication number Publication date
FI3568475T3 (fi) 2023-05-15
HRP20230345T1 (hr) 2023-06-09
EP3568475A4 (en) 2020-09-23
HUE062204T2 (hu) 2023-10-28
US20180201977A1 (en) 2018-07-19
EP4177342B1 (en) 2023-12-27
ES2942577T3 (es) 2023-06-02
EP3568475A1 (en) 2019-11-20
CY1126046T1 (el) 2023-11-15
US20190062806A1 (en) 2019-02-28
CN110072999A (zh) 2019-07-30
EP3568475B1 (en) 2023-03-08
JP2020503071A (ja) 2020-01-30
EP4177342C0 (en) 2023-12-27
US20200407777A1 (en) 2020-12-31
US10174362B2 (en) 2019-01-08
JP2020058396A (ja) 2020-04-16
US11655495B2 (en) 2023-05-23
JP2022069447A (ja) 2022-05-11
US20230304071A1 (en) 2023-09-28
MX2019006767A (es) 2019-08-22
JP6652692B2 (ja) 2020-02-26
PL3568475T3 (pl) 2023-06-19
PT3568475T (pt) 2023-04-18
MX2020003996A (es) 2020-07-22
CN113801876A (zh) 2021-12-17
US10774368B2 (en) 2020-09-15
CA3042088A1 (en) 2018-07-19
DK3568475T3 (da) 2023-04-17
EP4177342A1 (en) 2023-05-10
CN110072999B (zh) 2021-08-24
LT3568475T (lt) 2023-04-25
WO2018132827A1 (en) 2018-07-19

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