SI20637A - Aril- in heterociklil-substituirani pirimidinski derivati kot antikoagulanti - Google Patents

Aril- in heterociklil-substituirani pirimidinski derivati kot antikoagulanti Download PDF

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Publication number
SI20637A
SI20637A SI9920090A SI9920090A SI20637A SI 20637 A SI20637 A SI 20637A SI 9920090 A SI9920090 A SI 9920090A SI 9920090 A SI9920090 A SI 9920090A SI 20637 A SI20637 A SI 20637A
Authority
SI
Slovenia
Prior art keywords
alkyl
aryl
aralkyl
optionally substituted
halo
Prior art date
Application number
SI9920090A
Other languages
English (en)
Slovenian (sl)
Inventor
David D. Davey
Gary B. Phillips
Original Assignee
Berlex Laboratories, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Berlex Laboratories, Inc. filed Critical Berlex Laboratories, Inc.
Publication of SI20637A publication Critical patent/SI20637A/sl

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Communicable Diseases (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Separation Of Suspended Particles By Flocculating Agents (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SI9920090A 1998-12-04 1999-12-03 Aril- in heterociklil-substituirani pirimidinski derivati kot antikoagulanti SI20637A (sl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/205,498 US6127376A (en) 1998-12-04 1998-12-04 Aryl and heterocyclyl substituted pyrimidine derivatives as anti-coagulants
PCT/US1999/028537 WO2000033844A1 (en) 1998-12-04 1999-12-03 Aryl and heterocyclyl substituted pyrimidine derivatives as anti-coagulants

Publications (1)

Publication Number Publication Date
SI20637A true SI20637A (sl) 2002-02-28

Family

ID=22762435

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9920090A SI20637A (sl) 1998-12-04 1999-12-03 Aril- in heterociklil-substituirani pirimidinski derivati kot antikoagulanti

Country Status (26)

Country Link
US (2) US6127376A (cs)
EP (1) EP1135131A4 (cs)
JP (1) JP2002531506A (cs)
KR (1) KR20010093799A (cs)
CN (1) CN1329491A (cs)
AU (1) AU760370B2 (cs)
BG (1) BG105557A (cs)
BR (1) BR9915938A (cs)
CA (1) CA2354040A1 (cs)
CZ (1) CZ20011932A3 (cs)
EE (1) EE200100298A (cs)
HR (1) HRP20010499A2 (cs)
HU (1) HUP0104508A3 (cs)
IL (2) IL143347A0 (cs)
LT (1) LT4912B (cs)
LV (1) LV12783B (cs)
MX (1) MXPA01005656A (cs)
NO (1) NO20012701L (cs)
NZ (1) NZ512104A (cs)
PL (1) PL348034A1 (cs)
RO (1) RO120971B1 (cs)
RU (1) RU2001118466A (cs)
SI (1) SI20637A (cs)
SK (1) SK7632001A3 (cs)
WO (1) WO2000033844A1 (cs)
ZA (1) ZA200104235B (cs)

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Also Published As

Publication number Publication date
CN1329491A (zh) 2002-01-02
BR9915938A (pt) 2001-08-21
HRP20010499A2 (en) 2003-04-30
ZA200104235B (en) 2002-08-23
LT2001061A (en) 2001-12-27
CA2354040A1 (en) 2000-06-15
SK7632001A3 (en) 2001-12-03
CZ20011932A3 (cs) 2001-10-17
JP2002531506A (ja) 2002-09-24
HUP0104508A2 (hu) 2002-05-29
KR20010093799A (ko) 2001-10-29
US6127376A (en) 2000-10-03
LV12783A (en) 2002-01-20
EE200100298A (et) 2002-12-16
WO2000033844A1 (en) 2000-06-15
IL143347A0 (en) 2002-04-21
IL143347A (en) 2006-12-10
BG105557A (en) 2001-12-29
EP1135131A4 (en) 2002-01-02
PL348034A1 (en) 2002-05-06
US6372751B1 (en) 2002-04-16
NO20012701D0 (no) 2001-06-01
LV12783B (en) 2002-10-20
LT4912B (lt) 2002-04-25
NO20012701L (no) 2001-07-25
HUP0104508A3 (en) 2002-07-29
EP1135131A1 (en) 2001-09-26
AU760370B2 (en) 2003-05-15
NZ512104A (en) 2003-10-31
MXPA01005656A (es) 2002-04-24
RU2001118466A (ru) 2003-04-20
AU3107500A (en) 2000-06-26
RO120971B1 (ro) 2006-10-30

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