SI2010536T1 - Imidazo(1,2-b)piridazini, postopki za njihovo pripravo in njihova uporaba kot GABA receptorski ligandi - Google Patents

Imidazo(1,2-b)piridazini, postopki za njihovo pripravo in njihova uporaba kot GABA receptorski ligandi

Info

Publication number
SI2010536T1
SI2010536T1 SI200730332T SI200730332T SI2010536T1 SI 2010536 T1 SI2010536 T1 SI 2010536T1 SI 200730332 T SI200730332 T SI 200730332T SI 200730332 T SI200730332 T SI 200730332T SI 2010536 T1 SI2010536 T1 SI 2010536T1
Authority
SI
Slovenia
Prior art keywords
åpyridazines
imidazo
processes
preparation
receptor ligands
Prior art date
Application number
SI200730332T
Other languages
English (en)
Inventor
Jose Luis Falco
Albert Palomer
Antonio Guglietta
Original Assignee
Ferrer Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferrer Int filed Critical Ferrer Int
Publication of SI2010536T1 publication Critical patent/SI2010536T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SI200730332T 2006-03-29 2007-03-28 Imidazo(1,2-b)piridazini, postopki za njihovo pripravo in njihova uporaba kot GABA receptorski ligandi SI2010536T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06111899A EP1845098A1 (en) 2006-03-29 2006-03-29 Imidazo[1,2-b]pyridazines, their processes of preparation and their use as GABA receptor ligands
EP07727460A EP2010536B1 (en) 2006-03-29 2007-03-28 Imidazo [1, 2-b]pyridazines, their processes of preparation and their use as gaba receptor ligands
PCT/EP2007/052988 WO2007110437A1 (en) 2006-03-29 2007-03-28 Imidazo [1, 2-b] pyridazines, their processes of preparation and their use as gaba receptor ligands

Publications (1)

Publication Number Publication Date
SI2010536T1 true SI2010536T1 (sl) 2010-10-29

Family

ID=36323447

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200730332T SI2010536T1 (sl) 2006-03-29 2007-03-28 Imidazo(1,2-b)piridazini, postopki za njihovo pripravo in njihova uporaba kot GABA receptorski ligandi

Country Status (23)

Country Link
US (2) US8153789B2 (sl)
EP (2) EP1845098A1 (sl)
JP (1) JP5091944B2 (sl)
KR (1) KR20090008275A (sl)
CN (1) CN101448831B (sl)
AR (1) AR060212A1 (sl)
AT (1) ATE471325T1 (sl)
AU (1) AU2007231362B2 (sl)
BR (1) BRPI0709207A2 (sl)
CA (1) CA2647116C (sl)
CY (1) CY1111211T1 (sl)
DE (1) DE602007007203D1 (sl)
DK (1) DK2010536T3 (sl)
ES (1) ES2347182T3 (sl)
HK (1) HK1127917A1 (sl)
MX (1) MX2008012274A (sl)
NO (1) NO20084375L (sl)
PL (1) PL2010536T3 (sl)
PT (1) PT2010536E (sl)
RU (1) RU2486188C9 (sl)
SI (1) SI2010536T1 (sl)
TW (1) TWI403512B (sl)
WO (2) WO2007110438A1 (sl)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1713784A1 (en) * 2004-02-12 2006-10-25 Neurogen Corporation Imidazo-pyridazines, triazolo-pyridazines and related benzodiazepine receptor ligands
US8217177B2 (en) 2006-07-14 2012-07-10 Amgen Inc. Fused heterocyclic derivatives and methods of use
US8198448B2 (en) 2006-07-14 2012-06-12 Amgen Inc. Fused heterocyclic derivatives and methods of use
PE20080403A1 (es) 2006-07-14 2008-04-25 Amgen Inc Derivados heterociclicos fusionados y metodos de uso
FR2918061B1 (fr) 2007-06-28 2010-10-22 Sanofi Aventis Derives de 6-cycloamino-3-(pyridin-4-yl)imidazo°1,2-b!- pyridazine,leur preparation et leur application en therapeutique.
CA2704137A1 (en) * 2007-10-30 2009-05-07 Nihon Medi-Physics Co., Ltd. Use of novel compound having affinity for amyloid, and process for production of the same
US7868001B2 (en) * 2007-11-02 2011-01-11 Hutchison Medipharma Enterprises Limited Cytokine inhibitors
CA2710016A1 (en) * 2007-12-21 2009-07-02 The University Of Sydney Translocator protein ligands
EP2103614A1 (en) * 2008-03-18 2009-09-23 Santhera Pharmaceuticals (Schweiz) AG Substituted imidazopyrimidine, imidazopyrazine and imidazopyridazine derivatives as melanocortin-4 receptor modulators
US8497278B2 (en) * 2008-05-19 2013-07-30 Sunovion Pharmaceuticals Inc. Imidazo[1,2-a]pyridine compounds
US8071595B2 (en) 2008-06-25 2011-12-06 Envivo Pharmaceuticals, Inc. 1,2-disubstituted heterocyclic compounds
US20100267730A1 (en) * 2008-10-09 2010-10-21 Giuseppe Alvaro Novel compounds
RU2531274C2 (ru) * 2009-05-07 2014-10-20 Энвиво Фармасьютикалз, Инк. Феноксиметильные гетероциклические соединения
TWI617559B (zh) 2010-12-22 2018-03-11 江蘇恆瑞醫藥股份有限公司 ２－芳基咪唑并［１，２－ｂ］嗒．２－苯基咪唑并［１，２－ａ］吡啶，和２－苯基咪唑并［１，２－ａ］吡衍生物
UA112028C2 (uk) * 2012-12-14 2016-07-11 Пфайзер Лімітед Похідні імідазопіридазину як модулятори гамка-рецептора
GB201321734D0 (en) * 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic Agents

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2492382A1 (fr) * 1980-10-22 1982-04-23 Synthelabo Derives d'imidazo (1,2-a) pyridine, leur preparation et leur application en therapeutique
DE3542661A1 (de) * 1985-12-03 1987-06-04 Bayer Ag Imidazopyridazinalkensaeureamide, verfahren zu ihrer herstellung, zwischenprodukte zu ihrer herstellung
DE8808030U1 (de) * 1987-07-04 1988-11-03 Krones Ag Hermann Kronseder Maschinenfabrik, 8402 Neutraubling Etikettiervorrichtung für Behälter
WO1989001333A1 (en) * 1987-08-07 1989-02-23 The Australian National University IMIDAZO[1,2-b]PYRIDAZINES
ATE283270T1 (de) * 1997-04-25 2004-12-15 Takeda Chemical Industries Ltd Condensierte pyridazine derivate,deren herstellung und verwendung
WO1999036423A1 (en) * 1998-01-14 1999-07-22 Merck Sharp & Dohme Limited Triazolo-pyridazine derivatives as ligands for gaba receptors
KR20010087738A (ko) * 1998-10-21 2001-09-21 다케다 야쿠힌 고교 가부시키가이샤 축합 피리다진 유도체, 이의 제조 방법 및 용도
PT1218382E (pt) * 1999-10-08 2004-06-30 Gruenenthal Gmbh Derivados de imidazo-3-il-amina biciclica
KR20020050275A (ko) * 1999-11-11 2002-06-26 다케다 야쿠힌 고교 가부시키가이샤 융합 피리다진 유도체를 함유하는 점비제
JP2002371042A (ja) * 2001-06-12 2002-12-26 Takeda Chem Ind Ltd ジアミン化合物、その製造法および用途
PT1483265E (pt) * 2002-03-05 2007-01-31 Lilly Co Eli Derivados de purina como inibidores de quinase
GB0210124D0 (en) * 2002-05-02 2002-06-12 Merck Sharp & Dohme Therapeutic agents
MXPA05006438A (es) * 2002-12-18 2005-09-08 Mallinckrodt Inc Derivados de acetamidas de heteroarilo.
ES2222813B1 (es) * 2003-07-24 2005-12-16 Ferrer Internacional, S.A. N-(3-(3-sustituidas-pirazolo(1,5-a)pirimidin-7-il)-fenil)-sulfonamidas y composiciones y metodos relacionados.
ATE421962T1 (de) * 2004-11-11 2009-02-15 Ferrer Int Imidazoä1,2-aüpyridinverbindungen, zusammensetzungen, anwendungen und verfahren, die damit in zusammenhang stehen
WO2006083682A2 (en) * 2005-01-28 2006-08-10 H.Lundbeck A/S Polymorphic forms of a gabaa agonist
EP1803722A1 (en) * 2006-01-03 2007-07-04 Ferrer Internacional, S.A. Imidazo[1,2-a]pyridin-3-yl-acetic acid hydrazides, processes for their preparation and pharmaceutical uses thereof
BRPI0717928A2 (pt) * 2006-10-30 2013-11-05 Novartis Ag Imidazopiridazinas como inibidores da cinase de lipídio pi3k

Also Published As

Publication number Publication date
US8993562B2 (en) 2015-03-31
US20090176788A1 (en) 2009-07-09
CN101448831A (zh) 2009-06-03
RU2486188C2 (ru) 2013-06-27
EP2010536A1 (en) 2009-01-07
EP2010536B1 (en) 2010-06-16
RU2486188C9 (ru) 2013-08-10
US8153789B2 (en) 2012-04-10
TWI403512B (zh) 2013-08-01
DE602007007203D1 (de) 2010-07-29
HK1127917A1 (en) 2009-10-09
WO2007110438A1 (en) 2007-10-04
JP5091944B2 (ja) 2012-12-05
CA2647116C (en) 2013-12-31
PL2010536T3 (pl) 2010-11-30
AU2007231362B2 (en) 2012-07-19
NO20084375L (no) 2008-10-17
JP2009531384A (ja) 2009-09-03
BRPI0709207A2 (pt) 2011-06-28
CN101448831B (zh) 2013-05-01
DK2010536T3 (da) 2010-10-04
CA2647116A1 (en) 2007-10-04
WO2007110437A1 (en) 2007-10-04
KR20090008275A (ko) 2009-01-21
ATE471325T1 (de) 2010-07-15
ES2347182T3 (es) 2010-10-26
AU2007231362A1 (en) 2007-10-04
MX2008012274A (es) 2008-11-12
EP1845098A1 (en) 2007-10-17
RU2008142841A (ru) 2010-05-10
PT2010536E (pt) 2010-09-03
TW200813062A (en) 2008-03-16
CY1111211T1 (el) 2015-06-11
AR060212A1 (es) 2008-06-04
US20120040979A1 (en) 2012-02-16

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