PL2010536T3 - Imidazo[1,2-b]pirydazyny, sposoby ich otrzymywania oraz ich zastosowanie jako ligandów receptora GABA - Google Patents

Imidazo[1,2-b]pirydazyny, sposoby ich otrzymywania oraz ich zastosowanie jako ligandów receptora GABA

Info

Publication number
PL2010536T3
PL2010536T3 PL07727460T PL07727460T PL2010536T3 PL 2010536 T3 PL2010536 T3 PL 2010536T3 PL 07727460 T PL07727460 T PL 07727460T PL 07727460 T PL07727460 T PL 07727460T PL 2010536 T3 PL2010536 T3 PL 2010536T3
Authority
PL
Poland
Prior art keywords
pyridazines
imidazo
processes
preparation
receptor ligands
Prior art date
Application number
PL07727460T
Other languages
English (en)
Inventor
José Luis Falcó
Albert Palomer
Antonio Guglietta
Original Assignee
Ferrer Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferrer Int filed Critical Ferrer Int
Publication of PL2010536T3 publication Critical patent/PL2010536T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PL07727460T 2006-03-29 2007-03-28 Imidazo[1,2-b]pirydazyny, sposoby ich otrzymywania oraz ich zastosowanie jako ligandów receptora GABA PL2010536T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06111899A EP1845098A1 (en) 2006-03-29 2006-03-29 Imidazo[1,2-b]pyridazines, their processes of preparation and their use as GABA receptor ligands
PCT/EP2007/052988 WO2007110437A1 (en) 2006-03-29 2007-03-28 Imidazo [1, 2-b] pyridazines, their processes of preparation and their use as gaba receptor ligands
EP07727460A EP2010536B1 (en) 2006-03-29 2007-03-28 Imidazo [1, 2-b]pyridazines, their processes of preparation and their use as gaba receptor ligands

Publications (1)

Publication Number Publication Date
PL2010536T3 true PL2010536T3 (pl) 2010-11-30

Family

ID=36323447

Family Applications (1)

Application Number Title Priority Date Filing Date
PL07727460T PL2010536T3 (pl) 2006-03-29 2007-03-28 Imidazo[1,2-b]pirydazyny, sposoby ich otrzymywania oraz ich zastosowanie jako ligandów receptora GABA

Country Status (22)

Country Link
US (2) US8153789B2 (pl)
EP (2) EP1845098A1 (pl)
JP (1) JP5091944B2 (pl)
KR (1) KR20090008275A (pl)
CN (1) CN101448831B (pl)
AR (1) AR060212A1 (pl)
AT (1) ATE471325T1 (pl)
AU (1) AU2007231362B2 (pl)
BR (1) BRPI0709207A2 (pl)
CA (1) CA2647116C (pl)
CY (1) CY1111211T1 (pl)
DE (1) DE602007007203D1 (pl)
DK (1) DK2010536T3 (pl)
ES (1) ES2347182T3 (pl)
MX (1) MX2008012274A (pl)
NO (1) NO20084375L (pl)
PL (1) PL2010536T3 (pl)
PT (1) PT2010536E (pl)
RU (1) RU2486188C9 (pl)
SI (1) SI2010536T1 (pl)
TW (1) TWI403512B (pl)
WO (2) WO2007110437A1 (pl)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1713784A1 (en) * 2004-02-12 2006-10-25 Neurogen Corporation Imidazo-pyridazines, triazolo-pyridazines and related benzodiazepine receptor ligands
PE20080403A1 (es) 2006-07-14 2008-04-25 Amgen Inc Derivados heterociclicos fusionados y metodos de uso
US8217177B2 (en) 2006-07-14 2012-07-10 Amgen Inc. Fused heterocyclic derivatives and methods of use
US8198448B2 (en) 2006-07-14 2012-06-12 Amgen Inc. Fused heterocyclic derivatives and methods of use
FR2918061B1 (fr) * 2007-06-28 2010-10-22 Sanofi Aventis Derives de 6-cycloamino-3-(pyridin-4-yl)imidazo°1,2-b!- pyridazine,leur preparation et leur application en therapeutique.
EP2216052A4 (en) * 2007-10-30 2012-11-21 Nihon Mediphysics Co Ltd USE OF A NEW COMPOUND WITH AFFINITY FOR AMYLOID AND METHOD FOR THE PRODUCTION THEREOF
US7868001B2 (en) * 2007-11-02 2011-01-11 Hutchison Medipharma Enterprises Limited Cytokine inhibitors
JP2011506487A (ja) * 2007-12-21 2011-03-03 ザ・ユニバーシティ・オブ・シドニー トランスロケータータンパク質リガンド
EP2103614A1 (en) * 2008-03-18 2009-09-23 Santhera Pharmaceuticals (Schweiz) AG Substituted imidazopyrimidine, imidazopyrazine and imidazopyridazine derivatives as melanocortin-4 receptor modulators
CA2724842A1 (en) * 2008-05-19 2009-11-26 Sunovion Pharmaceuticals Inc. Imidazo[1,2-a]pyridine compounds
BRPI0914772A2 (pt) 2008-06-25 2015-10-20 Envivo Pharmaceuticals Inc compostos heterocíclicos 1,2-dissubstituídos
US20100267730A1 (en) * 2008-10-09 2010-10-21 Giuseppe Alvaro Novel compounds
CN105125547A (zh) 2009-05-07 2015-12-09 费瑞姆医药有限公司 苯氧基甲基杂环化合物
TWI617559B (zh) * 2010-12-22 2018-03-11 江蘇恆瑞醫藥股份有限公司 ２－芳基咪唑并［１，２－ｂ］嗒．２－苯基咪唑并［１，２－ａ］吡啶，和２－苯基咪唑并［１，２－ａ］吡衍生物
UA112028C2 (uk) * 2012-12-14 2016-07-11 Пфайзер Лімітед Похідні імідазопіридазину як модулятори гамка-рецептора
GB201321734D0 (en) * 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic Agents

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2492382A1 (fr) * 1980-10-22 1982-04-23 Synthelabo Derives d'imidazo (1,2-a) pyridine, leur preparation et leur application en therapeutique
DE3542661A1 (de) * 1985-12-03 1987-06-04 Bayer Ag Imidazopyridazinalkensaeureamide, verfahren zu ihrer herstellung, zwischenprodukte zu ihrer herstellung
DE8808030U1 (de) * 1987-07-04 1988-11-03 Krones Ag Hermann Kronseder Maschinenfabrik, 8402 Neutraubling Etikettiervorrichtung für Behälter
WO1989001333A1 (en) * 1987-08-07 1989-02-23 The Australian National University IMIDAZO[1,2-b]PYRIDAZINES
CA2285264A1 (en) * 1997-04-25 1998-11-05 Michiyo Gyoten Condensed pyridazine derivatives, their production and use
CA2315219A1 (en) * 1998-01-14 1999-07-22 Merck Sharp & Dohme Limited Triazolo-pyridazine derivatives as ligands for gaba receptors
CN1329614A (zh) * 1998-10-21 2002-01-02 武田药品工业株式会社 稠合的哒嗪衍生物、它们的制备方法和用途
EP1218382B1 (de) * 1999-10-08 2004-01-28 Grünenthal GmbH Bicyclische imidazo-3-yl-aminderivate
KR20020050275A (ko) * 1999-11-11 2002-06-26 다케다 야쿠힌 고교 가부시키가이샤 융합 피리다진 유도체를 함유하는 점비제
JP2002371042A (ja) * 2001-06-12 2002-12-26 Takeda Chem Ind Ltd ジアミン化合物、その製造法および用途
WO2003076442A1 (en) * 2002-03-05 2003-09-18 Eli Lilly And Company Purine derivatives as kinase inhibitors
GB0210124D0 (en) * 2002-05-02 2002-06-12 Merck Sharp & Dohme Therapeutic agents
ES2320758T3 (es) * 2002-12-18 2009-05-28 Mallinckrodt Inc. Sintesis de heteroaril acetamidas.
ES2222813B1 (es) * 2003-07-24 2005-12-16 Ferrer Internacional, S.A. N-(3-(3-sustituidas-pirazolo(1,5-a)pirimidin-7-il)-fenil)-sulfonamidas y composiciones y metodos relacionados.
RU2007121864A (ru) * 2004-11-11 2008-12-20 Феррер Интернасионал ИМИДАЗО[1,2-a]ПИРИДИНОВЫЕ СОЕДИНЕНИЯ (ВАРИАНТЫ), СПОСОБ ИХ ПОЛУЧЕНИЯ (ВАРИАНТЫ), КОМПОЗИЦИЯ НА ИХ ОСНОВЕ, СПОСОБ ЛЕЧЕНИЯ ИЛИ ПРОФИЛАКТИКИ ЗАБОЛЕВАНИЙ, СВЯЗАННЫХ С МОДУЛЯЦИЕЙ РЕЦЕПТОРОВ GABAA, ИЛИ α1-GABAA, ИЛИ α2-GABAA (ВАРИАНТЫ)
EP1848420A4 (en) * 2005-01-28 2008-01-23 Merck & Co Inc POLYMORPH SHAPES OF A GABAA AGONIST
EP1803722A1 (en) * 2006-01-03 2007-07-04 Ferrer Internacional, S.A. Imidazo[1,2-a]pyridin-3-yl-acetic acid hydrazides, processes for their preparation and pharmaceutical uses thereof
MX2009004623A (es) * 2006-10-30 2009-05-15 Novartis Ag Imidazopiridazinas como inhibidores de la lipido cinasa pi3k.

Also Published As

Publication number Publication date
SI2010536T1 (sl) 2010-10-29
CY1111211T1 (el) 2015-06-11
CA2647116A1 (en) 2007-10-04
JP2009531384A (ja) 2009-09-03
DE602007007203D1 (de) 2010-07-29
US8993562B2 (en) 2015-03-31
ES2347182T3 (es) 2010-10-26
EP2010536A1 (en) 2009-01-07
EP1845098A1 (en) 2007-10-17
WO2007110438A1 (en) 2007-10-04
US20090176788A1 (en) 2009-07-09
CN101448831A (zh) 2009-06-03
EP2010536B1 (en) 2010-06-16
TWI403512B (zh) 2013-08-01
ATE471325T1 (de) 2010-07-15
PT2010536E (pt) 2010-09-03
TW200813062A (en) 2008-03-16
US20120040979A1 (en) 2012-02-16
CN101448831B (zh) 2013-05-01
WO2007110437A1 (en) 2007-10-04
BRPI0709207A2 (pt) 2011-06-28
NO20084375L (no) 2008-10-17
RU2486188C2 (ru) 2013-06-27
KR20090008275A (ko) 2009-01-21
MX2008012274A (es) 2008-11-12
HK1127917A1 (en) 2009-10-09
RU2008142841A (ru) 2010-05-10
JP5091944B2 (ja) 2012-12-05
DK2010536T3 (da) 2010-10-04
AU2007231362B2 (en) 2012-07-19
US8153789B2 (en) 2012-04-10
AU2007231362A1 (en) 2007-10-04
AR060212A1 (es) 2008-06-04
RU2486188C9 (ru) 2013-08-10
CA2647116C (en) 2013-12-31

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