DE602007007203D1 - Imidazoä1,2-büpyridazine, verfahren zu ihrer herstellung und ihre verwendung als gaba-rezeptor-liganden - Google Patents

Imidazoä1,2-büpyridazine, verfahren zu ihrer herstellung und ihre verwendung als gaba-rezeptor-liganden

Info

Publication number
DE602007007203D1
DE602007007203D1 DE602007007203T DE602007007203T DE602007007203D1 DE 602007007203 D1 DE602007007203 D1 DE 602007007203D1 DE 602007007203 T DE602007007203 T DE 602007007203T DE 602007007203 T DE602007007203 T DE 602007007203T DE 602007007203 D1 DE602007007203 D1 DE 602007007203D1
Authority
DE
Germany
Prior art keywords
imidazoä1
büpyridazine
preparation
receptor ligands
gaba receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602007007203T
Other languages
English (en)
Inventor
Jose Luis Falco
Albert Palomer
Antonio Guglietta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ferrer Internacional SA
Original Assignee
Ferrer Internacional SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferrer Internacional SA filed Critical Ferrer Internacional SA
Publication of DE602007007203D1 publication Critical patent/DE602007007203D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE602007007203T 2006-03-29 2007-03-28 Imidazoä1,2-büpyridazine, verfahren zu ihrer herstellung und ihre verwendung als gaba-rezeptor-liganden Active DE602007007203D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06111899A EP1845098A1 (de) 2006-03-29 2006-03-29 Imidazo[1,2-b]pyridazinen, deren Herstellungverfahren und ihre Verwendung als GABA Rezeptor Liganden
PCT/EP2007/052988 WO2007110437A1 (en) 2006-03-29 2007-03-28 Imidazo [1, 2-b] pyridazines, their processes of preparation and their use as gaba receptor ligands

Publications (1)

Publication Number Publication Date
DE602007007203D1 true DE602007007203D1 (de) 2010-07-29

Family

ID=36323447

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602007007203T Active DE602007007203D1 (de) 2006-03-29 2007-03-28 Imidazoä1,2-büpyridazine, verfahren zu ihrer herstellung und ihre verwendung als gaba-rezeptor-liganden

Country Status (23)

Country Link
US (2) US8153789B2 (de)
EP (2) EP1845098A1 (de)
JP (1) JP5091944B2 (de)
KR (1) KR20090008275A (de)
CN (1) CN101448831B (de)
AR (1) AR060212A1 (de)
AT (1) ATE471325T1 (de)
AU (1) AU2007231362B2 (de)
BR (1) BRPI0709207A2 (de)
CA (1) CA2647116C (de)
CY (1) CY1111211T1 (de)
DE (1) DE602007007203D1 (de)
DK (1) DK2010536T3 (de)
ES (1) ES2347182T3 (de)
HK (1) HK1127917A1 (de)
MX (1) MX2008012274A (de)
NO (1) NO20084375L (de)
PL (1) PL2010536T3 (de)
PT (1) PT2010536E (de)
RU (1) RU2486188C9 (de)
SI (1) SI2010536T1 (de)
TW (1) TWI403512B (de)
WO (2) WO2007110437A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090023737A1 (en) * 2004-02-12 2009-01-22 Neurogen Corporation Imidazo-Pyridazines, Triazolo-Pyridazines and Related Benzodiazepine Receptor Ligands
PE20080403A1 (es) 2006-07-14 2008-04-25 Amgen Inc Derivados heterociclicos fusionados y metodos de uso
US8198448B2 (en) 2006-07-14 2012-06-12 Amgen Inc. Fused heterocyclic derivatives and methods of use
US8217177B2 (en) 2006-07-14 2012-07-10 Amgen Inc. Fused heterocyclic derivatives and methods of use
FR2918061B1 (fr) * 2007-06-28 2010-10-22 Sanofi Aventis Derives de 6-cycloamino-3-(pyridin-4-yl)imidazo°1,2-b!- pyridazine,leur preparation et leur application en therapeutique.
EP2216052A4 (de) * 2007-10-30 2012-11-21 Nihon Mediphysics Co Ltd Verwendung einer neuen verbindung mit affinität für amyloid und verfahren zu ihrer herstellung
US7868001B2 (en) * 2007-11-02 2011-01-11 Hutchison Medipharma Enterprises Limited Cytokine inhibitors
WO2009079683A1 (en) * 2007-12-21 2009-07-02 The University Of Sydney Translocator protein ligands
EP2103614A1 (de) * 2008-03-18 2009-09-23 Santhera Pharmaceuticals (Schweiz) AG Substituiertes Imidazopyrimidin, Imidazopyrazin und Imidazopyridazinderivate als Melanocortin-4-Rezeptormodulatoren
JP5774982B2 (ja) * 2008-05-19 2015-09-09 サノビオン ファーマシューティカルズ インクＳｕｎｏｖｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． イミダゾ［１，２−ａ］ピリジン化合物
BRPI0914772A2 (pt) * 2008-06-25 2015-10-20 Envivo Pharmaceuticals Inc compostos heterocíclicos 1,2-dissubstituídos
US20100267730A1 (en) * 2008-10-09 2010-10-21 Giuseppe Alvaro Novel compounds
PL2617420T3 (pl) 2009-05-07 2016-04-29 Forum Pharmaceuticals Inc Heterocykliczne związki fenoksymetylu
TWI617559B (zh) * 2010-12-22 2018-03-11 江蘇恆瑞醫藥股份有限公司 ２－芳基咪唑并［１，２－ｂ］嗒．２－苯基咪唑并［１，２－ａ］吡啶，和２－苯基咪唑并［１，２－ａ］吡衍生物
UA112028C2 (uk) * 2012-12-14 2016-07-11 Пфайзер Лімітед Похідні імідазопіридазину як модулятори гамка-рецептора
GB201321734D0 (en) * 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic Agents

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2492382A1 (fr) * 1980-10-22 1982-04-23 Synthelabo Derives d'imidazo (1,2-a) pyridine, leur preparation et leur application en therapeutique
DE3542661A1 (de) * 1985-12-03 1987-06-04 Bayer Ag Imidazopyridazinalkensaeureamide, verfahren zu ihrer herstellung, zwischenprodukte zu ihrer herstellung
DE8808030U1 (de) * 1987-07-04 1988-11-03 Krones Ag Hermann Kronseder Maschinenfabrik, 8402 Neutraubling, De
WO1989001333A1 (en) * 1987-08-07 1989-02-23 The Australian National University IMIDAZO[1,2-b]PYRIDAZINES
CA2285264A1 (en) * 1997-04-25 1998-11-05 Michiyo Gyoten Condensed pyridazine derivatives, their production and use
US6303597B1 (en) * 1998-01-14 2001-10-16 Merck Sharp & Dohme Limited Triazolo-pyridazine derivatives as ligands for GABA receptors
CA2348022A1 (en) * 1998-10-21 2000-04-27 Takeda Chemical Industries, Ltd. Condensed pyridazine derivatives, their production and use
SK286788B6 (sk) * 1999-10-08 2009-05-07 Grnenthal Gmbh Bicyklické deriváty imidazo-3-yl-amínu, spôsob ich výroby, ich použitie a liečivá obsahujúce tieto látky
WO2001034152A1 (fr) * 1999-11-11 2001-05-17 Takeda Chemical Industries, Ltd. Gouttes nasales contenant des derives de pyridazine condenses
JP2002371042A (ja) * 2001-06-12 2002-12-26 Takeda Chem Ind Ltd ジアミン化合物、その製造法および用途
ES2276048T3 (es) * 2002-03-05 2007-06-16 Eli Lilly And Company Derivados de purina como inhibidores de cinasa.
GB0210124D0 (en) * 2002-05-02 2002-06-12 Merck Sharp & Dohme Therapeutic agents
EP1575952B1 (de) * 2002-12-18 2009-02-18 Mallinckrodt Inc. Synthese von heteroaryl acetamiden
ES2222813B1 (es) * 2003-07-24 2005-12-16 Ferrer Internacional, S.A. N-(3-(3-sustituidas-pirazolo(1,5-a)pirimidin-7-il)-fenil)-sulfonamidas y composiciones y metodos relacionados.
CA2585315A1 (en) * 2004-11-11 2006-05-18 Ferrer Internacional, S.A. Imidazo[1,2-a]pyridine compounds, compositions, uses and methods related thereto
WO2006083682A2 (en) * 2005-01-28 2006-08-10 H.Lundbeck A/S Polymorphic forms of a gabaa agonist
EP1803722A1 (de) * 2006-01-03 2007-07-04 Ferrer Internacional, S.A. Imidazo[1,2-a]pyridin-3-yl-Essigsäure-Hydrazide, Verfahren zur ihrer Herstellung und ihre Verwendung als Arzneimittel
WO2008052733A1 (en) * 2006-10-30 2008-05-08 Novartis Ag Imidazopyridazines as pi3k lipid kinase inhibitors

Also Published As

Publication number Publication date
US20090176788A1 (en) 2009-07-09
US8153789B2 (en) 2012-04-10
RU2008142841A (ru) 2010-05-10
NO20084375L (no) 2008-10-17
BRPI0709207A2 (pt) 2011-06-28
US8993562B2 (en) 2015-03-31
ATE471325T1 (de) 2010-07-15
HK1127917A1 (en) 2009-10-09
AR060212A1 (es) 2008-06-04
AU2007231362B2 (en) 2012-07-19
WO2007110438A1 (en) 2007-10-04
DK2010536T3 (da) 2010-10-04
CN101448831A (zh) 2009-06-03
JP2009531384A (ja) 2009-09-03
PT2010536E (pt) 2010-09-03
TW200813062A (en) 2008-03-16
ES2347182T3 (es) 2010-10-26
PL2010536T3 (pl) 2010-11-30
AU2007231362A1 (en) 2007-10-04
CA2647116A1 (en) 2007-10-04
CN101448831B (zh) 2013-05-01
MX2008012274A (es) 2008-11-12
SI2010536T1 (sl) 2010-10-29
RU2486188C9 (ru) 2013-08-10
EP1845098A1 (de) 2007-10-17
CA2647116C (en) 2013-12-31
EP2010536B1 (de) 2010-06-16
TWI403512B (zh) 2013-08-01
RU2486188C2 (ru) 2013-06-27
WO2007110437A1 (en) 2007-10-04
KR20090008275A (ko) 2009-01-21
CY1111211T1 (el) 2015-06-11
EP2010536A1 (de) 2009-01-07
US20120040979A1 (en) 2012-02-16
JP5091944B2 (ja) 2012-12-05

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