SI2004155T1 - Inhibitorji agregacije proteinov - Google Patents
Inhibitorji agregacije proteinov Download PDFInfo
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- SI2004155T1 SI2004155T1 SI200732019T SI200732019T SI2004155T1 SI 2004155 T1 SI2004155 T1 SI 2004155T1 SI 200732019 T SI200732019 T SI 200732019T SI 200732019 T SI200732019 T SI 200732019T SI 2004155 T1 SI2004155 T1 SI 2004155T1
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- 239000003112 inhibitor Substances 0.000 title claims 2
- 230000004845 protein aggregation Effects 0.000 title claims 2
- 150000001875 compounds Chemical class 0.000 claims abstract 14
- 150000003839 salts Chemical class 0.000 claims abstract 7
- 238000011282 treatment Methods 0.000 claims abstract 5
- 239000003814 drug Substances 0.000 claims abstract 4
- 150000004677 hydrates Chemical class 0.000 claims abstract 4
- 239000012453 solvate Substances 0.000 claims abstract 4
- -1 diaminophenothiazine compound Chemical class 0.000 claims 14
- 102000019355 Synuclein Human genes 0.000 claims 11
- 108050006783 Synuclein Proteins 0.000 claims 11
- 201000010099 disease Diseases 0.000 claims 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 7
- 238000000034 method Methods 0.000 claims 6
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 5
- 206010012289 Dementia Diseases 0.000 claims 4
- 208000018737 Parkinson disease Diseases 0.000 claims 4
- 208000009144 Pure autonomic failure Diseases 0.000 claims 4
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 claims 4
- 125000001313 C5-C10 heteroaryl group Chemical group 0.000 claims 3
- 230000002776 aggregation Effects 0.000 claims 3
- 238000004220 aggregation Methods 0.000 claims 3
- 125000001931 aliphatic group Chemical group 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 230000004770 neurodegeneration Effects 0.000 claims 3
- 206010003694 Atrophy Diseases 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 206010034010 Parkinsonism Diseases 0.000 claims 2
- 230000037444 atrophy Effects 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 238000003745 diagnosis Methods 0.000 claims 2
- 229960003638 dopamine Drugs 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 210000004558 lewy body Anatomy 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 238000004393 prognosis Methods 0.000 claims 2
- 125000006413 ring segment Chemical group 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 230000009885 systemic effect Effects 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 208000032859 Synucleinopathies Diseases 0.000 claims 1
- 125000000129 anionic group Chemical group 0.000 claims 1
- 150000001450 anions Chemical class 0.000 claims 1
- 230000000890 antigenic effect Effects 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- CVXBEEMKQHEXEN-UHFFFAOYSA-N carbaryl Chemical compound C1=CC=C2C(OC(=O)NC)=CC=CC2=C1 CVXBEEMKQHEXEN-UHFFFAOYSA-N 0.000 claims 1
- 229960005286 carbaryl Drugs 0.000 claims 1
- 125000005488 carboaryl group Chemical group 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 239000003086 colorant Substances 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 230000000069 prophylactic effect Effects 0.000 claims 1
- 238000011321 prophylaxis Methods 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 6
- 229940079593 drug Drugs 0.000 abstract 2
- 150000002990 phenothiazines Chemical class 0.000 abstract 2
- LZILOGCFZJDPTG-UHFFFAOYSA-N 10h-phenothiazine-3,7-diamine Chemical compound C1=C(N)C=C2SC3=CC(N)=CC=C3NC2=C1 LZILOGCFZJDPTG-UHFFFAOYSA-N 0.000 abstract 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 208000034799 Tauopathies Diseases 0.000 abstract 1
- XQAXGZLFSSPBMK-UHFFFAOYSA-M [7-(dimethylamino)phenothiazin-3-ylidene]-dimethylazanium;chloride;trihydrate Chemical compound O.O.O.[Cl-].C1=CC(=[N+](C)C)C=C2SC3=CC(N(C)C)=CC=C3N=C21 XQAXGZLFSSPBMK-UHFFFAOYSA-M 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 229960000907 methylthioninium chloride Drugs 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/18—[b, e]-condensed with two six-membered rings
- C07D279/20—[b, e]-condensed with two six-membered rings with hydrogen atoms directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/003—Thiazine dyes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0465—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2835—Movement disorders, e.g. Parkinson, Huntington, Tourette
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Claims (25)
- EP 2 004 155 BI Inhibitorji agregacije proteinov Patentni zahtevki1. Uporaba diaminofenotiazinske spojine v izdelavi zdravila za inhibiranje ali reverzijo agregacije sinukleina, kjer je agregacija povezana z bolezenskim stanjem, ki se manifestira kot nevrodegeneracija in/ali klinična demenca, pri čemer je bolezen izbrana izmed: Parkinsonove bolezni (PD), demence z Lewyjevimi telesci (DLB), multiple sistemske atrofije (MSA), z zdravilom-induciranega parkinsonizma; čiste avtonomne odpovedi (PAF), in kjer je navedeno zdravilo za zdravljenje navedenega bolezenskega stanja in kjer se v navedenem zdravljenju diaminofenotiazinska spojina daje oralno kot bodisi: (i) odmeme enote okoli 10, 20, 30, 40, 50, 60, 80, 90, 100, 110, 120 ali 130 mg trikrat dnevno; ali (ii) odmeme enote okoli 10, 20, 30, 40, 50, 60, 80, 90, 100, 110, 120, 130, 140, 150, 160, 170, 180, 190 ali 200 mg dvakrat dnevno; ali (iii) odmerek manjši od ali enak 400 mg skupnega dnevnega odmerka, kjer je navedena spojina izbrana izmed spojin z naslednjimi formulami:kjer je vsak od R1, R2, R4, R6, R8 in R9 neodvisno izbran izmed: -Η; -F; -Cl; -Br; -I; -OH; -OR; -SH; -SR; -N02; -C(=0)R; -C(=0)0H; -C(=0)0R; -C(=0)NH2; -C(=0)NHR; -C(=0)NR2; -C(=0)NRn1RN2; -NH2; -NHR; -NR2; -NRn1RN2; -NHC(=0)H; -NRC(=0)H; -NHC(=0)R; -NRC(=0)R; -R; kjer je vsak R neodvisno izbran izmed: nesubstituiranega alifatskega Cj^alkila; substituiranega alifatskega Ci^alkila; nesubstituiranega alifatskega C2.6alkenila; substituiranega alifatskega C2.6alkenila; nesubstituiranega C3.6cikloalkila; substituiranega C3.6cikloalkila; nesubstituiranega C6.10karboarila; substituiranega C6.iokarboarila; nesubstituiranega Cs^oheteroarila; substituiranega C5.i0heteroarila; nesubstituiranega C6-iokarboaril-Ci.4alkila; substituiranega C6.i0karboaril-Ci^alkila; kjer v vsaki skupini -NRN1RN2, neodvisno, RN1 in RN2 skupaj z atomom dušika, na katerega sta vezana, tvorita obroč, ki ima od 3 do 7 obročnih atomov; in kjer je v vsaki skupini -NR3NAR3NA: vsak od R3NA in R3NB neodvisno izbran izmed: -H; nesubstituiranega alifatskega Ci^alkila; substituiranega alifatskega C^alkila; nesubstituiranega alifatskega C2-6alkenila; substituiranega alifatskega C2-6alkenila; nesubstituiranega C3.6cikloalkila; substituiranega C3.6cikloalkila; nesubstituiranega C6.i0karboarila; substituiranega C6.10karboarila; nesubstituiranega Cs.ioheteroarila; substituiranega C5.i0heteroarila; nesubstituiranega C6-iokarboaril-Ci_4alkila; substituiranega C6.iokarboaril-Ci.4alkila; ali: R3NA in R3NB skupaj z atomom dušika, na katerega sta vezana, tvorita obroč, ki ima od 3 do 7 obročnih atomov; in kjer je skupina -NR7NAR7NB enaka kot -NR3naR3NB; in kjer je X- eden ali več anionskih protiionov, da se doseže električna nevtralnost; in farmacevtsko sprejemljivih soli, mešanih soli, hidratov in solvatov le-teh.
- 2. Uporaba po zahtevku 1, kjer je vsak od R1, R2, R4, R6, R8 in R9 neodvisno izbran izmed: -H; -R.
- 3. Uporaba po zahtevku 1 ali zahtevku 2, kjer je vsak R neodvisno izbran izmed: nesubstituiranega alifatskega Ci.6alkila; substituiranega alifatskega Ci^alkila.
- 4. Uporaba po katerem koli od zahtevkov 1 do 3, kjer so substituenti na R, če so prisotni, neodvisno izbrani izmed: -F; -CI; -Br; -I; -OH; -OR; -C(=0)0H; -C(=0)0R’; -R’, kjer je vsak R’ neodvisno izbran izmed: nesubstituiranega alifatskega Ci.6alkila; nesubstituiranega alifatskega C2^alkenila; nesubstituiranega C3.6cikloalkila; nesubstituiranega C6.iokarboarila; nesubstituiranega C5.ioheteroarila; nesubstituiranega C6.10karboaril-Ci.4alkila.
- 5. Uporaba po zahtevku 1, kjer je vsak od R1, R2, R4, R6, R8 in R9 neodvisno izbran izmed: -H, -Me, -Et, -nPr in -iPr.
- 6. Uporaba po zahtevku 5, kjer je vsak od R1, R2, R4, R6, R8 in R9 neodvisno izbran izmed: -H, -Me in -Et.
- 7. Uporaba po zahtevku 1, kjer je vsak od R1, R2, R4, R6, R8 in R9 neodvisno izbran izmed: -H in -Me.
- 8. Uporaba po zahtevku 7, kjer je vsak od R1, R2, R4, R6, R8 in R9 -H.
- 9. Uporaba po katerem koli od zahtevkov od 1 do 8, kjer je v vsaki skupini -NR3naR3NB vsak od R3NA in R3NB neodvisno izbran izmed: -H, -Me, -Et, -nPr in _iPr.
- 10. Uporaba po zahtevku 9, kjer je v vsaki skupini -NR3NAR3NB vsak od R3NA in R3NB neodvisno izbran izmed: -H in -Me.
- 11. Uporaba po katerem koli od zahtevkov od 1 do 10, kjer je X-, če je prisoten, eden ali več anionskih protiionov, da se doseže električna nevtralnost, po izbiri izbran izmed: C1‘, Br ali Γ.
- 12. Uporaba po zahtevku 1, kjer je spojina izbrana izmed naslednjih spojin in farmacevtsko sprejemljivih soli, mešanih soli, hidratov in solvatov le-teh:
- 13. Diaminofenotiazinska spojina, kot je opisana v katerem koli od zahtevkov od 1 do 12, za uporabo v postopku zdravljenja ali profilaksi nevrodegenerativnega bolezenskega stanja in/ali klinične demence, povezane/ga z agregacijo sinukleina, pri čemer postopek obsega dajanje subjektu profilaktično ali terapevtsko učinkovite količine navedene diaminofenotiazinske spojine ali terapevtskega sestavka, ki obsega le-to, tako da se inhibira agregacija sinukleina, kjer je agregacija povezana z bolezenskim stanjem, ki se manifestira kot nevrodegeneracija in/ali klinična demenca, pri čemer je bolezen izbrana izmed: Parkinsonove bolezni (PD), demence z Lewyjevimi telesci (DLB), multiple sistemske atrofije (MSA), z zdravilom- induciranega parkinsonizma, čiste avtonomne odpovedi (PAF), kjer se v navedenem postopku diaminofenotiazinska spojina daje oralno kot bodisi: (i) odmeme enote okoli 10, 20, 30, 40, 50, 60, 80, 90, 100, 110, 120 ali 130 mg trikrat dnevno; ali (ii) odmeme enote okoli 10, 20, 30, 40, 50, 60, 80, 90, 100, 110, 120, 130, 140, 150, 160, 170, 180, 190 ali 200 mg dvakrat dnevno; ali (iii) odmerek manjši od ali enak 400 mg skupnega dnevnega odmerka.
- 14. Uporaba po katerem koli od zahtevkov od 1 do 12, kjer navedeno zdravljenje obsega dajanje navedene diaminofenotiazinske spojine v kombinaciji s spojino, ki modulira dopaminske nivoje pri sesalcu, ki naj se ga zdravi.
- 15. Uporaba po katerem koli od zahtevkov od 1 do 12 ali 14, kjer se daje dnevni celokupni odmerek, ki je večji od ali enak 300 mg, 200 mg ali 100 mg.
- 16. Spojina po zahtevku 13, kjer navedeno zdravljenje obsega dajanje navedene diaminofenotiazinske spojine v kombinaciji s spojino, ki modulira dopaminske nivoje pri sesalcu, ki naj se ga zdravi.
- 17. Spojina po zahtevku 13 ali 16, kjer se daje dnevni celokupni odmerek, ki je večji od ali enak 300, 200 ali 100 mg.
- 18. Uporaba diaminofenotiazinske spojine, ki je sposobna markirati agregiran sinuklein, v postopku izdelave diagnostičnega ali prognostičnega reagenta za uporabo v diagnozi ali prognozi sinukleinopatijskega bolezenskega stanja, kjer je navedena diaminofenotiazinska spojina spojina, kot je opisana v katerem koli od zahtevkov od 1 do 12, in vključuje, je konjugirana na, je kelirana z ali je drugače povezana z enim ali več izotopi, radioizotopi, pozitrone-emitirajočimi atomi, magnetnimi resonančnimi markerji, barvili, fluorescentnimi markerji ali antigenskimi skupinami.
- 19. Uporaba po zahtevku 18, kjer je vsaj eden od obročnih ogljikovih atomov od diaminofenotiazinske spojine nC in/ali je vsaj eden od ogljikovih atomov od vsaj enega od substituentov R1, R2, R4, R6, R8, R9, R3NA, R3NB, R™A in R7*® nC.
- 20. Uporaba po zahtevku 19, izbrana izmed naslednjih spojin in farmacevtsko sprejemljivih soli, mešanih soli, hidratov in solvatov le-teh:
- 21. Postopek markiranja agregiranega sinukleina, ki obsega stopnje: kontaktiranje agregiranega sinukleina z diaminofenotiazinsko spojino, kot je opisana v katerem koli od zahtevkov od 18 do 20.
- 22. Diaminofenotiazinska spojina, kot je opisana v katerem koli od zahtevkov od 18 do 20, za uporabo v postopku diagnoze ali prognoze sinukleinopatije pri subjektu, za katerega se predvideva, da trpi zaradi bolezni, ki obsega stopnje: (i) uvedbo navedene diaminofenotiazinske spojine v subjekt, (ii) določitev prisotnosti in/ali količine navedene spojine, vezane na sinuklein ali agregiran sinuklein v možganih subjekta, (iii) koreliranje rezultata določitve, narejene v (ii), z bolezenskim stanjem subjekta.
- 23. Uporaba po katerem koli od zahtevkov od 1 do 12 ali 14 do 15 ali 18 do 20, kjer je sinuklein a-sinuklein.
- 24. Postopek po zahtevku 21, kjer je sinukelin a-sinuklein.
- 25. Spojina za uporabo po katerem koli od zahtevkov 13 ali 16 do 17, kjer je sinuklein a-sinuklein.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US78670006P | 2006-03-29 | 2006-03-29 | |
EP07712961.7A EP2004155B1 (en) | 2006-03-29 | 2007-03-28 | Inhibitors of protein aggregation |
PCT/GB2007/001105 WO2007110629A1 (en) | 2006-03-29 | 2007-03-28 | Inhibitors of protein aggregation |
Publications (1)
Publication Number | Publication Date |
---|---|
SI2004155T1 true SI2004155T1 (sl) | 2018-05-31 |
Family
ID=38068838
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI200732019T SI2004155T1 (sl) | 2006-03-29 | 2007-03-28 | Inhibitorji agregacije proteinov |
Country Status (13)
Country | Link |
---|---|
US (3) | US8263589B2 (sl) |
EP (1) | EP2004155B1 (sl) |
JP (1) | JP5654748B2 (sl) |
CN (2) | CN103735554B (sl) |
AU (1) | AU2007231126B2 (sl) |
CA (1) | CA2645946C (sl) |
DK (1) | DK2004155T3 (sl) |
ES (1) | ES2667002T3 (sl) |
MY (1) | MY153198A (sl) |
PL (1) | PL2004155T3 (sl) |
PT (1) | PT2004155T (sl) |
SI (1) | SI2004155T1 (sl) |
WO (1) | WO2007110629A1 (sl) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
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JP5186212B2 (ja) | 2004-09-23 | 2013-04-17 | ウィスタ ラボラトリーズ リミテッド | メチルチオニニウム塩化物(mtc)などのジアミノフェノチアジニウム化合物を化学合成および精製する方法 |
CN103735554B (zh) | 2006-03-29 | 2018-03-20 | 维斯塔实验室有限公司 | 蛋白聚集抑制剂 |
CN104119294B (zh) | 2006-03-29 | 2018-10-30 | 维斯塔实验室有限公司 | 3,7-二氨基-10h-吩噻嗪化合物的制备方法 |
FR2903696B1 (fr) | 2006-07-12 | 2011-02-11 | Provence Technologies | Procede de purification de composes diaminophenothiazium |
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EP2004155A1 (en) | 2008-12-24 |
US20110118242A1 (en) | 2011-05-19 |
CN103735554B (zh) | 2018-03-20 |
ES2667002T3 (es) | 2018-05-09 |
CN101460157A (zh) | 2009-06-17 |
MY153198A (en) | 2015-01-29 |
US9174954B2 (en) | 2015-11-03 |
US20140221359A1 (en) | 2014-08-07 |
US8263589B2 (en) | 2012-09-11 |
JP5654748B2 (ja) | 2015-01-14 |
CN101460157B (zh) | 2015-09-02 |
WO2007110629A1 (en) | 2007-10-04 |
PL2004155T3 (pl) | 2018-08-31 |
DK2004155T3 (en) | 2018-04-30 |
JP2009531404A (ja) | 2009-09-03 |
PT2004155T (pt) | 2018-05-02 |
CN103735554A (zh) | 2014-04-23 |
CA2645946A1 (en) | 2007-10-04 |
AU2007231126B2 (en) | 2012-11-01 |
CA2645946C (en) | 2014-04-01 |
AU2007231126A1 (en) | 2007-10-04 |
EP2004155B1 (en) | 2018-02-21 |
US20090209526A1 (en) | 2009-08-20 |
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