SI1656347T1 - Substituirani indolni derivati za farmacevtske sestavke za zdravljenje respiratornih bolezni - Google Patents

Substituirani indolni derivati za farmacevtske sestavke za zdravljenje respiratornih bolezni

Info

Publication number
SI1656347T1
SI1656347T1 SI200431554T SI200431554T SI1656347T1 SI 1656347 T1 SI1656347 T1 SI 1656347T1 SI 200431554 T SI200431554 T SI 200431554T SI 200431554 T SI200431554 T SI 200431554T SI 1656347 T1 SI1656347 T1 SI 1656347T1
Authority
SI
Slovenia
Prior art keywords
pharmaceutical composition
respiratory diseases
indole derivatives
substituted indole
treating respiratory
Prior art date
Application number
SI200431554T
Other languages
English (en)
Slovenian (sl)
Inventor
Roger Victor Bonnert
Anthony Ronald Cook
Timothy Jon Luker
Rukhsana Tasneem Mohammed
Stephen Thom
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of SI1656347T1 publication Critical patent/SI1656347T1/sl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/30Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32Oxygen atoms
    • C07D209/36Oxygen atoms in position 3, e.g. adrenochrome
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/02Nasal agents, e.g. decongestants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
SI200431554T 2003-08-18 2004-08-16 Substituirani indolni derivati za farmacevtske sestavke za zdravljenje respiratornih bolezni SI1656347T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0302232A SE0302232D0 (sv) 2003-08-18 2003-08-18 Novel Compounds
PCT/GB2004/003502 WO2005019171A1 (en) 2003-08-18 2004-08-16 Substituted indole derivatives for pharmaceutical composition for treating respiratory diseases
EP04768065A EP1656347B1 (en) 2003-08-18 2004-08-16 Substituted indole derivatives for pharmaceutical composition for treating respiratory diseases

Publications (1)

Publication Number Publication Date
SI1656347T1 true SI1656347T1 (sl) 2011-01-31

Family

ID=28450248

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200431554T SI1656347T1 (sl) 2003-08-18 2004-08-16 Substituirani indolni derivati za farmacevtske sestavke za zdravljenje respiratornih bolezni

Country Status (18)

Country Link
US (1) US7709521B2 (enExample)
EP (1) EP1656347B1 (enExample)
JP (1) JP4709758B2 (enExample)
AR (1) AR045462A1 (enExample)
AT (1) ATE484494T1 (enExample)
CY (1) CY1110977T1 (enExample)
DE (1) DE602004029580D1 (enExample)
DK (1) DK1656347T3 (enExample)
ES (1) ES2352201T3 (enExample)
MY (1) MY143367A (enExample)
PL (1) PL1656347T3 (enExample)
PT (1) PT1656347E (enExample)
SA (1) SA04250255B1 (enExample)
SE (1) SE0302232D0 (enExample)
SI (1) SI1656347T1 (enExample)
TW (1) TW200510303A (enExample)
UY (1) UY28473A1 (enExample)
WO (1) WO2005019171A1 (enExample)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200307542A (en) 2002-05-30 2003-12-16 Astrazeneca Ab Novel compounds
SE0201635D0 (sv) 2002-05-30 2002-05-30 Astrazeneca Ab Novel compounds
SE0202241D0 (sv) * 2002-07-17 2002-07-17 Astrazeneca Ab Novel Compounds
SE0301569D0 (sv) * 2003-05-27 2003-05-27 Astrazeneca Ab Novel compounds
SE0302232D0 (sv) 2003-08-18 2003-08-18 Astrazeneca Ab Novel Compounds
SE0303180D0 (sv) * 2003-11-26 2003-11-26 Astrazeneca Ab Novel compounds
DE602005006539D1 (de) 2004-03-11 2008-06-19 Actelion Pharmaceuticals Ltd Tetrahydropyridoindolderivate
PL1833791T3 (pl) 2004-12-27 2011-12-30 Actelion Pharmaceuticals Ltd Pochodne 2,3,4,9-tetrahydro-1H-karbazolu jako antagonisty receptora CRTH2
GB0500604D0 (en) 2005-01-13 2005-02-16 Astrazeneca Ab Novel process
GB0505048D0 (en) * 2005-03-11 2005-04-20 Oxagen Ltd Compounds with PGD antagonist activity
EP1911759A4 (en) 2005-07-22 2010-07-21 Shionogi & Co AZAINDOL DERIVATIVE ANTAGONISTIC EFFECT ON PGD2 RECEPTOR
ES2372701T3 (es) 2005-07-22 2012-01-25 Shionogi & Co., Ltd. Derivado de indol que tiene actividad antagonista del receptor de pgd2.
GB0521275D0 (en) * 2005-10-19 2005-11-30 Argenta Discovery Ltd 3-Aminoindole compounds
WO2007138282A2 (en) 2006-05-26 2007-12-06 Astrazeneca Ab Bi-aryl or aryl-heteroaryl substituted indoles
US20150072963A1 (en) * 2006-06-16 2015-03-12 The Trustees Of The University Of Pennsylvania Compositions and methods for regulating hair growth
WO2007149312A2 (en) 2006-06-16 2007-12-27 The Trustees Of The University Of Pennsylvania Methods and compositions for inhibiting or reducing hair loss, acne, rosacea, prostate cancer, and bph
AU2007279079A1 (en) 2006-07-22 2008-01-31 Oxagen Limited Compounds having CRTH2 antagonist activity
PT2051962E (pt) 2006-08-07 2012-01-10 Actelion Pharmaceuticals Ltd Derivados do ácido (3-amino-1,2,3,4-tetrahidro-9hcarbazol- 9-il)-acético
HRP20130900T1 (hr) 2007-04-11 2013-11-08 Kissei Pharmaceutical Co., Ltd. Derivat (aza)indola i njegova uporaba u medicinske svrhe
US7960567B2 (en) * 2007-05-02 2011-06-14 Amgen Inc. Compounds and methods useful for treating asthma and allergic inflammation
PT2229358E (pt) 2007-12-14 2011-06-29 Pulmagen Therapeutics Asthma Ltd Indoles e sua utilização terapêutica
SI2250161T1 (sl) 2008-01-18 2014-04-30 Atopix Therapeutics Limited Spojine, ki imajo aktivnost crth2 antagonista
US7750027B2 (en) 2008-01-18 2010-07-06 Oxagen Limited Compounds having CRTH2 antagonist activity
JP2011509990A (ja) 2008-01-22 2011-03-31 オキサジェン リミテッド Crth2アンタゴニスト活性を有する化合物
JP2011509991A (ja) 2008-01-22 2011-03-31 オキサジェン リミテッド Crth2アンタゴニスト活性を有する化合物
WO2009151910A2 (en) * 2008-05-25 2009-12-17 Wyeth Combination product of receptor tyrosine kinase inhibitor and fatty acid synthase inhibitor for treating cancer
MY150774A (en) * 2008-12-25 2014-02-28 Taisho Pharmaceutical Co Ltd Isoquinoline derivative
AR076590A1 (es) * 2009-05-19 2011-06-22 Vivia Biotech Sl Metodos para proveer pruebas medicinales personalizada ex vivo para neoplasmas hematologicos
EP2451780B1 (en) * 2009-07-06 2013-06-19 AstraZeneca AB Intermediates and processes for the preparation of 4-(acetylamino))-3-[(4-chloro-phenyl)thio]-2-methyl-1h-indole-1-acetic acid
BR112012020273A8 (pt) * 2010-02-11 2017-12-26 Univ Vanderbilt compostos de pirazolopiridina, pirazolopirazina, pirazolopirimidina, pirazolotiofeno e pirazolotiazol como pontencializadores alostéricos de mglur4, composições e métodos de tratamento de disfunção neurológica
NZ603108A (en) 2010-03-22 2014-05-30 Actelion Pharmaceuticals Ltd 3-(heteroaryl-amino)-1,2,3,4-tetrahydro-9h-carbazole derivatives and their use as prostaglandin d2 receptor modulators
EP2586772A4 (en) 2010-06-23 2013-11-13 Taisho Pharmaceutical Co Ltd isoquinoline
EP2457900A1 (en) 2010-11-25 2012-05-30 Almirall, S.A. New pyrazole derivatives having CRTh2 antagonistic behaviour
HUE028972T2 (en) 2011-04-14 2017-01-30 Actelion Pharmaceuticals Ltd 7- (Heteroarylamino) -6,7,8,9-tetrahydropyrido [1,2-a] indole acetic acid derivatives and their use as prostaglandin D2 receptor modulators
EP2526945A1 (en) 2011-05-25 2012-11-28 Almirall, S.A. New CRTH2 Antagonists
EP2548876A1 (en) 2011-07-18 2013-01-23 Almirall, S.A. New CRTh2 antagonists
EP2548863A1 (en) 2011-07-18 2013-01-23 Almirall, S.A. New CRTh2 antagonists.
EP2790696A1 (en) 2011-12-16 2014-10-22 Atopix Therapeutics Limited Combination of crth2 antagonist and a proton pump inhibitor for the treatment of eosinophilic esophagitis
KR102205774B1 (ko) * 2012-03-21 2021-01-20 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 모발 성장을 조절하는 방법 및 조성물
CN106103435B (zh) 2014-03-17 2018-11-16 爱杜西亚药品有限公司 氮杂吲哚乙酸衍生物及彼等作为前列腺素d2受体调节剂的用途
MX2016011900A (es) 2014-03-18 2016-12-05 Actelion Pharmaceuticals Ltd Derivados de acido azaindol-acetico y su uso como moduladores del receptor de prostaglandina d2.
GB201407820D0 (en) 2014-05-02 2014-06-18 Atopix Therapeutics Ltd Polymorphic form
GB201407807D0 (en) 2014-05-02 2014-06-18 Atopix Therapeutics Ltd Polymorphic form
TWI695831B (zh) 2014-09-13 2020-06-11 香港商南北兄弟藥業投資有限公司 Crth2拮抗劑化合物及其用途
EP4420734A3 (en) 2015-02-13 2024-11-06 Institut National de la Santé et de la Recherche Médicale Ptgdr-1 and/or ptgdr-2 antagonists for preventing and/or treating systemic lupus erythematosus
MX2018001217A (es) 2015-07-30 2018-09-12 Univ Pennsylvania Alelos polimorficos de nucleotidos individuales del gen humano dp-2 para la deteccion de la susceptibilidad a la inhibicion del crecimiento del cabello por pgd2.
PL3350179T3 (pl) 2015-09-15 2021-08-02 Idorsia Pharmaceuticals Ltd Krystaliczne postacie
WO2022092141A1 (ja) * 2020-10-28 2022-05-05 塩野義製薬株式会社 抗ウイルス活性を有するアミド誘導体

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE790679A (fr) * 1971-11-03 1973-04-27 Ici Ltd Derives de l'indole
JPH0615542B2 (ja) 1986-07-22 1994-03-02 吉富製薬株式会社 ピラゾロピリジン化合物
US5095031A (en) * 1990-08-20 1992-03-10 Abbott Laboratories Indole derivatives which inhibit leukotriene biosynthesis
WO1993005020A1 (en) 1991-09-06 1993-03-18 Merck & Co., Inc. Indoles as inhibitors of hiv reverse transcriptase
FR2692574B1 (fr) 1992-06-23 1995-06-23 Sanofi Elf Derives hydroxy-4 benzenethio, leur preparation ainsi que leur utilisation pour la preparation de derives aminoalkoxybenzenesulfonyles.
EP0686148A4 (en) 1993-02-24 1996-02-07 Merck & Co Inc INHIBITORS OF HIV INVERSE TRANSCRIPTASE
US5486525A (en) 1993-12-16 1996-01-23 Abbott Laboratories Platelet activating factor antagonists: imidazopyridine indoles
US5567711A (en) 1995-04-19 1996-10-22 Abbott Laboratories Indole-3-carbonyl and indole-3-sulfonyl derivatives as platelet activating factor antagonists
TW472045B (en) 1996-09-25 2002-01-11 Astra Ab Protein kinase C inhibitor compounds, method for their preparation, pharmaceutical composition thereof and intermediate used for their preparation
WO1999009007A1 (en) 1997-08-21 1999-02-25 American Home Products Corporation Solid phase synthesis of 2,3-disubstituted indole compounds
ES2198033T3 (es) 1997-12-19 2004-01-16 Eli Lilly And Company Compuestos de imidazolina hipoglucemicos.
US6916841B2 (en) 1998-02-25 2005-07-12 Genetics Institute, Llc Inhibitors of phospholipase enzymes
WO2000078761A1 (en) 1999-06-23 2000-12-28 Sepracor, Inc. Indolyl-benzimidazole antibacterials, and methods of use thereof
WO2001032621A1 (en) 1999-10-29 2001-05-10 Wakunaga Pharmaceutical Co., Ltd. Novel indole derivatives and drugs containing the same as the active ingredient
WO2001047922A2 (en) 1999-12-24 2001-07-05 Aventis Pharma Limited Azaindoles
IL152682A0 (en) * 2000-05-31 2003-06-24 Astrazeneca Ab Indole derivatives with vascular damaging activity
US6878522B2 (en) * 2000-07-07 2005-04-12 Baiyong Li Methods for the identification of compounds useful for the treatment of disease states mediated by prostaglandin D2
TWI317634B (en) 2001-12-13 2009-12-01 Nat Health Research Institutes Aroyl indoles compounds
MXPA04007414A (es) 2002-02-01 2004-10-11 Hoffmann La Roche Indoles sustituidos como agonistas alfa-1.
SE0200411D0 (sv) 2002-02-05 2002-02-05 Astrazeneca Ab Novel use
SE0200356D0 (sv) 2002-02-05 2002-02-05 Astrazeneca Ab Novel use
US7534897B2 (en) * 2002-05-16 2009-05-19 Shionogi & Co., Ltd. Indole arylsulfonaimide compounds exhibiting PGD 2 receptor antagonism
TW200307542A (en) 2002-05-30 2003-12-16 Astrazeneca Ab Novel compounds
SE0201635D0 (sv) * 2002-05-30 2002-05-30 Astrazeneca Ab Novel compounds
SE0202241D0 (sv) * 2002-07-17 2002-07-17 Astrazeneca Ab Novel Compounds
SE0202463D0 (sv) 2002-08-14 2002-08-14 Astrazeneca Ab Novel compounds
SE0301569D0 (sv) 2003-05-27 2003-05-27 Astrazeneca Ab Novel compounds
SE0302232D0 (sv) 2003-08-18 2003-08-18 Astrazeneca Ab Novel Compounds
US20070232681A1 (en) 2003-10-14 2007-10-04 Oxagen Limited Compounds Having Crth2 Antagonist Activity
SE0303180D0 (sv) 2003-11-26 2003-11-26 Astrazeneca Ab Novel compounds
GB0500604D0 (en) 2005-01-13 2005-02-16 Astrazeneca Ab Novel process
GB2422831A (en) 2005-02-04 2006-08-09 Oxagen Ltd Pyrrolopyridines and their use in the treatment of diseases mediated by PGD2 at the CRTH2 receptor
WO2007138282A2 (en) 2006-05-26 2007-12-06 Astrazeneca Ab Bi-aryl or aryl-heteroaryl substituted indoles
EP2037910A1 (en) 2006-06-08 2009-03-25 Neurokey A/S Use of cannabinoid receptor agonists as hypothermia inducing drugs for the treatment of ischemia
CA2656150A1 (en) 2006-06-28 2008-01-03 Sanofi-Aventis New cxcr2 inhibitors

Also Published As

Publication number Publication date
JP2007502804A (ja) 2007-02-15
PT1656347E (pt) 2010-12-09
SA04250255B1 (ar) 2009-02-25
JP4709758B2 (ja) 2011-06-22
DK1656347T3 (da) 2011-01-10
US7709521B2 (en) 2010-05-04
EP1656347B1 (en) 2010-10-13
WO2005019171A1 (en) 2005-03-03
DE602004029580D1 (de) 2010-11-25
ATE484494T1 (de) 2010-10-15
MY143367A (en) 2011-04-29
CY1110977T1 (el) 2015-06-11
ES2352201T3 (es) 2011-02-16
AR045462A1 (es) 2005-10-26
US20060264444A1 (en) 2006-11-23
PL1656347T3 (pl) 2011-02-28
EP1656347A1 (en) 2006-05-17
TW200510303A (en) 2005-03-16
SE0302232D0 (sv) 2003-08-18
UY28473A1 (es) 2005-03-31

Similar Documents

Publication Publication Date Title
PL1656347T3 (pl) Podstawione pochodne indolu do środków farmaceutycznych do leczenia chorób układu oddechowego
PL1656346T3 (pl) 1,2,3,4-Tetrapodstawiony indol do leczenia chorób dróg oddechowych
AP2005003283A0 (en) Indole derivatives useful for the treatment os diseases
GB0312832D0 (en) 2-amino-pyridine derivatives useful for the treatment of diseases
TWI369987B (en) New pharmaceutical compositions for the treatment of hyper-proliferative disorders
IL226562A0 (en) Pharmacy combinations containing benzoxazine for the treatment of respiratory diseases
ZA200701584B (en) Biphenyloxyacetic acid derivatives for the treatment of respiratory disease
ZA200604352B (en) Azepinondole derivatives as pharmaceutical agents
PL1690550T3 (pl) Środek do leczenia międzybłoniaka
IL173908A0 (en) Pharmaceutical compositions for treating premature ejaculation by pulmonary inhalation
IL184934A0 (en) 4-oxoquinazoline-3-yl-benzamide derivatives for the treatment of cytokine diseases
IL187739A0 (en) New 2-azetidinone derivatives for the treatment of hyperlipidaemic diseases
SI1685125T1 (sl) Derivati pirola, primerni za zdravljenje proliferativnih bolezni
IL186676A0 (en) 4-phenyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline derivatives as medicaments for the treatment of infertility
IL185444A0 (en) Novel drugs for treating respiratory diseases
IL188856A0 (en) Novel piperidine derivatives as chemokine receptor modulators useful for the treatment of respiratory diseases
HUP0401523A3 (en) Indole-2-carboxamide derivatives, pharmaceutical compositions containing them and process for producing them
IL186831A0 (en) 4-phenyl- 5-oxo - 1,4,5,6,7,8 - hexahydroquinoline derivatives as medicaments for the treatment of infertility
GB0228305D0 (en) Therapeutic composition for respiratory delivery
HU0500145D0 (en) Composition for the treatment of oral diseases
GB0219153D0 (en) Substituted glycine derivatives for use as medicaments
EP1490048A4 (en) PHARMACEUTICAL COMPOSITION FOR THE PREVENTION OR TREATMENT OF RESPIRATORY DISEASES
ZA200603126B (en) Pharmaceutical compositions for therapeutic use
GB0408297D0 (en) Indole derivatives for the treatment of diseases
HK1071523A (en) Pharmaceutical composition for preventing or treating respiratory disease