SI0902016T1 - A process and intermediate compounds for the preparation of amlodipine benzene sulphonate - Google Patents
A process and intermediate compounds for the preparation of amlodipine benzene sulphonateInfo
- Publication number
- SI0902016T1 SI0902016T1 SI9830190T SI9830190T SI0902016T1 SI 0902016 T1 SI0902016 T1 SI 0902016T1 SI 9830190 T SI9830190 T SI 9830190T SI 9830190 T SI9830190 T SI 9830190T SI 0902016 T1 SI0902016 T1 SI 0902016T1
- Authority
- SI
- Slovenia
- Prior art keywords
- ämethylü
- chem
- formula
- preparation
- preparing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
- C07C69/716—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU9701379A HU221810B1 (hu) | 1997-08-12 | 1997-08-12 | Eljárás amlodipin-bezilát előállítására és az eljárás intermedierjei |
EP98115155A EP0902016B1 (en) | 1997-08-12 | 1998-08-12 | A process and intermediate compounds for the preparation of amlodipine benzene sulphonate |
Publications (1)
Publication Number | Publication Date |
---|---|
SI0902016T1 true SI0902016T1 (en) | 2002-08-31 |
Family
ID=89995490
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI9830190T SI0902016T1 (en) | 1997-08-12 | 1998-08-12 | A process and intermediate compounds for the preparation of amlodipine benzene sulphonate |
Country Status (13)
Country | Link |
---|---|
US (1) | US6046337A (cs) |
EP (1) | EP0902016B1 (cs) |
AT (1) | ATE216988T1 (cs) |
CZ (1) | CZ291430B6 (cs) |
DE (1) | DE69805143T2 (cs) |
ES (1) | ES2175573T3 (cs) |
HR (1) | HRP980440B1 (cs) |
HU (1) | HU221810B1 (cs) |
PL (2) | PL192097B1 (cs) |
RU (1) | RU2163597C2 (cs) |
SI (1) | SI0902016T1 (cs) |
SK (1) | SK283422B6 (cs) |
UA (1) | UA57722C2 (cs) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA72768C2 (en) * | 1999-07-05 | 2005-04-15 | Richter Gedeon Vegyeszet | A method for obtaining amilodipine benzenesulphonate |
US7266501B2 (en) * | 2000-03-02 | 2007-09-04 | Akiba Electronics Institute Llc | Method and apparatus for accommodating primary content audio and secondary content remaining audio capability in the digital audio production process |
WO2002053540A1 (en) | 2000-12-29 | 2002-07-11 | Pfizer Limited | Aspartate derivative of amlodipine as calcium channel antagonist |
AT5874U1 (de) | 2000-12-29 | 2003-01-27 | Bioorg Bv | Pharmazeutische zubereitungen enthaltend amlodipinmaleat |
ES2254495T4 (es) | 2000-12-29 | 2007-06-16 | Pfizer Limited | Hemimaleato de amlodipina. |
EP1309556B1 (en) | 2000-12-29 | 2004-11-24 | Pfizer Limited | Amlodipine fumarate |
MXPA03005882A (es) * | 2000-12-29 | 2005-04-19 | Pfizer Ltd | Derivado amida de amlodipina. |
EP1346214A2 (en) | 2000-12-29 | 2003-09-24 | Pfizer Limited | Reference standards and processes for determining the purity or stability of amlodipine maleate |
US6653481B2 (en) | 2000-12-29 | 2003-11-25 | Synthon Bv | Process for making amlodipine |
US7335380B2 (en) * | 2000-12-29 | 2008-02-26 | Synthon Ip Inc. | Amlodipine free base |
WO2002053542A1 (en) | 2000-12-29 | 2002-07-11 | Pfizer Limited | Process for making amlodipine maleate |
BR0116554A (pt) | 2000-12-29 | 2004-02-03 | Pfizer Ltd | Composto, composição farmacêutica para o tratamento da angina ou hipertensão, processo, processo para o tratamento ou prevenção da angina ou hipertensão, composição do ingrediente farmaceuticamente ativo e composição farmacêutica para o tratamento ou prevenção da angina ou hipertensão |
KR100374767B1 (ko) * | 2001-03-13 | 2003-03-03 | 한미약품공업 주식회사 | 개선된 암로디핀의 제조 방법 |
US7153970B2 (en) | 2001-07-06 | 2006-12-26 | Lek Pharmaceuticals D.D. | High purity amlodipine benzenesulfonate and a process for its preparation |
US6680334B2 (en) | 2001-08-28 | 2004-01-20 | Pfizer Inc | Crystalline material |
AR037565A1 (es) * | 2001-11-21 | 2004-11-17 | Synthon Bv | Formas de sales de amlodipina y procedimientos para prepararlas. |
US6699892B2 (en) | 2002-06-04 | 2004-03-02 | Yung Shin Pharmaceutical Industrial Co., Ltd. | Pharmaceutically acceptable salt of amlodipine and method of preparing the same |
US6784297B2 (en) | 2002-09-04 | 2004-08-31 | Kopran Limited | Process for the preparation of anti-ischemic and anti-hypertensive drug amlodipine besylate |
US6608206B1 (en) * | 2002-10-30 | 2003-08-19 | Council Of Scientific & Industrial Research | Process for making S(-) Amlodipine salts |
WO2005089353A2 (en) * | 2004-03-16 | 2005-09-29 | Sepracor Inc. | (s)-amlodipine malate |
KR100807336B1 (ko) | 2006-10-23 | 2008-02-28 | 명문제약주식회사 | 암로디핀의 제조를 위한 신규한 중간체 화합물, 이의 제조방법 및 이를 이용한 암로디핀의 제조 방법 |
HU230877B1 (hu) * | 2008-09-30 | 2018-11-29 | EGIS Gyógyszergyár NyR | Stabil kombinációs gyógyszerkészítmény |
CN102070516A (zh) * | 2011-02-22 | 2011-05-25 | 广东东阳光药业有限公司 | 一种制备氨氯地平的方法 |
RU2755349C1 (ru) * | 2021-02-16 | 2021-09-15 | Федеральное государственное автономное образовательное учреждение высшего образования "Белгородский государственный национальный исследовательский университет" (НИУ "БелГУ") | Применение бензил 6-({ 2-[(3,4-диметилфенил)амино]-2-оксоэтил} тио)-2-метил-4-(4-хлорфенил)-5-циано-1,4-дигидропиридин-3-карбоксилата в качестве гепатопротекторного средства |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK161312C (da) * | 1982-03-11 | 1991-12-09 | Pfizer | Analogifremgangsmaade til fremstilling af 2-aminoalkoxymethyl-4-phenyl-6-methyl-1,4-dihydropyridin-3,5-dicarboxylsyreestere eller syreadditionssalte deraf samt phthalimidoderivater til anvendelse som udgangsmateriale ved fremgangsmaaden |
GB8608335D0 (en) * | 1986-04-04 | 1986-05-08 | Pfizer Ltd | Pharmaceutically acceptable salts |
US5001119A (en) * | 1987-11-25 | 1991-03-19 | Schwartz Arthur G | 16-substituted androstanes and 16-substituted androstenes |
FR2652083B1 (fr) * | 1989-09-20 | 1992-01-24 | Ador Cie | Nouveau procede de separation d'isomeres optiques des derives de la dihydro-1,4 pyridine. |
AU652747B2 (en) * | 1990-04-10 | 1994-09-08 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Pyridines as medicaments |
US5389654A (en) * | 1992-11-26 | 1995-02-14 | Lek, Tovarna, Farmacevtskih In Kemicnih . . . | 3-ethyl 5-methyl(±)2-[2-(N-tritylamino)ethoxymethyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-6-methyl-3,5-pyridinedicarboxylate |
SI9200344B (sl) * | 1992-11-26 | 1998-06-30 | Lek, | Postopek za pripravo amlodipin benzensulfonata |
-
1997
- 1997-08-12 HU HU9701379A patent/HU221810B1/hu not_active IP Right Cessation
-
1998
- 1998-07-30 CZ CZ19982396A patent/CZ291430B6/cs not_active IP Right Cessation
- 1998-08-03 SK SK1045-98A patent/SK283422B6/sk unknown
- 1998-08-10 UA UA98084353A patent/UA57722C2/uk unknown
- 1998-08-11 PL PL375449A patent/PL192097B1/pl not_active IP Right Cessation
- 1998-08-11 RU RU98115586/04A patent/RU2163597C2/ru not_active IP Right Cessation
- 1998-08-11 HR HR980440A patent/HRP980440B1/xx not_active IP Right Cessation
- 1998-08-11 PL PL327952A patent/PL191995B1/pl not_active IP Right Cessation
- 1998-08-12 SI SI9830190T patent/SI0902016T1/xx unknown
- 1998-08-12 AT AT98115155T patent/ATE216988T1/de not_active IP Right Cessation
- 1998-08-12 ES ES98115155T patent/ES2175573T3/es not_active Expired - Lifetime
- 1998-08-12 DE DE69805143T patent/DE69805143T2/de not_active Expired - Fee Related
- 1998-08-12 US US09/133,108 patent/US6046337A/en not_active Expired - Fee Related
- 1998-08-12 EP EP98115155A patent/EP0902016B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
HU9701379D0 (en) | 1997-10-28 |
EP0902016B1 (en) | 2002-05-02 |
HRP980440B1 (en) | 2003-06-30 |
HRP980440A2 (en) | 1999-06-30 |
SK104598A3 (en) | 1999-03-12 |
PL327952A1 (en) | 1999-02-15 |
EP0902016A3 (en) | 2000-01-05 |
EP0902016A1 (en) | 1999-03-17 |
US6046337A (en) | 2000-04-04 |
RU2163597C2 (ru) | 2001-02-27 |
PL191995B1 (pl) | 2006-08-31 |
CZ291430B6 (cs) | 2003-03-12 |
CZ239698A3 (cs) | 1999-02-17 |
PL192097B1 (pl) | 2006-08-31 |
UA57722C2 (uk) | 2003-07-15 |
HU221810B1 (hu) | 2003-01-28 |
ATE216988T1 (de) | 2002-05-15 |
HUP9701379A3 (en) | 2000-06-28 |
HUP9701379A2 (hu) | 2000-05-28 |
ES2175573T3 (es) | 2002-11-16 |
SK283422B6 (sk) | 2003-07-01 |
DE69805143T2 (de) | 2002-11-28 |
DE69805143D1 (de) | 2002-06-06 |
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