WO1999057095A3 - Process for the preparation of a pharmaceutical intermediate - Google Patents

Process for the preparation of a pharmaceutical intermediate Download PDF

Info

Publication number
WO1999057095A3
WO1999057095A3 PCT/HU1999/000034 HU9900034W WO9957095A3 WO 1999057095 A3 WO1999057095 A3 WO 1999057095A3 HU 9900034 W HU9900034 W HU 9900034W WO 9957095 A3 WO9957095 A3 WO 9957095A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
formula
pharmaceutical intermediate
dichlorophenyl
dihydro
Prior art date
Application number
PCT/HU1999/000034
Other languages
French (fr)
Other versions
WO1999057095A2 (en
Inventor
Gyula Simig
Nagy Peter Kotay
Jozsef Barkoczy
Gyoergy Krasznai
Kalman Nagy
Donath Gyoergyi Vereczkeyne
Norbert Nemeth
Tibor Szabo
Ilona Sztruhar
Laszlo Ladanyi
Laszlo Balazs
Imre Doman
Zoltan Greff
Zoltan Ratkai
Peter Seres
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Gyula Simig
Nagy Peter Kotay
Jozsef Barkoczy
Gyoergy Krasznai
Kalman Nagy
Donath Gyoergyi Vereczkeyne
Norbert Nemeth
Tibor Szabo
Ilona Sztruhar
Laszlo Ladanyi
Laszlo Balazs
Imre Doman
Zoltan Greff
Zoltan Ratkai
Peter Seres
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egyt Gyogyszervegyeszeti Gyar, Gyula Simig, Nagy Peter Kotay, Jozsef Barkoczy, Gyoergy Krasznai, Kalman Nagy, Donath Gyoergyi Vereczkeyne, Norbert Nemeth, Tibor Szabo, Ilona Sztruhar, Laszlo Ladanyi, Laszlo Balazs, Imre Doman, Zoltan Greff, Zoltan Ratkai, Peter Seres filed Critical Egyt Gyogyszervegyeszeti Gyar
Priority to AU38401/99A priority Critical patent/AU3840199A/en
Publication of WO1999057095A2 publication Critical patent/WO1999057095A2/en
Publication of WO1999057095A3 publication Critical patent/WO1999057095A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C249/02—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of compounds containing imino groups

Abstract

The invention relates to a process for the preparation of (±)-4-(S,R)- [(3,4-dichlorophenyl) -3,4-dihydro-1(2H) -naphthalene-1-ylidene] -methylamine of Formula (I) by reacting 4-(3,4-dichlorophenyl) -3,4-dihydro-1(2H) -naphthalene-1-one of Formula (II) with methyl amine which comprises carrying out the reaction in the absence of a dehydrating agent, in a lower alkanol. The compound of Formula (I) is a useful pharmaceutical intermediate.
PCT/HU1999/000034 1998-05-05 1999-05-03 Process for the preparation of a pharmaceutical intermediate WO1999057095A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU38401/99A AU3840199A (en) 1998-05-05 1999-05-03 Process for the preparation of a pharmaceutical intermediate

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HUP9801024 1998-05-05
HU9801024A HU226423B1 (en) 1998-05-05 1998-05-05 Process for producing a 1(2h)-naphtalene-1-ylidene derivative

Publications (2)

Publication Number Publication Date
WO1999057095A2 WO1999057095A2 (en) 1999-11-11
WO1999057095A3 true WO1999057095A3 (en) 2000-01-13

Family

ID=89996510

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/HU1999/000034 WO1999057095A2 (en) 1998-05-05 1999-05-03 Process for the preparation of a pharmaceutical intermediate

Country Status (3)

Country Link
AU (1) AU3840199A (en)
HU (1) HU226423B1 (en)
WO (1) WO1999057095A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU32700A (en) 1999-06-09 2002-03-18 Pfizer Products Inc. Process for preparing sertraline from chiral tetralone
HUP0500215A2 (en) * 2002-05-10 2005-06-28 Jirí Stohandl Process for the manufacture of sertraline

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4536518A (en) * 1979-11-01 1985-08-20 Pfizer Inc. Antidepressant derivatives of cis-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine
US4855500A (en) * 1988-05-04 1989-08-08 Pfizer Inc. Process for preparing a ketimine
WO1999036394A1 (en) * 1998-01-16 1999-07-22 Pfizer Products Inc. Novel process for preparing a ketimine

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4536518A (en) * 1979-11-01 1985-08-20 Pfizer Inc. Antidepressant derivatives of cis-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine
US4855500A (en) * 1988-05-04 1989-08-08 Pfizer Inc. Process for preparing a ketimine
WO1999036394A1 (en) * 1998-01-16 1999-07-22 Pfizer Products Inc. Novel process for preparing a ketimine

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
OSHIRO Y ET AL: "Novel cerebroprotective agents with central nervous system stimulating activity. 1. Synthesis and pharmacology of the 1-amino-7-hydroxyindan derivatives", JOURNAL OF MEDICINAL CHEMISTRY,US,AMERICAN CHEMICAL SOCIETY. WASHINGTON, vol. 34, pages 2004-2013, XP002113231, ISSN: 0022-2623 *

Also Published As

Publication number Publication date
HUP9801024A1 (en) 2000-08-28
WO1999057095A2 (en) 1999-11-11
HU226423B1 (en) 2008-12-29
AU3840199A (en) 1999-11-23
HU9801024D0 (en) 1998-06-29

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