SK283422B6 - Spôsob prípravy 3-etyl-5-metyl-2-(2-aminoetoxymetyl)-4-(2- chlórfenyl)-6-metyl-1,4-dihydro-3,5-pyridíndikarboxylátovej soli benzénsulfónovej kyseliny a medziprodukty na jej prípravu - Google Patents

Spôsob prípravy 3-etyl-5-metyl-2-(2-aminoetoxymetyl)-4-(2- chlórfenyl)-6-metyl-1,4-dihydro-3,5-pyridíndikarboxylátovej soli benzénsulfónovej kyseliny a medziprodukty na jej prípravu Download PDF

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Publication number
SK283422B6
SK283422B6 SK1045-98A SK104598A SK283422B6 SK 283422 B6 SK283422 B6 SK 283422B6 SK 104598 A SK104598 A SK 104598A SK 283422 B6 SK283422 B6 SK 283422B6
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SK
Slovakia
Prior art keywords
formula
methyl
ethyl
organic solvent
process according
Prior art date
Application number
SK1045-98A
Other languages
English (en)
Slovak (sk)
Other versions
SK104598A3 (en
Inventor
D�Niel B�Zsing
Kov�Nyi Gy�Rgyi Lax
Gyula Simig
Gyrgy KRASZNAI
G�Bor Blask�
P�Ter T�Mpe
Klmn Nagy
Vereczkey Gy�Rgyi Don�Th
G�Bor N�Met
Norbert N�Meth
Original Assignee
Egis Gy�Gyszergy�R Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egis Gy�Gyszergy�R Rt. filed Critical Egis Gy�Gyszergy�R Rt.
Publication of SK104598A3 publication Critical patent/SK104598A3/sk
Publication of SK283422B6 publication Critical patent/SK283422B6/sk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/716—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
SK1045-98A 1997-08-12 1998-08-03 Spôsob prípravy 3-etyl-5-metyl-2-(2-aminoetoxymetyl)-4-(2- chlórfenyl)-6-metyl-1,4-dihydro-3,5-pyridíndikarboxylátovej soli benzénsulfónovej kyseliny a medziprodukty na jej prípravu SK283422B6 (sk)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU9701379A HU221810B1 (hu) 1997-08-12 1997-08-12 Eljárás amlodipin-bezilát előállítására és az eljárás intermedierjei

Publications (2)

Publication Number Publication Date
SK104598A3 SK104598A3 (en) 1999-03-12
SK283422B6 true SK283422B6 (sk) 2003-07-01

Family

ID=89995490

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1045-98A SK283422B6 (sk) 1997-08-12 1998-08-03 Spôsob prípravy 3-etyl-5-metyl-2-(2-aminoetoxymetyl)-4-(2- chlórfenyl)-6-metyl-1,4-dihydro-3,5-pyridíndikarboxylátovej soli benzénsulfónovej kyseliny a medziprodukty na jej prípravu

Country Status (13)

Country Link
US (1) US6046337A (cs)
EP (1) EP0902016B1 (cs)
AT (1) ATE216988T1 (cs)
CZ (1) CZ291430B6 (cs)
DE (1) DE69805143T2 (cs)
ES (1) ES2175573T3 (cs)
HR (1) HRP980440B1 (cs)
HU (1) HU221810B1 (cs)
PL (2) PL192097B1 (cs)
RU (1) RU2163597C2 (cs)
SI (1) SI0902016T1 (cs)
SK (1) SK283422B6 (cs)
UA (1) UA57722C2 (cs)

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UA72768C2 (en) * 1999-07-05 2005-04-15 Richter Gedeon Vegyeszet A method for obtaining amilodipine benzenesulphonate
US7266501B2 (en) * 2000-03-02 2007-09-04 Akiba Electronics Institute Llc Method and apparatus for accommodating primary content audio and secondary content remaining audio capability in the digital audio production process
WO2002053540A1 (en) 2000-12-29 2002-07-11 Pfizer Limited Aspartate derivative of amlodipine as calcium channel antagonist
AT5874U1 (de) 2000-12-29 2003-01-27 Bioorg Bv Pharmazeutische zubereitungen enthaltend amlodipinmaleat
ES2254495T4 (es) 2000-12-29 2007-06-16 Pfizer Limited Hemimaleato de amlodipina.
EP1309556B1 (en) 2000-12-29 2004-11-24 Pfizer Limited Amlodipine fumarate
MXPA03005882A (es) * 2000-12-29 2005-04-19 Pfizer Ltd Derivado amida de amlodipina.
EP1346214A2 (en) 2000-12-29 2003-09-24 Pfizer Limited Reference standards and processes for determining the purity or stability of amlodipine maleate
US6653481B2 (en) 2000-12-29 2003-11-25 Synthon Bv Process for making amlodipine
US7335380B2 (en) * 2000-12-29 2008-02-26 Synthon Ip Inc. Amlodipine free base
WO2002053542A1 (en) 2000-12-29 2002-07-11 Pfizer Limited Process for making amlodipine maleate
BR0116554A (pt) 2000-12-29 2004-02-03 Pfizer Ltd Composto, composição farmacêutica para o tratamento da angina ou hipertensão, processo, processo para o tratamento ou prevenção da angina ou hipertensão, composição do ingrediente farmaceuticamente ativo e composição farmacêutica para o tratamento ou prevenção da angina ou hipertensão
KR100374767B1 (ko) * 2001-03-13 2003-03-03 한미약품공업 주식회사 개선된 암로디핀의 제조 방법
US7153970B2 (en) 2001-07-06 2006-12-26 Lek Pharmaceuticals D.D. High purity amlodipine benzenesulfonate and a process for its preparation
US6680334B2 (en) 2001-08-28 2004-01-20 Pfizer Inc Crystalline material
AR037565A1 (es) * 2001-11-21 2004-11-17 Synthon Bv Formas de sales de amlodipina y procedimientos para prepararlas.
US6699892B2 (en) 2002-06-04 2004-03-02 Yung Shin Pharmaceutical Industrial Co., Ltd. Pharmaceutically acceptable salt of amlodipine and method of preparing the same
US6784297B2 (en) 2002-09-04 2004-08-31 Kopran Limited Process for the preparation of anti-ischemic and anti-hypertensive drug amlodipine besylate
US6608206B1 (en) * 2002-10-30 2003-08-19 Council Of Scientific & Industrial Research Process for making S(-) Amlodipine salts
WO2005089353A2 (en) * 2004-03-16 2005-09-29 Sepracor Inc. (s)-amlodipine malate
KR100807336B1 (ko) 2006-10-23 2008-02-28 명문제약주식회사 암로디핀의 제조를 위한 신규한 중간체 화합물, 이의 제조방법 및 이를 이용한 암로디핀의 제조 방법
HU230877B1 (hu) * 2008-09-30 2018-11-29 EGIS Gyógyszergyár NyR Stabil kombinációs gyógyszerkészítmény
CN102070516A (zh) * 2011-02-22 2011-05-25 广东东阳光药业有限公司 一种制备氨氯地平的方法
RU2755349C1 (ru) * 2021-02-16 2021-09-15 Федеральное государственное автономное образовательное учреждение высшего образования "Белгородский государственный национальный исследовательский университет" (НИУ "БелГУ") Применение бензил 6-({ 2-[(3,4-диметилфенил)амино]-2-оксоэтил} тио)-2-метил-4-(4-хлорфенил)-5-циано-1,4-дигидропиридин-3-карбоксилата в качестве гепатопротекторного средства

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK161312C (da) * 1982-03-11 1991-12-09 Pfizer Analogifremgangsmaade til fremstilling af 2-aminoalkoxymethyl-4-phenyl-6-methyl-1,4-dihydropyridin-3,5-dicarboxylsyreestere eller syreadditionssalte deraf samt phthalimidoderivater til anvendelse som udgangsmateriale ved fremgangsmaaden
GB8608335D0 (en) * 1986-04-04 1986-05-08 Pfizer Ltd Pharmaceutically acceptable salts
US5001119A (en) * 1987-11-25 1991-03-19 Schwartz Arthur G 16-substituted androstanes and 16-substituted androstenes
FR2652083B1 (fr) * 1989-09-20 1992-01-24 Ador Cie Nouveau procede de separation d'isomeres optiques des derives de la dihydro-1,4 pyridine.
AU652747B2 (en) * 1990-04-10 1994-09-08 Byk Gulden Lomberg Chemische Fabrik Gmbh Pyridines as medicaments
US5389654A (en) * 1992-11-26 1995-02-14 Lek, Tovarna, Farmacevtskih In Kemicnih . . . 3-ethyl 5-methyl(±)2-[2-(N-tritylamino)ethoxymethyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-6-methyl-3,5-pyridinedicarboxylate
SI9200344B (sl) * 1992-11-26 1998-06-30 Lek, Postopek za pripravo amlodipin benzensulfonata

Also Published As

Publication number Publication date
HU9701379D0 (en) 1997-10-28
EP0902016B1 (en) 2002-05-02
HRP980440B1 (en) 2003-06-30
HRP980440A2 (en) 1999-06-30
SK104598A3 (en) 1999-03-12
PL327952A1 (en) 1999-02-15
EP0902016A3 (en) 2000-01-05
EP0902016A1 (en) 1999-03-17
US6046337A (en) 2000-04-04
RU2163597C2 (ru) 2001-02-27
PL191995B1 (pl) 2006-08-31
CZ291430B6 (cs) 2003-03-12
SI0902016T1 (en) 2002-08-31
CZ239698A3 (cs) 1999-02-17
PL192097B1 (pl) 2006-08-31
UA57722C2 (uk) 2003-07-15
HU221810B1 (hu) 2003-01-28
ATE216988T1 (de) 2002-05-15
HUP9701379A3 (en) 2000-06-28
HUP9701379A2 (hu) 2000-05-28
ES2175573T3 (es) 2002-11-16
DE69805143T2 (de) 2002-11-28
DE69805143D1 (de) 2002-06-06

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