SI0736525T1 - Benzonitriles as 5-HT agonists and antagonists - Google Patents

Benzonitriles as 5-HT agonists and antagonists

Info

Publication number
SI0736525T1
SI0736525T1 SI9630240T SI9630240T SI0736525T1 SI 0736525 T1 SI0736525 T1 SI 0736525T1 SI 9630240 T SI9630240 T SI 9630240T SI 9630240 T SI9630240 T SI 9630240T SI 0736525 T1 SI0736525 T1 SI 0736525T1
Authority
SI
Slovenia
Prior art keywords
benzonitriles
agonists
antagonists
Prior art date
Application number
SI9630240T
Other languages
English (en)
Inventor
Henning Dr Boettcher
Karl Ulrich Dr Buehring
Hartmut Dr Greiner
Gerd Bartoszyk
Christoph Dr Seyfried
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of SI0736525T1 publication Critical patent/SI0736525T1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
SI9630240T 1995-04-05 1996-03-28 Benzonitriles as 5-HT agonists and antagonists SI0736525T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19512639A DE19512639A1 (de) 1995-04-05 1995-04-05 Benzonitrile und -fluoride
EP96104955A EP0736525B1 (de) 1995-04-05 1996-03-28 Benzonitrile als 5-HT Agonisten und Antagonisten

Publications (1)

Publication Number Publication Date
SI0736525T1 true SI0736525T1 (en) 2001-02-28

Family

ID=7758788

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9630240T SI0736525T1 (en) 1995-04-05 1996-03-28 Benzonitriles as 5-HT agonists and antagonists

Country Status (28)

Country Link
US (1) US6310068B1 (da)
EP (1) EP0736525B1 (da)
JP (1) JP3834098B2 (da)
KR (1) KR100437751B1 (da)
CN (1) CN1072209C (da)
AR (1) AR002982A1 (da)
AT (1) ATE194595T1 (da)
AU (1) AU709708B2 (da)
BR (1) BR9601275A (da)
CA (1) CA2173418C (da)
CO (1) CO4700469A1 (da)
CY (1) CY2242B1 (da)
CZ (1) CZ289449B6 (da)
DE (2) DE19512639A1 (da)
DK (1) DK0736525T3 (da)
ES (1) ES2150039T3 (da)
GR (1) GR3034514T3 (da)
HU (1) HUP9600876A3 (da)
NO (1) NO305903B1 (da)
PL (1) PL183147B1 (da)
PT (1) PT736525E (da)
RU (1) RU2168508C2 (da)
SI (1) SI0736525T1 (da)
SK (1) SK281457B6 (da)
TR (1) TR199600286A2 (da)
TW (1) TW323279B (da)
UA (1) UA45325C2 (da)
ZA (1) ZA962768B (da)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR004229A1 (es) * 1995-11-06 1998-11-04 Wyeth Corp Derivados indolalquilo de benzodioxanmetilamina y su uso para preparar medicamentos
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
JP2002534411A (ja) * 1999-01-07 2002-10-15 ワイス 鬱病の処置のためのアリールピペラジニル−シクロヘキシルインドール誘導体
EP1140840B1 (en) * 1999-01-13 2006-03-22 Bayer Pharmaceuticals Corp. -g(v)-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
JP2002534468A (ja) * 1999-01-13 2002-10-15 バイエル コーポレイション ｐ３８キナーゼ阻害剤としてのω−カルボキシアリール置換ジフェニル尿素
US8124630B2 (en) 1999-01-13 2012-02-28 Bayer Healthcare Llc ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
BR0115296A (pt) * 2000-11-14 2003-09-02 Merck Patent Ges Mit Beschonkt Uso de inibidores de recaptação de sorotonina e agonistas de 5ht1a combinados
UA76130C2 (en) 2000-11-20 2006-07-17 Merck Patent Gmbh Use of compounds combining properties of selective inhibitors of serotonin re-uptake and agonists of 5-ht1a receptor for treatment of irritable bowel syndrome
AR035521A1 (es) * 2000-12-22 2004-06-02 Lundbeck & Co As H Derivados de 3-indolina y composicion farmaceutica que los comprende
US7371763B2 (en) * 2001-04-20 2008-05-13 Bayer Pharmaceuticals Corporation Inhibition of raf kinase using quinolyl, isoquinolyl or pyridyl ureas
ES2393900T3 (es) * 2001-12-03 2012-12-28 Bayer Healthcare Llc Compuestos de aril-urea en combinación con otros agentes citostáticos o citotóxicos para tratamiento de cánceres humanos
US20030207872A1 (en) * 2002-01-11 2003-11-06 Bayer Corporation Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
EP2324825A1 (en) 2002-02-11 2011-05-25 Bayer Healthcare LLC Aryl ureas with angiogenesis inhibiting activity
WO2003068229A1 (en) 2002-02-11 2003-08-21 Bayer Pharmaceuticals Corporation Pyridine, quinoline, and isoquinoline n-oxides as kinase inhibitors
US7557129B2 (en) 2003-02-28 2009-07-07 Bayer Healthcare Llc Cyanopyridine derivatives useful in the treatment of cancer and other disorders
ATE366108T1 (de) 2003-05-20 2007-07-15 Bayer Pharmaceuticals Corp Diaryl-harnstoffe für durch pdgfr vermittelte krankheiten
NZ580384A (en) 2003-07-23 2011-03-31 Bayer Pharmaceuticals Corp 4{4-[3-(4-chloro-3-trifluoromethylphenyl)-ureido]-3-fluorophenoxy}-pyridine-2-carboxylic acid methylamide and metabolites for the treatment and prevention of diseases and conditions
TWI367098B (en) * 2004-12-23 2012-07-01 Kowa Co Treating agent for glaucoma
CN102875538A (zh) * 2012-10-16 2013-01-16 北京诚创思达医药科技有限公司 维拉唑酮或其盐酸盐的制备方法
US9598401B2 (en) 2013-07-29 2017-03-21 Sunshine Lake Pharma Co., Ltd. Substituted heteroaryl compounds and methods of use thereof
US9714232B2 (en) 2013-12-20 2017-07-25 Sunshine Lake Pharma Co., Ltd. Substituted piperazine compounds and methods of use thereof
WO2016192657A1 (en) 2015-06-03 2016-12-08 Sunshine Lake Pharma Co., Ltd. Substituted piperazine compounds and methods of use and use thereof
CA3077383A1 (en) 2017-09-29 2019-04-04 Sunshine Lake Pharma Co., Ltd. Substituted pyrimidine piperazine compound and use thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1075156A (en) 1963-08-27 1967-07-12 Luso Farmaco Inst Substituted piperazines
US3468882A (en) 1966-10-07 1969-09-23 Sterling Drug Inc Phenylhydrazone derivatives as intermediates for preparing indoles
DE2138865A1 (de) 1970-08-15 1973-02-22 Sumitomo Chemical Co 3-indolylpiperazine, verfahren zu ihrer herstellung und arzneimittel
GB8830312D0 (en) 1988-12-28 1989-02-22 Lundbeck & Co As H Heterocyclic compounds
DE4101686A1 (de) * 1991-01-22 1992-07-23 Merck Patent Gmbh Indolderivate

Also Published As

Publication number Publication date
KR960037675A (ko) 1996-11-19
KR100437751B1 (ko) 2004-08-25
CA2173418C (en) 2007-06-12
TR199600286A2 (tr) 1997-03-21
RU2168508C2 (ru) 2001-06-10
AU5040896A (en) 1996-10-17
CY2242B1 (en) 2003-07-04
CO4700469A1 (es) 1998-12-29
CN1072209C (zh) 2001-10-03
NO305903B1 (no) 1999-08-16
JP3834098B2 (ja) 2006-10-18
CZ289449B6 (cs) 2002-01-16
AR002982A1 (es) 1998-05-27
DE19512639A1 (de) 1996-10-10
NO961346D0 (no) 1996-04-02
JPH09151174A (ja) 1997-06-10
EP0736525B1 (de) 2000-07-12
PL313632A1 (en) 1996-10-14
CZ96496A3 (en) 1996-10-16
CN1137036A (zh) 1996-12-04
AU709708B2 (en) 1999-09-02
UA45325C2 (uk) 2002-04-15
US6310068B1 (en) 2001-10-30
DK0736525T3 (da) 2000-10-30
GR3034514T3 (en) 2000-12-29
PT736525E (pt) 2000-12-29
NO961346L (no) 1996-10-07
HUP9600876A3 (en) 2000-04-28
ES2150039T3 (es) 2000-11-16
ATE194595T1 (de) 2000-07-15
HUP9600876A2 (hu) 1998-09-28
SK281457B6 (sk) 2001-03-12
BR9601275A (pt) 1998-01-13
TW323279B (da) 1997-12-21
HU9600876D0 (en) 1996-05-28
PL183147B1 (pl) 2002-05-31
SK40396A3 (en) 1996-11-06
CA2173418A1 (en) 1996-10-06
ZA962768B (en) 1996-11-13
EP0736525A1 (de) 1996-10-09
DE59605568D1 (de) 2000-08-17

Similar Documents

Publication Publication Date Title
CY2242B1 (en) Benzonitriles and -fluorides as 5-ht agonists and antagonists
PL312182A1 (en) Oestrogen agonists/antagonists
PL331900A1 (en) 1,4-heterocyclic inhibitors of metaloprotease
PL331838A1 (en) 1,3-diheterocyclic inhibitors of metaloproteases
SG50791A1 (en) New substituted oxazolidinones
AU4422293A (en) Substituted 2-amidotetralins as melatonin agonists and antagonists
ZA974147B (en) Somatostatin agonists and antagonists.
HU9601240D0 (en) Beta-adrenerg agonists
AU4772497A (en) Constrained somatostatin agonists and antagonists
HU9601176D0 (en) Adhesion-receptor antagonists
AU7659998A (en) N-triazolyl-2-indolecarboxamides and their use as cck-a agonists
HU9702039D0 (en) Estrogen agonist/antagonists treatment of atheroscerosis
HK1048318B (zh) 取代的3-苯基-5-烷氧基-1，3，4-噁二唑-2-酮及其作為脂酶抑制劑的用途
HU9503191D0 (en) Adhesion-receptor antagonists
EP1023269A4 (en) BETA3-ADRENORECEPTOR AGONISTS, AGONIST COMPOSITIONS AND METHODS OF USE
ZA9811346B (en) Substituted heterocyclic benzocycloalkenes and their use as an analgesic
PL333079A1 (en) Piparazinic derivatives as antagonists of neurokinin
AU4178497A (en) HTm4, methods of treatment and assays, agonists and antagonists
AU3935897A (en) B1-bradykinin receptor antagonists and use thereof
PL307138A1 (en) Amyline antagonists and agonists
AU1809595A (en) Phenylpyrrole derivatives and their use as dopamine d3 antagonists
ZA977491B (en) Use of polyhydroxycarboxylamides as EP additives.
AU4551499A (en) Multivalent agonists, partial agonists, inverse agonists and antagonists of the 5-HT3 receptors
HUP0000262A3 (en) Endoparasiticidal agents
AU1251399A (en) N-alkylation of 5-amino-2,4,6-triiodo-isophthalamides