SI0705255T1 - N-morpholino-n-nitrosaminoacetonitril cyclodextrin inclusion complexes - Google Patents

N-morpholino-n-nitrosaminoacetonitril cyclodextrin inclusion complexes

Info

Publication number
SI0705255T1
SI0705255T1 SI9530435T SI9530435T SI0705255T1 SI 0705255 T1 SI0705255 T1 SI 0705255T1 SI 9530435 T SI9530435 T SI 9530435T SI 9530435 T SI9530435 T SI 9530435T SI 0705255 T1 SI0705255 T1 SI 0705255T1
Authority
SI
Slovenia
Prior art keywords
complexes
sin
pct
ions
cyclodextrin
Prior art date
Application number
SI9530435T
Other languages
English (en)
Inventor
Joseph Geczy
Andrasne Vikmon
Jozsef Szejtli
Lajos Szente
Julianna Szeman
Original Assignee
Therabel Ind Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Therabel Ind Sa filed Critical Therabel Ind Sa
Publication of SI0705255T1 publication Critical patent/SI0705255T1/xx

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
    • C08B37/0015—Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Nanotechnology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medical Informatics (AREA)
  • Biochemistry (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Biophysics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Detergent Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SI9530435T 1994-04-26 1995-04-25 N-morpholino-n-nitrosaminoacetonitril cyclodextrin inclusion complexes SI0705255T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
HU9401183A HU218280B (en) 1994-04-26 1994-04-26 Cyclodextrin inclusion complexes containing sin-1a which are stable intheir solid state, process for their preparation and pharmaceutical compositions containing the comlexes
PCT/HU1995/000011 WO1995029172A1 (en) 1994-04-26 1995-04-25 N-morpholino-n-nitrosaminoacetonitril cyclodextrin inclusion complexes
EP95918104A EP0705255B1 (en) 1994-04-26 1995-04-25 N-morpholino-n-nitrosaminoacetonitril cyclodextrin inclusion complexes

Publications (1)

Publication Number Publication Date
SI0705255T1 true SI0705255T1 (en) 2001-04-30

Family

ID=10985114

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9530435T SI0705255T1 (en) 1994-04-26 1995-04-25 N-morpholino-n-nitrosaminoacetonitril cyclodextrin inclusion complexes

Country Status (32)

Country Link
US (1) US5698535A (ro)
EP (1) EP0705255B1 (ro)
JP (1) JP3434828B2 (ro)
KR (1) KR960703404A (ro)
CN (1) CN1060164C (ro)
AT (1) ATE197708T1 (ro)
AU (1) AU694219B2 (ro)
BG (1) BG61974B1 (ro)
BR (1) BR9506155A (ro)
CA (1) CA2163539C (ro)
CZ (1) CZ316395A3 (ro)
DE (1) DE69519463T2 (ro)
DK (1) DK0705255T3 (ro)
ES (1) ES2153897T3 (ro)
FI (1) FI956156A0 (ro)
GR (1) GR3035356T3 (ro)
HR (1) HRP950249A2 (ro)
HU (1) HU218280B (ro)
IL (1) IL113491A (ro)
LT (1) LT4167B (ro)
LV (1) LV11543B (ro)
MD (1) MD1419G2 (ro)
NO (1) NO311030B1 (ro)
NZ (1) NZ285149A (ro)
PL (1) PL312183A1 (ro)
PT (1) PT705255E (ro)
RO (1) RO114449B1 (ro)
RU (1) RU2136698C1 (ro)
SI (1) SI0705255T1 (ro)
SK (1) SK155195A3 (ro)
WO (1) WO1995029172A1 (ro)
YU (1) YU25995A (ro)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6143746A (en) * 1994-01-21 2000-11-07 Icos Corporation Tetracyclic cyclic GMP-specific phosphodiesterase inhibitors, process of preparation and use
WO2001036490A2 (en) * 1999-11-12 2001-05-25 Pitha & Pitha Llc Crystalline mixtures of partial methyl ethers of beta-cyclodextrin and related compounds
FR2805462B1 (fr) * 2000-02-24 2003-08-15 Therabel Res Nouvelle forme galenique orale a liberation prolongee de la molsidomine
TWI321054B (en) 2000-12-19 2010-03-01 California Inst Of Techn Compositions containing inclusion complexes
EP1219306A1 (en) 2000-12-29 2002-07-03 Nicox S.A. Compositions comprising cyclodextrins and NO- releasing drugs
EP2277551B1 (en) 2002-09-06 2013-05-08 Cerulean Pharma Inc. Cyclodextrin-based polymers for delivering the therapeutic agents covalently bound thereto
US8357377B2 (en) * 2002-10-09 2013-01-22 Suzie Hwang Pun Cyclodextrin-based materials, compositions and uses related thereto
JP2010516625A (ja) 2007-01-24 2010-05-20 インサート セラピューティクス， インコーポレイテッド 制御された薬物送達のためのテザー基を有するポリマー−薬物コンジュゲート
CN102781237A (zh) * 2009-11-23 2012-11-14 天蓝制药公司 用于传递治疗剂的基于环糊精的聚合物
WO2014055493A1 (en) 2012-10-02 2014-04-10 Cerulean Pharma Inc. Methods and systems for polymer precipitation and generation of particles
US10793327B2 (en) 2017-10-09 2020-10-06 Terumo Bct Biotechnologies, Llc Lyophilization container and method of using same
EP3938742A1 (en) 2019-03-14 2022-01-19 Terumo BCT Biotechnologies, LLC Multi-part lyophilization container and method of use
CN116249522A (zh) * 2020-07-20 2023-06-09 深圳迈瑞生物医疗电子股份有限公司 一种组合物的血小板解聚用途、解聚试剂及解聚方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5039705A (en) * 1989-09-15 1991-08-13 The United States Of America As Represented By The Department Of Health And Human Services Anti-hypertensive compositions of secondary amine-nitric oxide adducts and use thereof
US5208233A (en) * 1989-09-15 1993-05-04 The United States Of America As Represented By The Department Of Health And Human Services Anti-hypertensive compositions of secondary amine-nitric oxide adducts and use thereof
US5212204A (en) * 1989-10-18 1993-05-18 The United States Of America As Represented By The Department Of Health And Human Services Antihypertensive compositions and use thereof
HU211648A9 (en) * 1990-03-28 1995-12-28 Chinoin Gyogyszer Es Vegyeszet Inclusion complexes of 3-morpholino-sydnonimine or its salts or its tautomer isomer, process for the preparation thereof, and pharmaceutical compositions containing the same
CA2119572C (en) * 1991-09-24 2005-07-05 Larry Kay Keefer Oxygen substituted derivatives of nucleophile-nitric oxide adducts as nitric oxide donor prodrugs
US5389675A (en) * 1992-03-27 1995-02-14 The United States Of America As Represented By The Department Of Health And Human Services Mixed ligand metal complexes of nitric oxide-nucleophile adducts useful as cardiovascular agents

Also Published As

Publication number Publication date
JPH09503546A (ja) 1997-04-08
CA2163539C (en) 2003-04-01
DE69519463T2 (de) 2001-06-28
HUT70750A (en) 1995-10-30
EP0705255B1 (en) 2000-11-22
BG61974B1 (bg) 1998-11-30
LV11543A (lv) 1996-10-20
CZ316395A3 (en) 1996-05-15
LV11543B (en) 1996-12-20
AU694219B2 (en) 1998-07-16
JP3434828B2 (ja) 2003-08-11
LT95133A (en) 1996-10-25
HU218280B (en) 2000-07-28
IL113491A (en) 2002-03-10
PL312183A1 (en) 1996-04-01
YU25995A (sh) 1998-08-14
MD950440A (ro) 1997-10-31
FI956156A (fi) 1995-12-20
HRP950249A2 (en) 1997-10-31
PT705255E (pt) 2001-05-31
EP0705255A1 (en) 1996-04-10
NO955283L (no) 1995-12-22
KR960703404A (ko) 1996-08-17
CA2163539A1 (en) 1995-11-02
HU9401183D0 (en) 1994-07-28
MD1419F2 (ro) 2000-02-29
DK0705255T3 (da) 2000-12-11
US5698535A (en) 1997-12-16
LT4167B (en) 1997-06-25
NO311030B1 (no) 2001-10-01
DE69519463D1 (de) 2000-12-28
FI956156A0 (fi) 1995-12-20
CN1128028A (zh) 1996-07-31
ATE197708T1 (de) 2000-12-15
NO955283D0 (no) 1995-12-22
AU2415995A (en) 1995-11-16
GR3035356T3 (en) 2001-05-31
WO1995029172A1 (en) 1995-11-02
ES2153897T3 (es) 2001-03-16
RO114449B1 (ro) 1999-04-30
NZ285149A (en) 1998-06-26
SK155195A3 (en) 1997-05-07
MD1419G2 (ro) 2000-11-30
IL113491A0 (en) 1995-07-31
RU2136698C1 (ru) 1999-09-10
CN1060164C (zh) 2001-01-03
BG100313A (bg) 1996-07-31
BR9506155A (pt) 1996-04-16

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