SG45864A1 - Novel selective inhibitors of viral or bacterial neuraminidases - Google Patents
Novel selective inhibitors of viral or bacterial neuraminidasesInfo
- Publication number
- SG45864A1 SG45864A1 SG1997004840A SG1997004840A SG45864A1 SG 45864 A1 SG45864 A1 SG 45864A1 SG 1997004840 A SG1997004840 A SG 1997004840A SG 1997004840 A SG1997004840 A SG 1997004840A SG 45864 A1 SG45864 A1 SG 45864A1
- Authority
- SG
- Singapore
- Prior art keywords
- viral
- selective inhibitors
- neuraminidase
- compounds
- novel selective
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Epoxy Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Polyesters Or Polycarbonates (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39524595A | 1995-02-27 | 1995-02-27 | |
US08/476,946 US5866601A (en) | 1995-02-27 | 1995-06-06 | Carbocyclic compounds |
US58056795A | 1995-12-29 | 1995-12-29 | |
PCT/US1996/002882 WO1996026933A1 (en) | 1995-02-27 | 1996-02-26 | Novel selective inhibitors of viral or bacterial neuraminidases |
Publications (1)
Publication Number | Publication Date |
---|---|
SG45864A1 true SG45864A1 (en) | 1999-04-27 |
Family
ID=27410155
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG1997004840A SG45864A1 (en) | 1995-02-27 | 1996-02-26 | Novel selective inhibitors of viral or bacterial neuraminidases |
Country Status (27)
Country | Link |
---|---|
US (3) | US5952375A (zh) |
EP (1) | EP0759917B1 (zh) |
JP (3) | JP3300365B2 (zh) |
KR (1) | KR100447096B1 (zh) |
CN (2) | CN100409844C (zh) |
AT (2) | ATE191711T1 (zh) |
AU (1) | AU720933B2 (zh) |
BR (2) | BR9607098B8 (zh) |
CZ (1) | CZ297945B6 (zh) |
DE (4) | DE759917T1 (zh) |
DK (1) | DK0759917T3 (zh) |
ES (2) | ES2118674T3 (zh) |
GR (1) | GR3033914T3 (zh) |
HK (1) | HK1026893A1 (zh) |
HU (1) | HU228450B1 (zh) |
LU (1) | LU90991I2 (zh) |
MX (1) | MX9706496A (zh) |
NL (1) | NL300105I2 (zh) |
NO (1) | NO318455B1 (zh) |
NZ (1) | NZ306625A (zh) |
PL (1) | PL194173B1 (zh) |
PT (1) | PT759917E (zh) |
RU (1) | RU2181357C2 (zh) |
SG (1) | SG45864A1 (zh) |
SI (1) | SI9620042A (zh) |
UA (1) | UA56128C2 (zh) |
WO (1) | WO1996026933A1 (zh) |
Families Citing this family (85)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3300365B2 (ja) * | 1995-02-27 | 2002-07-08 | ギリアード サイエンシーズ,インコーポレイテッド | ウイルスまたは細菌ノイラミニダーゼの新規な選択的インヒビター |
US5714509A (en) * | 1995-05-03 | 1998-02-03 | The University Of Alabama | Inhibitors of bacterial sialidase and methods of making and using the same |
US5763483A (en) * | 1995-12-29 | 1998-06-09 | Gilead Sciences, Inc. | Carbocyclic compounds |
US6093816A (en) | 1996-06-27 | 2000-07-25 | Isis Pharmaceuticals, Inc. | Cationic lipids |
US6518438B2 (en) | 1996-08-23 | 2003-02-11 | Gilead Sciences, Inc. | Preparation of cyclohexene carboxylate derivatives |
US5859284A (en) | 1996-08-23 | 1999-01-12 | Gilead Sciences, Inc. | Preparation of carbocyclic compounds |
PT920410E (pt) * | 1996-08-23 | 2002-07-31 | Gilead Sciences Inc | Preparacao de derivados de carboxilato de ciclo-hexeno |
US5994377A (en) * | 1996-10-21 | 1999-11-30 | Gilead Sciences, Inc. | Piperidine compounds |
WO1998017647A1 (en) * | 1996-10-21 | 1998-04-30 | Gilead Sciences, Inc. | Piperidine compounds |
HUP9904009A3 (en) * | 1996-11-14 | 2001-07-30 | Biota Scient Man Pty Ltd Melbo | Method and novel compounds for use therein |
WO1999006369A1 (en) * | 1997-08-01 | 1999-02-11 | University Of Florida | Neuraminidase inhibitors |
US5886213A (en) * | 1997-08-22 | 1999-03-23 | Gilead Sciences, Inc. | Preparation of carbocyclic compounds |
NZ502988A (en) * | 1997-09-17 | 2002-08-28 | Gilead Sciences Inc | 5-Acetamido-4-amino-2-propionyloxy-6-isopropoxy-1-cyclohexene useful for treating influenza |
US20040053999A1 (en) * | 1997-09-17 | 2004-03-18 | Bischofberger Norbert W. | Novel compounds and methods for synthesis and therapy |
TW477783B (en) * | 1997-12-12 | 2002-03-01 | Gilead Sciences Inc | Novel compounds useful as neuraminidase inhibitors and pharmaceutical compositions containing same |
AU2200199A (en) * | 1997-12-17 | 1999-07-19 | Biocryst Pharmaceuticals, Inc. | Substituted cyclopentane and cyclopentene compounds useful as neuraminidase inhibitors |
TR200003065T2 (tr) * | 1998-04-23 | 2001-02-21 | Abbott Laboratories | Nöraminidazların inhibitörleri olarak pirolidinler. |
US6455571B1 (en) | 1998-04-23 | 2002-09-24 | Abbott Laboratories | Inhibitors of neuraminidases |
US6518305B1 (en) | 1998-04-23 | 2003-02-11 | Abbott Laboratories | Five-membered carbocyclic and heterocyclic inhibitors of neuraminidases |
ES2167975T3 (es) * | 1998-05-13 | 2002-05-16 | Hoffmann La Roche | Procedimiento para la preparacion de acido shikimico y sus derivados. |
WO2000029385A1 (en) * | 1998-11-13 | 2000-05-25 | Gilead Sciences, Inc. | 1,4,5,6-tetrahydro-pyridazine derivatives, their preparation and their use as neuraminidase inhibitors |
AUPP913999A0 (en) * | 1999-03-12 | 1999-04-01 | Biota Scientific Management Pty Ltd | Novel chemical compounds and their use |
EP1059283B1 (en) | 1999-06-11 | 2003-05-28 | F. Hoffmann-La Roche Ag | Process for preparing neuraminidase inhibitor ro-64-0796 |
DE19930177B4 (de) | 1999-06-30 | 2007-02-08 | Nikolai Vladimirovich Bovin | Intermolekular assoziierende Verbindungen und deren Verwendung |
BR0010525A (pt) * | 1999-10-19 | 2002-11-26 | Abbott Lab | cido 1-ciclo-hexeno-1-carboxìlico e 1-ciclo-hexeno-1carboxilatos como inibidores de neuraminidase |
US6593314B1 (en) | 1999-10-19 | 2003-07-15 | Abbott Laboratories | Neuraminidase inhibitors |
US6627396B1 (en) * | 1999-10-28 | 2003-09-30 | The Regents Of The University Of California | Influenza sensor |
JP2001131144A (ja) * | 1999-11-02 | 2001-05-15 | Sagami Chem Res Center | 7−アザビシクロ[4.1.0]ヘプト−3−エン−3−カルボン酸エステル類の製造方法 |
US6462226B1 (en) | 1999-12-03 | 2002-10-08 | Hoffmann-La Roche Inc. | Process for the preparation of 4,5-diamino shikimic acid derivatives |
US6797832B1 (en) | 1999-12-27 | 2004-09-28 | Sagami Chemical Research Center | Process for the production of 5-oxy-7-oxabicyclo [4.1.0] hept-3-ene-3-carboxylic acid esters |
US8642051B2 (en) * | 2000-03-21 | 2014-02-04 | Suzanne Jaffe Stillman | Method of hydration; infusion packet system(s), support member(s), delivery system(s), and method(s); with business model(s) and Method(s) |
WO2001080892A1 (fr) * | 2000-04-25 | 2001-11-01 | Sankyo Company, Limited | Substances preventives de la grippe |
GB0015324D0 (en) * | 2000-06-22 | 2000-08-16 | Biota Scient Management | Medicaments |
CZ301813B6 (cs) | 2000-06-27 | 2010-06-30 | F. Hoffmann-La Roche Ag | Zpusob prípravy farmaceutické kompozice |
AUPR001000A0 (en) | 2000-09-08 | 2000-10-05 | Biota Scientific Management Pty Ltd | Novel chemical compounds and their use |
WO2002092555A1 (fr) * | 2001-05-11 | 2002-11-21 | Sankyo Company, Limited | Derives d'acides sialiques |
US6964784B2 (en) | 2002-03-07 | 2005-11-15 | Optigenex, Inc. | Method of preparation and composition of a water soluble extract of the bioactive component of the plant species uncaria for enhancing immune, anti-inflammatory, anti-tumor and dna repair processes of warm blooded animals |
US7807174B2 (en) * | 2002-11-22 | 2010-10-05 | Nexbio, Inc. | Class of therapeutic protein based molecules |
US7122684B2 (en) | 2003-03-13 | 2006-10-17 | Roche Colorado Corporation | Process for preparing 1,2-diamino compounds |
CN1805966B (zh) * | 2003-06-16 | 2013-03-13 | 捷克科学院有机化学和生物化学研究所 | 作为抗病毒核苷酸类似物的含膦酸酯基团的嘧啶化合物 |
WO2007053792A2 (en) * | 2005-11-05 | 2007-05-10 | Amplyx Pharmaceuticals, Inc. | Improving the pharmacokinetics of protease inhibitors and other drugs |
EP2204359A1 (en) | 2005-11-25 | 2010-07-07 | Hetero Drugs Limited | Improved process for oseltamivir phosphate |
KR100819759B1 (ko) | 2005-12-01 | 2008-04-07 | (주)파인켐 | 아자이드 화합물의 폭발성을 제거한 공정을 이용한 1,2-다이아미노 화합물 또는 이의 부가염 제조 방법 |
CA2633538A1 (en) * | 2005-12-28 | 2007-07-05 | F. Hoffmann-La Roche Ag | Epoxide intermediate in the tamiflu synthesis |
JP5255429B2 (ja) * | 2006-02-20 | 2013-08-07 | 中外製薬株式会社 | リン酸オセルタミビル含有医薬組成物 |
US20080063722A1 (en) * | 2006-09-08 | 2008-03-13 | Advanced Inhalation Research, Inc. | Composition of a Spray-Dried Powder for Pulmonary Delivery of a Long Acting Neuraminidase Inhibitor (LANI) |
US20080306098A1 (en) * | 2006-11-06 | 2008-12-11 | Mutz Mitchell W | Pharmacokinetics of protease inhibitors and other drugs |
US8227425B2 (en) | 2007-01-23 | 2012-07-24 | Therapicon Srl | Antiviral compounds |
US20080194801A1 (en) * | 2007-02-14 | 2008-08-14 | Swanson Basil I | Robust multidentate ligands for diagnosis and anti-viral drugs for influenza and related viruses |
EP2145010A1 (en) * | 2007-04-13 | 2010-01-20 | Monsanto Technology, LLC | Use of glyphosate to produce shikimic acid in microorganisms |
US20090054334A1 (en) * | 2007-05-23 | 2009-02-26 | Mutz Mitchell W | Combinatorial improvement of bifunctional drug properties |
KR101535691B1 (ko) * | 2007-08-31 | 2015-07-09 | 아카데미아 시니카 | 항인플루엔자 활성을 갖는 포스포네이트 동종체를 함유하는 오셀타미비르의 합성 |
WO2009052303A2 (en) * | 2007-10-16 | 2009-04-23 | Monsanto Technology Llc | Processes for producing and recovering shikimic acid |
US20100284993A1 (en) * | 2007-10-24 | 2010-11-11 | Mutz Mitchell W | Enhancing the Efficacy of Anti-Infective Therapeutics |
WO2009078813A1 (en) * | 2007-12-19 | 2009-06-25 | Nanyang Technological University | Method of forming oseltamivir and derivatives thereof |
US8334319B2 (en) * | 2008-01-04 | 2012-12-18 | Roche Palo Alto Llc | Polymorphic forms of oseltamivir phosphate |
US20100081713A1 (en) * | 2008-03-19 | 2010-04-01 | CombinatoRx, (Singapore) Pte. Ltd. | Compositions and methods for treating viral infections |
EP2276479B1 (en) | 2008-04-15 | 2014-07-02 | SineVir Therapeutics LLC | Prodrugs of neuraminidase inhibitors |
TWI491416B (zh) | 2008-12-24 | 2015-07-11 | Daiichi Sankyo Co Ltd | 吸入用乾燥粉末醫藥組成物 |
CN101486664B (zh) * | 2008-12-31 | 2013-09-04 | 北京大学深圳研究生院 | 用作流感病毒神经氨酸酶抑制剂的多取代五元环小分子化合物 |
MX2011012134A (es) | 2009-05-15 | 2012-02-08 | Redx Pharma Ltd | Derivados de farmaco de oxido-reduccion. |
WO2011021223A2 (en) * | 2009-08-19 | 2011-02-24 | Msn Laboratories Limited | Novel salts of ethyl (3r, 4s, 5r)-4,5-imino-3-(l-ethylpropoxy)-1- cvclohexene-1-carboxylate and its use |
KR20120115262A (ko) * | 2009-11-11 | 2012-10-17 | 쓰리엠 이노베이티브 프로퍼티즈 캄파니 | 중합체 조성물 및 그의 제조 방법 및 물품 |
IT1396620B1 (it) | 2009-11-25 | 2012-12-14 | Therapicon Srl | Analoghi chimerici |
EP2593430A1 (en) | 2010-07-16 | 2013-05-22 | Grindeks | Derivatives of 1,4-dihydropyridine possessing antiviral efficacy |
AT510585B1 (de) * | 2010-11-18 | 2012-05-15 | Apeptico Forschung & Entwicklung Gmbh | Zusammensetzung umfassend ein peptid und ein hemmstoff der viralen neuraminidase |
KR101369584B1 (ko) | 2011-04-19 | 2014-03-06 | 일양약품주식회사 | 페닐-이속사졸 유도체 및 그의 제조방법 |
EP2578218A1 (en) | 2011-10-06 | 2013-04-10 | Grindeks, A Joint Stock Company | Antiviral efficacy of disodium 2,6-dimethyl-1,4-dihydropyridine-3,5-bis(carbonyloxyacetate) and its derivatives |
DE102011117128A1 (de) | 2011-10-28 | 2013-05-02 | Christian-Albrechts-Universität Zu Kiel | Verbindungen zur Therapie der Influenza |
RU2469020C1 (ru) * | 2011-11-08 | 2012-12-10 | Александр Васильевич Иващенко | (3r,4r,5s)-5-амино-4-ациламино-3-(1-этил-пропокси)-циклогекс-1-ен-карбоновые кислоты, их эфиры и способ применения |
RU2489422C1 (ru) * | 2012-05-12 | 2013-08-10 | Александр Васильевич Иващенко | Фторзамещенные (3r,4r,5s)-5-гуанидино-4-ациламино-3-(пентан-3-илокси)циклогексен-1-карбоновые кислоты, их эфиры и способ применения |
RU2521593C1 (ru) * | 2013-02-27 | 2014-06-27 | Общество с ограниченной ответственностью "Интеллектуальный Диалог" | Моно и дифторзамещенные этил (3r,4r,5s)-5-азидо-4-ацетиламино-3-(1-этилпропокси)-циклогексен-1-карбоксилаты, способ получения и применения |
JP6453050B2 (ja) * | 2013-11-15 | 2019-01-16 | 国立大学法人富山大学 | 2−デオキシ−2,3−ジデヒドロシアル酸誘導体およびその製造法 |
CN103819357B (zh) * | 2014-01-28 | 2016-03-16 | 浙江大学 | (-)-有效霉醇叠氮四乙酸酯的制备方法 |
CN105980348B (zh) * | 2014-02-14 | 2018-09-14 | 东亚荣养株式会社 | 环状烃化合物 |
CN107072976A (zh) | 2014-05-12 | 2017-08-18 | 葛兰素史克知识产权第二有限公司 | 用于治疗传染性疾病的包含Danirixin的药物组合物 |
US9392814B2 (en) | 2014-06-06 | 2016-07-19 | Nicholas J. Singer | Delivery system for drinks |
GB2532178A (en) * | 2014-06-09 | 2016-05-18 | Redx Pharma Plc | Antiviral compounds |
RS62434B1 (sr) | 2014-12-26 | 2021-11-30 | Univ Emory | Antivirusni n4-hidroksicitidin derivati |
USD773313S1 (en) | 2015-06-23 | 2016-12-06 | Nicholas J. Singer | Package |
US10676428B2 (en) | 2015-12-17 | 2020-06-09 | Ramot At Tel-Aviv University Ltd. | Antiviral agents for amantadine-resistant influenza A |
KR102339817B1 (ko) | 2016-06-30 | 2021-12-16 | 한미약품 주식회사 | 오셀타미비어 함유 경구용 고형제제 및 그 제조방법 |
WO2018030463A1 (ja) * | 2016-08-10 | 2018-02-15 | 塩野義製薬株式会社 | 置換された多環性ピリドン誘導体およびそのプロドラッグを含有する医薬組成物 |
CN111372592A (zh) | 2017-12-07 | 2020-07-03 | 埃默里大学 | N4-羟基胞苷及衍生物和与其相关的抗病毒用途 |
KR20200106607A (ko) | 2019-03-05 | 2020-09-15 | 주식회사 코아팜바이오 | 오셀타미비르 함유 의약 조성물 |
Family Cites Families (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4968788A (en) * | 1986-04-04 | 1990-11-06 | Board Of Regents, The University Of Texas System | Biologically reversible phosphate and phosphonate protective gruops |
US5206400A (en) * | 1986-07-07 | 1993-04-27 | Ohio State University | Diastereomeric mono- and di-substituted diamino cyclohexane compounds and the method of preparation thereof |
US5175273A (en) * | 1988-07-01 | 1992-12-29 | Genentech, Inc. | Nucleic acid intercalating agents |
US5270340A (en) * | 1988-12-27 | 1993-12-14 | Bayer Aktiengesellschaft | Substituted 2-cyclohexen-1-yl-amine fungicidal and herbicidal agents |
AP249A (en) * | 1990-04-24 | 1993-03-17 | Biota Scient Management Pty Ltd | Anti-viral compounds. |
WO1992006691A1 (en) * | 1990-10-19 | 1992-04-30 | Biota Scientific Management Pty. Ltd. | Anti-viral compounds that bind the active site of influenza neuramidase and display in vivo activity against orthomyxovirus and paramyxovirus |
DE4033415A1 (de) * | 1990-10-20 | 1992-04-23 | Bayer Ag | Antimikrobielle mittel sowie substituierte 2-cyclohexan-1-yl-amin-derivate und deren herstellung |
DE4131311A1 (de) * | 1991-09-20 | 1993-04-01 | Basf Ag | Dihydropyranderivate und diese enthaltende pflanzenschutzmittel |
CA2081068C (en) * | 1991-10-23 | 2005-11-29 | Laurence Mark Von Itzstein | Antiviral 4-substituted-2-deoxy-2,3-didehydro-derivatives of .alpha.-d-neuraminic acid |
GB9126725D0 (en) * | 1991-12-17 | 1992-02-12 | Glaxo Group Ltd | Process |
FR2687674B1 (fr) * | 1992-02-07 | 1995-05-19 | Roussel Uclaf | Nouveaux derives de la pyridone, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant. |
US5292938A (en) * | 1992-04-13 | 1994-03-08 | Associated Universities, Inc. | Synthesis of 4-substituted-trans-1, 2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation of stable radiometal antibody immunoconjugates for therapy and spect and pet imaging |
US5633360A (en) | 1992-04-14 | 1997-05-27 | Gilead Sciences, Inc. | Oligonucleotide analogs capable of passive cell membrane permeation |
GB9220327D0 (en) * | 1992-09-25 | 1992-11-11 | Glaxo Group Ltd | Process |
GB9220241D0 (en) * | 1992-09-25 | 1992-11-11 | Glaxo Group Ltd | Process |
US5639786A (en) * | 1992-12-04 | 1997-06-17 | Biota Scientific Management, Pty., Ltd. | Antiviral 4-substituted-2-deoxy-2,3-didehydro-derivatives of α-D-neuraninic acid |
US5514798A (en) * | 1993-06-02 | 1996-05-07 | Gilead Sciences, Inc. | Method and cyclic carbonates for nucleotide analogues |
US5819730A (en) * | 1993-06-09 | 1998-10-13 | Glaxo Wellcome Australia Ltd. | Device for administering pharmaceutical substances |
GB9311873D0 (en) * | 1993-06-09 | 1993-07-28 | Glaxo Group Ltd | Process |
GB9312531D0 (en) * | 1993-06-17 | 1993-08-04 | Glaxo Group Ltd | Process |
GB9325841D0 (en) * | 1993-12-17 | 1994-02-23 | Glaxo Group Ltd | Chemical compounds |
GB9400206D0 (en) * | 1994-01-07 | 1994-03-02 | Glaxo Group Ltd | Chemical compound |
AUPM354694A0 (en) * | 1994-01-27 | 1994-02-17 | Biota Scientific Management Pty Ltd | Chemical compounds |
US5985859A (en) * | 1994-04-14 | 1999-11-16 | The University Of Alabama | Methods of inhibiting bacterial sialidase |
GB9410817D0 (en) * | 1994-05-28 | 1994-07-20 | Glaxo Group Ltd | Medicaments |
AUPM725794A0 (en) * | 1994-08-03 | 1994-08-25 | Biota Scientific Management Pty Ltd | Chemical compounds |
US5556963A (en) * | 1994-08-05 | 1996-09-17 | Oklahoma Medical Research Foundation | Synthesis of 4-alkoxy-N-acetylneuraminic acid |
US5512596A (en) * | 1994-09-02 | 1996-04-30 | Gilead Sciences, Inc. | Aromatic compounds |
CA2203570A1 (en) | 1994-11-04 | 1996-05-17 | Lawrence R. Mcgee | Thiepane compounds inhibiting and detecting hiv protease |
JP3300365B2 (ja) * | 1995-02-27 | 2002-07-08 | ギリアード サイエンシーズ,インコーポレイテッド | ウイルスまたは細菌ノイラミニダーゼの新規な選択的インヒビター |
US5866601A (en) * | 1995-02-27 | 1999-02-02 | Gilead Sciences, Inc. | Carbocyclic compounds |
US5602277A (en) * | 1995-03-30 | 1997-02-11 | Biocryst Pharmaceuticals, Inc. | Substituted benzene derivatives useful as neuraminidase inhibitors |
US5714509A (en) * | 1995-05-03 | 1998-02-03 | The University Of Alabama | Inhibitors of bacterial sialidase and methods of making and using the same |
GB9510141D0 (en) | 1995-05-19 | 1995-07-12 | Biota Scient Management | Chemical compounds |
AU709127B2 (en) * | 1995-05-19 | 1999-08-19 | Biota Scientific Management Pty Ltd | 6-carboxamido dihydropyran derivatives |
GB9525389D0 (en) | 1995-12-12 | 1996-02-14 | Biota Scient Management Ltd | Chemical compounds |
GB9516276D0 (en) * | 1995-08-08 | 1995-10-11 | Biota Scient Management | Chemical compounds |
US5763483A (en) * | 1995-12-29 | 1998-06-09 | Gilead Sciences, Inc. | Carbocyclic compounds |
US5859284A (en) | 1996-08-23 | 1999-01-12 | Gilead Sciences, Inc. | Preparation of carbocyclic compounds |
PT920410E (pt) | 1996-08-23 | 2002-07-31 | Gilead Sciences Inc | Preparacao de derivados de carboxilato de ciclo-hexeno |
EP0882721A4 (en) * | 1996-09-10 | 1999-12-22 | Daikin Ind Ltd | 4-SUBSTITUTED 2,7-DIDEOXY-7-FLUORO-2,3-DIDEHYDRO SIAL ACIDS |
US5886213A (en) | 1997-08-22 | 1999-03-23 | Gilead Sciences, Inc. | Preparation of carbocyclic compounds |
-
1996
- 1996-02-26 JP JP52644296A patent/JP3300365B2/ja not_active Expired - Lifetime
- 1996-02-26 CZ CZ0269097A patent/CZ297945B6/cs not_active IP Right Cessation
- 1996-02-26 NZ NZ306625A patent/NZ306625A/xx not_active IP Right Cessation
- 1996-02-26 AT AT96912404T patent/ATE191711T1/de active
- 1996-02-26 DE DE0759917T patent/DE759917T1/de active Pending
- 1996-02-26 AT AT99117934T patent/ATE305453T1/de active
- 1996-02-26 MX MX9706496A patent/MX9706496A/es unknown
- 1996-02-26 ES ES96912404T patent/ES2118674T3/es not_active Expired - Lifetime
- 1996-02-26 PL PL96322000A patent/PL194173B1/pl unknown
- 1996-02-26 HU HU9800026A patent/HU228450B1/hu unknown
- 1996-02-26 DE DE69635231T patent/DE69635231T2/de not_active Expired - Lifetime
- 1996-02-26 ES ES99117934T patent/ES2249863T3/es not_active Expired - Lifetime
- 1996-02-26 PT PT96912404T patent/PT759917E/pt unknown
- 1996-02-26 BR BRPI9607098-6B8D patent/BR9607098B8/pt unknown
- 1996-02-26 CN CNB011247142A patent/CN100409844C/zh not_active Expired - Lifetime
- 1996-02-26 RU RU97116714/04A patent/RU2181357C2/ru active
- 1996-02-26 SG SG1997004840A patent/SG45864A1/en unknown
- 1996-02-26 WO PCT/US1996/002882 patent/WO1996026933A1/en active IP Right Grant
- 1996-02-26 EP EP96912404A patent/EP0759917B1/en not_active Expired - Lifetime
- 1996-02-26 AU AU53571/96A patent/AU720933B2/en not_active Expired
- 1996-02-26 BR BR9607098A patent/BR9607098A/pt not_active IP Right Cessation
- 1996-02-26 CN CNB961901330A patent/CN1185223C/zh not_active Expired - Lifetime
- 1996-02-26 DE DE69607704T patent/DE69607704T2/de not_active Expired - Lifetime
- 1996-02-26 US US08/606,624 patent/US5952375A/en not_active Expired - Lifetime
- 1996-02-26 DE DE2002199052 patent/DE10299052I1/de active Pending
- 1996-02-26 UA UA97094796A patent/UA56128C2/uk unknown
- 1996-02-26 KR KR1019970705932A patent/KR100447096B1/ko not_active IP Right Cessation
- 1996-02-26 SI SI9620042A patent/SI9620042A/sl not_active IP Right Cessation
- 1996-02-26 DK DK96912404T patent/DK0759917T3/da active
- 1996-05-24 US US08/653,034 patent/US20050176758A1/en not_active Abandoned
-
1997
- 1997-08-26 NO NO19973908A patent/NO318455B1/no not_active IP Right Cessation
-
1999
- 1999-04-08 US US09/288,091 patent/US6225341B1/en not_active Expired - Lifetime
-
2000
- 2000-07-07 GR GR20000401599T patent/GR3033914T3/el unknown
- 2000-08-02 HK HK00104830A patent/HK1026893A1/xx not_active IP Right Cessation
-
2001
- 2001-08-24 JP JP2001255372A patent/JP4234917B2/ja not_active Expired - Lifetime
-
2002
- 2002-10-29 NL NL300105C patent/NL300105I2/nl unknown
- 2002-12-11 LU LU90991C patent/LU90991I2/fr unknown
-
2005
- 2005-07-15 JP JP2005207906A patent/JP2006036770A/ja not_active Withdrawn
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SG45864A1 (en) | Novel selective inhibitors of viral or bacterial neuraminidases | |
TR200000723T2 (tr) | Altı elemanlı halkalar ihtiva eden bileşikler ve ilaç olarak kullanımları. | |
PT788605E (pt) | Deteccao de anticorpos bacterianos por polarizacao de fluorescencia | |
PT922226E (pt) | Processo para a avaliacao do estado de um organismo por meio de medicao de peptideos | |
BR9811039A (pt) | Citocina de mamìferos: interleucina-b30 e reagentes relacionados | |
WO1997011690A3 (en) | Inhibitors of regulatory pathways | |
PT923394E (pt) | Sistema de bomba com deteccao de erro para nutricao clinica | |
BR9812783A (pt) | "sistemas de detecção para o registro de interações e as relações funcionais de proteìnas" | |
EP0639647A3 (en) | Method for the detection of nucleic acid sequences. | |
PT807178E (pt) | Proteinas de micobacterias, microrganismos que as produzem e suas utilizacoes vacinicas e para a deteccao da tuberculose | |
WO1999036568A3 (de) | Verfahren zum identifizieren von t-zell-stimulierenden proteinfragmenten | |
CY1108288T1 (el) | Αντισωματα για το αντιγονο κυτταρων langerhans θηλαστικων και χρησεις τους | |
EP0976734A3 (en) | Selective inhibitors of viral or bacterial neuraminidase | |
AU2126400A (en) | Detection of small molecules by use of a piezoelectric sensor | |
IT1232482B (it) | Sistema di valvole,ad esempio per analizzatori | |
AU3219400A (en) | Methods and reagents for molecular detection of hiv-1 groups m, n and | |
WO1999010365A3 (en) | 5',5'-linked oligomers having anti-thrombin activity | |
FR2728904B1 (fr) | Reactif peptidique permettant de detecter une infection primaire a virus d'epstein-barr par recherche des anticorps correspondants, et procede d'utilisation de ce reactif | |
DE59808864D1 (de) | System zur Ermittlung des Nährstoffbedarfes | |
ITRM930038A0 (it) | Corredo per analisi microbiologiche mediante coltura. | |
ATE158815T1 (de) | Hippurikasegen | |
UA2743S (uk) | Пляшка для токайських вин | |
ITCN960010A1 (it) | Sistema di vibrola per chitarra e strumenti simili. | |
NZ505580A (en) | Method of treating immunodeficiences using neutrokine alpha |