TR200000723T2 - Altı elemanlı halkalar ihtiva eden bileşikler ve ilaç olarak kullanımları. - Google Patents

Altı elemanlı halkalar ihtiva eden bileşikler ve ilaç olarak kullanımları.

Info

Publication number
TR200000723T2
TR200000723T2 TR2000/00723T TR200000723T TR200000723T2 TR 200000723 T2 TR200000723 T2 TR 200000723T2 TR 2000/00723 T TR2000/00723 T TR 2000/00723T TR 200000723 T TR200000723 T TR 200000723T TR 200000723 T2 TR200000723 T2 TR 200000723T2
Authority
TR
Turkey
Prior art keywords
components
medicine
compounds containing
group
membered rings
Prior art date
Application number
TR2000/00723T
Other languages
English (en)
Inventor
W. Bischofberger Norbert
C. Dahl Terrence
J. M. Hitchcock Michael
U. Kim Choung
Lew Willard
Liu Hongtao
G. Mills Roger
A. Williams Matthew
Original Assignee
Gilead Sciences, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences, Inc. filed Critical Gilead Sciences, Inc.
Publication of TR200000723T2 publication Critical patent/TR200000723T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/62—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/52—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/63—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/16—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)

Abstract

Yeni bilesenler tarif edilmistir. Bilesenler, genellikle, bir asidik grubu, bir bazik grubu, bir amino muadili veya N-asili ve istege bagli olarak bir hidroksilenmis alken moitesine sahip bir grubu kapsar. Bulusun engelleyicilerini kapsayan farmasotik kompozisyonlar da ayrica tarif edilmistir. Nöraminidas içermesinden süphe edilen numunelerde nöraminidas engelleme yöntemleri de ayrica tarif edilmistir. Antijenik materyaller, polimerler, antijenler bulusun bilesenlerini etiketlerle birlestirir ve nöraminidas aktivitesini tetkik etmek için tahlil yöntemleri de ayrica tarif edilmistir.
TR2000/00723T 1997-09-17 1998-09-15 Altı elemanlı halkalar ihtiva eden bileşikler ve ilaç olarak kullanımları. TR200000723T2 (tr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5930897P 1997-09-17 1997-09-17
US93864497A 1997-09-26 1997-09-26
US6019597P 1997-09-26 1997-09-26

Publications (1)

Publication Number Publication Date
TR200000723T2 true TR200000723T2 (tr) 2001-06-21

Family

ID=27369627

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/00723T TR200000723T2 (tr) 1997-09-17 1998-09-15 Altı elemanlı halkalar ihtiva eden bileşikler ve ilaç olarak kullanımları.

Country Status (15)

Country Link
EP (1) EP1015417A1 (tr)
JP (1) JP2001516739A (tr)
KR (1) KR20010024123A (tr)
CN (1) CN1272105A (tr)
AR (1) AR013960A1 (tr)
AU (1) AU747702B2 (tr)
BR (1) BR9812649A (tr)
CA (1) CA2303323A1 (tr)
EA (1) EA003989B1 (tr)
ID (1) ID25516A (tr)
IL (1) IL134691A0 (tr)
IN (1) IN190983B (tr)
NZ (1) NZ502988A (tr)
TR (1) TR200000723T2 (tr)
WO (1) WO1999014185A1 (tr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4102022B2 (ja) * 1997-12-17 2008-06-18 バイオクリスト・ファマシューティカルズ インク． ノイラミニダーゼ阻害剤として有用な置換シクロペンタン及びシクロペンテン化合物
US6455571B1 (en) 1998-04-23 2002-09-24 Abbott Laboratories Inhibitors of neuraminidases
US6518305B1 (en) 1998-04-23 2003-02-11 Abbott Laboratories Five-membered carbocyclic and heterocyclic inhibitors of neuraminidases
EP1059283B1 (en) 1999-06-11 2003-05-28 F. Hoffmann-La Roche Ag Process for preparing neuraminidase inhibitor ro-64-0796
US6593314B1 (en) 1999-10-19 2003-07-15 Abbott Laboratories Neuraminidase inhibitors
AU7608100A (en) * 1999-10-19 2001-04-30 Abbott Laboratories 1-cyclohexene-1-carboxylic acid and 1-cyclohexene-1-carboxylates as neuraminidase inhibitors
JP2001131144A (ja) * 1999-11-02 2001-05-15 Sagami Chem Res Center ７−アザビシクロ［４．１．０］ヘプト−３−エン−３−カルボン酸エステル類の製造方法
US6403824B2 (en) 2000-02-22 2002-06-11 Hoffmann-La Roche Inc. Process for the preparation for 4,5-diamino shikimic acid derivatives
WO2001080892A1 (fr) * 2000-04-25 2001-11-01 Sankyo Company, Limited Substances preventives de la grippe
WO2002092555A1 (fr) * 2001-05-11 2002-11-21 Sankyo Company, Limited Derives d'acides sialiques
US7122684B2 (en) 2003-03-13 2006-10-17 Roche Colorado Corporation Process for preparing 1,2-diamino compounds
WO2007074091A2 (en) 2005-12-28 2007-07-05 F. Hoffmann-La Roche Ag Epoxide intermediate in the tamiflu synthesis
US8334319B2 (en) * 2008-01-04 2012-12-18 Roche Palo Alto Llc Polymorphic forms of oseltamivir phosphate
WO2011059994A2 (en) * 2009-11-11 2011-05-19 3M Innovative Properties Company Polymeric compositions and method of making and articles thereof
DE102011117128A1 (de) 2011-10-28 2013-05-02 Christian-Albrechts-Universität Zu Kiel Verbindungen zur Therapie der Influenza
RU2469020C1 (ru) * 2011-11-08 2012-12-10 Александр Васильевич Иващенко (3r,4r,5s)-5-амино-4-ациламино-3-(1-этил-пропокси)-циклогекс-1-ен-карбоновые кислоты, их эфиры и способ применения
CN102659615B (zh) * 2012-05-09 2014-05-07 中国药科大学 奥司他韦衍生物、其制备方法及其医药用途
RU2520836C1 (ru) * 2013-02-27 2014-06-27 Александр Васильевич Иващенко (3r,4r,5s)-4-амино-5-(2,2-дифторацетиламино)-3-(1-этилпропокси)-циклогекс-1-енкарбоновая кислота и ее эфиры, способ их получения и применения
RU2633085C2 (ru) * 2014-05-20 2017-10-11 Российская Федерация, от имени которой выступает Федеральное государственное казенное учреждение "Войсковая часть 68240" Противовирусное лекарственное средство в виде капсул и способ его получения
CN105439884A (zh) * 2015-10-27 2016-03-30 沈阳药科大学 一种奥司他韦的制备方法
CN108047076B (zh) * 2017-12-26 2020-05-08 杭州新博思生物医药有限公司 一种奥司他韦对映异构体的制备方法
CN110194728B (zh) * 2019-06-19 2021-04-30 湖南华腾制药有限公司 磷酸奥司他韦中间体的连续化合成方法
WO2022022448A1 (zh) * 2020-07-29 2022-02-03 广州市恒诺康医药科技有限公司 神经氨酸酶抑制剂类化合物、其药物组合物及其用途
CN116375595A (zh) * 2023-03-31 2023-07-04 重庆医药高等专科学校 一种磷酸奥司他韦的制备方法及精制方法
CN116666669B (zh) * 2023-07-25 2023-10-03 四川大学 VN负载的Ir团簇及其制备方法与其在催化剂中的用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ288492B6 (en) * 1990-04-24 2001-06-13 Biota Scient Management Derivatives of alpha-D-neuraminic acid, process of their preparation, their use and pharmaceutical preparations based thereon
WO1992006691A1 (en) * 1990-10-19 1992-04-30 Biota Scientific Management Pty. Ltd. Anti-viral compounds that bind the active site of influenza neuramidase and display in vivo activity against orthomyxovirus and paramyxovirus
ATE305453T1 (de) * 1995-02-27 2005-10-15 Gilead Sciences Inc Selektive inhibitoren viraler oder bakterieller neuraminidase
US5763483A (en) * 1995-12-29 1998-06-09 Gilead Sciences, Inc. Carbocyclic compounds
DK0920410T3 (da) * 1996-08-23 2002-06-10 Gilead Sciences Inc Fremgangsmåde til fremstilling af cyclohexencarboxylatderivater

Also Published As

Publication number Publication date
EA003989B1 (ru) 2003-12-25
NZ502988A (en) 2002-08-28
JP2001516739A (ja) 2001-10-02
ID25516A (id) 2000-10-05
EA200000332A1 (ru) 2000-10-30
AU9569498A (en) 1999-04-05
IL134691A0 (en) 2001-04-30
KR20010024123A (ko) 2001-03-26
CN1272105A (zh) 2000-11-01
AR013960A1 (es) 2001-01-31
EP1015417A1 (en) 2000-07-05
BR9812649A (pt) 2000-08-22
AU747702B2 (en) 2002-05-16
WO1999014185A1 (en) 1999-03-25
IN190983B (tr) 2003-09-06
CA2303323A1 (en) 1999-03-25

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