SG45864A1 - Novel selective inhibitors of viral or bacterial neuraminidases - Google Patents

Novel selective inhibitors of viral or bacterial neuraminidases

Info

Publication number
SG45864A1
SG45864A1 SG1997004840A SG1997004840A SG45864A1 SG 45864 A1 SG45864 A1 SG 45864A1 SG 1997004840 A SG1997004840 A SG 1997004840A SG 1997004840 A SG1997004840 A SG 1997004840A SG 45864 A1 SG45864 A1 SG 45864A1
Authority
SG
Singapore
Prior art keywords
viral
selective inhibitors
neuraminidase
compounds
novel selective
Prior art date
Application number
SG1997004840A
Other languages
English (en)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27410155&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG45864(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/476,946 external-priority patent/US5866601A/en
Application filed filed Critical
Publication of SG45864A1 publication Critical patent/SG45864A1/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D309/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/16Antivirals for RNA viruses for influenza or rhinoviruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
SG1997004840A 1995-02-27 1996-02-26 Novel selective inhibitors of viral or bacterial neuraminidases SG45864A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US39524595A 1995-02-27 1995-02-27
US08/476,946 US5866601A (en) 1995-02-27 1995-06-06 Carbocyclic compounds
US58056795A 1995-12-29 1995-12-29
PCT/US1996/002882 WO1996026933A1 (en) 1995-02-27 1996-02-26 Novel selective inhibitors of viral or bacterial neuraminidases

Publications (1)

Publication Number Publication Date
SG45864A1 true SG45864A1 (en) 1999-04-27

Family

ID=27410155

Family Applications (1)

Application Number Title Priority Date Filing Date
SG1997004840A SG45864A1 (en) 1995-02-27 1996-02-26 Novel selective inhibitors of viral or bacterial neuraminidases

Country Status (27)

Country Link
US (3) US5952375A (ja)
EP (1) EP0759917B1 (ja)
JP (3) JP3300365B2 (ja)
KR (1) KR100447096B1 (ja)
CN (2) CN1185223C (ja)
AT (2) ATE191711T1 (ja)
AU (1) AU720933B2 (ja)
BR (2) BR9607098A (ja)
CZ (1) CZ297945B6 (ja)
DE (4) DE69607704T2 (ja)
DK (1) DK0759917T3 (ja)
ES (2) ES2118674T3 (ja)
GR (1) GR3033914T3 (ja)
HK (1) HK1026893A1 (ja)
HU (1) HU228450B1 (ja)
LU (1) LU90991I2 (ja)
MX (1) MX9706496A (ja)
NL (1) NL300105I2 (ja)
NO (1) NO318455B1 (ja)
NZ (1) NZ306625A (ja)
PL (1) PL194173B1 (ja)
PT (1) PT759917E (ja)
RU (1) RU2181357C2 (ja)
SG (1) SG45864A1 (ja)
SI (1) SI9620042A (ja)
UA (1) UA56128C2 (ja)
WO (1) WO1996026933A1 (ja)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU228450B1 (en) * 1995-02-27 2013-03-28 Gilead Sciences Inc Novel selective inhibitors of viral or bacterial neuraminidases
US5714509A (en) * 1995-05-03 1998-02-03 The University Of Alabama Inhibitors of bacterial sialidase and methods of making and using the same
US5763483A (en) * 1995-12-29 1998-06-09 Gilead Sciences, Inc. Carbocyclic compounds
US6093816A (en) 1996-06-27 2000-07-25 Isis Pharmaceuticals, Inc. Cationic lipids
US6518438B2 (en) 1996-08-23 2003-02-11 Gilead Sciences, Inc. Preparation of cyclohexene carboxylate derivatives
US5859284A (en) * 1996-08-23 1999-01-12 Gilead Sciences, Inc. Preparation of carbocyclic compounds
NZ507106A (en) * 1996-08-23 2003-01-31 Gilead Sciences Inc Preparation of cyclohexene carboxylate derivatives
US5994377A (en) * 1996-10-21 1999-11-30 Gilead Sciences, Inc. Piperidine compounds
KR20000052702A (ko) * 1996-10-21 2000-08-25 헨슬레이 맥스 디. 피페리딘 화합물
CA2271249C (en) * 1996-11-14 2010-07-20 Biota Scientific Management Pty. Ltd. Macromolecular neuraminidase-binding compounds
WO1999006369A1 (en) * 1997-08-01 1999-02-11 University Of Florida Neuraminidase inhibitors
US5886213A (en) * 1997-08-22 1999-03-23 Gilead Sciences, Inc. Preparation of carbocyclic compounds
WO1999014185A1 (en) * 1997-09-17 1999-03-25 Gilead Sciences, Inc. Compounds containing six-membered rings, processes for their preparation, and their use as medicaments
US20040053999A1 (en) * 1997-09-17 2004-03-18 Bischofberger Norbert W. Novel compounds and methods for synthesis and therapy
TW477783B (en) * 1997-12-12 2002-03-01 Gilead Sciences Inc Novel compounds useful as neuraminidase inhibitors and pharmaceutical compositions containing same
CN1282316A (zh) * 1997-12-17 2001-01-31 生物晶体药品股份有限公司 用作神经氨酸酶抑制剂的取代环戊烷和环戊烯化合物
US6518305B1 (en) 1998-04-23 2003-02-11 Abbott Laboratories Five-membered carbocyclic and heterocyclic inhibitors of neuraminidases
US6455571B1 (en) 1998-04-23 2002-09-24 Abbott Laboratories Inhibitors of neuraminidases
TR200003065T2 (tr) * 1998-04-23 2001-02-21 Abbott Laboratories Nöraminidazların inhibitörleri olarak pirolidinler.
DE69900483T2 (de) * 1998-05-13 2002-06-27 Hoffmann La Roche Verfahren zur Herstellung von Shikiminsäure und deren Derivate
AU1476900A (en) * 1998-11-13 2000-06-05 Gilead Sciences, Inc. 1,4,5,6-tetrahydro-pyridazine derivatives, their preparation and their use as neuraminidase inhibitors
AUPP913999A0 (en) * 1999-03-12 1999-04-01 Biota Scientific Management Pty Ltd Novel chemical compounds and their use
ES2198244T3 (es) * 1999-06-11 2004-02-01 F. Hoffmann-La Roche Ag Procedimiento para la preparacion de inhibidor ro-64-0796 de la neuraminidasa.
DE19930177B4 (de) 1999-06-30 2007-02-08 Nikolai Vladimirovich Bovin Intermolekular assoziierende Verbindungen und deren Verwendung
WO2001028981A1 (en) * 1999-10-19 2001-04-26 Abbott Laboratories 1-cyclohexene-1-carboxylic acid and 1-cyclohexene-1-carboxylates as neuraminidase inhibitors
US6593314B1 (en) 1999-10-19 2003-07-15 Abbott Laboratories Neuraminidase inhibitors
US6627396B1 (en) * 1999-10-28 2003-09-30 The Regents Of The University Of California Influenza sensor
JP2001131144A (ja) * 1999-11-02 2001-05-15 Sagami Chem Res Center 7−アザビシクロ[4.1.0]ヘプト−3−エン−3−カルボン酸エステル類の製造方法
US6462226B1 (en) * 1999-12-03 2002-10-08 Hoffmann-La Roche Inc. Process for the preparation of 4,5-diamino shikimic acid derivatives
CN1184216C (zh) * 1999-12-27 2005-01-12 财团法人相模中央化学研究所 制备5-氧代-7-氧杂双环[4.1.0]庚-3-烯-3-羧酸酯的方法
US8642051B2 (en) * 2000-03-21 2014-02-04 Suzanne Jaffe Stillman Method of hydration; infusion packet system(s), support member(s), delivery system(s), and method(s); with business model(s) and Method(s)
AU2001252578A1 (en) * 2000-04-25 2001-11-07 Sankyo Company Limited Preventives for influenza
GB0015324D0 (en) * 2000-06-22 2000-08-16 Biota Scient Management Medicaments
SI1296656T1 (sl) 2000-06-27 2006-12-31 Hoffmann La Roche Postopek priprave sestavka
AUPR001000A0 (en) 2000-09-08 2000-10-05 Biota Scientific Management Pty Ltd Novel chemical compounds and their use
WO2002092555A1 (fr) * 2001-05-11 2002-11-21 Sankyo Company, Limited Derives d'acides sialiques
US6964784B2 (en) * 2002-03-07 2005-11-15 Optigenex, Inc. Method of preparation and composition of a water soluble extract of the bioactive component of the plant species uncaria for enhancing immune, anti-inflammatory, anti-tumor and dna repair processes of warm blooded animals
US7807174B2 (en) * 2002-11-22 2010-10-05 Nexbio, Inc. Class of therapeutic protein based molecules
US7122684B2 (en) 2003-03-13 2006-10-17 Roche Colorado Corporation Process for preparing 1,2-diamino compounds
DE602004031115D1 (de) * 2003-06-16 2011-03-03 Acad Of Science Czech Republic Pyrimidinverbindungen mit phosphonatgruppen als antivirale nucleotidanaloga
WO2007053792A2 (en) * 2005-11-05 2007-05-10 Amplyx Pharmaceuticals, Inc. Improving the pharmacokinetics of protease inhibitors and other drugs
EP1951654B1 (en) * 2005-11-25 2011-05-25 Hetero Drugs Limited Improved process for oseltamivir phosphate
KR100819759B1 (ko) 2005-12-01 2008-04-07 (주)파인켐 아자이드 화합물의 폭발성을 제거한 공정을 이용한 1,2-다이아미노 화합물 또는 이의 부가염 제조 방법
EP2178819A2 (en) * 2005-12-28 2010-04-28 F.Hoffmann-La Roche Ag Epoxide intermediate in the tamiflu synthesis
AU2007218733B2 (en) 2006-02-20 2012-11-15 Chugai Seiyaku Kabushiki Kaisha Pharmaceutical composition comprising oseltamivir phosphate
US20080063722A1 (en) * 2006-09-08 2008-03-13 Advanced Inhalation Research, Inc. Composition of a Spray-Dried Powder for Pulmonary Delivery of a Long Acting Neuraminidase Inhibitor (LANI)
US20080306098A1 (en) * 2006-11-06 2008-12-11 Mutz Mitchell W Pharmacokinetics of protease inhibitors and other drugs
WO2008090151A1 (en) 2007-01-23 2008-07-31 Therapicon Srl Antiviral compounds
US20080194801A1 (en) * 2007-02-14 2008-08-14 Swanson Basil I Robust multidentate ligands for diagnosis and anti-viral drugs for influenza and related viruses
US8435769B2 (en) 2007-04-13 2013-05-07 Monsanto Technology Llc Use of glyphosate to produce shikimic acid in microorganisms
US20090054334A1 (en) * 2007-05-23 2009-02-26 Mutz Mitchell W Combinatorial improvement of bifunctional drug properties
CN101883569B (zh) * 2007-08-31 2013-08-21 梁启铭 具有抗流感活性之含奥司他伟膦酸酯同系物的合成
BRPI0818236B1 (pt) 2007-10-16 2020-07-21 Monsanto Technology Llc processo para recuperação do ácido chiquímico de um fluxo de processo aquoso compreendendo ainda glifosato
WO2009055042A1 (en) * 2007-10-24 2009-04-30 Amplyx Pharmaceuticals, Inc. Enhancing the efficacy of anti-infective therapeutics
WO2009078813A1 (en) * 2007-12-19 2009-06-25 Nanyang Technological University Method of forming oseltamivir and derivatives thereof
US8334319B2 (en) * 2008-01-04 2012-12-18 Roche Palo Alto Llc Polymorphic forms of oseltamivir phosphate
US20100081713A1 (en) * 2008-03-19 2010-04-01 CombinatoRx, (Singapore) Pte. Ltd. Compositions and methods for treating viral infections
WO2009129305A2 (en) 2008-04-15 2009-10-22 Tsrl, Inc. Prodrugs of neuraminidase inhibitors
TWI491416B (zh) 2008-12-24 2015-07-11 Daiichi Sankyo Co Ltd 吸入用乾燥粉末醫藥組成物
CN101486664B (zh) * 2008-12-31 2013-09-04 北京大学深圳研究生院 用作流感病毒神经氨酸酶抑制剂的多取代五元环小分子化合物
EP2429991B1 (en) 2009-05-15 2014-09-10 Redx Pharma Limited Redox drug derivatives
WO2011021223A2 (en) * 2009-08-19 2011-02-24 Msn Laboratories Limited Novel salts of ethyl (3r, 4s, 5r)-4,5-imino-3-(l-ethylpropoxy)-1- cvclohexene-1-carboxylate and its use
WO2011059994A2 (en) * 2009-11-11 2011-05-19 3M Innovative Properties Company Polymeric compositions and method of making and articles thereof
IT1396620B1 (it) 2009-11-25 2012-12-14 Therapicon Srl Analoghi chimerici
US20130131126A1 (en) 2010-07-16 2013-05-23 Jsc Grindeks Derivatives of 1,4-dihydropyridine possessing antiviral efficacy
AT510585B1 (de) * 2010-11-18 2012-05-15 Apeptico Forschung & Entwicklung Gmbh Zusammensetzung umfassend ein peptid und ein hemmstoff der viralen neuraminidase
KR101369584B1 (ko) 2011-04-19 2014-03-06 일양약품주식회사 페닐-이속사졸 유도체 및 그의 제조방법
EP2578218A1 (en) 2011-10-06 2013-04-10 Grindeks, A Joint Stock Company Antiviral efficacy of disodium 2,6-dimethyl-1,4-dihydropyridine-3,5-bis(carbonyloxyacetate) and its derivatives
DE102011117128A1 (de) * 2011-10-28 2013-05-02 Christian-Albrechts-Universität Zu Kiel Verbindungen zur Therapie der Influenza
RU2469020C1 (ru) * 2011-11-08 2012-12-10 Александр Васильевич Иващенко (3r,4r,5s)-5-амино-4-ациламино-3-(1-этил-пропокси)-циклогекс-1-ен-карбоновые кислоты, их эфиры и способ применения
RU2489422C1 (ru) * 2012-05-12 2013-08-10 Александр Васильевич Иващенко Фторзамещенные (3r,4r,5s)-5-гуанидино-4-ациламино-3-(пентан-3-илокси)циклогексен-1-карбоновые кислоты, их эфиры и способ применения
RU2521593C1 (ru) * 2013-02-27 2014-06-27 Общество с ограниченной ответственностью "Интеллектуальный Диалог" Моно и дифторзамещенные этил (3r,4r,5s)-5-азидо-4-ацетиламино-3-(1-этилпропокси)-циклогексен-1-карбоксилаты, способ получения и применения
JP6453050B2 (ja) * 2013-11-15 2019-01-16 国立大学法人富山大学 2−デオキシ−2,3−ジデヒドロシアル酸誘導体およびその製造法
CN103819357B (zh) * 2014-01-28 2016-03-16 浙江大学 (-)-有效霉醇叠氮四乙酸酯的制备方法
US9950989B2 (en) 2014-02-14 2018-04-24 Toa Eiyo Ltd. Cyclic hydrocarbon compound
WO2015173701A2 (en) 2014-05-12 2015-11-19 Glaxosmithkline Intellectual Property (No. 2) Limited Pharmaceutical compositions for treating infectious diseases
US9392814B2 (en) 2014-06-06 2016-07-19 Nicholas J. Singer Delivery system for drinks
GB2532178A (en) * 2014-06-09 2016-05-18 Redx Pharma Plc Antiviral compounds
SG11201705069YA (en) 2014-12-26 2017-07-28 Univ Emory N4-hydroxycytidine and derivatives and anti-viral uses related thereto
USD773313S1 (en) 2015-06-23 2016-12-06 Nicholas J. Singer Package
EP3389787B1 (en) 2015-12-17 2024-05-15 Thomas Jefferson University Sulfonamide derivatives as antiviral agents for drug-resistant influenza a
KR102339817B1 (ko) 2016-06-30 2021-12-16 한미약품 주식회사 오셀타미비어 함유 경구용 고형제제 및 그 제조방법
CN110494141A (zh) * 2016-08-10 2019-11-22 盐野义制药株式会社 含有被取代的多环性吡啶酮衍生物及其前药的药物组合物
EP3706762A4 (en) 2017-12-07 2021-09-01 Emory University N4-HYDROXYCYTIDINE AND DERIVATIVES AND ANTIVIRAL USES IN RELATION TO IT
KR20200106607A (ko) 2019-03-05 2020-09-15 주식회사 코아팜바이오 오셀타미비르 함유 의약 조성물

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4968788A (en) * 1986-04-04 1990-11-06 Board Of Regents, The University Of Texas System Biologically reversible phosphate and phosphonate protective gruops
US5206400A (en) * 1986-07-07 1993-04-27 Ohio State University Diastereomeric mono- and di-substituted diamino cyclohexane compounds and the method of preparation thereof
US5175273A (en) * 1988-07-01 1992-12-29 Genentech, Inc. Nucleic acid intercalating agents
US5270340A (en) * 1988-12-27 1993-12-14 Bayer Aktiengesellschaft Substituted 2-cyclohexen-1-yl-amine fungicidal and herbicidal agents
AP249A (en) * 1990-04-24 1993-03-17 Biota Scient Management Pty Ltd Anti-viral compounds.
WO1992006691A1 (en) * 1990-10-19 1992-04-30 Biota Scientific Management Pty. Ltd. Anti-viral compounds that bind the active site of influenza neuramidase and display in vivo activity against orthomyxovirus and paramyxovirus
DE4033415A1 (de) * 1990-10-20 1992-04-23 Bayer Ag Antimikrobielle mittel sowie substituierte 2-cyclohexan-1-yl-amin-derivate und deren herstellung
DE4131311A1 (de) * 1991-09-20 1993-04-01 Basf Ag Dihydropyranderivate und diese enthaltende pflanzenschutzmittel
AU659501B2 (en) * 1991-10-23 1995-05-18 Biota Scientific Management Pty Ltd Antiviral 4-substituted-2-deoxy-2,3-didehydro-derivatives of alpha-D-neuraminic acid
GB9126725D0 (en) * 1991-12-17 1992-02-12 Glaxo Group Ltd Process
FR2687674B1 (fr) * 1992-02-07 1995-05-19 Roussel Uclaf Nouveaux derives de la pyridone, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant.
US5292938A (en) * 1992-04-13 1994-03-08 Associated Universities, Inc. Synthesis of 4-substituted-trans-1, 2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation of stable radiometal antibody immunoconjugates for therapy and spect and pet imaging
US5633360A (en) 1992-04-14 1997-05-27 Gilead Sciences, Inc. Oligonucleotide analogs capable of passive cell membrane permeation
GB9220241D0 (en) * 1992-09-25 1992-11-11 Glaxo Group Ltd Process
GB9220327D0 (en) * 1992-09-25 1992-11-11 Glaxo Group Ltd Process
US5639786A (en) * 1992-12-04 1997-06-17 Biota Scientific Management, Pty., Ltd. Antiviral 4-substituted-2-deoxy-2,3-didehydro-derivatives of α-D-neuraninic acid
US5514798A (en) * 1993-06-02 1996-05-07 Gilead Sciences, Inc. Method and cyclic carbonates for nucleotide analogues
GB9311873D0 (en) * 1993-06-09 1993-07-28 Glaxo Group Ltd Process
US5819730A (en) * 1993-06-09 1998-10-13 Glaxo Wellcome Australia Ltd. Device for administering pharmaceutical substances
GB9312531D0 (en) * 1993-06-17 1993-08-04 Glaxo Group Ltd Process
GB9325841D0 (en) * 1993-12-17 1994-02-23 Glaxo Group Ltd Chemical compounds
GB9400206D0 (en) * 1994-01-07 1994-03-02 Glaxo Group Ltd Chemical compound
AUPM354694A0 (en) * 1994-01-27 1994-02-17 Biota Scientific Management Pty Ltd Chemical compounds
US5985859A (en) * 1994-04-14 1999-11-16 The University Of Alabama Methods of inhibiting bacterial sialidase
GB9410817D0 (en) * 1994-05-28 1994-07-20 Glaxo Group Ltd Medicaments
AUPM725794A0 (en) * 1994-08-03 1994-08-25 Biota Scientific Management Pty Ltd Chemical compounds
US5556963A (en) * 1994-08-05 1996-09-17 Oklahoma Medical Research Foundation Synthesis of 4-alkoxy-N-acetylneuraminic acid
US5512596A (en) * 1994-09-02 1996-04-30 Gilead Sciences, Inc. Aromatic compounds
CA2203570A1 (en) 1994-11-04 1996-05-17 Lawrence R. Mcgee Thiepane compounds inhibiting and detecting hiv protease
HU228450B1 (en) * 1995-02-27 2013-03-28 Gilead Sciences Inc Novel selective inhibitors of viral or bacterial neuraminidases
US5866601A (en) * 1995-02-27 1999-02-02 Gilead Sciences, Inc. Carbocyclic compounds
US5602277A (en) 1995-03-30 1997-02-11 Biocryst Pharmaceuticals, Inc. Substituted benzene derivatives useful as neuraminidase inhibitors
US5714509A (en) * 1995-05-03 1998-02-03 The University Of Alabama Inhibitors of bacterial sialidase and methods of making and using the same
GB9510141D0 (en) 1995-05-19 1995-07-12 Biota Scient Management Chemical compounds
HUP9801766A3 (en) * 1995-05-19 2000-09-28 Biota Scient Managemant Pty Lt 6-carboxamido dihydropyran derivatives, process for producing them and medicaments containing the same
GB9525389D0 (en) 1995-12-12 1996-02-14 Biota Scient Management Ltd Chemical compounds
GB9516276D0 (en) * 1995-08-08 1995-10-11 Biota Scient Management Chemical compounds
US5763483A (en) * 1995-12-29 1998-06-09 Gilead Sciences, Inc. Carbocyclic compounds
NZ507106A (en) 1996-08-23 2003-01-31 Gilead Sciences Inc Preparation of cyclohexene carboxylate derivatives
US5859284A (en) 1996-08-23 1999-01-12 Gilead Sciences, Inc. Preparation of carbocyclic compounds
AU711845B2 (en) * 1996-09-10 1999-10-21 Daikin Industries, Ltd. 4-substituted-2,7-dideoxy-7-fluoro-2,3-didehydro-sialic acid compounds
US5886213A (en) 1997-08-22 1999-03-23 Gilead Sciences, Inc. Preparation of carbocyclic compounds

Also Published As

Publication number Publication date
PL322000A1 (en) 1998-01-05
HUP9800026A2 (hu) 1999-09-28
HK1026893A1 (en) 2000-12-29
NO973908L (no) 1997-10-27
JP4234917B2 (ja) 2009-03-04
US5952375A (en) 1999-09-14
EP0759917B1 (en) 2000-04-12
NZ306625A (en) 2001-04-27
ES2118674T1 (es) 1998-10-01
CN100409844C (zh) 2008-08-13
MX9706496A (es) 1997-11-29
ES2249863T3 (es) 2006-04-01
DK0759917T3 (da) 2000-07-31
AU5357196A (en) 1996-09-18
ES2118674T3 (es) 2000-08-16
JP3300365B2 (ja) 2002-07-08
DE10299052I1 (de) 2003-05-22
BR9607098B8 (pt) 2014-11-18
DE69607704T2 (de) 2000-12-28
CN1347693A (zh) 2002-05-08
ATE191711T1 (de) 2000-04-15
SI9620042A (sl) 1998-12-31
CZ297945B6 (cs) 2007-05-02
AU720933B2 (en) 2000-06-15
PL194173B1 (pl) 2007-05-31
DE69635231T2 (de) 2006-07-13
HU228450B1 (en) 2013-03-28
LU90991I2 (fr) 2003-02-11
KR19980703600A (ko) 1998-12-05
WO1996026933A1 (en) 1996-09-06
DE759917T1 (de) 1998-10-22
US6225341B1 (en) 2001-05-01
KR100447096B1 (ko) 2005-10-11
NL300105I1 (nl) 2003-01-06
NO973908D0 (no) 1997-08-26
BR9607098A (pt) 1997-11-04
HUP9800026A3 (en) 2002-04-29
UA56128C2 (uk) 2003-05-15
EP0759917A1 (en) 1997-03-05
JP2006036770A (ja) 2006-02-09
ATE305453T1 (de) 2005-10-15
NO318455B1 (no) 2005-03-21
DE69635231D1 (de) 2006-02-09
CN1147813A (zh) 1997-04-16
GR3033914T3 (en) 2000-11-30
JP2002161074A (ja) 2002-06-04
JPH11501908A (ja) 1999-02-16
PT759917E (pt) 2000-10-31
DE69607704D1 (de) 2000-05-18
RU2181357C2 (ru) 2002-04-20
CN1185223C (zh) 2005-01-19
CZ269097A3 (en) 1997-11-12
NL300105I2 (nl) 2003-02-03
US20050176758A1 (en) 2005-08-11

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